{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:43:53Z","timestamp":1789829033590,"version":"4.0.1"},"reference-count":191,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Fund","doi-asserted-by":"publisher","award":["TKP2021-EGA-23"],"award-info":[{"award-number":["TKP2021-EGA-23"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Fund","doi-asserted-by":"publisher","award":["OTKA-K128875"],"award-info":[{"award-number":["OTKA-K128875"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Office of Hungary","doi-asserted-by":"publisher","award":["TKP2021-EGA-23"],"award-info":[{"award-number":["TKP2021-EGA-23"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"National Research, Development and Innovation Office of Hungary","doi-asserted-by":"publisher","award":["OTKA-K128875"],"award-info":[{"award-number":["OTKA-K128875"]}],"id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This review summarizes the current understanding of the role of transient receptor potential melastatin-subfamily member 7 (TRPM7) channels in the pathophysiology of neoplastic diseases. The TRPM family represents the largest and most diverse group in the TRP superfamily. Its subtypes are expressed in virtually all human organs playing a central role in (patho)physiological events. The TRPM7 protein (along with TRPM2 and TRPM6) is unique in that it has kinase activity in addition to the channel function. Numerous studies demonstrate the role of TRPM7 chanzyme in tumorigenesis and in other tumor hallmarks such as proliferation, migration, invasion and metastasis. Here we provide an up-to-date overview about the possible role of TRMP7 in a broad range of malignancies such as tumors of the nervous system, head and neck cancers, malignant neoplasms of the upper gastrointestinal tract, colorectal carcinoma, lung cancer, neoplasms of the urinary system, breast cancer, malignant tumors of the female reproductive organs, prostate cancer and other neoplastic pathologies. Experimental data show that the increased expression and\/or function of TRPM7 are observed in most malignant tumor types. Thus, TRPM7 chanzyme may be a promising target in tumor therapy.<\/jats:p>","DOI":"10.3390\/ijms25020719","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T10:06:43Z","timestamp":1704449203000},"page":"719","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Role of TRPM7 in Oncogenesis"],"prefix":"10.3390","volume":"25","author":[{"given":"L\u00e1szl\u00f3","family":"K\u00f6les","sequence":"first","affiliation":[{"name":"Department of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary"},{"name":"Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polett","family":"Ribiczey","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary"},{"name":"Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Szebeni","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00f3f","family":"K\u00e1d\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-0469","authenticated-orcid":false,"given":"Tibor","family":"Zelles","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary"},{"name":"Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089 Budapest, Hungary"},{"name":"Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, H-1083, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"Zsembery","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-981-10-7757-9_6","article-title":"Transient Receptor Potential (TRP) Channels","volume":"87","author":"Samanta","year":"2018","journal-title":"Subcell. Biochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0092-8674(02)00670-0","article-title":"The TRP channels, a remarkably functional family","volume":"108","author":"Montell","year":"2002","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1124\/pr.55.4.6","article-title":"International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: Transient receptor potential channels","volume":"55","author":"Clapham","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41392-023-01464-x","article-title":"TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ceca.2005.06.028","article-title":"TRP channels: An overview","volume":"38","author":"Pedersen","year":"2005","journal-title":"Cell Calcium"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"102400","DOI":"10.1016\/j.ceca.2021.102400","article-title":"Role of TRPM7 kinase in cancer","volume":"96","author":"Meng","year":"2021","journal-title":"Cell Calcium"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.apsb.2021.11.001","article-title":"The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies","volume":"12","author":"Zhong","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zong, G.F., Deng, R., Yu, S.Y., Wang, A.Y., Wei, Z.H., Zhao, Y., and Lu, Y. (2022). Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315289"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bai, S., Wei, Y., Liu, R., Chen, Y., Ma, W., Wang, M., Chen, L., Luo, Y., and Du, J. (2023). The role of transient receptor potential channels in metastasis. Biomed. Pharmacother., 158.","DOI":"10.1016\/j.biopha.2022.114074"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Perna, A., Sellitto, C., Komici, K., Hay, E., Rocca, A., De Blasiis, P., Lucariello, A., Moccia, F., and Guerra, G. (2022). Transient Receptor Potential (TRP) Channels in Tumor Vascularization. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214253"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Karska, J., Kowalski, S., Saczko, J., Moisescu, M.G., and Kulbacka, J. (2023). Mechanosensitive Ion Channels and Their Role in Cancer Cells. Membranes, 13.","DOI":"10.3390\/membranes13020167"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Piciu, F., Balas, M., Badea, M.A., and Cucu, D. (2023). TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation. Antioxidants, 12.","DOI":"10.20944\/preprints202305.1357.v1"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Otero-Sobrino, A., Blanco-Carlon, P., Navarro-Aguadero, M.A., Gallardo, M., Martinez-Lopez, J., and Velasco-Estevez, M. (2023). Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241813710"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Szallasi, A. (2023). \u201cThermoTRP\u201d Channel Expression in Cancers: Implications for Diagnosis and Prognosis (Practical Approach by a Pathologist). Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24109098"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1111\/bph.12414","article-title":"Transient receptor potential (TRP) channels: A clinical perspective","volume":"171","author":"Kaneko","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/1568026611313030001","article-title":"TRP channels as therapeutic targets","volume":"13","author":"Kaneko","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"re3","DOI":"10.1126\/stke.2722005re3","article-title":"The TRP superfamily of cation channels","volume":"2005","author":"Montell","year":"2005","journal-title":"Sci. STKE"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-007-0265-3_1","article-title":"Structural biology of TRP channels","volume":"704","author":"Li","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.biochem.75.103004.142819","article-title":"TRP channels","volume":"76","author":"Venkatachalam","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Nilius, B., and Owsianik, G. (2011). The transient receptor potential family of ion channels. Genome Biol., 12.","DOI":"10.1186\/gb-2011-12-3-218"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ceca.2006.05.002","article-title":"TRP channels and Ca2+ signaling","volume":"40","author":"Minke","year":"2006","journal-title":"Cell Calcium"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signalling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3389\/fphar.2020.00968","article-title":"Calcium Permeable Channels in Cancer Hallmarks","volume":"11","author":"Tajada","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Marini, M., Titiz, M., Souza Monteiro de Araujo, D., Geppetti, P., Nassini, R., and De Logu, F. (2023). TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches. Biomolecules, 13.","DOI":"10.3390\/biom13101557"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102111","DOI":"10.1016\/j.ceca.2019.102111","article-title":"A structural overview of the ion channels of the TRPM family","volume":"85","author":"Huang","year":"2020","journal-title":"Cell Calcium"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.tips.2004.10.004","article-title":"The TRPM ion channel subfamily: Molecular, biophysical and functional features","volume":"25","author":"Fleig","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Hantute-Ghesquier, A., Haustrate, A., Prevarskaya, N., and Lehen\u2019kyi, V. (2018). TRPM Family Channels in Cancer. Pharmaceuticals, 11.","DOI":"10.3390\/ph11020058"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S0960-9822(03)00431-7","article-title":"TRPM5 is a voltage-modulated and Ca-activated monovalent selective cation channel","volume":"13","author":"Hofmann","year":"2003","journal-title":"Curr. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0092-8674(02)00719-5","article-title":"TRPM4 is a Ca-activated nonselective cation channel mediating cell membrane depolarization","volume":"109","author":"Launay","year":"2002","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Jimenez, I., Prado, Y., Marchant, F., Otero, C., Eltit, F., Cabello-Verrugio, C., Cerda, O., and Simon, F. (2020). TRPM Channels in Human Diseases. Cells, 9.","DOI":"10.3390\/cells9122604"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Chubanov, V., Kottgen, M., Touyz, R.M., and Gudermann, T. (2023). TRPM channels in health and disease. Nat. Rev. Nephrol.","DOI":"10.1038\/s41581-023-00777-y"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1113\/JP274006","article-title":"The TRPM7 channel kinase regulates store-operated calcium entry","volume":"595","author":"Faouzi","year":"2017","journal-title":"J. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/978-3-642-54215-2_21","article-title":"TRPM7","volume":"222","author":"Fleig","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1058519","article-title":"TRP-PLIK, a bifunctional protein with kinase and ion channel activities","volume":"291","author":"Runnels","year":"2001","journal-title":"Science"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"50643","DOI":"10.1074\/jbc.C400441200","article-title":"Phosphorylation of annexin I by TRPM7 channel-kinase","volume":"279","author":"Dorovkov","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jmb.2008.02.057","article-title":"TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation","volume":"378","author":"Clark","year":"2008","journal-title":"J. Mol. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1074\/jbc.M308820200","article-title":"Characterization of the protein kinase activity of TRPM7\/ChaK1, a protein kinase fused to the transient receptor potential ion channel","volume":"279","author":"Ryazanova","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1038\/s41388-019-1140-8","article-title":"Inhibition of TRPM7 blocks MRTF\/SRF-dependent transcriptional and tumorigenic activity","volume":"39","author":"Voringer","year":"2020","journal-title":"Oncogene"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/s41467-017-01960-z","article-title":"TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut","volume":"8","author":"Romagnani","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/978-3-540-34891-7_19","article-title":"The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7","volume":"179","author":"Penner","year":"2007","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2174\/138920111793937880","article-title":"TRPM6 and TRPM7: A Mul-TRP-PLIK-cation of channel functions","volume":"12","author":"Runnels","year":"2011","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"39328","DOI":"10.1074\/jbc.M111.264341","article-title":"Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels","volume":"286","author":"Zierler","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/35079092","article-title":"LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability","volume":"411","author":"Nadler","year":"2001","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kuras, Z., Yun, Y.H., Chimote, A.A., Neumeier, L., and Conforti, L. (2012). KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043859"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kadar, K., Juhasz, V., Foldes, A., Racz, R., Zhang, Y., Lochli, H., Kato, E., Koles, L., Steward, M.C., and DenBesten, P. (2021). TRPM7-Mediated Calcium Transport in HAT-7 Ameloblasts. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083992"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1684\/mrh.2014.0354","article-title":"From magnesium to magnesium transporters in cancer: TRPM7, a novel signature in tumour development","volume":"26","author":"Trapani","year":"2013","journal-title":"Magnes. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1517\/14728222.2014.940894","article-title":"Oncogenic role and therapeutic target of transient receptor potential melastatin 7 channel in malignancy","volume":"18","author":"Zhou","year":"2014","journal-title":"Expert. Opin. Ther. Targets"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Yee, N.S. (2017). Role of TRPM7 in Cancer: Potential as Molecular Biomarker and Therapeutic Target. Pharmaceuticals, 10.","DOI":"10.3390\/ph10020039"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Cordier, C., Prevarskaya, N., and Lehen\u2019kyi, V. (2021). TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer. Cancers, 13.","DOI":"10.3390\/cancers13246322"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"102521","DOI":"10.1016\/j.ceca.2021.102521","article-title":"Modulators of TRPM7 and its potential as a drug target for brain tumours","volume":"101","author":"Ji","year":"2022","journal-title":"Cell Calcium"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Wang, Z.B., Zhang, X., Xiao, F., Liu, Z.Q., Liao, Q.J., Wu, N., and Wang, J. (2023). Roles of TRPM7 in ovarian cancer. Biochem. Pharmacol., 217.","DOI":"10.1016\/j.bcp.2023.115857"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5582\/bst.8.1","article-title":"Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer","volume":"8","author":"Chen","year":"2014","journal-title":"Biosci. Trends"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1074\/jbc.M117.817635","article-title":"TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway","volume":"293","author":"Almasi","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"78312","DOI":"10.18632\/oncotarget.20826","article-title":"TRPM5 mediates acidic extracellular pH signaling and TRPM5 inhibition reduces spontaneous metastasis in mouse B16-BL6 melanoma cells","volume":"8","author":"Maeda","year":"2017","journal-title":"Oncotarget"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.imr.2016.04.004","article-title":"Role of transient receptor potential melastatin type 7 channel in gastric cancer","volume":"5","author":"Kim","year":"2016","journal-title":"Integr. Med. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1065935","DOI":"10.3389\/fonc.2022.1065935","article-title":"On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications","volume":"12","author":"Ciaglia","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"14556","DOI":"10.1002\/jcp.28168","article-title":"The oncogenic roles of TRPM ion channels in cancer","volume":"234","author":"Wong","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Santoni, G., Maggi, F., Morelli, M.B., Santoni, M., and Marinelli, O. (2019). Transient Receptor Potential Cation Channels in Cancer Therapy. Med. Sci., 7.","DOI":"10.3390\/medsci7120108"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"102078","DOI":"10.1016\/j.ceca.2019.102078","article-title":"Dysregulation of Mg(2+) homeostasis contributes to acquisition of cancer hallmarks","volume":"83","author":"Trapani","year":"2019","journal-title":"Cell Calcium"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/978-3-030-12457-1_24","article-title":"Targeting Transient Receptor Potential Channels by MicroRNAs Drives Tumor Development and Progression","volume":"1131","author":"Santoni","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_61","first-page":"397","article-title":"Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis","volume":"73","year":"2016","journal-title":"Bol. Med. Hosp. Infant. Mex."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.3892\/ijo.2015.2919","article-title":"Inhibition of the transient receptor potential melastatin-2 channel causes increased DNA damage and decreased proliferation in breast adenocarcinoma cells","volume":"46","author":"Hopkins","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3892\/or.2015.4131","article-title":"Enhanced cytotoxicity in triple-negative and estrogen receptor-positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel","volume":"34","author":"Koh","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Chodon, D., Guilbert, A., Dhennin-Duthille, I., Gautier, M., Telliez, M.S., Sevestre, H., and Ouadid-Ahidouch, H. (2010). Estrogen regulation of TRPM8 expression in breast cancer cells. BMC Cancer, 10.","DOI":"10.1186\/1471-2407-10-212"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8969","DOI":"10.1007\/s13277-014-2077-8","article-title":"TRPM8 promotes aggressiveness of breast cancer cells by regulating EMT via activating AKT\/GSK-3beta pathway","volume":"35","author":"Liu","year":"2014","journal-title":"Tumour Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1098448","DOI":"10.3389\/fphar.2023.1098448","article-title":"Therapeutic potential of TRPM8 channels in cancer treatment","volume":"14","author":"Ochoa","year":"2023","journal-title":"Front. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1159\/000335795","article-title":"High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: Correlation with pathological parameters","volume":"28","author":"Gautier","year":"2011","journal-title":"Cell Physiol. Biochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6107(03)00060-9","article-title":"Alpha-kinases: Analysis of the family and comparison with conventional protein kinases","volume":"85","author":"Drennan","year":"2004","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Huang, C., Qin, Y., Liu, H., Liang, N., Chen, Y., Ma, D., Han, Z., Xu, X., Zhou, X., and He, J. (2017). Downregulation of a novel long noncoding RNA TRPM2-AS promotes apoptosis in non-small cell lung cancer. Tumour Biol., 39.","DOI":"10.1177\/1010428317691191"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2010.04.023","article-title":"Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma","volume":"297","author":"Yee","year":"2010","journal-title":"Cancer Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1200\/JCO.2001.19.2.568","article-title":"Melastatin expression and prognosis in cutaneous malignant melanoma","volume":"19","author":"Duncan","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0046-8177(00)80003-9","article-title":"Patterns of melastatin mRNA expression in melanocytic tumors","volume":"31","author":"Deeds","year":"2000","journal-title":"Hum. Pathol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"41783","DOI":"10.18632\/oncotarget.6157","article-title":"Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells","volume":"6","author":"Holzmann","year":"2015","journal-title":"Oncotarget"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12032-017-0987-1","article-title":"Downregulation of TRPM7 suppressed migration and invasion by regulating epithelial-mesenchymal transition in prostate cancer cells","volume":"34","author":"Chen","year":"2017","journal-title":"Med. Oncol."},{"key":"ref_75","first-page":"7537","article-title":"TRPM2 promotes the proliferation and invasion of pancreatic ductal adenocarcinoma","volume":"17","author":"Lin","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"E851","DOI":"10.1002\/ijc.27487","article-title":"Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration","volume":"131","author":"Rybarczyk","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.neo.2017.01.004","article-title":"The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90\u03b1\/uPA\/MMP2 pathway","volume":"19","author":"Rybarczyk","year":"2017","journal-title":"Neoplasia"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1600-0625.2012.01565.x","article-title":"Role of TRPM in melanocytes and melanoma","volume":"21","author":"Guo","year":"2012","journal-title":"Exp. Dermatol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s13277-013-1167-3","article-title":"The combination of TRPM8 and TRPA1 expression causes an invasive phenotype in lung cancer","volume":"35","author":"Du","year":"2014","journal-title":"Tumour Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1100\/tsw.2010.149","article-title":"TRP channels in human prostate","volume":"10","author":"Nilius","year":"2010","journal-title":"Sci. World J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/pcan.2009.55","article-title":"Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation","volume":"13","author":"Zeng","year":"2010","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Chinig\u00f2, G., Castel, H., Chever, O., and Gkika, D. (2021). TRP Channels in Brain Tumors. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.617801"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/cns.12354","article-title":"Suppression of TRPM7 inhibits proliferation, migration, and invasion of malignant human glioma cells","volume":"21","author":"Leng","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"14721","DOI":"10.1007\/s13277-016-5317-2","article-title":"TRPM7 channel inhibition mediates midazolam-induced proliferation loss in human malignant glioma","volume":"37","author":"Chen","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.3390\/md13042505","article-title":"Xyloketal B suppresses glioblastoma cell proliferation and migration in vitro through inhibiting TRPM7-regulated PI3K\/Akt and MEK\/ERK signaling pathways","volume":"13","author":"Chen","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"16321","DOI":"10.18632\/oncotarget.3872","article-title":"Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion","volume":"6","author":"Chen","year":"2015","journal-title":"Oncotarget"},{"key":"ref_88","first-page":"8","article-title":"Lidocaine suppresses glioma cell proliferation by inhibiting TRPM7 channels","volume":"9","author":"Leng","year":"2017","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"35124","DOI":"10.18632\/oncotarget.16703","article-title":"Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP","volume":"8","author":"Sander","year":"2017","journal-title":"Oncotarget"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"102307","DOI":"10.1016\/j.ceca.2020.102307","article-title":"Inhibition of TRPM7 with waixenicin A reduces glioblastoma cellular functions","volume":"92","author":"Wong","year":"2020","journal-title":"Cell Calcium"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"11239","DOI":"10.18632\/oncotarget.14496","article-title":"Activation of TRPM7 by naltriben enhances migration and invasion of glioblastoma cells","volume":"8","author":"Wong","year":"2017","journal-title":"Oncotarget"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/ejn.15647","article-title":"Inhibition of TRPM7 with carvacrol suppresses glioblastoma functions in vivo","volume":"55","author":"Alanazi","year":"2022","journal-title":"Eur. J. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1016\/j.cellsig.2014.08.020","article-title":"TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways","volume":"26","author":"Liu","year":"2014","journal-title":"Cell Signal"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"590723","DOI":"10.3389\/fphar.2020.590723","article-title":"TRPM7 Induces Tumorigenesis and Stemness Through Notch Activation in Glioma","volume":"11","author":"Wan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3389\/fonc.2019.01413","article-title":"TRPM7 Induces Mechanistic Target of Rap1b Through the Downregulation of miR-28-5p in Glioma Proliferation and Invasion","volume":"9","author":"Wan","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"110306","DOI":"10.1016\/j.cellsig.2022.110306","article-title":"LncRNA HOTAIR sponges miR-301a-3p to promote glioblastoma proliferation and invasion through upregulating FOSL1","volume":"94","author":"Guo","year":"2022","journal-title":"Cell Signal"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1007\/s13277-015-3577-x","article-title":"Gene expressions of TRP channels in glioblastoma multiforme and relation with survival","volume":"36","author":"Alptekin","year":"2015","journal-title":"Tumour Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"6327","DOI":"10.1111\/jcmm.13931","article-title":"Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels","volume":"22","author":"Tian","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"33302","DOI":"10.18632\/oncotarget.26048","article-title":"The vesicular transfer of CLIC1 from glioblastoma to microvascular endothelial cells requires TRPM7","volume":"9","author":"Thuringer","year":"2018","journal-title":"Oncotarget"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.18632\/oncotarget.2283","article-title":"N-Myc-induced up-regulation of TRPM6\/TRPM7 channels promotes neuroblastoma cell proliferation","volume":"5","author":"Zhang","year":"2014","journal-title":"Oncotarget"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.fob.2014.10.012","article-title":"MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines","volume":"4","author":"Lange","year":"2014","journal-title":"FEBS Open Bio"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"109985","DOI":"10.18632\/oncotarget.22452","article-title":"FTY-720 induces apoptosis in neuroblastoma via multiple signaling pathways","volume":"8","author":"Lange","year":"2017","journal-title":"Oncotarget"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ejcb.2014.07.001","article-title":"Function and regulation of the channel-kinase TRPM7 in health and disease","volume":"93","author":"Visser","year":"2014","journal-title":"Eur. J. Cell Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sj.emboj.7600931","article-title":"TRPM7, a novel regulator of actomyosin contractility and cell adhesion","volume":"25","author":"Clark","year":"2006","journal-title":"EMBO J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ceca.2013.09.003","article-title":"TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells","volume":"54","author":"Visser","year":"2013","journal-title":"Cell Calcium"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.18632\/oncotarget.3315","article-title":"TRPM7 maintains progenitor-like features of neuroblastoma cells: Implications for metastasis formation","volume":"6","author":"Middelbeek","year":"2015","journal-title":"Oncotarget"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejcb.2016.06.008","article-title":"The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression","volume":"95","author":"Middelbeek","year":"2016","journal-title":"Eur. J. Cell Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1254\/jphs.FP0040273","article-title":"Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells","volume":"95","author":"Hanano","year":"2004","journal-title":"J. Pharmacol. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ceca.2010.03.003","article-title":"TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca2+ influx","volume":"47","author":"Chen","year":"2010","journal-title":"Cell Calcium"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.canlet.2014.09.032","article-title":"TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma","volume":"356","author":"Chen","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"9273","DOI":"10.1007\/s13277-015-4636-z","article-title":"Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis","volume":"37","author":"Qin","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"10929","DOI":"10.1158\/0008-5472.CAN-07-1121","article-title":"Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: Role in cell proliferation","volume":"67","author":"Jiang","year":"2007","journal-title":"Cancer Res."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Tian, K., Zhou, E., Xue, X., Yan, S., Chen, Y., Qiao, P., Yang, L., and Chen, X. (2021). hsa_circ_0023305 Enhances Laryngeal Squamous Cell Carcinoma Progression and Modulates TRPM7 via miR-218-5p Sponging. Biomed. Res. Int., 2021.","DOI":"10.1155\/2021\/9968499"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.18632\/aging.204154","article-title":"TRPM7 via calcineurin\/NFAT pathway mediates metastasis and chemotherapeutic resistance in head and neck squamous cell carcinoma","volume":"14","author":"Chen","year":"2022","journal-title":"Aging"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.21873\/anticanres.11429","article-title":"Transient Receptor Potential Melastatin 7 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma","volume":"37","author":"Nakashima","year":"2017","journal-title":"Anticancer. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1111\/j.1349-7006.2008.00982.x","article-title":"Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer","volume":"99","author":"Kim","year":"2008","journal-title":"Cancer Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1139\/y11-114","article-title":"The role of transient receptor potential channel blockers in human gastric cancer cell viability","volume":"90","author":"Kim","year":"2012","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3831\/KPI.2012.15.003","article-title":"Involvement of Transient Receptor Potential Melastatin 7 Channels in Sophorae Radix-induced Apoptosis in Cancer Cells: Sophorae Radix and TRPM7","volume":"15","author":"Kim","year":"2012","journal-title":"J. Pharmacopunct."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"102053","DOI":"10.1016\/j.ceca.2019.06.007","article-title":"TRP channels in gastric cancer: New hopes and clinical perspectives","volume":"82","author":"Sterea","year":"2019","journal-title":"Cell Calcium"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1742-7843.2011.00706.x","article-title":"Transient receptor potential melastatin 7 channels are involved in ginsenoside Rg3-induced apoptosis in gastric cancer cells","volume":"109","author":"Kim","year":"2011","journal-title":"Basic. Clin. Pharmacol. Toxicol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3831\/KPI.2013.16.011","article-title":"Effects of Ulmi Pumilae Cortex on AGS Gastric Cancer Cells","volume":"16","author":"Lim","year":"2013","journal-title":"J. Pharmacopunct."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3831\/KPI.2013.16.016","article-title":"Buxus Microphylla var. Koreana Nakai Extract for the Treatment of Gastric Cancer","volume":"16","author":"Lee","year":"2013","journal-title":"J. Pharmacopunct."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.3892\/ijmm.2014.1704","article-title":"Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells","volume":"33","author":"Kim","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1742-7843.2012.00929.x","article-title":"The role of waixenicin A as transient receptor potential melastatin 7 blocker","volume":"112","author":"Kim","year":"2013","journal-title":"Basic. Clin. Pharmacol. Toxicol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"7249726","DOI":"10.1155\/2021\/7249726","article-title":"Prognostic Value of TRPM7 Expression and Factor XIIIa-Expressing Tumor-Associated Macrophages in Gastric Cancer","volume":"2021","author":"Calik","year":"2021","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5142\/jgr.2013.37.201","article-title":"Involvement of melastatin type transient receptor potential 7 channels in ginsenoside Rd-induced apoptosis in gastric and breast cancer cells","volume":"37","author":"Kim","year":"2013","journal-title":"J. Ginseng Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1242\/dmm.004564","article-title":"Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer","volume":"4","author":"Yee","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"415158","DOI":"10.6064\/2012\/415158","article-title":"TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets","volume":"2012","author":"Yee","year":"2012","journal-title":"Scientifica"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1242\/bio.20137088","article-title":"Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: Required for cancer cell invasion and implicated in tumor growth and metastasis","volume":"4","author":"Yee","year":"2015","journal-title":"Biol. Open"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Auwercx, J., Kischel, P., Lefebvre, T., Jonckheere, N., Vanlaeys, A., Gu\u00e9nin, S., Radoslavova, S., Van Seuningen, I., Ouadid-Ahidouch, H., and Kocher, H.M. (2022). TRPM7 Modulates Human Pancreatic Stellate Cell Activation. Cells, 11.","DOI":"10.3390\/cells11142255"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.canlet.2011.12.007","article-title":"Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma","volume":"318","author":"Yee","year":"2012","journal-title":"Cancer Lett."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Lefebvre, T., Rybarczyk, P., Bretaudeau, C., Vanlaeys, A., Cousin, R., Brassart-Pasco, S., Chatelain, D., Dhennin-Duthille, I., Ouadid-Ahidouch, H., and Brassart, B. (2020). TRPM7\/RPSA Complex Regulates Pancreatic Cancer Cell Migration. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00549"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1139\/y11-136","article-title":"Differential expression of TRPM7 in rat hepatoma and embryonic and adult hepatocytes","volume":"90","author":"Lam","year":"2012","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.yexcr.2016.09.022","article-title":"Bradykinin promotes migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2","volume":"349","author":"Chen","year":"2016","journal-title":"Exp. Cell Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"16538","DOI":"10.1038\/srep16538","article-title":"Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin","volume":"5","author":"Castiglioni","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"40538","DOI":"10.1038\/srep40538","article-title":"The different expression of TRPM7 and MagT1 impacts on the proliferation of colon carcinoma cells sensitive or resistant to doxorubicin","volume":"7","author":"Cazzaniga","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12964-017-0187-9","article-title":"Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice","volume":"15","author":"Huang","year":"2017","journal-title":"Cell Commun. Signal"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.dld.2020.05.027","article-title":"TRPM7 is overexpressed in human IBD-related and sporadic colorectal cancer and correlates with tumor grade","volume":"52","author":"Pugliese","year":"2020","journal-title":"Dig. Liver Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3233\/CBM-190666","article-title":"TRPM7 deficiency suppresses cell proliferation, migration, and invasion in human colorectal cancer via regulation of epithelial-mesenchymal transition","volume":"26","author":"Su","year":"2019","journal-title":"Cancer Biomark."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Lee, J.C., Bae, A.N., Lee, H.J., and Lee, J.H. (2022). Clinical and Prognostic Values of TRPM7 in Colon and Rectal Cancers. Medicina, 58.","DOI":"10.3390\/medicina58111582"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/mc.22387","article-title":"Calcium\/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study","volume":"55","author":"Zhu","year":"2016","journal-title":"Mol. Carcinog."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/ajcn\/86.3.743","article-title":"The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk","volume":"86","author":"Dai","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1684\/mrh.2020.0470","article-title":"Magnesium deficiency with high calcium-to-magnesium ratio promotes a metastatic phenotype in the CT26 colon cancer cell line","volume":"33","author":"Kumar","year":"2020","journal-title":"Magnes. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ceca.2011.09.003","article-title":"EGF enhances the migration of cancer cells by up-regulation of TRPM7","volume":"50","author":"Gao","year":"2011","journal-title":"Cell Calcium"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Liu, K., Xu, S.H., Chen, Z., Zeng, Q.X., Li, Z.J., and Chen, Z.M. (2018). TRPM7 overexpression enhances the cancer stem cell-like and metastatic phenotypes of lung cancer through modulation of the Hsp90\u03b1\/uPA\/MMP2 signaling pathway. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-5050-x"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41416-020-0991-7","article-title":"A novel TRPM7\/O-GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma","volume":"123","author":"Luanpitpong","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1158\/1541-7786.MCR-17-0767","article-title":"TRPM7 Regulates AKT\/FOXO1-Dependent Tumor Growth and Is an Independent Prognostic Indicator in Renal Cell Carcinoma","volume":"16","author":"Zhao","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4111\/icu.2018.59.4.263","article-title":"Down-regulation of transient receptor potential melastatin member 7 prevents migration and invasion of renal cell carcinoma cells via inactivation of the Src and Akt pathway","volume":"59","author":"Ha","year":"2018","journal-title":"Investig. Clin. Urol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s12576-014-0319-6","article-title":"Potential role of transient receptor potential (TRP) channels in bladder cancer cells","volume":"64","author":"Mizuno","year":"2014","journal-title":"J. Physiol. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.3892\/or.2017.5883","article-title":"TRPM7 is overexpressed in bladder cancer and promotes proliferation, migration, invasion and tumor growth","volume":"38","author":"Gao","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.3892\/ol.2016.5359","article-title":"Potential role of melastatin-related transient receptor potential cation channel subfamily M gene expression in the pathogenesis of urinary bladder cancer","volume":"12","author":"Ceylan","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"72941","DOI":"10.18632\/oncotarget.12146","article-title":"Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1\/2 pathway","volume":"7","author":"Cao","year":"2016","journal-title":"Oncotarget"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Lee, E.H., Chun, S.Y., Kim, B., Yoon, B.H., Lee, J.N., Kim, B.S., Yoo, E.S., Lee, S., Song, P.H., and Kwon, T.G. (2020). Knockdown of TRPM7 prevents tumor growth, migration, and invasion through the Src, Akt, and JNK pathway in bladder cancer. BMC Urol., 20.","DOI":"10.1186\/s12894-020-00714-2"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Che, X., Zhan, J., Zhao, F., Zhong, Z., Chen, M., Han, R., and Wang, Y. (2021). Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways. Biomed. Res. Int., 2021.","DOI":"10.1155\/2021\/4340950"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"C493","DOI":"10.1152\/ajpcell.00624.2008","article-title":"Evidence that TRPM7 is required for breast cancer cell proliferation","volume":"297","author":"Guilbert","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1158\/0008-5472.CAN-11-3863","article-title":"TRPM7 is required for breast tumor cell metastasis","volume":"72","author":"Middelbeek","year":"2012","journal-title":"Cancer Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1016\/j.ejca.2013.07.008","article-title":"Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain","volume":"49","author":"Guilbert","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.canlet.2013.01.031","article-title":"TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway","volume":"333","author":"Meng","year":"2013","journal-title":"Cancer Lett."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12032-014-0051-3","article-title":"The association between single-nucleotide polymorphisms of TRPM7 gene and breast cancer in Han Population of Northeast China","volume":"31","author":"Shen","year":"2014","journal-title":"Med. Oncol."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Wang, Y., Lu, R., Chen, P., Cui, R., Ji, M., Zhang, X., Hou, P., and Qu, Y. (2022). Promoter methylation of transient receptor potential melastatin-related 7 (TRPM7) predicts a better prognosis in patients with Luminal A breast cancers. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-10038-z"},{"key":"ref_161","first-page":"1","article-title":"Serum calcium levels, TRPM7, TRPC1, microcalcifications, and breast cancer using breast imaging reporting and data system scores","volume":"2013","author":"Mandavilli","year":"2012","journal-title":"Breast Cancer (Dove Med. Press)"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41598-018-36496-9","article-title":"Deposition of calcium in an in vitro model of human breast tumour calcification reveals functional role for ALP activity, altered expression of osteogenic genes and dysregulation of the TRPM7 ion channel","volume":"9","author":"Morgan","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.mehy.2010.02.037","article-title":"Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?","volume":"75","author":"Sahmoun","year":"2010","journal-title":"Med. Hypotheses"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Liu, H., Dilger, J.P., and Lin, J. (2020). The Role of Transient Receptor Potential Melastatin 7 (TRPM7) in Cell Viability: A Potential Target to Suppress Breast Cancer Cell Cycle. Cancers, 12.","DOI":"10.3390\/cancers12010131"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Liu, H., Dilger, J.P., and Lin, J. (2021). Lidocaine Suppresses Viability and Migration of Human Breast Cancer Cells: TRPM7 as a Target for Some Breast Cancer Cell Lines. Cancers, 13.","DOI":"10.3390\/cancers13020234"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"118894","DOI":"10.1016\/j.lfs.2020.118894","article-title":"Carvacrol affects breast cancer cells through TRPM7 mediated cell cycle regulation","volume":"266","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.bbagen.2017.01.034","article-title":"Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion","volume":"1861","author":"Song","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1038\/onc.2013.187","article-title":"Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent","volume":"33","author":"Davis","year":"2014","journal-title":"Oncogene"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbrc.2015.01.141","article-title":"A role for calcium in the regulation of ATP-binding cassette, sub-family C, member 3 (ABCC3) gene expression in a model of epidermal growth factor-mediated breast cancer epithelial-mesenchymal transition","volume":"458","author":"Stewart","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Wang, H., Li, B., Asha, K., Pangilinan, R.L., Thuraisamy, A., Chopra, H., Rokudai, S., Yu, Y., Prives, C.L., and Zhu, Y. (2021). The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation. J. Biol. Chem., 297.","DOI":"10.1016\/j.jbc.2021.101292"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1002\/jcp.29820","article-title":"Suppression of TRPM7 enhances TRAIL-induced apoptosis in triple-negative breast cancer cells","volume":"235","author":"Song","year":"2020","journal-title":"J. Cell Physiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1016\/j.bbadis.2018.04.017","article-title":"TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4","volume":"1864","author":"Kuipers","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.7314\/APJCP.2014.15.9.3955","article-title":"Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma","volume":"15","author":"Wang","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.bbrc.2014.10.118","article-title":"TRPM7 is required for ovarian cancer cell growth, migration and invasion","volume":"454","author":"Wang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13046-019-1061-y","article-title":"TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K \/ AKT oncogenic signaling","volume":"38","author":"Liu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13046-022-02252-1","article-title":"TRPM7 silencing modulates glucose metabolic reprogramming to inhibit the growth of ovarian cancer by enhancing AMPK activation to promote HIF-1\u03b1 degradation","volume":"41","author":"Chen","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cbi.2019.01.036","article-title":"miR-543 inhibites cervical cancer growth and metastasis by targeting TRPM7","volume":"302","author":"Liu","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/kjm2.12398","article-title":"Tumor suppressor miR-192-5p targets TRPM7 and inhibits proliferation and invasion in cervical cancer","volume":"37","author":"Dong","year":"2021","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"e14157","DOI":"10.14814\/phy2.14157","article-title":"TRPM7 is involved in acid-induced necrotic cell death in a manner sensitive to progesterone in human cervical cancer cells","volume":"7","author":"Numata","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3906\/sag-1810-176","article-title":"Is there any difference between endometrial hyperplasia and endometrial carcinoma in terms of expression of TRPM2 and TRPM7 ion channels?","volume":"49","author":"Pala","year":"2019","journal-title":"Turk. J. Med. Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1074\/jbc.M112.393918","article-title":"Increase in serum Ca2+\/Mg2+ ratio promotes proliferation of prostate cancer cells by activating TRPM7 channels","volume":"288","author":"Sun","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.bbamcr.2014.04.019","article-title":"Cholesterol-induced activation of TRPM7 regulates cell proliferation, migration, and viability of human prostate cells","volume":"1843","author":"Sun","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Schoolmeesters, A., Brown, D.D., and Fedorov, Y. (2012). Kinome-wide functional genomics screen reveals a novel mechanism of TNF\u03b1-induced nuclear accumulation of the HIF-1\u03b1 transcription factor in cancer cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031270"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.7314\/APJCP.2015.16.10.4469","article-title":"Inhibition of Transient Receptor Potential Melastain 7 Enhances Apoptosis Induced by TRAIL in PC-3 cells","volume":"16","author":"Lin","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1469693","DOI":"10.1155\/2016\/1469693","article-title":"Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K\/Akt and MAPK Signaling Pathways","volume":"2016","author":"Luo","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/mc.22797","article-title":"TGF\u03b2-induced epithelial-to-mesenchymal transition in prostate cancer cells is mediated via TRPM7 expression","volume":"57","author":"Sun","year":"2018","journal-title":"Mol. Carcinog."},{"key":"ref_187","first-page":"6724810","article-title":"Suppression of TRPM7 Inhibited Hypoxia-Induced Migration and Invasion of Androgen-Independent Prostate Cancer Cells by Enhancing RACK1-Mediated Degradation of HIF-1alpha","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1038\/sj.jid.5700710","article-title":"Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis","volume":"127","author":"McNeill","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Prouteau, A., Mottier, S., Primot, A., Cadieu, E., Bachelot, L., Botherel, N., Cabillic, F., Houel, A., Cornevin, L., and Kergal, C. (2022). Canine Oral Melanoma Genomic and Transcriptomic Study Defines Two Molecular Subgroups with Different Therapeutical Targets. Cancers, 14.","DOI":"10.3390\/cancers14020276"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3892\/ol.2022.13228","article-title":"Transient receptor potential channels in multiple myeloma","volume":"23","author":"Meng","year":"2022","journal-title":"Oncol. Lett."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13046-021-01876-z","article-title":"O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination","volume":"40","author":"Samart","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/2\/719\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:40:55Z","timestamp":1760103655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/2\/719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,5]]},"references-count":191,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25020719"],"URL":"https:\/\/doi.org\/10.3390\/ijms25020719","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,5]]}}}