{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:06:16Z","timestamp":1793210776286,"version":"4.5.0"},"reference-count":69,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"project DARTBAC","award":["NWA.1292.19.354"],"award-info":[{"award-number":["NWA.1292.19.354"]}]},{"name":"Dutch Research Council (NWO)","award":["NWA.1292.19.354"],"award-info":[{"award-number":["NWA.1292.19.354"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Diabetes affected 537 million adults in 2021, costing a total of USD 966 billion dollars in healthcare. One of the most common complications associated with diabetes corresponds to the development of diabetic foot ulcers (DFUs). DFUs affect around 15% of diabetic patients; these ulcers have impaired healing due to neuropathy, arterial disease, infection, and aberrant extracellular matrix (ECM) degradation, among other factors. The bioactive-glass-based materials discussed in this systematic review show promising results in accelerating diabetic wound healing. It can be concluded that the addition of BG is extremely valuable with regard to the wound healing rate and wound healing quality, since BG activates fibroblasts, enhances M1-to-M2 phenotype switching, induces angiogenesis, and initiates the formation of granulation tissue and re-epithelization of the wound. In addition, a higher density and deposition and better organization of collagen type III are seen. This systematic review was made using the PRISMA guideline and intends to contribute to the advancement of diabetic wound healing therapeutic strategies development by providing an overview of the materials currently being developed and their effect in diabetic wound healing in vitro and in vivo.<\/jats:p>","DOI":"10.3390\/ijms25021152","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T03:50:56Z","timestamp":1705549856000},"page":"1152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Bioactive-Glass-Based Materials with Possible Application in Diabetic Wound Healing: A Systematic Review"],"prefix":"10.3390","volume":"25","author":[{"given":"Marian","family":"Vargas Guerrero","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands"},{"name":"Laboratory for Experimental Orthopaedics, Faculty of Health, Medicine & Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0446-3002","authenticated-orcid":false,"given":"Floor M. A.","family":"Aendekerk","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands"},{"name":"Laboratory for Experimental Orthopaedics, Faculty of Health, Medicine & Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands"},{"name":"Laboratory for Experimental Orthopaedics, Faculty of Health, Medicine & Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-572X","authenticated-orcid":false,"given":"Jan","family":"Geurts","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Lucchesi","sequence":"additional","affiliation":[{"name":"Bonalive Biomaterials, 20750 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobus J. 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[10th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5897\/JPAP2013.0001","article-title":"The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus","volume":"4","author":"Ozougwu","year":"2013","journal-title":"J. Physiol. Pathophysiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1111\/dme.13808","article-title":"Prevalence and predictors of delayed clinical diagnosis of Type 2 diabetes: A longitudinal cohort study","volume":"35","author":"Gopalan","year":"2018","journal-title":"Diabet. Med. A J. Br. Diabet. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.2337\/dc13-2101","article-title":"Estimating the Delay Between Onset and Diagnosis of Type 2 Diabetes From the Time Course of Retinopathy Prevalence","volume":"37","author":"Porta","year":"2014","journal-title":"Diabetes Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4103\/0970-0358.197238","article-title":"Healing ulcers and preventing their recurrences in the diabetic foot","volume":"49","author":"Sabapathy","year":"2016","journal-title":"Indian J. Plast. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.mpmed.2018.11.001","article-title":"The diabetic foot","volume":"47","author":"Boulton","year":"2019","journal-title":"Medicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/dmrr.216","article-title":"Diabetic foot ulcers: A quality of life issue","volume":"17","author":"Vileikyte","year":"2001","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI32169","article-title":"Cellular and Molecular Basis of Wound Healing in Diabetes","volume":"117","author":"Brem","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_9","first-page":"389","article-title":"Diabetic Foot. Part 1: Ulcers and Infections","volume":"55","author":"Ferreira","year":"2020","journal-title":"Rev. Bras. Ortop."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Okonkwo, U., and DiPietro, L. (2017). Diabetes and Wound Angiogenesis. Int. J. Mol. Sci, 18.","DOI":"10.3390\/ijms18071419"},{"key":"ref_11","first-page":"31","article-title":"Basic Science of Wound Healing","volume":"26","author":"Leaper","year":"2008","journal-title":"Surgery"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1053\/nbin.2001.23176","article-title":"Physiology of Wound Healing","volume":"1","author":"Strodtbeck","year":"2001","journal-title":"Newborn Infant Nurs. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1021\/acsbiomaterials.0c00528","article-title":"Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing","volume":"6","author":"Mehrabi","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/jdv.18854","article-title":"Wound healing and microbiome, an unexpected relationship","volume":"37","author":"Canchy","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cjtee.2017.06.001","article-title":"The molecular biology in wound healing & non-healing wound","volume":"20","author":"Qing","year":"2017","journal-title":"Chin. J. Traumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1039\/D2BM00620K","article-title":"Construction of multifunctional wound dresings with their application in chronic wound treatment","volume":"10","author":"Long","year":"2022","journal-title":"Biomater. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kiss, C., Connoley, D., Connelly, K., Horne, K., Korman, T., Woolley, I., and Lau, J. (2022). Long-Term Outcomes in Patients on Life-Long Antibiotics:A Five-Year Cohort Study. Antibiotics, 11.","DOI":"10.3390\/antibiotics11010062"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Perez-Favila, A., Martinez-Fierro, M.L., Rodriguez-Lazalde, J.G., Cid-Baez, M.A., Zamudio-Osuna, M.D.J., Martinez-Blanco, M.D.R., Mollinedo-Monta\u00f1o, F.E., Rodriguez-Sanchez, I.P., Casta\u00f1eda-Miranda, R., and Garza-Veloz, I. (2019). Current Therapeutic Strategies in Diabetic Foot Ulcers. Medicina, 55.","DOI":"10.3390\/medicina55110714"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"126525","DOI":"10.1016\/j.cej.2020.126525","article-title":"Antibacterial and angiogenic wound dressings for chronic persistent skin injury","volume":"404","author":"Wang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4103\/2231-4040.111523","article-title":"Bioglass: A Novel Biocompatible Innovation","volume":"4","author":"Lakshmi","year":"2013","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kunisch, E., Fiehn, L.A., Saur, M., Arango-Ospina, M., Merle, C., Hagmann, S., Stiller, A., Hupa, L., Renkawitz, T., and Boccaccini, A.R. (2023). A comparative in vitro and in vivo analysis of the biological properties of the 45S5-, 1393-, and 0106-B1-bioactive glass compositions using human bone marrow-derived stromal cells and a rodent critical size femoral defect model. Biomater. Adv., 153.","DOI":"10.1016\/j.bioadv.2023.213521"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6775","DOI":"10.1038\/s41598-023-34042-w","article-title":"Multifunctional Zn and Ag co-doped bioactive glass nanoparticles for bone therapeutic and regeneration","volume":"13","author":"Naruphontjirakul","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"122404","DOI":"10.1016\/j.jnoncrysol.2023.122404","article-title":"A review on bioactive glass, its modifications and applications in healthcare sectors","volume":"614","author":"Aparajita","year":"2023","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"tkac038","DOI":"10.1093\/burnst\/tkac038","article-title":"Bioactive glass-based fibrous wound dressings","volume":"10","author":"Homaeigohar","year":"2022","journal-title":"Burns Trauma"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1039\/C8TB02938E","article-title":"Dose-dependent modulation effects of bioactive glass particles on macrophages and diabetic wound healing","volume":"7","author":"Xie","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1002\/anie.201405310","article-title":"Bioactive Glasses-Structure and Properties","volume":"54","author":"Brauer","year":"2015","journal-title":"Angew. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1098\/rspa.2008.0462","article-title":"Structural models of bioactive glasses from molecular dynamics simulations","volume":"495","author":"Tilocca","year":"2009","journal-title":"Proc. R. Soc. A"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Crush, J., Hussain, A., Seah, K., and Khan, W. (2021). Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.643781"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"122371","DOI":"10.1016\/j.jnoncrysol.2023.122371","article-title":"Evaluation of in vitro bioactivity and angiogenesis-promoting effect for mesoporous bioactive glass codoped with copper and silver","volume":"613","author":"Li","year":"2023","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.actbio.2017.06.046","article-title":"Multifunctional bioactive glass and glass-ceramic biomaterials with antibacterial properties for repair and regeneration of bone tissue","volume":"59","author":"Fernandes","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jbm.a.32564","article-title":"Antibacterial effects and dissolution behavior of six bioactive glasses","volume":"93A","author":"Zhang","year":"2009","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_33","first-page":"25","article-title":"Cotton Candy that Heals? Borate Glass Nanofibers Look Promising","volume":"90","author":"Wray","year":"2011","journal-title":"Am. Ceram. Soc. Bull."},{"key":"ref_34","unstructured":"Jung, S.B., Day, D.E., Day, T., Stoecker, W., and Taylor, P. (2011). Treatment of non-healing diabetic venous stasis ulcers with bioactive glass nanofibers. Wound Repair Regen., 19."},{"key":"ref_35","first-page":"A27","article-title":"Treatment of chronic ulcers with bioactive borate glass nanofibers","volume":"20","author":"Jung","year":"2012","journal-title":"Wound Repair Regen."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1179\/1753555714Y.0000000167","article-title":"In vitro assessment of degradation and mineralisation of V2O5 substituted borate bioactive glass scaffolds","volume":"29","author":"Deliormanli","year":"2014","journal-title":"Mater. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.actbio.2018.01.019","article-title":"Highly Efficient Local Delivery of Endothelial Progenitor Cells Significantly Potentiates Angiogenesis and Full-thickness Wound Healing","volume":"69","author":"Wang","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Elshazly, N., Khalil, A., Saad, M., Patruno, M., Chakraborty, J., and Marei, M. (2020). Efficacy of Bioactive Glass Nanofibers Tested for Oral Mucosal Regeneration in Rabbits with Induced Diabetes. Materials, 13.","DOI":"10.3390\/ma13112603"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2005422","DOI":"10.1002\/adfm.202005422","article-title":"Bioactive Self-Pumping Composite Wound Dressings with Micropore Array Modified Janus Membrane for Enhanced Diabetic Wound Healing","volume":"30","author":"Bao","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"110083","DOI":"10.1016\/j.msec.2019.110083","article-title":"Electrospun chitosan\/PVA\/bioglass Nanofibrous membrane with spatially designed structure for accelerating chronic wound healing","volume":"105","author":"Chen","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Chen, Y.-H., Rao, Z.-F., Liu, Y.-J., Liu, X.-S., Liu, Y.-F., Xu, L.-J., Wang, Z.-Q., Guo, J.-Y., Zhang, L., and Dong, Y.-S. (2021). Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing. Biomolecules, 11.","DOI":"10.3390\/biom11050702"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1039\/C7TB01484H","article-title":"A highly bioactive bone extracellular matrix-biomimetic nanofibrous system with rapid angiogenesis promotes diabetic wound healing","volume":"5","author":"Gao","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"130634","DOI":"10.1016\/j.cej.2021.130634","article-title":"Cryogenic 3D printed hydrogel scaffolds loading exosomes accelerate diabetic wound healing","volume":"426","author":"Hu","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Jana, S., Datta, P., Das, H., Jaiswal, S., Ghosh, P., Lahiri, D., Kundu, B., and Kumar, S. (2022). Copper and cobalt doped bioactive glass-fish dermal collagen electrospun mat triggers key events of diabetic wound healing in full-thickness skin defect model. J. Mech. Behav. Biomed. Mater., 134.","DOI":"10.1016\/j.jmbbm.2022.105414"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1021\/acsabm.0c00143","article-title":"A Mussel-Inspired Extracellular Matrix-Mimicking Composite Scaffold for Diabetic Wound Healing","volume":"3","author":"Jiang","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"30103","DOI":"10.1021\/acsami.8b09191","article-title":"Bioactive Injectable Hydrogels Containing Desferrioxamine and Bioglass for Diabetic Wound Healing","volume":"10","author":"Kong","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1039\/C7TB00124J","article-title":"A patterned nanocomposite membrane for high-efficiency healing of diabetic wound","volume":"5","author":"Li","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.7150\/thno.41839","article-title":"Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.actbio.2022.04.010","article-title":"45S5 Bioglass works synergistically with siRNA to downregulate the expression of matrix metalloproteinase-9 in diabetic wounds","volume":"145","author":"Li","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Lin, C., Mao, C., Zhang, J., and Li, Y. (2012). Healing effect of bioactive glass ointment on fullthickness skin wounds. Biomed. Mater., 7.","DOI":"10.1088\/1748-6041\/7\/4\/045017"},{"key":"ref_51","first-page":"1063","article-title":"Enhanced healing of full-thickness diabetic wounds using bioactive glass and Yunnan baiyao ointments","volume":"29","author":"Mao","year":"2014","journal-title":"Biomaterials"},{"key":"ref_52","first-page":"29787","article-title":"Multilayer Injectable Hydrogel System Sequentially Delivers Bioactive Substances for Each Wound Healing Stage","volume":"12","author":"Ma","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.2217\/nnm-2020-0053","article-title":"A bioglass sustained-release scaffold with ECM-like structure for enhanced diabetic wound healing","volume":"15","author":"Zhang","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1007\/s10570-022-04570-1","article-title":"Antibacterial and wound healing properties of cellulose acetate electrospun nanofibers loaded with bioactive glass nanoparticles; in-vivo study","volume":"29","author":"Sharaf","year":"2022","journal-title":"Cellulose"},{"key":"ref_55","first-page":"3496","article-title":"Bioactive glass promotes the barrier functional behaviors of keratinocytes and improves the Re-epithelialization in wound healing in diabetic rats","volume":"6","author":"Tang","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"109569","DOI":"10.1016\/j.compositesb.2021.109569","article-title":"Engineered multifunctional nanocomposite hydrogel dressing to promote vascularization and anti-inflammation by sustained releasing of Mg2+ in diabetic wounds","volume":"231","author":"Zhu","year":"2022","journal-title":"Compos. Part B"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Drago, L., Toscano, M., and Bottagisio, M. (2018). Recent Evidence on Bioactive Glass Antimicrobial and Antibiofilm Activity: A Mini-Review. Materials, 11.","DOI":"10.3390\/ma11020326"},{"key":"ref_58","unstructured":"Oliver, T., and Mutluoglu, M. (2023, August 11). Diabetic Foot Ulcer NCBI: StatPearls Publishing, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537328\/."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00204-014-1355-y","article-title":"Copper: Toxicological relevance and mechanisms","volume":"88","author":"Gaetke","year":"2014","journal-title":"Arch. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.matlet.2013.04.075","article-title":"Facile synthesis and in vitro bioactivity of monodispersed mesoporous bioactive glass sub-micron spheres","volume":"106","author":"Hu","year":"2013","journal-title":"Mater. Lett."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1007\/s00018-016-2268-0","article-title":"Transition from inflammation to proliferation: A critical step during wound healing","volume":"73","author":"Li","year":"2016","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Adair, T.H., and Montani, J.P. (2010). Angiogenesis, Morgan & Claypool Life Sciences.","DOI":"10.4199\/C00017ED1V01Y201009ISP010"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4103\/2347-9264.165438","article-title":"Role of angiogenesis and angiogenic factors in acute and chronic wound healing","volume":"2","author":"Honnegowda","year":"2015","journal-title":"Plast. Aesthetic Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jcot.2021.01.017","article-title":"The current burden of diabetic foot disease","volume":"17","author":"Edmonds","year":"2021","journal-title":"J. Clin. Orthop. Trauma"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Zhou, P., Garcia, B.L., and Kotsakis, G.A. (2022). Comparison of antibacterial and antibiofilm activity of bioactive glass compounds S53P4 and 45S5. BMC Miocrobiol., 22.","DOI":"10.1186\/s12866-022-02617-8"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Vergnaud, F., Mekonnen, B., El Abbassi, A., Vichery, C., and Nedelec, J.-M. (2023). Correlating the Effect of Composition and Textural Propertieson Bioactivity for Pristine and Copper-Doped BinaryMesoporous Bioactive Glass Nanoparticle. Materials, 16.","DOI":"10.3390\/ma16206690"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10856-008-3564-5","article-title":"Study on antibacterial effect of 45S5 Bioglass\u00ae","volume":"20","author":"Hu","year":"2009","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/jbm.a.32678","article-title":"Antibacterial effects of sol-gel-derived bioactive glass nanoparticle on aerobic bacteria","volume":"94A","author":"Mortazavi","year":"2010","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_69","first-page":"288","article-title":"Comparative Study of Calcium Content on in vitro Biological and Antibacterial Properties of Silicon-Based Bioglass","volume":"13","author":"Morteza","year":"2019","journal-title":"Int. J. Chem. Mol. Eng."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/2\/1152\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:49:13Z","timestamp":1760104153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/2\/1152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":69,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25021152"],"URL":"https:\/\/doi.org\/10.3390\/ijms25021152","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]}}}