{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:19:41Z","timestamp":1792804781153,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Center of Research and Development (NCBiR)","award":["ERA-NET-NEURON\/19\/2018"],"award-info":[{"award-number":["ERA-NET-NEURON\/19\/2018"]}],"id":[{"id":"https:\/\/ror.org\/044wgz941","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Center of Research and Development (NCBiR)","award":["POIR.01.01.01-00-0235\/20-00"],"award-info":[{"award-number":["POIR.01.01.01-00-0235\/20-00"]}],"id":[{"id":"https:\/\/ror.org\/044wgz941","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Epilepsy, a neurological disorder affecting over 50 million individuals globally, is characterized by an enduring predisposition and diverse consequences, both neurobiological and social. Acquired epilepsy, constituting 30% of cases, often results from brain-damaging injuries like ischemic stroke. With one third of epilepsy cases being resistant to existing drugs and without any preventive therapeutics for epileptogenesis, identifying anti-epileptogenic targets is crucial. Stroke being a leading cause of acquired epilepsy, particularly in the elderly, prompts the need for understanding post-stroke epileptogenesis. Despite the challenges in studying stroke-evoked epilepsy in rodents due to poor long-term survival rates, in this presented study the use of an animal care protocol allowed for comprehensive investigation. We highlight the role of matrix metalloproteinase-9 (MMP-9) in post-stroke epileptogenesis, emphasizing MMP-9 involvement in mouse models and its potential as a therapeutic target. Using a focal Middle Cerebral Artery occlusion model, this study demonstrates MMP-9 activation following ischemia, influencing susceptibility to seizures. MMP-9 knockout reduces epileptic features, while overexpression exacerbates them. The findings show that MMP-9 is a key player in post-stroke epileptogenesis, presenting opportunities for future therapies and expanding our understanding of acquired epilepsy.<\/jats:p>","DOI":"10.3390\/ijms25020896","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T05:24:12Z","timestamp":1704950652000},"page":"896","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Matrix Metalloproteinase-9 Contributes to Epilepsy Development after Ischemic Stroke in Mice"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9268-5208","authenticated-orcid":false,"given":"Barbara","family":"Pijet","sequence":"first","affiliation":[{"name":"Laboratory of Neurobiology, Braincity, Nencki Institute of Experimental Biology, Pasteura 3, 02-093 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Kostrzewska-Ksi\u0119zyk","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology, Braincity, Nencki Institute of Experimental Biology, Pasteura 3, 02-093 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Pijet-Kucicka","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology, Braincity, Nencki Institute of Experimental Biology, Pasteura 3, 02-093 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7207-3490","authenticated-orcid":false,"given":"Leszek","family":"Kaczmarek","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology, Braincity, Nencki Institute of Experimental Biology, Pasteura 3, 02-093 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","article-title":"Epileptic seizures and epilepsy: Definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)","volume":"46","author":"Fisher","year":"2005","journal-title":"Epilepsia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000503831","article-title":"The Epidemiology of Epilepsy","volume":"54","author":"Beghi","year":"2020","journal-title":"Neuroepidemiology"},{"key":"ref_3","unstructured":"World Health Organization (2019). 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