{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:45:16Z","timestamp":1792449916566,"version":"4.5.0"},"reference-count":110,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Post-viral fatigue syndrome (PVFS) encompasses a wide range of complex neuroimmune disorders of unknown causes characterised by disabling post-exertional fatigue, myalgia and joint pain, cognitive impairments, unrefreshing sleep, autonomic dysfunction, and neuropsychiatric symptoms. It includes myalgic encephalomyelitis, also known as chronic fatigue syndrome (ME\/CFS); fibromyalgia (FM); and more recently post-COVID-19 condition (long COVID). To date, there are no definitive clinical case criteria and no FDA-approved pharmacological therapies for PVFS. Given the current lack of effective treatments, there is a need to develop novel therapeutic strategies for these disorders. Mitochondria, the cellular organelles responsible for tissue energy production, have recently garnered attention in research into PVFS due to their crucial role in cellular bioenergetic metabolism in these conditions. The accumulating literature has identified a link between mitochondrial dysfunction and low-grade systemic inflammation in ME\/CFS, FM, and long COVID. To address this issue, this article aims to critically review the evidence relating to mitochondrial dysfunction in the pathogenesis of these disorders; in particular, it aims to evaluate the effectiveness of coenzyme Q10 supplementation on chronic fatigue and pain symptoms as a novel therapeutic strategy for the treatment of PVFS.<\/jats:p>","DOI":"10.3390\/ijms25010574","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T13:02:58Z","timestamp":1704114178000},"page":"574","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview"],"prefix":"10.3390","volume":"25","author":[{"given":"David","family":"Mantle","sequence":"first","affiliation":[{"name":"Pharma Nord (UK) Ltd., Morpeth, Northumberland NE61 2DB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain Parry","family":"Hargreaves","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6356-0836","authenticated-orcid":false,"given":"Joan Carles","family":"Domingo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2481-3052","authenticated-orcid":false,"given":"Jesus","family":"Castro-Marrero","sequence":"additional","affiliation":[{"name":"Research Unit in ME\/CFS and Long COVID, Rheumatology Division, Vall d\u2019Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1187163","DOI":"10.3389\/fmed.2023.1187163","article-title":"ME\/CFS and Long COVID share similar symptoms and biological abnormalities: Road map to the literature","volume":"10","author":"Komaroff","year":"2023","journal-title":"Front. Med."},{"key":"ref_2","first-page":"82","article-title":"Chronic \u201cpost-infectious\u201d fatigue syndrome","volume":"76","author":"Komaroff","year":"1993","journal-title":"Trans. Am. Acad. Insur. Med."},{"key":"ref_3","first-page":"20499361211009385","article-title":"COVID-19 and post-infectious myalgic encephalomyelitis\/chronic fatigue syndrome: A narrative review","volume":"8","author":"Poenaru","year":"2021","journal-title":"Ther. Adv. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3390\/pathophysiology29030033","article-title":"Autoimmune Autonomic Dysfunction Syndromes: Potential Involvement and Pathophysiology Related to Complex Regional Pain Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Silicone Breast Implant-Related Symptoms and Post-COVID Syndrome","volume":"29","author":"Mahroum","year":"2022","journal-title":"Pathophysiology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/fampra\/cmi021","article-title":"The prognosis of different fatigue diagnostic labels: A longitudinal survey","volume":"22","author":"Hamilton","year":"2005","journal-title":"Fam. Pract."},{"key":"ref_6","first-page":"146","article-title":"Enteroviruses and postviral fatigue syndrome","volume":"173","author":"Behan","year":"1993","journal-title":"Ciba Found. Symp."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"735784","DOI":"10.3389\/fpsyt.2021.735784","article-title":"Clinical Heterogeneity in ME\/CFS. A Way to Understand Long-COVID19 Fatigue","volume":"12","author":"Murga","year":"2021","journal-title":"Front. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/bph.13702","article-title":"Treatment and management of chronic fatigue syndrome\/myalgic encephalomyelitis: All roads lead to Rome","volume":"174","author":"Santillo","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1126\/science.abo1261","article-title":"Understanding myalgic encephalomyelitis","volume":"377","year":"2022","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e2849","DOI":"10.1002\/brb3.2849","article-title":"Fatigue after COVID-19 in non-hospitalized patients according to sex","volume":"13","author":"Mazurkiewicz","year":"2023","journal-title":"Brain Behav."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.reuma.2015.05.007","article-title":"Gender differences in chronic fatigue syndrome","volume":"12","author":"Faro","year":"2016","journal-title":"Reumatol. Clin."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1090747","DOI":"10.3389\/fneur.2023.1090747","article-title":"Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic","volume":"14","author":"Bonilla","year":"2023","journal-title":"Front. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"101794","DOI":"10.1016\/j.berh.2022.101794","article-title":"Long COVID and rheumatology: Clinical, diagnostic, and therapeutic implications","volume":"36","author":"Calabrese","year":"2022","journal-title":"Best. Pract. Res. Clin. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/ijpvm.ijpvm_508_21","article-title":"Post-COVID-19 Syndrome Mechanisms, Prevention and Management","volume":"14","author":"Najafi","year":"2023","journal-title":"Int. J. Prev. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13643-023-02250-0","article-title":"A systematic review and meta-analysis of long COVID symptoms","volume":"12","author":"Natarajan","year":"2023","journal-title":"Syst. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e13989","DOI":"10.1111\/eci.13989","article-title":"The definition of long COVID used in interventional studies","volume":"53","author":"Haslam","year":"2023","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Arabi, M., Al-Najjar, Y., Sharma, O., Kamal, I., Javed, A., Gohil, H.S., Paul, P., Al-Khalifa, A.M., Laws, S., and Zakaria, D. (2023). Role of previous infection with SARS-CoV-2 in protecting against omicron reinfections and severe complications of COVID-19 compared to pre-omicron variants: A systematic review. BMC Infect. Dis., 23.","DOI":"10.1186\/s12879-023-08328-3"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/eurheartj\/ehac031","article-title":"Long COVID: Post-acute sequelae of COVID-19 with a cardiovascular focus","volume":"43","author":"Raman","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/apa.15673","article-title":"Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19","volume":"110","author":"Ludvigsson","year":"2021","journal-title":"Acta Paediatr."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tate, W.P., Walker, M.O.M., Peppercorn, K., Blair, A.L.H., and Edgar, C.D. (2023). Towards a Better Understanding of the Complexities of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome and Long COVID. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065124"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e2315","DOI":"10.1002\/rmv.2315","article-title":"Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies","volume":"32","author":"Yong","year":"2022","journal-title":"Rev. Med. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/pm\/pnab308","article-title":"Pain-Related Post-Exertional Malaise in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) and Fibromyalgia: A Systematic Review and Three-Level Meta-Analysis","volume":"23","author":"Barhorst","year":"2022","journal-title":"Pain. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Cardinali, D.P., Brown, G.M., and Pandi-Perumal, S.R. (2022). Possible Application of Melatonin in Long COVID. Biomolecules, 12.","DOI":"10.3390\/biom12111646"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1089\/acm.2008.0376","article-title":"Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis\/chronic fatigue syndrome and fibromyalgia","volume":"16","author":"Porter","year":"2010","journal-title":"J. Altern. Complement. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1177\/17423953221113605","article-title":"Patient-led integrated cognitive behavioural therapy for management of long COVID with comorbid depression and anxiety in primary care\u2014A case study","volume":"18","author":"Skilbeck","year":"2022","journal-title":"Chronic Illn."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e28373","DOI":"10.1002\/jmv.28373","article-title":"Effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome","volume":"95","author":"Parker","year":"2023","journal-title":"J. Med. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Annesley, S.J., and Fisher, P.R. (2019). Mitochondria in Health and Disease. Cells, 8.","DOI":"10.3390\/cells8070680"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"San-Millan, I. (2023). The Key Role of Mitochondrial Function in Health and Disease. Antioxidants, 12.","DOI":"10.3390\/antiox12040782"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1172\/JCI61398","article-title":"A mitochondrial bioenergetic etiology of disease","volume":"123","author":"Wallace","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"606824","DOI":"10.3389\/fmed.2020.606824","article-title":"Will COVID-19 Lead to Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome?","volume":"7","author":"Komaroff","year":"2020","journal-title":"Front. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.molmed.2021.06.002","article-title":"Insights from myalgic encephalomyelitis\/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome","volume":"27","author":"Komaroff","year":"2021","journal-title":"Trends Mol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12967-020-02452-3","article-title":"A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis\/chronic fatigue syndrome\/systemic exertion intolerance disease","volume":"18","author":"Holden","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_33","first-page":"1","article-title":"Chronic fatigue syndrome and mitochondrial dysfunction","volume":"2","author":"Myhill","year":"2009","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1089\/ars.2013.5346","article-title":"Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia?","volume":"19","author":"Cordero","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e6500","DOI":"10.7717\/peerj.6500","article-title":"Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types","volume":"7","author":"Tomas","year":"2019","journal-title":"PeerJ"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(84)91871-3","article-title":"Excessive intracellular acidosis of skeletal muscle on exercise in a patient with a post-viral exhaustion\/fatigue syndrome. A 31P nuclear magnetic resonance study","volume":"1","author":"Arnold","year":"1984","journal-title":"Lancet"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000119233","article-title":"Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome","volume":"32","author":"Plioplys","year":"1995","journal-title":"Neuropsychobiology"},{"key":"ref_38","first-page":"183","article-title":"Is SARS-CoV-2 the only cause of long-COVID?","volume":"24","author":"Trevino","year":"2022","journal-title":"AIDS Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1125208","DOI":"10.3389\/fnins.2023.1125208","article-title":"Brainstem volume changes in myalgic encephalomyelitis\/chronic fatigue syndrome and long COVID patients","volume":"17","author":"Thapaliya","year":"2023","journal-title":"Front. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Tomas, C., Brown, A., Strassheim, V., Elson, J.L., Newton, J., and Manning, P. (2017). Cellular bioenergetics is impaired in patients with chronic fatigue syndrome. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186802"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.mito.2011.05.005","article-title":"Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome","volume":"11","author":"Smits","year":"2011","journal-title":"Mitochondrion"},{"key":"ref_42","first-page":"169","article-title":"Oxidative stress and mitochondrial dysfunction in fibromyalgia","volume":"31","author":"Cordero","year":"2010","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/path.5471","article-title":"Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19)","volume":"251","author":"Bourgonje","year":"2020","journal-title":"J. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"C258","DOI":"10.1152\/ajpcell.00224.2020","article-title":"Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis","volume":"319","author":"Singh","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tcb.2020.01.006","article-title":"Mitochondrial Functions in Infection and Immunity","volume":"30","author":"Tiku","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41586-020-2332-7","article-title":"Proteomics of SARS-CoV-2-infected host cells reveals therapy targets","volume":"583","author":"Bojkova","year":"2020","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s10020-018-0046-1","article-title":"Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis patients","volume":"24","author":"Cabanas","year":"2018","journal-title":"Mol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s10020-019-0083-4","article-title":"Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome\/ Myalgic Encephalomyelitis patients","volume":"25","author":"Cabanas","year":"2019","journal-title":"Mol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"687806","DOI":"10.3389\/fimmu.2021.687806","article-title":"Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment","volume":"12","author":"Cabanas","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.3389\/fimmu.2019.02545","article-title":"Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells from Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome Patients","volume":"10","author":"Cabanas","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Missailidis, D., Annesley, S.J., and Fisher, P.R. (2019). Pathological Mechanisms Underlying Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome. Diagnostics, 9.","DOI":"10.20944\/preprints201907.0196.v1"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s12035-013-8553-0","article-title":"The emerging role of autoimmunity in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/cfs)","volume":"49","author":"Morris","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1097\/j.pain.0000000000001996","article-title":"A genetic polymorphism that is associated with mitochondrial energy metabolism increases risk of fibromyalgia","volume":"161","author":"Parisien","year":"2020","journal-title":"Pain"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ovrom, E.A., Mostert, K.A., Khakhkhar, S., McKee, D.P., Yang, P., and Her, Y.F. (2023). A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia. Biomedicines, 11.","DOI":"10.3390\/biomedicines11041119"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1186\/s12967-022-03815-8","article-title":"Genetic risk factors for ME\/CFS identified using combinatorial analysis","volume":"20","author":"Das","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Campisi, L., and La Motta, C. (2022). The Use of the Coenzyme Q10 as a Food Supplement in the Management of Fibromyalgia: A Critical Review. Antioxidants, 11.","DOI":"10.3390\/antiox11101969"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Fernandez-Araque, A., Verde, Z., Torres-Ortega, C., Sainz-Gil, M., Velasco-Gonzalez, V., Gonzalez-Bernal, J.J., and Mielgo-Ayuso, J. (2022). Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia\u2014A Systematic Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092462"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-3-030-55035-6_5","article-title":"Targeted Treatment of Age-Related Fibromyalgia with Supplemental Coenzyme Q10","volume":"1286","author":"Hargreaves","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Lowry, E., Marley, J., McVeigh, J.G., McSorley, E., Allsopp, P., and Kerr, D. (2020). Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis. Nutrients, 12.","DOI":"10.3390\/nu12092664"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ctim.2019.01.022","article-title":"Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies","volume":"43","author":"Mehrabani","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1089\/ars.2014.6181","article-title":"Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?","volume":"22","author":"Cordero","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.clnu.2015.07.010","article-title":"Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome: A randomized, controlled, double-blind trial","volume":"35","author":"Segundo","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Castro-Marrero, J., Segundo, M.J., Lacasa, M., Martinez-Martinez, A., Sentanes, R.S., and Alegre-Martin, J. (2021). Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 13.","DOI":"10.3390\/nu13082658"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1089\/ars.2022.0018","article-title":"Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome?","volume":"36","author":"Domingo","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trsl.2018.07.014","article-title":"Mitochondria in innate immune signaling","volume":"202","author":"Banoth","year":"2018","journal-title":"Transl. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6974","DOI":"10.1128\/JVI.01918-14","article-title":"MAVS Coordination of Antiviral Innate Immunity","volume":"89","author":"Vazquez","year":"2015","journal-title":"J. Virol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00018-022-04469-x","article-title":"The double-membrane vesicle (DMV): A virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses","volume":"79","author":"Roingeard","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.tim.2020.05.009","article-title":"Double-Membrane Vesicles as Platforms for Viral Replication","volume":"28","author":"Wolff","year":"2020","journal-title":"Trends Microbiol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Singh, S.P., Amar, S., Gehlot, P., Patra, S.K., Kanwar, N., and Kanwal, A. (2021). Mitochondrial Modulations, Autophagy Pathways Shifts in Viral Infections: Consequences of COVID-19. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158180"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41423-021-00807-4","article-title":"SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy","volume":"19","author":"Li","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Dutta, S., Das, N., and Mukherjee, P. (2020). Picking up a Fight: Fine Tuning Mitochondrial Innate Immune Defenses Against RNA Viruses. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.01990"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"693","DOI":"10.4149\/BLL_2020_113","article-title":"The importance of coenzyme Q10 and its ratio to cholesterol in the progress of chronic kidney diseases linked to non-communicable diseases","volume":"121","author":"Gvozdjakova","year":"2020","journal-title":"Bratisl. Med. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10238-022-00871-8","article-title":"Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome","volume":"23","author":"Barletta","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"100539","DOI":"10.1016\/j.lanepe.2022.100539","article-title":"High-dose coenzyme Q10 therapy versus placebo in patients with post COVID-19 condition: A randomized, phase 2, crossover trial","volume":"24","author":"Hansen","year":"2023","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1089\/ars.2013.5260","article-title":"Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia?","volume":"19","author":"Cordero","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/JCP.0000000000000097","article-title":"Coenzyme q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: Results of a small clinical trial","volume":"34","author":"Cordero","year":"2014","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/cns.12668","article-title":"Effect of Coenzyme Q(10) on Psychopathological Symptoms in Fibromyalgia Patients","volume":"23","author":"Culic","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Cordero, M.D., Cano-Garcia, F.J., Alcocer-Gomez, E., De Miguel, M., and Sanchez-Alcazar, J.A. (2012). Oxidative stress correlates with headache symptoms in fibromyalgia: Coenzyme Q10 effect on clinical improvement. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035677"},{"key":"ref_79","first-page":"20","article-title":"Role for a water-soluble form of CoQ10 in female subjects affected by fibromyalgia. A preliminary study","volume":"35","author":"Rossi","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/10715762.2019.1645955","article-title":"Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction","volume":"53","author":"Sawaddiruk","year":"2019","journal-title":"Free Radic. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/147323000203000213","article-title":"An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome","volume":"30","author":"Lister","year":"2002","journal-title":"J. Int. Med. Res."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Schweiger, V., Secchettin, E., Castellani, C., Martini, A., Mazzocchi, E., Picelli, A., Polati, E., Donadello, K., Valenti, M.T., and Dalle Carbonare, L. (2020). Comparison between Acupuncture and Nutraceutical Treatment with Migratens((R)) in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial. Nutrients, 12.","DOI":"10.3390\/nu12030821"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Israel, A., Schaffer, A.A., Cicurel, A., Feldhamer, I., Tal, A., Cheng, K., Sinha, S., Schiff, E., Lavie, G., and Ruppin, E. (2021). Identification of drugs associated with reduced severity of COVID-19: A case-control study in a large population. medRxiv.","DOI":"10.7554\/eLife.68165.sa2"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/biof.1293","article-title":"Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome","volume":"42","author":"Fukuda","year":"2016","journal-title":"Biofactors"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1089\/ars.2012.4892","article-title":"Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia?","volume":"18","author":"Cordero","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1179\/1351000212Y.0000000036","article-title":"Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: Amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation","volume":"18","author":"Miyamae","year":"2013","journal-title":"Redox Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"111147","DOI":"10.1016\/j.exger.2020.111147","article-title":"Age-related mitochondrial dysfunction as a key factor in COVID-19 disease","volume":"142","author":"Navas","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.jiph.2020.09.015","article-title":"Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone","volume":"13","author":"Caruso","year":"2020","journal-title":"J. Infect. Public. Health"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41591-022-01689-3","article-title":"Long-term cardiovascular outcomes of COVID-19","volume":"28","author":"Xie","year":"2022","journal-title":"Nat. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/j.jcmg.2022.07.006","article-title":"Coronary Microvascular Health in Patients With Prior COVID-19 Infection","volume":"15","author":"Ahmed","year":"2022","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/s41591-022-01837-9","article-title":"A multisystem, cardio-renal investigation of post-COVID-19 illness","volume":"28","author":"Morrow","year":"2022","journal-title":"Nat. Med."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Mantle, D., Heaton, R.A., and Hargreaves, I.P. (2021). Coenzyme Q10 and Immune Function: An Overview. Antioxidants, 10.","DOI":"10.3390\/antiox10050759"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-3-030-71697-4_13","article-title":"COVID-19, Coenzyme Q10 and Selenium","volume":"1327","author":"Hargreaves","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.ijcard.2012.04.156","article-title":"Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens","volume":"167","author":"Alehagen","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jchf.2014.06.008","article-title":"The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: Results from Q-SYMBIO: A randomized double-blind trial","volume":"2","author":"Mortensen","year":"2014","journal-title":"JACC Heart Fail."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Nacul, L., Authier, F.J., Scheibenbogen, C., Lorusso, L., Helland, I.B., Martin, J.A., Sirbu, C.A., Mengshoel, A.M., Polo, O., and Behrends, U. (2021). European Network on Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME\/CFS in Europe. Medicina, 57.","DOI":"10.3390\/medicina57050510"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"56","DOI":"10.17305\/bjbms.2003.3572","article-title":"Dossier for marketing authorization in the European Union","volume":"3","author":"Todic","year":"2003","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"20420986211038436","DOI":"10.1177\/20420986211038436","article-title":"Monitoring the manufacturing and quality of medicines: A fundamental task of pharmacovigilance","volume":"12","author":"Sardella","year":"2021","journal-title":"Ther. Adv. Drug Saf."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1211\/0022357021778970","article-title":"Pharmaceutical quality of different Ginkgo biloba brands","volume":"54","author":"Kressmann","year":"2002","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1055\/a-0581-5203","article-title":"Ginkgo biloba Food Supplements on the European Market\u2014Adulteration Patterns Revealed by Quality Control of Selected Samples","volume":"84","author":"Czigle","year":"2018","journal-title":"Planta Med."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Walkowiak, A., Wnuk, K., Cyrankiewicz, M., and Kupcewicz, B. (2022). Discrimination of Adulterated Ginkgo Biloba Products Based on 2T2D Correlation Spectroscopy in UV-Vis Range. Molecules, 27.","DOI":"10.3390\/molecules27020433"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Mantle, D., Millichap, L., Castro-Marrero, J., and Hargreaves, I.P. (2023). Primary Coenzyme Q10 Deficiency: An Update. Antioxidants, 12.","DOI":"10.3390\/antiox12081652"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Mantle, D., and Dybring, A. (2020). Bioavailability of Coenzyme Q10: An Overview of the Absorption Process and Subsequent Metabolism. Antioxidants, 9.","DOI":"10.3390\/antiox9050386"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.nut.2018.05.020","article-title":"Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization","volume":"57","author":"Navas","year":"2019","journal-title":"Nutrition"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Mantle, D., Lopez-Lluch, G., and Hargreaves, I.P. (2023). Coenzyme Q10 Metabolism: A Review of Unresolved Issues. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032585"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/07315724.2001.10719063","article-title":"Biochemical functions of coenzyme Q10","volume":"20","author":"Crane","year":"2001","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.biocel.2014.01.020","article-title":"Coenzyme Q10 as a therapy for mitochondrial disease","volume":"49","author":"Hargreaves","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"042","DOI":"10.21926\/obm.icm.2004042","article-title":"A Potential Role of Coenzyme Q10 Deficiency in Severe SARS-CoV-2 Infection","volume":"5","author":"Polymeropoulos","year":"2020","journal-title":"OBM Integr. Complement. Med."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Chen, T.H., Chang, C.J., and Hung, P.H. (2023). Possible Pathogenesis and Prevention of Long COVID: SARS-CoV-2-Induced Mitochondrial Disorder. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098034"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Mantle, D., and Hargreaves, I.P. (2022). Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation. Int. J. Mol. 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