{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:43:44Z","timestamp":1790711024829,"version":"4.1.0"},"reference-count":172,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by chronic synovitis and the progressive destruction of cartilage and bone. RA is commonly accompanied by extra-articular comorbidities. The pathogenesis of RA and its comorbidities is complex and not completely elucidated. The assembly of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activates caspase-1, which induces the maturation of interleukin (IL)-1\u03b2 and IL-18 and leads to the cleavage of gasdermin D with promoting pyroptosis. Accumulative evidence indicates the pathogenic role of NLRP3 inflammasome signaling in RA and its comorbidities, including atherosclerotic cardiovascular disease, osteoporosis, and interstitial lung diseases. Although the available therapeutic agents are effective for RA treatment, their high cost and increased infection rate are causes for concern. Recent evidence revealed the components of the NLRP3 inflammasome as potential therapeutic targets in RA and its comorbidities. In this review, we searched the MEDLINE database using the PubMed interface and reviewed English-language literature on the NLRP3 inflammasome in RA and its comorbidities from 2000 to 2023. The current evidence reveals that the NLRP3 inflammasome contributes to the pathogenesis of RA and its comorbidities. Consequently, the components of the NLRP3 inflammasome signaling pathway represent promising therapeutic targets, and ongoing research might lead to the development of new, effective treatments for RA and its comorbidities.<\/jats:p>","DOI":"10.3390\/ijms25010626","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T11:31:50Z","timestamp":1704281510000},"page":"626","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review"],"prefix":"10.3390","volume":"25","author":[{"given":"Po-Ku","family":"Chen","sequence":"first","affiliation":[{"name":"Rheumatology and Immunology Center, China Medical University Hospital, No. 2, Yude Road, Taichung 40447, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung 40447, Taiwan"},{"name":"Translational Medicine Laboratory, Rheumatology and Immunology Center, Taichung 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-1329","authenticated-orcid":false,"given":"Kuo-Tung","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan"},{"name":"Division of Allergy, Immunology, and Rheumatology, Taichung Veterans General Hospital, Taichung 40705, Taiwan"},{"name":"Faculty of Medicine, National Yang-Ming University, Taipei 112304, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1266-1423","authenticated-orcid":false,"given":"Der-Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Center, China Medical University Hospital, No. 2, Yude Road, Taichung 40447, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung 40447, Taiwan"},{"name":"Translational Medicine Laboratory, Rheumatology and Immunology Center, Taichung 40447, Taiwan"},{"name":"College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan"},{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMra2103726","article-title":"Rheumatoid arthritis: Common origins, divergent mechanisms","volume":"388","author":"Gravallese","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_3","first-page":"358","article-title":"Nationwide population-based epidemiologic study of rheumatoid arthritis in Taiwan","volume":"30","author":"Lai","year":"2012","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s12016-012-8346-7","article-title":"Genetics of rheumatoid arthritis\u2014A comprehensive review","volume":"45","author":"Kurko","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrrheum.2012.237","article-title":"Genetics and epigenetics of rheumatoid arthritis","volume":"9","author":"Viatte","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1093\/rheumatology\/ket414","article-title":"Rheumatoid arthritis pathophysiology: Update on emerging cytokine and cytokine-associated cell targets","volume":"53","author":"Furst","year":"2014","journal-title":"Rheumatology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"102400","DOI":"10.1016\/j.jaut.2019.102400","article-title":"The etiology of rheumatoid arthritis","volume":"110","author":"Scherer","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1007165","DOI":"10.3389\/fimmu.2022.1007165","article-title":"Gut microbiota and rheuamtoid arthritis: From pathogenesis to novel therapeutic opportunisties","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41584-021-00652-9","article-title":"Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases","volume":"17","author":"Szekanecz","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"732933","DOI":"10.3389\/fimmu.2021.732933","article-title":"NLRP3 inflammasome: Checkpoint connecting innate and adaptive immunity in autoimmune diseases","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mitrovi\u0107, J., Hrka\u010d, S., Te\u010der, J., Golob, M., Ljilja Posavec, A., Kolar Mitrovi\u0107, H., and Grgurevi\u0107, L. (2023). Pathogenesis of extraarticular manifestations in rheumatoid arthritis\u2014A comprehensive review. Biomedicines, 11.","DOI":"10.3390\/biomedicines11051262"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/annrheumdis-2013-204223","article-title":"Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: Results of an international, cross-sectional study (COMORA)","volume":"73","author":"Emery","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/ar2669","article-title":"Epidemiological studies in incidence, prevalence, mortality and comorbidity of the rheumatic diseases","volume":"11","author":"Gabriel","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrrheum.2011.75","article-title":"Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE","volume":"7","author":"Symmons","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/annrheumdis-2011-200726","article-title":"Risk of incident cardiovascular events in patients with rheumatoid arthritis: A meta-analysis of observational studies","volume":"71","author":"Thomas","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/art.25009","article-title":"Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis","volume":"61","author":"Rho","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/1529-0131(200003)43:3<522::AID-ANR7>3.0.CO;2-Y","article-title":"Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis","volume":"43","author":"Haugeberg","year":"2000","journal-title":"Arthritis Rheum."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"R154","DOI":"10.1186\/ar3107","article-title":"Risk of osteoporotic fracture in a large population-based cohort of patients with rheumatoid arthritis","volume":"12","author":"Kim","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1183\/09059180.00008014","article-title":"Rheumatoid arthritis-associated lung disease","volume":"24","author":"Shaw","year":"2015","journal-title":"Eur. Respir. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.semarthrit.2020.07.011","article-title":"Risk of interstitial lung disease in patients with newly diagnosed systemic autoimmune rheumatic disease: A nationwide, population-based cohort study","volume":"50","author":"Ng","year":"2020","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/acr.22108","article-title":"Barriers to optimal disease control for rheumatoid arthritis patients with moderate and high disease activity","volume":"66","author":"Tymms","year":"2014","journal-title":"Arthritis Care Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Scott, I.C., Machin, A., Mallen, C.D., and Hider, S.L. (2018). The extra-articular impacts of rheumatoid arthritis: Moving towards holistic care. BMC Rheumatol., 2.","DOI":"10.1186\/s41927-018-0039-2"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature06664","article-title":"The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response","volume":"452","author":"Muruve","year":"2008","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00281-007-0079-y","article-title":"NALP inflammasome: A central role in innate immunity","volume":"29","author":"Martinon","year":"2007","journal-title":"Semin. Immunopathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molmed.2010.11.001","article-title":"Inflammasomes and autoimmunity","volume":"17","author":"Shaw","year":"2011","journal-title":"Trends Mol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: Molecular activation and regulation to therapeutics","volume":"9","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","article-title":"The NLRP3 inflammasome: Activation and regulation","volume":"48","author":"Xu","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1084\/jem.20142384","article-title":"Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1\u03b2","volume":"212","author":"Kim","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3899\/jrheum.161354","article-title":"Elevated Expression of the NLRP3 Inflammasome and Its Correlation with Disease Activity in Adult-onset Still Disease","volume":"44","author":"Hsieh","year":"2017","journal-title":"J. Rheumatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/art.37882","article-title":"Beyond the NLRP3 inflammasome: Autoinflammatory diseases reach adolescence","volume":"65","author":"Gattorno","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1007705","DOI":"10.3389\/fimmu.2022.1007705","article-title":"NLRP3 inflammasome and NLRP3-related autoinflammatory diseases: From cryopyrin function to targeted therapies","volume":"13","author":"Moltrasio","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1365-2567.2009.03174.x","article-title":"Expression and function of the NALP3 inflammasome in rheumatoid synovium","volume":"129","author":"Kolly","year":"2010","journal-title":"Immunology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9656270","DOI":"10.1155\/2016\/9656270","article-title":"NLRP3 inflammasome plays an important role in the pathogenesis of collagen-induced arthritis","volume":"2016","author":"Zhang","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2147\/ITT.S288547","article-title":"Contribution of Toll-like receptors and the NLRP3 inflammasome in rheumatoid arthritis pathophysiology","volume":"10","author":"Unterberger","year":"2021","journal-title":"Immuno Targets Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"931690","DOI":"10.3389\/fimmu.2022.931690","article-title":"Role of NLRP3 inflammasome in rheumatoid arthritis","volume":"13","author":"Yin","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Murakami, T., Nakaminami, Y., Takahata, Y., Hata, K., and Nishimura, R. (2022). Activation and function of NLRP3 inflammasome in bone and joint-related diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105365"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/ard.2004.025577","article-title":"Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium","volume":"64","author":"Rosengren","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cei.13167","article-title":"NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis","volume":"194","author":"Guo","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"102336","DOI":"10.1016\/j.jaut.2019.102336","article-title":"Complement C1q synergizes with PTX3 in promoting NLRP3 inflammasome over-activation and pyroptosis in rheumatoid arthritis","volume":"106","author":"Wu","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41423-019-0201-9","article-title":"ACPAs promote IL-1\u03b2 production in rheumatoid arthritis by activating the NLRP3 inflammasome","volume":"17","author":"Dong","year":"2020","journal-title":"Cell Mol. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1078569","DOI":"10.3389\/fphys.2022.1078569","article-title":"Calcium-sensing receptor-mediated NLRP3 inflammasome activation in rheumatoid arthritis and autoinflammation","volume":"13","author":"Werner","year":"2023","journal-title":"Front. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1273174","DOI":"10.3389\/fimmu.2023.1273174","article-title":"Mechanistic and therapeutic insights into the function of NLRP3 inflammasome in sterile arthritis","volume":"14","author":"Xiao","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/art.41752","article-title":"2021 American College of Rheumatology guideline for the treatment of rheumatoid arthritis","volume":"73","author":"Fraenkel","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"vi12","DOI":"10.1093\/rheumatology\/keab609","article-title":"Recent progress in treatments of rheumatoid arthritis: An overview of developments in biologics and small molecules, and remaining unmet needs","volume":"60","author":"Tanaka","year":"2021","journal-title":"Rheumatology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/ard-2022-223356","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease modifying antirheumatic drugs: 2022 update","volume":"82","author":"Smolen","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/annrheumdis-2020-218398","article-title":"Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: A consensus statement","volume":"80","author":"Nash","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/ard-2022-223365","article-title":"Efficacy of synthetic and biological DMARDs: A systemic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis","volume":"82","author":"Kerschbaumer","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Mueller, R.B., Hasler, C., Popp, F., Mattow, F., Durmisi, M., Souza, A., Hasler, P., Rubbert-Roth, A., Schulze-Koops, H., and Kempis, J.V. (2019). Effectiveness, tolerability, and safety of tofacitinib in rheumatoid arthritis: A Retrospective Analysis of Real-World Data from the St. Gallen and Aarau Cohorts. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101548"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1056\/NEJMoa1310476","article-title":"Tofacitinib versus methotrexate in rheumatoid arthritis","volume":"370","author":"Lee","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1136\/annrheumdis-2014-207178","article-title":"Efficacy and safety of tofacitinib following inadequate response to conventional synthetic or biological disease-modifying antirheumatic drugs","volume":"75","author":"Burmester","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Mekni, N., De Rosa, M., Cipollina, C., Gulotta, M.R., De Simone, G., Lombino, J., Padova, A., and Perricone, U. (2019). In silico insights towards the identification of NLRP3 druggable hot spots. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20204974"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s10753-023-01795-5","article-title":"Therapeutic potential of targeting the NLRP3 inflammasome in rheumatod arthritis","volume":"46","author":"Gao","year":"2023","journal-title":"Inflammation"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"14447","DOI":"10.1021\/acs.jmedchem.3c01370","article-title":"Recent progress and prospects of small molecules for NLRP3 inflammasome inhibition","volume":"66","author":"Li","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ishikawa, Y., and Terao, C. (2020). The impact of cigarette smoking on risk of rheumatoid arthritis: A narrative review. Cells, 9.","DOI":"10.3390\/cells9020475"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1093\/rheumatology\/keab049","article-title":"Association between environmental air pollution and rheumatoid arthritis flares","volume":"60","author":"Adami","year":"2021","journal-title":"Rheumatology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cmet.2019.06.016","article-title":"The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation","volume":"30","author":"Li","year":"2019","journal-title":"Cell Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1161\/ATVBAHA.108.179705","article-title":"Inflammation in Atherosclerosis","volume":"32","author":"Libby","year":"2012","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/art.23650","article-title":"High ten-year risk of cardiovascular disease in newly diagnosed rheumatoid arthritis patients","volume":"58","author":"Kremers","year":"2008","journal-title":"Arthritis Rheumatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/art.24092","article-title":"Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta-analysis of observational studies","volume":"59","author":"Choi","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jbspin.2010.07.016","article-title":"Traditional cardiovascular risk factors in rheumatoid arthritis: A meta-analysis","volume":"78","author":"Boyer","year":"2011","journal-title":"Jt. Bone Spine"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/rheumatology\/keu376","article-title":"Inflammatory burden interacts with conventional cardiovascular risk factors for carotid plaque formation in rheumatoid arthritis","volume":"54","author":"Im","year":"2015","journal-title":"Rheumatology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/acr.22722","article-title":"Prednisone use and risk of mortality in patients with rheumatoid arthritis: Moderation by use of disease-modifying antirheumatic drugs","volume":"68","author":"Dasgupta","year":"2016","journal-title":"Arthritis Care Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/phar.1584","article-title":"Safety of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease","volume":"35","author":"Danelich","year":"2015","journal-title":"Pharmacotherapy"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Maehlen, M.T., Provan, S.A., de Rooy, D.P., van der Helm-van, A.H., Krabben, A., Saxne, T., Lindqvist, E., Semb, A.G., Uhlig, T., and van der Heijde, D. (2013). Associations between APOE Genotypes and Disease Susceptibility, Joint Damage and Lipid Levels in Patients with Rheumatoid Arthritis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0060970"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1136\/ard.2010.135871","article-title":"Lipid paradox in rheumatoid arthritis: The impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease","volume":"70","author":"Myasoedova","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1038\/s41598-017-04063-3","article-title":"Electronegative low-density lipoprotein increases the risk of ischemic lower-extremity peripheral artery disease in uremia patients on maintenance hemodialysis","volume":"7","author":"Chang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Chang, C.Y., Chen, C.H., Chen, Y.M., Hsieh, T.Y., Li, J.P., Shen, M.Y., Lan, J.L., and Chen, D.Y. (2019). Association between Negatively Charged Low-Density Lipoprotein L5 and Subclinical Atherosclerosis in Rheumatoid Arthritis Patients. J. Clin. Med., 8.","DOI":"10.3390\/jcm8020177"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1194\/jlr.M700305-JLR200","article-title":"Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1","volume":"49","author":"Tang","year":"2008","journal-title":"J. Lipid Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Chang, C.K., Chen, P.K., Lan, J.L., Chang, S.H., Hsieh, T.Y., Liao, P.J., Chen, C.H., and Chen, D.Y. (2020). Association of Electronegative LDL with Macrophage Foam Cell Formation and CD11c Expression in Rheumatoid Arthritis Patients. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165883"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1002\/art.22117","article-title":"Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis","volume":"54","author":"Geusens","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/hmg\/ddab158","article-title":"Rheumatoid arthritis and osteoporosis: Shared genetic effect, pleiotropy and causality","volume":"30","author":"Yu","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1136\/annrheumdis-2014-205428","article-title":"Additive Effect of Anti-Citrullinated Protein Antibodies and Rheumatoid Factor on Bone Erosions in Patients with RA","volume":"74","author":"Hecht","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"101773","DOI":"10.1016\/j.berh.2022.101773","article-title":"Risk factors for osteoporosis and fractures in rheumatoid arthritis","volume":"36","author":"Baker","year":"2022","journal-title":"Best. Pract. Res. Clin. Rheumatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"210011","DOI":"10.1183\/16000617.0011-2021","article-title":"Rheumatoid arthritis-interstitial lung disease: Manifestations and current concepts in pathogenesis and management","volume":"30","author":"Kadura","year":"2021","journal-title":"Eur. Respir. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/ar3097","article-title":"Interstitial lung disease in connective tissue diseases: Evolving concepts of pathogenesis and management","volume":"12","author":"Castelino","year":"2010","journal-title":"Arthritis Res. Thera."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1183\/09031936.00019210","article-title":"Lung diseases directly associated with rheumatoid arthritis and their relationship to outcome","volume":"37","author":"Tsuchiya","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_78","first-page":"280","article-title":"Rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis: Shared mechanistic and phenotypic traits suggest overlapping disease mechanisms","volume":"67","author":"Paulin","year":"2015","journal-title":"Rev. Investig. Clin."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/BOR.0000000000000380","article-title":"Recent advances in the pathogenesis, prediction, and management of rheumatoid arthritis-associated interstitial lung disease","volume":"29","author":"Johnson","year":"2017","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41584-019-0275-x","article-title":"Mechanisms of lung disease development in rheumatoid arthritis","volume":"15","author":"Wang","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/rheumatology\/kew025","article-title":"Association of Human Leukocyte Antigen Alleles with Chronic Lung Diseases in Rheumatoid Arthritis","volume":"55","author":"Oka","year":"2016","journal-title":"Rheumatology"},{"key":"ref_82","first-page":"1049","article-title":"AB0007 Shared Genetic Predisposition in Rheumatoid Arthritis\u2013Interstitial Lung Disease and Familial Pulmonary Fibrosis","volume":"76","author":"Juge","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e002790","DOI":"10.1136\/rmdopen-2022-002790","article-title":"MUC5B promoter variant rs35705950, rare but significant susceptibility locus in rheumatoid arthritis-interstitial lung disease with usual interstitial pneumonia in Asian populations","volume":"8","author":"Joo","year":"2022","journal-title":"RMD Open"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1136\/annrheumdis-2020-217256","article-title":"Association of the RPA3-UMAD1 locus with interstitial lung diseases complicated with rheumatoid arthritis in Japanese","volume":"79","author":"Shirai","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"178ra40","DOI":"10.1126\/scitranslmed.3005580","article-title":"NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis","volume":"5","author":"Khandpur","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"L487","DOI":"10.1152\/ajplung.00301.2018","article-title":"Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A\/IL-17RA in human fibrotic interstitial lung disease","volume":"316","author":"Zhang","year":"2019","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2102149","DOI":"10.1183\/13993003.02149-2021","article-title":"Fine particles matter components and interstitial lung disease in rheumatoid arthritis","volume":"60","author":"Zhao","year":"2022","journal-title":"Eur. Respir. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/08830185.2017.1397656","article-title":"TLRs\/NLRs: Shaping the landscape of host immunity","volume":"37","author":"Dolasia","year":"2018","journal-title":"Int. Rev. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/14737159.2019.1615449","article-title":"The role of damage-associated molecular pattern for pathogenesis and biomarkers in adult-onset Still\u2019s disease","volume":"19","author":"Jung","year":"2019","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/eji.201747404","article-title":"The gasdermin-D pore acts a conduit for IL-1\u03b2 secretion in mice","volume":"48","author":"Heilig","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: Host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/1753425913484374","article-title":"Caspase-1: The inflammasome and beyond","volume":"20","author":"Sollberger","year":"2014","journal-title":"Innate Immun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"R568","DOI":"10.1016\/j.cub.2016.02.019","article-title":"Pyroptosis","volume":"26","author":"Lamkanfi","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Li, Z., Guo, J., and Bi, L. (2020). Role of the NLRP3 inflammasome in autoimmune diseases. Biomed. Pharmacother., 130.","DOI":"10.1016\/j.biopha.2020.110542"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41374-018-0135-3","article-title":"The role of Ca2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis","volume":"99","author":"Wu","year":"2019","journal-title":"Lab. Investig."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11588","article-title":"The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP","volume":"492","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Jiang, Q., Wang, X., Xu, X., Hu, L., Zhou, G., Liu, R., Yang, G., and Cui, D. (2023). Inflammasomes in rheumatoid arthritis: A pilot study. BMC Rheumatol., 7.","DOI":"10.1186\/s41927-023-00353-8"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/rheumatology\/kem372","article-title":"Genetic variations in proteins of the cryopyrine inflammasome influences the susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project)","volume":"47","author":"Kastbom","year":"2008","journal-title":"Rheumatology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1515\/jomb-2016-0008","article-title":"NLRP3 and CARD8 polymorphisms influence higher disease activity in rheumatoid arthritis","volume":"35","author":"Jenko","year":"2016","journal-title":"J. Med. Biochem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1111\/1756-185X.13016","article-title":"NLRP3 p.Q705K and CARD8 p.C10X single nucleotide polymorphisms are not associated with susceptibility to rheumatoid arthritis: A meta-analysis","volume":"20","author":"Yang","year":"2017","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Li, R.N., Ou, T.T., Lin, C.H., Lin, Y.Z., Fang, T.J., Chen, Y.J., Tseng, C.C., Sung, W.Y., Wu, C.C., and Yen, J.H. (2023). NLRP3 gene polymorphisms in rheumatoid arthritis and primary Sj\u00f6gren\u2019s syndrome patients. Diagnostics, 13.","DOI":"10.3390\/diagnostics13020206"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Sode, J., Vogel, U., Bank, S., Andersen, P.S., Thomsen, M.K., Hetland, M.L., Locht, H., Heegaard, N.H., and Andersen, V. (2014). Anti-TNF treatment response in rheumatoid arthritis patients is associated with genetic variation in the NLRP3-inflammasome. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100361"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/annrheumdis-2013-203276","article-title":"Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment","volume":"73","author":"Mathews","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e16814","DOI":"10.1016\/j.heliyon.2023.e16814","article-title":"Effect of NLRP3 inflammasome genes polymorphisms on disease susceptibility and response to TNF-\u03b1 inhibitors in Iraqi patients with rheumatoid arthritis","volume":"9","author":"Awni","year":"2023","journal-title":"Heliyon"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"443","DOI":"10.5551\/jat.RV17001","article-title":"Role of NLRP3 inflammasome in atherosclerosis","volume":"24","author":"Karasawa","year":"2017","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Baragetti, A., Catapano, A.L., and Magni, P. (2020). Multifactorial activation of NLRP3 inflammasome: Relevance for a precision approach to atherosclerotic cardiovascular risk and disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124459"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.4049\/jimmunol.1601563","article-title":"Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and Fc\u03b3R Cooperation and Is Dependent on CARD9","volume":"198","author":"Rhoads","year":"2017","journal-title":"J. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3892\/br.2013.155","article-title":"Q705K variant in NLRP3 gene confers protection against myocardial infarction in female individuals","volume":"1","author":"Varghese","year":"2013","journal-title":"Biomed. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1042\/CS20120572","article-title":"CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation","volume":"125","author":"Paramel","year":"2013","journal-title":"Clin. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/STROKEAHA.113.003393","article-title":"Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211 (p.C10X) with ischemic stroke","volume":"45","author":"Bai","year":"2014","journal-title":"Stroke"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1089\/dna.2012.1836","article-title":"CARD8 rs2043211 (p.C10X) polymorphism is not associated with disease susceptibility or cardiovascular events in Spanish rheumatoid arthritis patients","volume":"32","author":"Corrales","year":"2013","journal-title":"DNA Cell Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s10753-020-01357-z","article-title":"The Role of NLRP3 Inflammasome Activities in Bone Diseases and Vascular Calcification","volume":"44","author":"Yu","year":"2021","journal-title":"Inflammation"},{"key":"ref_114","first-page":"1084","article-title":"Effects of irisin on osteoblast apoptosis and osteoporosis in postmenopausal osteoporosis rats through upregulating Nrf2 and inhibiting NLRP3 inflammasome","volume":"19","author":"Xu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41420-022-01282-0","article-title":"The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"107781","DOI":"10.1016\/j.intimp.2021.107781","article-title":"Interleukin-17 induces pyroptosis in osteoblasts through the NLRP3 inflammasome pathway in vitro","volume":"96","author":"Lei","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/ard.2008.104786","article-title":"Interleukin-1 is essential for systemic inflammatory bone loss","volume":"69","author":"Polzer","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e3214","DOI":"10.1002\/jgm.3214","article-title":"Evaluation of genetic variants in IL-1B and its interaction with the predisposition of osteoporosis in the northwestern Chinese Han population","volume":"22","author":"He","year":"2020","journal-title":"J. Gene Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10753-012-9524-8","article-title":"IL-18 upregulates the production of key regulators of osteoclastogenesis from fibroblast-like synoviocytes in rheumatoid arthritis","volume":"36","author":"Zhang","year":"2013","journal-title":"Inflammation"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1183\/13993003.00564-2015","article-title":"NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung","volume":"47","author":"Lasithiotaki","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1002\/art.30568","article-title":"The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis","volume":"63","author":"Artlett","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Woo, S., Gandhi, S., Ghincea, A., Saber, T., Lee, C.J., and Ryu, C. (2023). Targeting the NLRP3 inflammasome and associated cytokines in scleroderma associated interstitial lung disease. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1254904"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Ramos-Martinez, E., Vega-S\u00e1nchez, A.E., P\u00e9rez-Rubio, G., Mejia, M., Buend\u00eda-Rold\u00e1n, I., Gonz\u00e1lez-P\u00e9rez, M.I., Mateos-Toledo, H.N., Andrade, W.A., Falf\u00e1n-Valencia, R., and Rojas-Serrano, J. (2023). Enhanced activity of the NLRP3 inflammasome in the lung of patients with anti-synthetase syndrome. Cells, 12.","DOI":"10.3390\/cells12010060"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41589-019-0277-7","article-title":"MCC950 directly targets the NLRP3 ATP- hydrolysis motif for inflammasome inhibition","volume":"15","author":"Coll","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"ref_126","first-page":"111","article-title":"Effects and mechanisms of potent caspase-1 inhibitor VX765 treatment on collagen induced arthritis in mice","volume":"34","author":"Zhang","year":"2016","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation","volume":"21","author":"Hu","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"841732","DOI":"10.3389\/fimmu.2022.841732","article-title":"Pyroptosis and its role in autoimmune diseases: A potential therapeutic target","volume":"13","author":"You","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1161\/ATVBAHA.117.309575","article-title":"NLRP3 inflammasome inhibition by MCC950 reduces atherosclerotic lesion development in apolipoprotein E-deficient mice-brief report","volume":"37","author":"Kritikou","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"19305","DOI":"10.1038\/s41598-021-98437-3","article-title":"The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages","volume":"11","author":"Zeng","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"111847","DOI":"10.1016\/j.yexcr.2020.111847","article-title":"VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis","volume":"389","author":"Li","year":"2020","journal-title":"Exp. Cell Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3892\/mmr.2023.13080","article-title":"Celastrol attenuates human parvovirus B19 NS1-induced NLRP3 inflammasome activation in macrophages","volume":"28","author":"Huang","year":"2023","journal-title":"Mol. Med. Rep."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"107879","DOI":"10.1016\/j.intimp.2021.107879","article-title":"Celastrol inhibits rheumatoid arthritis through the ROS-NF-\u03baB-NLRP3 inflammasome axis","volume":"98","author":"Jing","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_134","first-page":"158","article-title":"Efficacy of Baihu-Guizhi Decoction Combined with Western Medicine in Treating Rheumatoid Arthritis","volume":"36","author":"Wu","year":"2021","journal-title":"Chin. J. Urban. Rural. Enterp. Hyg."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"912933","DOI":"10.3389\/fimmu.2022.912933","article-title":"A novel drug combination of mangiferin and cinnamic acid alleviates rheumatoid arthritis by inhibiting TLR4\/NF-\u03baB\/NLRP3 activation-induced pyroptosis","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Ye, Q., Yan, T., Shen, J., Shi, X., Luo, F., and Ren, Y. (2023). Sulforaphene targets NLRP3 inflammasome to suppress M1 polarization of macrophages and inflammatory response in rheumatoid arthritis. J. Biochem. Mol. Toxicol., 37.","DOI":"10.1002\/jbt.23362"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Xu, R., Liu, Z., Hou, J., Huang, T., and Yang, M. (2018). Osthole improves colllagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress. Cell Mol. Biol. Lett., 23.","DOI":"10.1186\/s11658-018-0086-0"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"154640","DOI":"10.1016\/j.phymed.2022.154640","article-title":"Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome by regulating mitochondrial homeostasis for combating rheumatoid arthritis","volume":"110","author":"Jiang","year":"2023","journal-title":"Phytomemdicine"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"819053","DOI":"10.1155\/2014\/819053","article-title":"Scropolioside B inhibits IL-1\u03b2 and cytokines expression through NF-kB and inflammasome NLRP3 pathways","volume":"2014","author":"Zhu","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"301","DOI":"10.5603\/FHC.a2022.0025","article-title":"Wedelolactone ameliorate synovial inflammation and cardiac complications in a murine model of collagen-induced arthritis by inhibiting NF-\u03baB\/NLRP3 inflammasome activation","volume":"60","author":"Cao","year":"2022","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/s41598-017-01836-8","article-title":"Pro-inflammatory Ca++-activated K+ channels are inhibited by hydroxychloroquine","volume":"7","author":"Russo","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"110353","DOI":"10.1016\/j.intimp.2023.110353","article-title":"Chloroquine inhibits NLRP3 inflammasomes activation and alleviates renal fibrosis in mouse model of hyperuricemic nephropathy with aggravation by a high-fat-diet","volume":"120","author":"Cui","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_143","first-page":"CD005121","article-title":"Anakinra for rheumatoid arthritis","volume":"21","author":"Mertens","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"33680","DOI":"10.1038\/srep33680","article-title":"IL-18BP is decreased in osteoporotic women: Prevents inflammasome mediated IL-18 activation and reduces Th17 differentiation","volume":"6","author":"Mansoori","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.7150\/thno.47860","article-title":"Tofacitinib restores the balance of \u03b3\u03b4Treg\/\u03b3\u03b4T17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome","volume":"11","author":"Yang","year":"2021","journal-title":"Theranostics"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3389\/fphar.2019.00451","article-title":"MicroRNA post-transcriptional regulation of the NLRP3 inflammasome in immunopathologies","volume":"10","author":"Tezcan","year":"2019","journal-title":"Front. Pharm."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41419-019-1713-z","article-title":"miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock","volume":"10","author":"Xue","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function, and decay","volume":"11","author":"Krol","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/cmi.2010.19","article-title":"MicroRNAs: Critical regulators in Th17 cells and players in diseases","volume":"7","author":"Wei","year":"2010","journal-title":"Cell Mol. Immunol."},{"key":"ref_151","first-page":"3318","article-title":"MicroRNA-33 regulates the NLRP3 inflammasome signaling pathway in macrophages","volume":"17","author":"Xie","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s41419-021-04349-5","article-title":"RelA\/MicroRNA-30a\/NLRP3 signal axis is involved in rheumatoid arthritis via regulating NLRP3 inflammsome in macrophages","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.molimm.2022.01.002","article-title":"miR-223 in exosomes from bone marrow mesenchymal stem cells ameliorates rheumatoid arthritis via downregulation of NLRP3 expression in macrophages","volume":"143","author":"Huang","year":"2022","journal-title":"Mol. Immunol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"15676","DOI":"10.1038\/s41598-021-95028-0","article-title":"MicroRNA-223 inhibits IL-18-mediated neutrophil extracellular trap through regulating calcium influx in adult-onset Still\u2019s disease","volume":"11","author":"Liao","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature07672","article-title":"Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nrm3679","article-title":"RNA in unexpected places: Long non-coding RNA functions in diverse cellular contexts","volume":"14","author":"Geisler","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"12375","DOI":"10.1074\/jbc.R116.760884","article-title":"Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses","volume":"292","author":"Mathy","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/15384101.2020.1867788","article-title":"LncRNA MIAT downregulates IL-1\u03b2, TNF-\u03b1 to suppress macrophage inflammation but is suppressed by ATP-induced NLRP3 inflammasome activation","volume":"20","author":"Wang","year":"2021","journal-title":"Cell Cycle"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"11592","DOI":"10.3390\/ijms222111592","article-title":"Mesenchymmal stem cell-based therapy for rheumatoid arthritis","volume":"22","author":"Sarsenova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e2524","DOI":"10.1038\/cddis.2016.442","article-title":"Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheuamatoid arthritis","volume":"7","author":"Shin","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1042\/CS20210865","article-title":"Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease","volume":"136","author":"Jha","year":"2022","journal-title":"Clin. Sci."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Lanz, J., Biniaz-Harris, N., Kuvaldina, M., Jain, S., Lewis, K., and Fallon, B.A. (2023). Disulfiram: Mechanisms, applications, and challenges. Antibiotics, 12.","DOI":"10.3390\/antibiotics12030524"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"103300","DOI":"10.1016\/j.etap.2019.103300","article-title":"Comparative Effects of Mancozeb and Disulfiram-Induced Striated Muscle Myopathies in Long-Evans Rats","volume":"74","author":"Stephenson","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/ijp.ijp_930_21","article-title":"Diffuse Subendocardial Ischemia Secondary to Disulfiram-Alcohol Ingestion","volume":"54","author":"Agarwal","year":"2022","journal-title":"Indian. J. Pharmacol."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Song, J., He, G.N., and Dai, L. (2023). A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes. Biomed. Pharmacother., 162.","DOI":"10.1016\/j.biopha.2023.114705"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/pcn.13276","article-title":"Efficacy and safety of sulforaphane for treatment of mild to moderate depression in patients with history of cardiac interventions: A randomized, double-blind, placebo-controlled clinical trial","volume":"75","author":"Bagheri","year":"2021","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/eye.2016.298","article-title":"Hydroxychloroquine retinopathy","volume":"31","author":"Yusuf","year":"2017","journal-title":"Eye"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1055\/s-0041-1740986","article-title":"The ototoxicity of chloroquine and hydroxychloroquine: A systemic review","volume":"26","author":"Fernandes","year":"2022","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s40495-020-00243-4","article-title":"Side Effects of Chloroquine and Hydroxychloroquine on Skeletal Muscle: A Narrative Review","volume":"6","year":"2020","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_170","first-page":"319","article-title":"Cardiac complications attributed to hydroxychloroquine: A systemic review of the literature pre-COVID-19","volume":"17","author":"Fram","year":"2021","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_171","first-page":"840","article-title":"Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still\u2019s disease","volume":"77","author":"Gabay","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13075-019-1866-2","article-title":"Safety and efficacy of tofacitinib up to 9.5 years in the treatment of rheumatoid arthritis: Final results of a global, open-label, long-term extension study","volume":"21","author":"Wollenhaupt","year":"2019","journal-title":"Arthritis Res. Ther."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/626\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:39:08Z","timestamp":1760103548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,3]]},"references-count":172,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25010626"],"URL":"https:\/\/doi.org\/10.3390\/ijms25010626","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,3]]}}}