{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:57:47Z","timestamp":1791561467350,"version":"4.3.4"},"reference-count":165,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Bialystok","award":["B.SUB. 23.129\/01.S"],"award-info":[{"award-number":["B.SUB. 23.129\/01.S"]}]},{"name":"Medical University of Bialystok","award":["B.SUB.23.338\/01.I"],"award-info":[{"award-number":["B.SUB.23.338\/01.I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The number of children suffering from cardiovascular diseases (CVDs) is rising globally. Therefore, there is an urgent need to acquire a better understanding of the genetic factors and molecular mechanisms related to the pathogenesis of CVDs in order to develop new prevention and treatment strategies for the future. MicroRNAs (miRNAs) constitute a class of small non-coding RNA fragments that range from 17 to 25 nucleotides in length and play an essential role in regulating gene expression, controlling an abundance of biological aspects of cell life, such as proliferation, differentiation, and apoptosis, thus affecting immune response, stem cell growth, ageing and haematopoiesis. In recent years, the concept of miRNAs as diagnostic markers allowing discrimination between healthy individuals and those affected by CVDs entered the purview of academic debate. In this review, we aimed to systematise available information regarding miRNAs associated with arrhythmias, cardiomyopathies, myocarditis and congenital heart diseases in children. We focused on the targeted genes and metabolic pathways influenced by those particular miRNAs, and finally, tried to determine the future of miRNAs as novel biomarkers of CVD.<\/jats:p>","DOI":"10.3390\/ijms25020956","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T07:47:16Z","timestamp":1705045636000},"page":"956","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Role of miRNA in Cardiovascular Diseases in Children\u2014Systematic Review"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9342-6497","authenticated-orcid":false,"given":"Marta","family":"Pas\u0142awska","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Endocrinology, Diabetology with Cardiology Divisions, Medical University of Bialystok, J. Waszyngtona 17, 15-274 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Grodzka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology, Diabetology with Cardiology Divisions, Medical University of Bialystok, J. Waszyngtona 17, 15-274 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Peczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology, Diabetology with Cardiology Divisions, Medical University of Bialystok, J. Waszyngtona 17, 15-274 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Sawicka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology, Diabetology with Cardiology Divisions, Medical University of Bialystok, J. Waszyngtona 17, 15-274 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6316-5342","authenticated-orcid":false,"given":"Artur Tadeusz","family":"Bossowski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology, Diabetology with Cardiology Divisions, Medical University of Bialystok, J. Waszyngtona 17, 15-274 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"ref_1","unstructured":"(2020, December 09). The Top 10 Causes of Death. Available online: https:\/\/www.Who.Int\/News-Room\/Fact-Sheets\/Detail\/The-Top-10-Causes-Of-Death?Fbclid=Iwar2llcq33xsxbhssptiozzuynislhja4oroomf3cqs-Svkzfutpy20x7heo."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans Heterochronic Gene Lin-4 Encodes Small RNAs with Antisense Complementarity to Lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Tastsoglou, S., Miliotis, M., Kavakiotis, I., Alexiou, A., Gkotsi, E.C., Lambropoulou, A., Lygnos, V., Kotsira, V., Maroulis, V., and Zisis, D. (2021). Plasmir: A Manual Collection of Circulating Micrornas of Prognostic and Diagnostic Value. Cancers, 13.","DOI":"10.3390\/cancers13153680"},{"key":"ref_5","first-page":"826","article-title":"MiRNA Activation Is an Endogenous Gene Expression Pathway","volume":"15","author":"Vaschetto","year":"2018","journal-title":"RNA Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-3-319-74470-4_2","article-title":"The Emerging Roles of MicroRNAs in Stem Cell Aging","volume":"Volume 1056","author":"Dietrich","year":"2018","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0960-9822(03)00250-1","article-title":"The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism","volume":"13","author":"Xu","year":"2003","journal-title":"Curr. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of MicroRNA Biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.molcel.2016.09.004","article-title":"Pairing beyond the Seed Supports MicroRNA Targeting Specificity","volume":"64","author":"Broughton","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jordan-Alejandre, E., Campos-Parra, A.D., Castro-L\u00f3pez, D.L., and Silva-C\u00e1zares, M.B. (2023). Potential MiRNA Use as a Biomarker: From Breast Cancer Diagnosis to Metastasis. Cells, 12.","DOI":"10.3390\/cells12040525"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Condrat, C.E., Thompson, D.C., Barbu, M.G., Bugnar, O.L., Boboc, A., Cretoiu, D., Suciu, N., Cretoiu, S.M., and Voinea, S.C. (2020). MiRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis. Cells, 9.","DOI":"10.3390\/cells9020276"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.advms.2021.08.003","article-title":"Expression Levels of Serum Circulating MicroRNAs in Pediatric Patients with Ventricular and Supraventricular Arrhythmias","volume":"66","author":"Smolik","year":"2021","journal-title":"Adv. Med. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41390-021-01548-w","article-title":"Integrated Analysis of MiRNA\u2013MRNA Interaction in Pediatric Dilated Cardiomyopathy","volume":"92","author":"Hailu","year":"2022","journal-title":"Pediatr. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s12098-010-0276-x","article-title":"Arrhythmias in Children","volume":"78","author":"Jat","year":"2011","journal-title":"Indian J. Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.3892\/mmr.2015.3246","article-title":"Expression of Circulating MicroRNA-1 and MicroRNA-133 in Pediatric Patients with Tachycardia","volume":"11","author":"Sun","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.ijcard.2012.12.048","article-title":"Roles of MiR-1-1 and MiR-181c in Ventricular Septal Defects","volume":"168","author":"Li","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"46259","DOI":"10.1038\/srep46259","article-title":"Over-Expression of MicroRNA-1 Causes Arrhythmia by Disturbing Intracellular Trafficking System","volume":"7","author":"Su","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000315076","article-title":"Cellular Physiology Regulation of Human Cardiac Ion Channel Genes by MicroRNAs: Theoretical Perspective and Pathophysiological Implications","volume":"25","author":"Luo","year":"2010","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.7150\/ijbs.4630","article-title":"Overexpression of MicroRNA-1 Causes Atrioventricular Block in Rodents","volume":"9","author":"Zhang","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wahl, C.M., Schmidt, C., Hecker, M., and Ullrich, N.D. (2022). Distress-Mediated Remodeling of Cardiac Connexin-43 in a Novel Cell Model for Arrhythmogenic Heart Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231710174"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"151931","DOI":"10.1016\/j.acthis.2022.151931","article-title":"Fibroblast-Derived Exosomal MiRNA-133 Promotes Cardiomyocyte-Like Differentiation","volume":"124","author":"Xu","year":"2022","journal-title":"Acta Histochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"12363","DOI":"10.1074\/jbc.C700015200","article-title":"MicroRNA MiR-133 Represses HERG K+ Channel Expression Contributing to QT Prolongation in Diabetic Hearts","volume":"282","author":"Xiao","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3109\/00365513.2014.905696","article-title":"MicroRNAs in Cardiac Arrhythmia: DNA Sequence Variation of MiR-1 and MiR-133A in Long QT Syndrome","volume":"74","author":"Hedley","year":"2014","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e13322","DOI":"10.1111\/apha.13322","article-title":"MicroRNA-133 Suppresses ZFHX3-Dependent Atrial Remodelling and Arrhythmia","volume":"227","author":"Cheng","year":"2019","journal-title":"Acta Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12265-018-9814-0","article-title":"Circulating MicroRNAs: A Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis","volume":"11","author":"Goldberg","year":"2018","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1373\/clinchem.2011.173823","article-title":"Use of Circulating MicroRNAs to Diagnose Acute Myocardial Infarction","volume":"58","author":"Devaux","year":"2012","journal-title":"Clin. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yjmcc.2016.03.014","article-title":"MiR-21-3p Controls Sepsis-Associated Cardiac Dysfunction via Regulating SORBS2","volume":"94","author":"Wang","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/CIRCGENETICS.110.957415","article-title":"Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease","volume":"3","author":"Corsten","year":"2010","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41419-018-0805-5","article-title":"MicroRNA-21 Prevents Excessive Inflammation and Cardiac Dysfunction after Myocardial Infarction through Targeting KBTBD7","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4149\/gpb_2022066","article-title":"MicroRNA-21-3p\/Rcan1 Signaling Axis Affects Apoptosis of Cardiomyocytes of Sepsis Rats","volume":"42","author":"Gong","year":"2023","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00011-021-01535-1","article-title":"MiR-21 Participates in LPS-Induced Myocardial Injury by Targeting Bcl-2 and CDK6","volume":"71","author":"Li","year":"2022","journal-title":"Inflamm. Res."},{"key":"ref_32","first-page":"5510","article-title":"MicroRNA-381 Protects Myocardial Cell Function in Children and Mice with Viral Myocarditis via Targeting Cyclooxygenase-2 Expression","volume":"15","author":"Zhang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11936","DOI":"10.1080\/21655979.2021.2006967","article-title":"MicroRNA-381-3p Signatures as a Diagnostic Marker in Patients with Sepsis and Modulates Sepsis-Steered Cardiac Damage and Inflammation by Binding HMGB1","volume":"12","author":"Liu","year":"2021","journal-title":"Bioengineered"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s11626-018-0277-z","article-title":"MiR-381 Negatively Regulates Cardiomyocyte Survival by Suppressing Notch Signaling","volume":"54","author":"Lu","year":"2018","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"ref_35","first-page":"1439","article-title":"Protective Effect of MicroRNA-381 against Inflammatory Damage of Endothelial Cells during Coronary Heart Disease by Targeting CXCR4","volume":"21","author":"Li","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_36","first-page":"634","article-title":"MiR-217 and MiR-543 Downregulation Mitigates Inflammatory Response and Myocardial Injury in Children with Viral Myocarditis by Regulating the SIRT1\/AMPK\/NF-\u03baB Signaling Pathway","volume":"45","author":"Xia","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"361","DOI":"10.20452\/pamw.1093","article-title":"Role of MicroRNAs in Endothelial Cell Pathophysiology","volume":"121","author":"Staszel","year":"2011","journal-title":"Pol. Arch. Med. Wewn."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1159\/000453185","article-title":"Analysis of the Indicating Value of Cardiac Troponin I, Tumor Necrosis Factor-\u03b1, Interleukin-18, Mir-1 and Mir-146b for Viral Myocarditis among Children","volume":"40","author":"Wang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5603\/CJ.a2019.0036","article-title":"MiR-1\/133 Attenuates Cardiomyocyte Apoptosis and Electrical Remodeling in Mice with Viral Myocarditis","volume":"27","author":"Li","year":"2020","journal-title":"Cardiol. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s00705-013-1695-6","article-title":"MicroRNA-21 and -146b Are Involved in the Pathogenesis of Murine Viral Myocarditis by Regulating TH-17 Differentiation","volume":"158","author":"Liu","year":"2013","journal-title":"Arch. Virol."},{"key":"ref_41","first-page":"656","article-title":"MiR-146b Protects Cardiomyocytes Injury in Myocardial Ischemia\/Reperfusion by Targeting Smad4","volume":"9","author":"Di","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s00109-019-01817-6","article-title":"Hypoxia Drives Cardiac MiRNAs and Inflammation in the Right and Left Ventricle","volume":"97","author":"Chouvarine","year":"2019","journal-title":"J. Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/emmm.201202318","article-title":"MicroRNA-146 Represses Endothelial Activation by Inhibiting pro-Inflammatory Pathways","volume":"5","author":"Cheng","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.14715\/cmb\/2017.63.10.13","article-title":"Overexpression of MicroRNA-133b Reduces Myocardial Injuries in Children with Viral Myocarditis by Targeting Rab27B Gene","volume":"6","author":"Zhang","year":"2017","journal-title":"Cell. Mol. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s00296-018-4069-2","article-title":"MicroRNA Values in Children with Rheumatic Carditis: A Preliminary Study","volume":"38","author":"Gumus","year":"2018","journal-title":"Rheumatol. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1126\/science.1174381","article-title":"MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice","volume":"324","author":"Bonauer","year":"2009","journal-title":"Science"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"108910","DOI":"10.1016\/j.intimp.2022.108910","article-title":"Mesenchymal Stem Cells-Derived Extracellular Vesicles-Shuttled MicroRNA-223-3p Suppress Lipopolysaccharide-Induced Cardiac Inflammation, Pyroptosis, and Dysfunction","volume":"110","author":"Pan","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yjmcc.2013.01.005","article-title":"MiRNA Expression in Pediatric Failing Human Heart","volume":"57","author":"Stauffer","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.molimm.2019.10.027","article-title":"MicroRNA-223-3p Modulates Dendritic Cell Function and Ameliorates Experimental Autoimmune Myocarditis by Targeting the NLRP3 Inflammasome","volume":"117","author":"Chen","year":"2020","journal-title":"Mol. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.yexcr.2018.03.004","article-title":"MiR-223\/Pknox1 Axis Protects Mice from CVB3-Induced Viral Myocarditis by Modulating Macrophage Polarization","volume":"366","author":"Gou","year":"2018","journal-title":"Exp. Cell Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"376","DOI":"10.5114\/aoms.2019.82919","article-title":"Circulating MicroRNAs as Biomarkers for Myocardial Fibrosis in Patients with Left Ventricular Non-Compaction Cardiomyopathy","volume":"15","author":"Szemraj","year":"2019","journal-title":"Arch. Med. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Rangrez, A.Y., Hoppe, P., Kuhn, C., Zille, E., Frank, J., Frey, N., and Frank, D. (2017). MicroRNA MiR-301a Is a Novel Cardiac Regulator of Cofilin-2. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183901"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.4252\/wjsc.v11.i12.1130","article-title":"MiR-301a Promotes Embryonic Stem Cell Differentiation to Cardiomyocytes","volume":"11","author":"Zhen","year":"2019","journal-title":"World J. Stem Cells"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Clark, A.L., Maruyama, S., Sano, S., Accorsi, A., Girgenrath, M., Walsh, K., and Naya, F.J. (2016). MiR-410 and MiR-495 Are Dynamically Regulated in Diverse Cardiomyopathies and Their Inhibition Attenuates Pathological Hypertrophy. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151515"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000487044","article-title":"Attenuation of MicroRNA-495 Derepressed PTEN to Effectively Protect Rat Cardiomyocytes from Hypertrophy","volume":"139","author":"Fu","year":"2018","journal-title":"Cardiology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s12012-021-09667-w","article-title":"MicroRNA-17-5p Promotes Cardiac Hypertrophy by Targeting Mfn2 to Inhibit Autophagy","volume":"21","author":"Xu","year":"2021","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1172\/JCI36154","article-title":"MicroRNA-208a Is a Regulator of Cardiac Hypertrophy and Conduction in Mice","volume":"119","author":"Callis","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"773314","DOI":"10.3389\/fcvm.2021.773314","article-title":"MiR-208a in Cardiac Hypertrophy and Remodeling","volume":"8","author":"Huang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3109\/1354750X.2015.1118533","article-title":"Plasma MicroRNA Profiling of Children with Idiopathic Dilated Cardiomyopathy","volume":"21","author":"Temel","year":"2016","journal-title":"Biomarkers"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s43044-022-00300-x","article-title":"MiR-454-3p and MiR-194-5p Targeting Cardiac Sarcolemma Ion Exchange Transcripts Are Potential Noninvasive Diagnostic Biomarkers for Childhood Dilated Cardiomyopathy in Egyptian Patients","volume":"74","author":"Fayez","year":"2022","journal-title":"Egypt. Heart J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00109-018-1666-1","article-title":"Plasma MicroRNAs as Biomarkers for Lamin A\/C-Related Dilated Cardiomyopathy","volume":"96","author":"Toro","year":"2018","journal-title":"J. Mol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/1470320310368874","article-title":"Association of ACE I\/D Polymorphism in Tunisian Patients with Dilated Cardiomyopathy","volume":"11","author":"Mahjoub","year":"2010","journal-title":"JRAAS-J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11010-012-1546-x","article-title":"Circulating MiRNA as Novel Markers for Diastolic Dysfunction","volume":"376","author":"Nair","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2047-783X-18-10","article-title":"Polymorphism of ZBTB17 Gene Is Associated with Idiopathic Dilated Cardiomyopathy: A Case Control Study in a Han Chinese Population","volume":"18","author":"Li","year":"2013","journal-title":"Eur. J. Med. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/ejhg.2012.173","article-title":"Novel Mutations in the Sarcomeric Protein Myopalladin in Patients with Dilated Cardiomyopathy","volume":"21","author":"Meyer","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10974-013-9358-5","article-title":"Alpha-Tropomyosin Mutations in Inherited Cardiomyopathies","volume":"34","author":"Redwood","year":"2013","journal-title":"J. Muscle Res. Cell Motil."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1101\/gr.076653.108","article-title":"HBEGF, SRA1, and IK: Three Cosegregating Genes as Determinants of Cardiomyopathy","volume":"19","author":"Friedrichs","year":"2009","journal-title":"Genome Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/CIRCRESAHA.109.213256","article-title":"Myozap, a Novel Intercalated Disc Protein, Activates Serum Response Factor-Dependent Signaling and Is Required to Maintain Cardiac Function In Vivo","volume":"106","author":"Seeger","year":"2010","journal-title":"Circ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Wang, T., Li, T., Niu, X., Hu, L., Cheng, J., Guo, D., Ren, H., Zhao, R., Ji, Z., and Liu, P. (2023). ADSC-Derived Exosomes Attenuate Myocardial Infarction Injury by Promoting MiR-205-Mediated Cardiac Angiogenesis. Biol. Direct, 18.","DOI":"10.1186\/s13062-023-00361-1"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Brody, M.J., Hacker, T.A., Patel, J.R., Feng, L., Sadoshima, J., Tevosian, S.G., Balijepalli, R.C., Moss, R.L., and Lee, Y. (2012). Ablation of the Cardiac-Specific Gene Leucine-Rich Repeat Containing 10 (Lrrc10) Results in Dilated Cardiomyopathy. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051621"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.yjmcc.2008.04.013","article-title":"Molecular Basis of Funny Current (If) in Normal and Failing Human Heart","volume":"45","author":"Stillitano","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1093\/eurheartj\/ehp225","article-title":"Mutations in the ANKRD1 Gene Encoding CARP Are Responsible for Human Dilated Cardiomyopathy","volume":"30","author":"Charron","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.yexcr.2018.02.016","article-title":"Egr-1 Mediated Cardiac MiR-99 Family Expression Diverges Physiological Hypertrophy from Pathological Hypertrophy","volume":"365","author":"Ramasamy","year":"2018","journal-title":"Exp. Cell Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.scr.2013.11.008","article-title":"Cardiomyogenesis Is Controlled by the MiR-99a\/Let-7c Cluster and Epigenetic Modifications","volume":"12","author":"Coppola","year":"2014","journal-title":"Stem Cell Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Chen, D., Chen, Z., Jin, Y., Dragas, D., Zhang, L., Adjei, B.S., Wang, A., Dai, Y., and Zhou, X. (2013). MicroRNA-99 Family Members Suppress Homeobox A1 Expression in Epithelial Cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0080625"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.cardfail.2011.07.012","article-title":"A Cellular MicroRNA, Let-7i, Is a Novel Biomarker for Clinical Outcome in Patients with Dilated Cardiomyopathy","volume":"17","author":"Satoh","year":"2011","journal-title":"J. Card. Fail."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.healun.2015.01.979","article-title":"Circulating MicroRNA as a Biomarker for Recovery in Pediatric Dilated Cardiomyopathy","volume":"34","author":"Miyamoto","year":"2015","journal-title":"J. Heart Lung Transplant."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1080\/08830180903093796","article-title":"MiR-155: On the Crosstalk between Inflammation and Cancer","volume":"28","author":"Tili","year":"2009","journal-title":"Int. Rev. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1161\/CIRCRESAHA.114.303784","article-title":"Loss of MicroRNA-155 Protects the Heart from Pathological Cardiac Hypertrophy","volume":"114","author":"Seok","year":"2014","journal-title":"Circ. Res."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Liu, J.J., Zhao, C.M., Li, Z.G., Wang, Y.M., Miao, W., Wu, X.J., Wang, W.J., Liu, C., Wang, D., and Wang, K. (2016). MiR-218 Involvement in Cardiomyocyte Hypertrophy Is Likely through Targeting REST. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060848"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1161\/CIRCRESAHA.110.227926","article-title":"Microrna-218 Regulates Vascular Patterning by Modulation of Slit-Robo Signaling","volume":"107","author":"Small","year":"2010","journal-title":"Circ. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/nm.2037","article-title":"Nexilin Mutations Destabilize Cardiac Z-Disks and Lead to Dilated Cardiomyopathy","volume":"15","author":"Hassel","year":"2009","journal-title":"Nat. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/kjm2.12181","article-title":"MiR-636 Represses Cell Survival by Targeting CDK6\/Bcl-2 in Cervical Cancer","volume":"36","author":"Hu","year":"2020","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Misbah, M., Kumar, M., Lee, K.H., and Shen, S.C. (2022). Identification of Novel MiRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer. BioMed Res. Int., 2022.","DOI":"10.1155\/2022\/3825760"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12935-020-01725-7","article-title":"MiR-636 Inhibits EMT, Cell Proliferation and Cell Cycle of Ovarian Cancer by Directly Targeting Transcription Factor Gli2 Involved in Hedgehog Pathway","volume":"21","author":"Ma","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1475-2867-14-39","article-title":"MiR-639 Promotes the Proliferation and Invasion of Breast Cancer Cell In Vitro","volume":"14","author":"Li","year":"2014","journal-title":"Cancer Cell Int."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.biopha.2016.10.087","article-title":"MiR-639 Promoted Cell Proliferation and Cell Cycle in Human Thyroid Cancer by Suppressing CDKN1A Expression","volume":"84","author":"Lei","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1007\/s10620-021-07053-8","article-title":"Circ_0001955 Acts as a MiR-646 Sponge to Promote the Proliferation, Metastasis and Angiogenesis of Hepatocellular Carcinoma","volume":"67","author":"Li","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/bjc.2017.181","article-title":"MiR-646 Inhibited Cell Proliferation and EMT-Induced Metastasis by Targeting FOXK1 in Gastric Cancer","volume":"117","author":"Zhang","year":"2017","journal-title":"Br. J. Cancer"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41598-017-19138-4","article-title":"Circulating MicroRNA Signature for the Diagnosis of Childhood Dilated Cardiomyopathy","volume":"8","author":"Jiao","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/emmm.201200234","article-title":"Repression of MiR-142 by P300 and MAPK Is Required for Survival Signalling via Gp130 during Adaptive Hypertrophy","volume":"4","author":"Sharma","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.biopha.2018.09.146","article-title":"Overexpression of MiR-142-3p Improves Mitochondrial Function in Cardiac Hypertrophy","volume":"108","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/cbin.11053","article-title":"Inhibition of MicroRNA-143-3p Attenuates Myocardial Hypertrophy by Inhibiting Inflammatory Response","volume":"42","author":"Yu","year":"2018","journal-title":"Cell Biol. Int."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Ogawa, K., Noda, A., Ueda, J., Ogata, T., Matsuyama, R., Nishizawa, Y., Qiao, S., Iwata, S., Ito, M., and Fujihara, Y. (2020). Forced Expression of MiR-143 and -145 in Cardiomyocytes Induces Cardiomyopathy with a Reductive Redox Shift. Cell. Mol. Biol. Lett., 25.","DOI":"10.1186\/s11658-020-00232-x"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1242\/dev.050526","article-title":"The MiR-143-Adducin3 Pathway Is Essential for Cardiac Chamber Morphogenesis","volume":"137","author":"Deacon","year":"2010","journal-title":"Development"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Lozano-Velasco, E., Galiano-Torres, J., Jodar-Garcia, A., Aranega, A.E., and Franco, D. (2015). MiR-27 and MiR-125 Distinctly Regulate Muscle-Enriched Transcription Factors in Cardiac and Skeletal Myocytes. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/391306"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.bbagrm.2014.07.009","article-title":"Identification of Regulatory Elements Directing MiR-23a-MiR-27a-MiR-24-2 Transcriptional Regulation in Response to Muscle Hypertrophic Stimuli","volume":"1839","author":"Aranega","year":"2014","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"22","DOI":"10.7150\/ijbs.16298","article-title":"Let-7a Is an Antihypertrophic Regulator in the Heart via Targeting Calmodulin","volume":"13","author":"Zhou","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/eurheartj\/eht392","article-title":"A Signature of Circulating MicroRNAs Differentiates Takotsubo Cardiomyopathy from Acute Myocardial Infarction","volume":"35","author":"Jaguszewski","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Sonaglioni, A., Nicolosi, G.L., Rigamonti, E., Lombardo, M., and La Sala, L. (2022). Molecular Approaches and Echocardiographic Deformation Imaging in Detecting Myocardial Fibrosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810944"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S2352-4642(19)30402-X","article-title":"Global, Regional, and National Burden of Congenital Heart Disease, 1990\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"4","author":"Zimmerman","year":"2020","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s12098-017-2454-6","article-title":"Acyanotic and Cyanotic Congenital Heart Diseases","volume":"85","author":"Rohit","year":"2018","journal-title":"Indian J. Pediatr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3892\/etm.2020.9468","article-title":"MicroRNA-219-5p Participates in Cyanotic Congenital Heart Disease Progression by Regulating Cardiomyocyte Apoptosis","volume":"21","author":"Hu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12967-018-1411-0","article-title":"Clinical Significance of Circulating MicroRNAs as Markers in Detecting and Predicting Congenital Heart Defects in Children","volume":"16","author":"Song","year":"2018","journal-title":"J. Transl. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e202101215","DOI":"10.26508\/lsa.202101215","article-title":"MiR-486 Is Essential for Muscle Function and Suppresses a Dystrophic Transcriptome","volume":"5","author":"Samani","year":"2022","journal-title":"Life Sci. Alliance"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e125507","DOI":"10.1172\/jci.insight.125507","article-title":"MiR-486 Is Modulated by Stretch and Increases Ventricular Growth","volume":"4","author":"Lange","year":"2019","journal-title":"JCI Insight"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Sun, Y., Su, Q., Li, L., Wang, X., Lu, Y., and Liang, J. (2017). MiR-486 Regulates Cardiomyocyte Apoptosis by P53-Mediated BCL-2 Associated Mitochondrial Apoptotic Pathway. BMC Cardiovasc. Disord., 17.","DOI":"10.1186\/s12872-017-0549-7"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Li, D., Ji, L., Liu, L., Liu, Y., Hou, H., Yu, K., Sun, Q., and Zhao, Z. (2014). Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106318"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"35339","DOI":"10.1074\/jbc.M111.273276","article-title":"MiR-155 Inhibits Expression of the MEF2A Protein to Repress Skeletal Muscle Differentiation","volume":"286","author":"Seok","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s00246-016-1487-3","article-title":"Circulating MicroRNA as a Novel Biomarker for Pulmonary Arterial Hypertension Due to Congenital Heart Disease","volume":"38","author":"Chen","year":"2017","journal-title":"Pediatr. Cardiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"10173","DOI":"10.12659\/MSM.917662","article-title":"MicroRNA-204 as an Indicator of Severity of Pulmonary Hypertension in Children with Congenital Heart Disease Complicated with Pulmonary Hypertension","volume":"25","author":"Li","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"717208","DOI":"10.3389\/fgene.2021.717208","article-title":"Maternal Circulating Exosomal MiRNAs as Non-Invasive Biomarkers for the Prediction of Fetal Ventricular Septal Defect","volume":"12","author":"Jin","year":"2021","journal-title":"Front. Genet."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cca.2013.05.010","article-title":"Identification of Maternal Serum MicroRNAs as Novel Non-Invasive Biomarkers for Prenatal Detection of Fetal Congenital Heart Defects","volume":"424","author":"Zhu","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e12764","DOI":"10.1111\/cpr.12764","article-title":"Aberrant Expression of MiR-29b-3p Influences Heart Development and Cardiomyocyte Proliferation by Targeting NOTCH2","volume":"53","author":"Yang","year":"2020","journal-title":"Cell Prolif."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3892\/ijmm.2015.2399","article-title":"MicroRNA-375 Overexpression Influences P19 Cell Proliferation, Apoptosis and Differentiation through the Notch Signaling Pathway","volume":"37","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tcm.2014.07.005","article-title":"MiR-22 in Cardiac Remodeling and Disease","volume":"24","author":"Huang","year":"2014","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.biopha.2018.10.110","article-title":"Expression Profile of Maternal Circulating MicroRNAs as Non-Invasive Biomarkers for Prenatal Diagnosis of Congenital Heart Defects","volume":"109","author":"Gu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3389\/fgene.2020.00552","article-title":"Identification of MiRNA\u2013MRNA\u2013TFs Regulatory Network and Crucial Pathways Involved in Tetralogy of Fallot","volume":"11","author":"You","year":"2020","journal-title":"Front. Genet."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.12659\/MSM.897542","article-title":"Role of MicroRNA-93 I in Pathogenesis of Left Ventricular Remodeling via Targeting Cyclin-D1","volume":"23","author":"Zhang","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.carpath.2018.04.003","article-title":"Long Non-Coding RNA CHRF Facilitates Cardiac Hypertrophy through Regulating Akt3 via MiR-93","volume":"35","author":"Wo","year":"2018","journal-title":"Cardiovasc. Pathol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.cjca.2019.07.444","article-title":"Regulation of Mir-187b in Endotoxemic Primary Cardiomyocytes and Septic Murine Hearts Treated with Mesenchymal Stromal\/Stem Cells","volume":"35","author":"Ektesabi","year":"2019","journal-title":"Can. J. Cardiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.cjca.2013.07.002","article-title":"MicroRNA Deregulation in Right Ventricular Outflow Tract Myocardium in Nonsyndromic Tetralogy of Fallot","volume":"29","author":"Zhang","year":"2013","journal-title":"Can. J. Cardiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"19063","DOI":"10.1038\/s41598-019-55570-4","article-title":"Altered MicroRNA and Target Gene Expression Related to Tetralogy of Fallot","volume":"9","author":"Grunert","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"12847","DOI":"10.1038\/s41598-018-31243-6","article-title":"Sexual Difference of Small RNA Expression in Tetralogy of Fallot","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3390\/cells3030713","article-title":"MicroRNA-421 Dysregulation Is Associated with Tetralogy of Fallot","volume":"3","author":"Bittel","year":"2014","journal-title":"Cells"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.yjmcc.2017.11.015","article-title":"MicroRNA-34a Modulates the Notch Signaling Pathway in Mice with Congenital Heart Disease and Its Role in Heart Development","volume":"114","author":"Wu","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00246-017-1607-8","article-title":"MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children","volume":"38","year":"2017","journal-title":"Pediatr. Cardiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12265-019-09921-1","article-title":"Preoperative MiRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery","volume":"13","author":"Zloto","year":"2020","journal-title":"J Cardiovasc. Transl. Res."},{"key":"ref_129","first-page":"14221","article-title":"Down-Regulation of MicroRNA-184 Contributes to the Development of Cyanotic Congenital Heart Diseases","volume":"8","author":"Huang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejphar.2018.08.013","article-title":"MiR-182 Alleviates the Development of Cyanotic Congenital Heart Disease by Suppressing HES1","volume":"836","author":"Zhang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.3892\/mmr.2017.6934","article-title":"Bin Downregulation of MicroRNA-199a-5p Protects Cardiomyocytes in Cyanotic Congenital Heart Disease by Attenuating Endoplasmic Reticulum Stress","volume":"16","author":"Zhou","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cardfail.2014.09.013","article-title":"Micro-RNA Expression in Hypoplastic Left Heart Syndrome","volume":"21","author":"Sucharov","year":"2015","journal-title":"J. Card. Fail."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e21956","DOI":"10.1096\/fj.202100829RR","article-title":"Cardiomyocyte-Specific MiR-100 Overexpression Preserves Heart Function under Pressure Overload in Mice and Diminishes Fatty Acid Uptake as Well as ROS Production by Direct Suppression of Nox4 and CD36","volume":"35","author":"Smolka","year":"2021","journal-title":"FASEB J."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yjmcc.2015.02.019","article-title":"Natriuretic Peptide Receptor 3 (NPR3) Is Regulated by MicroRNA-100","volume":"82","author":"Wong","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_135","first-page":"5491","article-title":"Downregulation of MicroRNA-100 Protects H2O2-Induced Apoptosis in Neonatal Cardiomyocytes","volume":"8","author":"Chen","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00246-015-1325-z","article-title":"MiRNA-145 Regulates the Development of Congenital Heart Disease Through Targeting FXN","volume":"37","author":"Wang","year":"2016","journal-title":"Pediatr. Cardiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1017\/S1047951120004874","article-title":"Individual and Joint Effects of Genetic Polymorphisms in MicroRNA-Machinery Genes on Congenital Heart Disease Susceptibility","volume":"31","author":"Borghini","year":"2021","journal-title":"Cardiol. Young"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Toro, R., P\u00e9rez-Serra, A., Mangas, A., Campuzano, O., Sarquella-Brugada, G., Quezada-Feijoo, M., Ramos, M., Alcal\u00e1, M., Carrera, E., and Garc\u00eda-Padilla, C. (2022). MiR-16-5p Suppression Protects Human Cardiomyocytes against Endoplasmic Reticulum and Oxidative Stress-Induced Injury. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031036"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e2990","DOI":"10.1038\/cddis.2017.320","article-title":"P53-Mediated MiR-18 Repression Activates HSF2 for IGF-IIR-Dependent Myocyte Hypertrophy in Hypertension-Induced Heart Failure","volume":"8","author":"Huang","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/00015385.2021.1948207","article-title":"MiR-23b Targets GATA6 to down-Regulate IGF-1 and Promote the Development of Congenital Heart Disease","volume":"77","author":"Huang","year":"2022","journal-title":"Acta Cardiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tcm.2014.06.003","article-title":"An Emerging Role for the MiR-26 Family in Cardiovascular Disease","volume":"24","author":"Icli","year":"2014","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.bbrc.2018.06.104","article-title":"Mir-127-3p Inhibits the Proliferation of Myocytes by Targeting KMT5a","volume":"503","author":"Yuan","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s10529-020-02906-0","article-title":"MicroRNA-127-3p Regulates Myoblast Proliferation by Targeting Sept7","volume":"42","author":"Li","year":"2020","journal-title":"Biotechnol. Lett."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Wang, L., Qin, D., Shi, H., Zhang, Y., Li, H., and Han, Q. (2019). MiR-195-5p Promotes Cardiomyocyte Hypertrophy by Targeting MFN2 and FBXW7. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/1580982"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.biopha.2018.02.096","article-title":"MiR-204-5p Regulates C2C12 Myoblast Differentiation by Targeting MEF2C and ERR\u03b3","volume":"101","author":"Cheng","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.3892\/mmr.2017.7344","article-title":"Short-Term Vagus Nerve Stimulation Reduces Myocardial Apoptosis by Downregulating MicroRNA-205 in Rats with Chronic Heart Failure","volume":"16","author":"Xuan","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1080\/15476286.2020.1737443","article-title":"MiR-206 Knockout Shows It Is Critical for Myogenesis and Directly Regulates Newly Identified Target MRNAs","volume":"17","author":"Salant","year":"2020","journal-title":"RNA Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.1093\/nar\/gkl743","article-title":"MIR-206 Regulates Connexin43 Expression during Skeletal Muscle Development","volume":"34","author":"Anderson","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"108004","DOI":"10.1016\/j.diabres.2020.108004","article-title":"The Functions of MicroRNA-208 in the Heart","volume":"160","author":"Zhao","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1042\/CS20190099","article-title":"MicroRNA-302d Promotes the Proliferation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibiting LATS2 in the Hippo Pathway","volume":"133","author":"Xu","year":"2019","journal-title":"Clin. Sci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"7968905","DOI":"10.1155\/2017\/7968905","article-title":"Inhibition of MIR-302 Suppresses Hypoxia-Reoxygenation-Induced H9c2 Cardiomyocyte Death by Regulating Mcl-1 Expression","volume":"2017","author":"Fang","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s10529-020-03013-w","article-title":"MiR-375-3p Contributes to Hypoxia-Induced Apoptosis by Targeting Forkhead Box P1 (FOXP1) and Bcl2 like Protein 2 (Bcl2l2) in Rat Cardiomyocyte H9c2 Cells","volume":"43","author":"Li","year":"2021","journal-title":"Biotechnol. Lett."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"14198","DOI":"10.1002\/jcp.28116","article-title":"MicroRNA-375-3p Inhibitor Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy by Promoting Lactate Dehydrogenase B Expression","volume":"234","author":"Feng","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"12913","DOI":"10.1074\/jbc.M111.331751","article-title":"A Novel Cardiomyocyte-Enriched MicroRNA, MiR-378, Targets Insulin-like Growth Factor 1 Receptor: Implications in Postnatal Cardiac Remodeling and Cell Survival","volume":"287","author":"Knezevic","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.7150\/thno.22878","article-title":"MicroRNA-378 Suppresses Myocardial Fibrosis through a Paracrine Mechanism at the Early Stage of Cardiac Hypertrophy Following Mechanical Stress","volume":"8","author":"Yuan","year":"2018","journal-title":"Theranostics"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s10495-011-0683-0","article-title":"Overexpression of MicroRNA-378 Attenuates Ischemia-Induced Apoptosis by Inhibiting Caspase-3 Expression in Cardiac Myocytes","volume":"17","author":"Fang","year":"2012","journal-title":"Apoptosis"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/CIRCRESAHA.113.300975","article-title":"Regulation of Cardiac MicroRNAs by Cardiac MicroRNAs","volume":"113","author":"Matkovich","year":"2013","journal-title":"Circ. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.hrthm.2013.03.005","article-title":"Regulation of the SK3 Channel by MicroRNA-499\u2014Potential Role in Atrial Fibrillation","volume":"10","author":"Ling","year":"2013","journal-title":"Heart Rhythm"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/rna.28300","article-title":"MiR-499 Protects Cardiomyocytes from H2O2-Induced Apoptosis via Its Effects on Pdcd4 and Pacs2","volume":"11","author":"Wang","year":"2014","journal-title":"RNA Biol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s10529-019-02685-3","article-title":"MiR-499 Inhibited Hypoxia\/Reoxygenation Induced Cardiomyocytes Injury by Targeting SOX6","volume":"41","author":"Shi","year":"2019","journal-title":"Biotechnol. Lett."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1161\/CIRCRESAHA.112.265736","article-title":"Direct and Indirect Involvement of MicroRNA-499 in Clinical and Experimental Cardiomyopathy","volume":"111","author":"Matkovich","year":"2012","journal-title":"Circ. Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1536\/ihj.20-619","article-title":"Mir-518a-5p Targets Gzmb to Extenuate Vascular Endothelial Cell Injury Induced by Hypoxia-Reoxygenation and Thereby Improves Myocardial Ischemia","volume":"62","author":"Yang","year":"2021","journal-title":"Int. Heart J."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1002\/jcb.29710","article-title":"MiR-543 Regulates Myoblast Proliferation and Differentiation of C2C12 Cells by Targeting KLF6","volume":"121","author":"Kang","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/iub.2474","article-title":"MiR-543 in Human Mesenchymal Stem Cell\u2013Derived Exosomes Promotes Cardiac Microvascular Endothelial Cell Angiogenesis after Myocardial Infarction through COL4A1","volume":"73","author":"Yang","year":"2021","journal-title":"IUBMB Life"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3109\/17435390.2015.1017022","article-title":"Extensive Temporal Transcriptome and MicroRNA Analyses Identify Molecular Mechanisms Underlying Mitochondrial Dysfunction Induced by Multi-Walled Carbon Nanotubes in Human Lung Cells","volume":"9","author":"Nymark","year":"2015","journal-title":"Nanotoxicology"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/2\/956\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:45:20Z","timestamp":1760103920000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/2\/956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":165,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25020956"],"URL":"https:\/\/doi.org\/10.3390\/ijms25020956","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,12]]}}}