{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:14:20Z","timestamp":1787850860001,"version":"build-2784847793"},"reference-count":78,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32170788"],"award-info":[{"award-number":["32170788"]}]},{"name":"National Natural Science Foundation of China","award":["2022-PUMCH-B-023"],"award-info":[{"award-number":["2022-PUMCH-B-023"]}]},{"name":"National Natural Science Foundation of China","award":["ZK108000"],"award-info":[{"award-number":["ZK108000"]}]},{"name":"National Natural Science Foundation of China","award":["7232123"],"award-info":[{"award-number":["7232123"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["32170788"],"award-info":[{"award-number":["32170788"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-023"],"award-info":[{"award-number":["2022-PUMCH-B-023"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["ZK108000"],"award-info":[{"award-number":["ZK108000"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["7232123"],"award-info":[{"award-number":["7232123"]}]},{"name":"National Key Clinical Specialty Construction Project","award":["32170788"],"award-info":[{"award-number":["32170788"]}]},{"name":"National Key Clinical Specialty Construction Project","award":["2022-PUMCH-B-023"],"award-info":[{"award-number":["2022-PUMCH-B-023"]}]},{"name":"National Key Clinical Specialty Construction Project","award":["ZK108000"],"award-info":[{"award-number":["ZK108000"]}]},{"name":"National Key Clinical Specialty Construction Project","award":["7232123"],"award-info":[{"award-number":["7232123"]}]},{"name":"Beijing Natural Science Foundation","award":["32170788"],"award-info":[{"award-number":["32170788"]}]},{"name":"Beijing Natural Science Foundation","award":["2022-PUMCH-B-023"],"award-info":[{"award-number":["2022-PUMCH-B-023"]}]},{"name":"Beijing Natural Science Foundation","award":["ZK108000"],"award-info":[{"award-number":["ZK108000"]}]},{"name":"Beijing Natural Science Foundation","award":["7232123"],"award-info":[{"award-number":["7232123"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>With the explosion research on the gut microbiome in the recent years, much insight has been accumulated in comprehending the crosstalk between the gut microbiota community and host health. Acute pancreatitis (AP) is one of the gastrointestinal diseases associated with significant morbidity and subsequent mortality. Studies have elucidated that gut microbiota are engaged in the pathological process of AP. Herein, we summarize the major roles of the gut microbiome in the development of AP. We then portray the association between dysbiosis of the gut microbiota and the severity of AP. Finally, we illustrate the promises and challenges that arise when seeking to incorporate the microbiome in acute pancreatitis treatment.<\/jats:p>","DOI":"10.3390\/ijms25021159","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T03:50:56Z","timestamp":1705549856000},"page":"1159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Role of the Gut Microbiome in the Development of Acute Pancreatitis"],"prefix":"10.3390","volume":"25","author":[{"given":"Ruilin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4187-4842","authenticated-orcid":false,"given":"Qingyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Eight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0129-3541","authenticated-orcid":false,"given":"Zihan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanna","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duan","family":"Wang","sequence":"additional","affiliation":[{"name":"Eight-Year Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9430-9874","authenticated-orcid":false,"given":"Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"},{"name":"Clinical Epidemiology Unit, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","article-title":"Acute pancreatitis","volume":"396","author":"Boxhoorn","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute Pancreatitis: A Review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New insights into acute pancreatitis","volume":"16","author":"Lee","year":"2019","journal-title":"Nat. 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