{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:57:37Z","timestamp":1773215857710,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Science Foundation","award":["23-14-00230"],"award-info":[{"award-number":["23-14-00230"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Anemonopsis Siebold et Zucc. is an unstudied single-species genus belonging to the tribe Cimicifugeae (Ranunculaceae). The only species of this genus\u2014Anemonopsis macrophylla Siebold and Zucc.\u2014is endemic to Japan. There are no data on its chemical composition. This work is the first to determine (with liquid chromatography\u2013high-resolution mass spectrometry, LC-HRMS) the chemical composition of methanol extracts of leaves and flowers of A. macrophylla. More than 100 compounds were identified. In this plant, the classes of substances are coumarins (13 compounds), furocoumarins (3), furochromones (2), phenolic acids (21), flavonoids (27), and fatty acids and their derivatives (15 compounds). Isoferulic acid (detected in extracts from this plant) brings this species closer to plants of the genus Cimicifuga, one of the few genera containing this acid and ferulic acid at the same time. Isoferulic acid is regarded as a reference component of a quality indicator of Cimicifuga raw materials. The determined profiles of substances are identical between the leaf and flower methanol extracts. Differences in levels of some identified substances were revealed between the leaf and flower extracts of A. macrophylla; these differences may have a substantial impact on the manifestation of the biological and pharmacological effects of the extracts in question.<\/jats:p>","DOI":"10.3390\/ijms25020989","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T11:43:53Z","timestamp":1705059833000},"page":"989","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chemical Composition of Methanol Extracts from Leaves and Flowers of Anemonopsis macrophylla (Ranunculaceae)"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5213-2166","authenticated-orcid":false,"given":"Vera A.","family":"Kostikova","sequence":"first","affiliation":[{"name":"Central Siberian Botanical Garden, Siberian Branch of Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-6572","authenticated-orcid":false,"given":"Natalia V.","family":"Petrova","sequence":"additional","affiliation":[{"name":"Komarov Botanical Institute of Russian Academy of Sciences, St. Petersburg 197022, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8362-2443","authenticated-orcid":false,"given":"Alexander A.","family":"Chernonosov","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk 630090, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2577-2184","authenticated-orcid":false,"given":"Vladimir V.","family":"Koval","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk 630090, Russia"},{"name":"Department of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeniia R.","family":"Kovaleva","sequence":"additional","affiliation":[{"name":"Central Siberian Botanical Garden, Siberian Branch of Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia"},{"name":"Department of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6901-6375","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China"},{"name":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4844-0254","authenticated-orcid":false,"given":"Andrey S.","family":"Erst","sequence":"additional","affiliation":[{"name":"Central Siberian Botanical Garden, Siberian Branch of Russian Academy of Sciences (SB RAS), Novosibirsk 630090, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0305-1978(97)00102-6","article-title":"Phylogeny of Actaea including Cimicifuga (Ranunculaceae) inferred from nrDNA ITS sequence variation","volume":"26","author":"Compton","year":"1998","journal-title":"Biochem. 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