{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:27:58Z","timestamp":1776882478304,"version":"3.51.2"},"reference-count":97,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T00:00:00Z","timestamp":1705104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2020YFA0112901"],"award-info":[{"award-number":["2020YFA0112901"]}]},{"name":"National Key Research and Development Program of China","award":["2023YFC2508102"],"award-info":[{"award-number":["2023YFC2508102"]}]},{"name":"National Key Research and Development Program of China","award":["2012J01155"],"award-info":[{"award-number":["2012J01155"]}]},{"name":"National Key Research and Development Program of China","award":["2019J01037"],"award-info":[{"award-number":["2019J01037"]}]},{"name":"Natural Science Foundation of Fujian Province of China","award":["2020YFA0112901"],"award-info":[{"award-number":["2020YFA0112901"]}]},{"name":"Natural Science Foundation of Fujian Province of China","award":["2023YFC2508102"],"award-info":[{"award-number":["2023YFC2508102"]}]},{"name":"Natural Science Foundation of Fujian Province of China","award":["2012J01155"],"award-info":[{"award-number":["2012J01155"]}]},{"name":"Natural Science Foundation of Fujian Province of China","award":["2019J01037"],"award-info":[{"award-number":["2019J01037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Members of the C-X-C motif chemokine receptor (CXCR) superfamily play central roles in initiating the innate immune response in mammalian cells by orchestrating selective cell migration and immune cell activation. With its multilayered structure, the skin, which is the largest organ in the body, performs a crucial defense function, protecting the human body from harmful environmental threats and pathogens. CXCRs contribute to primary immunological defense; these receptors are differentially expressed by different types of skin cells and act as key players in initiating downstream innate immune responses. While the initiation of inflammatory responses by CXCRs is essential for pathogen elimination and tissue healing, overactivation of these receptors can enhance T-cell-mediated autoimmune responses, resulting in excessive inflammation and the development of several skin disorders, including psoriasis, atopic dermatitis, allergic contact dermatitis, vitiligo, autoimmune diseases, and skin cancers. In summary, CXCRs serve as critical links that connect innate immunity and adaptive immunity. In this article, we present the current knowledge about the functions of CXCRs in the homeostasis function of the skin and their contributions to the pathogenesis of allergic contact dermatitis and psoriasis. Furthermore, we will examine the research progress and efficacy of therapeutic approaches that target CXCRs.<\/jats:p>","DOI":"10.3390\/ijms25021005","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T04:03:26Z","timestamp":1705291406000},"page":"1005","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Involvement of Cysteine-X-Cysteine Motif Chemokine Receptors in Skin Homeostasis and the Pathogenesis of Allergic Contact Dermatitis and Psoriasis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-5338","authenticated-orcid":false,"given":"Wenjie","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/cmi.2017.134","article-title":"Chemokines in homeostasis and diseases","volume":"15","author":"Chen","year":"2018","journal-title":"Cell. 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