{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T01:38:54Z","timestamp":1769909934352,"version":"3.49.0"},"reference-count":73,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aim of this study was to evaluate the anti-inflammatory effect of fermented cabbage extract (FC) containing nitric oxide metabolites with silica (FCS) on 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis (AD) in BALB\/c mice. Atopic dermatitis-like allergic contact dermatitis was induced by DNFB challenge in the ear after DNFB sensitization on the dorsal skin of mice. FCS alleviated the severity of atopic dermatitis-like skin lesions. In addition, epidermis thickness of the ear and penetration of inflammatory cells in atopic dermatitis-like skin lesions were decreased after topical application of FCS. The serum levels of TNF-\u03b1 and IL-4 were measured in atopic dermatitis mice using ELISA kits, which were observed to be significantly decreased after topical application of FCS. This study demonstrates that the FCS can be used as a potential therapeutic for the treatment and prevention of AD.<\/jats:p>","DOI":"10.3390\/ijms25020775","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T07:59:20Z","timestamp":1704700760000},"page":"775","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica"],"prefix":"10.3390","volume":"25","author":[{"given":"Yun-Seong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4643-9719","authenticated-orcid":false,"given":"Byeong-Jun","family":"Ji","sequence":"additional","affiliation":[{"name":"HumanEnos LLC., Wanju 55347, Republic of Korea"},{"name":"Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Ock","family":"Pae","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Wonkwang University, Iksan 54538, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu-Weon","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Chemistry, KwangWoon University, Seoul 01897, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangpeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Environment Science & Biotechnology, Jeonju University, Jeonju 55069, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Soo","family":"Chun","sequence":"additional","affiliation":[{"name":"HumanEnos LLC., Wanju 55347, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sooah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Environment Science & Biotechnology, Jeonju University, Jeonju 55069, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4168\/aard.2019.7.3.113","article-title":"Atopic dermatitis mouse models","volume":"7","author":"Kim","year":"2019","journal-title":"Allergy Asthma Respir. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0923-1811(93)90767-J","article-title":"A speculative view of atopic dermatitis: Barrier dysfunction in pathogenesis","volume":"5","author":"Ogawa","year":"1993","journal-title":"J. Dermatol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4168\/aard.2013.1.1.20","article-title":"Atopic dermatitis and skin barrier dysfunction","volume":"1","author":"Kim","year":"2013","journal-title":"Allergy Asthma Respir. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0923-1811(95)00476-9","article-title":"ICAM-1 expression on keratinocytes in mechanically-injured skin of a patient with atopic dermatitis","volume":"12","author":"Matsunaga","year":"1996","journal-title":"J. Dermatol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1038\/sj.jid.5700726","article-title":"Skin contact irritation conditions the development and severity of allergic contact dermatitis","volume":"127","author":"Bonneville","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1084\/jem.189.5.779","article-title":"Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity","volume":"189","author":"Kehren","year":"1999","journal-title":"J. Exp. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"FSO37","DOI":"10.4155\/fso.15.37","article-title":"Nitric oxide therapy for dermatologic disease","volume":"1","author":"Brandon","year":"2015","journal-title":"Future Sci. OA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1021\/ja0291538","article-title":"Nitric Oxide-Releasing Fumed Silica Particles:\u2009 Synthesis, Characterization, and Biomedical Application","volume":"125","author":"Zhang","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref_9","first-page":"295","article-title":"Overview of the Endothelium","volume":"Volume 13","author":"Loscalzo","year":"1998","journal-title":"Thrombosis and Hemorrhage"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0140-6736(87)91481-4","article-title":"Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium","volume":"2","author":"Radomski","year":"1987","journal-title":"Lancet"},{"key":"ref_11","first-page":"H1705","article-title":"Effective diffusion distance of nitric oxide in the microcirculation","volume":"274","author":"Vaughn","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/CH-131758","article-title":"Nitric oxide metabolites (nitrite and nitrate) in several clinical condition","volume":"56","author":"Caimi","year":"2014","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jbm.a.30275","article-title":"Synthesis, characterization, and controlled nitric oxide release from S-nitrosothiol-derivatized fumed silica polymer filler particles","volume":"72","author":"Frost","year":"2005","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1002\/jbm.b.33711","article-title":"The accelerating effect of chitosan-silica hybrid dressing materials on the early phase of wound healing","volume":"105","author":"Park","year":"2017","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.actbio.2018.01.019","article-title":"Highly efficient local delivery of endothelial progenitor cells significantly potentiates angiogenesis and full-thickness wound healing","volume":"69","author":"Wang","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.biomaterials.2017.10.018","article-title":"Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-scavenging tissue adhesive for highly efficient regenerative wound healing","volume":"151","author":"Wu","year":"2018","journal-title":"Biomaterials"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1002\/anie.201401043","article-title":"Organ repair, hemostasis, and in vivo bonding of medical devices by aqueous solutions of nanoparticles","volume":"53","author":"Legrand","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/j.jid.2020.04.013","article-title":"A Nitric Oxide-Releasing Topical Medication as a Potential Treatment Option for Atopic Dermatitis through Antimicrobial and Anti-Inflammatory Activity","volume":"140","author":"Emma","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1742-481X.2011.00889.x","article-title":"Novel nitric oxide producing probiotic wound healing patch: Preparation and in vivo analysis in a New Zealand white rabbit model of ischaemic and infected wounds","volume":"9","author":"Mitchell","year":"2012","journal-title":"Int. Wound J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/bcpt.12817","article-title":"Curcumin ameliorates kidney function and oxidative stress in experimental chronic kidney disease","volume":"122","author":"Ali","year":"2018","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbi.2014.03.009","article-title":"Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide induced liver cirrhosis in rats","volume":"216","author":"Ali","year":"2014","journal-title":"Chem.-Biol. Interact."},{"key":"ref_22","first-page":"201","article-title":"The effect of high dietary salt consumption on renal function in Streptozotocin-induced diabetic male Wistar rats","volume":"6","author":"Asiwe","year":"2021","journal-title":"Int. J. Nutr. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1007\/s11356-017-0750-3","article-title":"Comparative analysis of the protective effects of curcumin and N-acetyl cysteine against paracetamol-induced hepatic, renal, and testicular toxicity in Wistar rats","volume":"25","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.fct.2013.05.059","article-title":"Effect of cadmium-polluted water on plasma levels of tumor necrosis factor-\u03b1, interleukin-6 and oxidative status biomarkers in rats: Protective effect of curcumin","volume":"59","author":"Alghasham","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1039\/c1np00051a","article-title":"Multitargeting by curcumin as revealed by molecular interaction studies","volume":"28","author":"Gupta","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.biopha.2018.01.072","article-title":"Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review","volume":"99","author":"Hosseini","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12011-015-0280-0","article-title":"Molecular and histopathological study on the ameliorative effects of curcumin against lead acetate-induced hepatotoxicity and nephrototoxicity in Wistar rats","volume":"167","author":"Soliman","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ranjana, S., Prakrati, G., Pradeep, K., Shashi, K.B., and Saurabh, K. (2020). Microbial Fermentation and Its Role in Quality Improvement of Fermented Foods. Fermentation, 6.","DOI":"10.3390\/fermentation6040106"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/pai.13045","article-title":"Do traditional fermented foods protect against infantile atopic dermatitis","volume":"30","author":"Velat","year":"2019","journal-title":"Pediatr Allergy Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.nutres.2015.11.011","article-title":"Fermented food intake is associated with a reduced likelihood of atopic dermatitis in an adult population (Korean National Health and Nutrition Examination)","volume":"36","author":"Park","year":"2016","journal-title":"Nutr Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1073\/pnas.0915139107","article-title":"Inhibitory role for GABA in autoimmune inflammation","volume":"107","author":"Bhat","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Salvo, E.D., Gangemi, S., Genovese, C., Cicero, N., and Casciaro, M. (2023). Polyphenols from Mediterranean Plants: Biological Activities for Skin Photoprotection in Atopic Dermatitis, Psoriasis, and Chronic Urticaria. Plants, 12.","DOI":"10.3390\/plants12203579"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jaci.2011.01.053","article-title":"Contrasting pathogenesis of atopic dermatitis and psoriasis\u2014Part I: Clinical and pathologic concepts","volume":"127","author":"Nograles","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1398-9995.2010.02483.x","article-title":"Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation","volume":"66","author":"Hong","year":"2011","journal-title":"Allergy"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Furue, M. (2020). Regulation of Skin Barrier Function via Competition between AHR Axis versus IL-13\/IL-4\u2012JAK\u2012STAT6\/STAT3 Axis: Pathogenic and Therapeutic Implications in Atopic Dermatitis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9113741"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1248\/bpb.b19-00088","article-title":"Current Understanding of Pathophysiological Mechanisms of Atopic Dermatitis: Interactions among Skin Barrier Dysfunction, Immune Abnormalities and Pruritus","volume":"43","author":"Fujii","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Yang, J.H., Lee, E., Lee, B.H., Cho, W.K., Ma, J.Y., and Park, K.I. (2018). Ethanolic Extracts of Artemisia apiacea Hance Improved Atopic Dermatitis-Like Skin Lesions In Vivo and Suppressed TNF-Alpha\/IFN-Gamma\u2013Induced Proinflammatory Chemokine Production In Vitro. Nutrients, 10.","DOI":"10.3390\/nu10070806"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic dermatitis","volume":"387","author":"Stephan","year":"2016","journal-title":"Lancet"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0966-3274(03)00050-9","article-title":"Influence of immunosuppressive drugs on dendritic cells","volume":"11","author":"Abe","year":"2003","journal-title":"Transpl. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1172\/JCI119473","article-title":"Mechanisms of nitric oxide-related antimicrobial activity","volume":"99","author":"Fang","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/nrmicro1004","article-title":"Antimicrobial reactive oxygen and nitrogen species: Concepts and controversies","volume":"2","author":"Fang","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_42","first-page":"177","article-title":"Antimicrobial properties of nitric oxide using diazeniumdiolates as the nitric oxide donor","volume":"6","author":"Raulli","year":"2002","journal-title":"Recent Res. Dev. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10787-007-0013-x","article-title":"Role of nitric oxide in inflammatory diseases","volume":"15","author":"Sharma","year":"2007","journal-title":"Inflammopharmacology"},{"key":"ref_44","first-page":"109","article-title":"Nitric oxide: Physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"H1767","DOI":"10.1152\/ajpheart.00544.2003","article-title":"Nitric oxide mediates protective effect of endothelin receptors antagonism during myocardial ischemia and perfusion","volume":"286","author":"Gonon","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1084\/jem.180.3.783","article-title":"Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major","volume":"180","author":"Stenger","year":"1994","journal-title":"J. Exp. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"21277","DOI":"10.1016\/S0021-9258(19)36601-3","article-title":"Epidermal Growth Factor Suppresses Nitric Oxide and Hydrogen Peroxide Production by Keratinocytes","volume":"267","author":"Heck","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0140-6736(94)91328-5","article-title":"Epidermal keratinocyte expression of inducible nitric oxide synthase in skin lesions of psoriasis vulgaris","volume":"344","author":"Fehsel","year":"1994","journal-title":"Lancet"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/1523-1747.ep12328204","article-title":"Inhibitors of nitric oxide synthase in human skin","volume":"106","author":"Goldsmith","year":"1996","journal-title":"J. Investig. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1021\/nn700191f","article-title":"Bactericidal efficacy of nitric oxide-releasing silica nanoparticles","volume":"2","author":"Hetrick","year":"2008","journal-title":"ACS Nano"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1016\/j.biomaterials.2009.01.052","article-title":"Anti-Biofilm Efficacy of Nitric Oxide-Releasing Silica Nanoparticles","volume":"30","author":"Hetrick","year":"2009","journal-title":"Biomaterials"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/niox.1996.0112","article-title":"A tutorial on the diffusability and reactivity of free nitric oxide","volume":"1","author":"Lancaster","year":"1997","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1021\/la052797j","article-title":"Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding","volume":"22","author":"Bagwe","year":"2006","journal-title":"Langmuir"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1021\/cm8007478","article-title":"Silica nanoparticles with continuously tunable sizes: Synthesis and size effects on cellular contrast imaging","volume":"20","author":"Jin","year":"2008","journal-title":"Chem. Mater."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1745-4514.2009.00329.x","article-title":"The antioxidative properties of white cabbage (Brassica oleracea var. capitata F. Alba) fresh and submitted to culinary processing","volume":"34","author":"Kusznierewicz","year":"2010","journal-title":"J. Food Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"11694","DOI":"10.1021\/jf802403d","article-title":"Free radical scavenging and antioxidant activity of ascorbigen versus ascorbic acid: Studies in vitro and in cultured human keratinocytes","volume":"56","author":"Wagner","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0308-8146(98)00016-8","article-title":"A study on the formation and stability of ascorbigen in an aqueous system","volume":"63","author":"Hrncirik","year":"1998","journal-title":"Food Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"7938","DOI":"10.1021\/jf048986+","article-title":"Glucosinolate derivatives in stored fermented cabbage","volume":"52","author":"Ciska","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_59","first-page":"16","article-title":"Influence of fermentation conditions of Brassica oleracea L. var. capitata on the volatile glucosinolate hydrolysis compounds of sauerkrauts","volume":"48","author":"Pihlava","year":"2012","journal-title":"Food Sci. Technol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6798","DOI":"10.1021\/jf0109017","article-title":"Plant-derived biomolecules in fermented cabbage","volume":"50","author":"Tolonen","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.phrs.2010.11.005","article-title":"Allyl, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured cells","volume":"63","author":"Ernst","year":"2011","journal-title":"Pharmacol. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.etp.2010.11.005","article-title":"Protective effect of sulforaphane against oxidative stress: Recent advances","volume":"64","author":"Chirino","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_63","first-page":"97","article-title":"Anti-nociceptive and anti-inflammatory effects of Geranii Herba","volume":"25","author":"Ju","year":"2010","journal-title":"Korea J. Herbol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/adc.67.3.277","article-title":"Increased plasma tumour necrosis factor-alpha concentration in atopic dermatitis","volume":"67","author":"Sumimoto","year":"1992","journal-title":"Arch. Dis. Child."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1081-1206(10)62853-0","article-title":"Human skin mast cells: In vitro and in vivo studies","volume":"83","author":"Church","year":"1999","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2222.1991.tb01757.x","article-title":"Biological properties of human skin mast cells","volume":"21","author":"Church","year":"1991","journal-title":"Clin. Exp. Allergy"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1067\/mjd.2002.124617","article-title":"Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: Changes in barrier function provide a sensitive indicator of disease activity","volume":"47","author":"Chamlin","year":"2002","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1600-0625.2009.00899.x","article-title":"Induction of eosinophil- and Th2-attracting epidermal chemokines and cutaneous late-phase reaction in tape-stripped skin","volume":"18","author":"Onoue","year":"2009","journal-title":"Exp. Dermatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/1523-1747.ep12343392","article-title":"Barrier disruption stimulates interleukin-1 alpha expression and release from a pre-formed pool in murine epidermis","volume":"106","author":"Wood","year":"1996","journal-title":"J. Investig. Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Park, J.S., Ryu, J.H., Kim, B.Y., Chun, H.S., Kim, M.S., and Shin, Y.I. (2023). Fermented Lettuce Extract Containing Nitric Oxide Metabolites Attenuates Inflammatory Parameters in Model Mice and in Human Fibroblast-Like Synoviocytes. Nutrients, 15.","DOI":"10.3390\/nu15051106"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1080\/00032711003763558","article-title":"A validated HPLC method for the determination of GABA by pre-column derivatization with 2,4-dinitrofluorodinitrobenzene and its application to plant GAD activity study","volume":"43","author":"Lu","year":"2010","journal-title":"Anal. Lett."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Jeong, S.Y., Kim, E., Zhang, M., Lee, Y.-S., Ji, B., Lee, S.-H., Cheong, Y.E., Yun, S.-I., Kim, Y.-S., and Kim, K.H. (2021). Antidiabetic Effect of Noodles Containing Fermented Lettuce Extracts. Metabolites, 11.","DOI":"10.3390\/metabo11080520"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7592","DOI":"10.1021\/jf050579q","article-title":"Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman","volume":"53","author":"Alasalvar","year":"2005","journal-title":"J. Agric. Food Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/2\/775\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:41:49Z","timestamp":1760103709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/2\/775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,8]]},"references-count":73,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25020775"],"URL":"https:\/\/doi.org\/10.3390\/ijms25020775","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,8]]}}}