{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:10:52Z","timestamp":1791389452787,"version":"4.3.3"},"reference-count":102,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fellow of Youth Innovation Promotion Association","award":["2020414"],"award-info":[{"award-number":["2020414"]}]},{"name":"Fellow of Youth Innovation Promotion Association","award":["23JRRA677"],"award-info":[{"award-number":["23JRRA677"]}]},{"name":"Fellow of Youth Innovation Promotion Association","award":["21JR7RA097"],"award-info":[{"award-number":["21JR7RA097"]}]},{"name":"Natural Science Foundation of Gansu Province","award":["2020414"],"award-info":[{"award-number":["2020414"]}]},{"name":"Natural Science Foundation of Gansu Province","award":["23JRRA677"],"award-info":[{"award-number":["23JRRA677"]}]},{"name":"Natural Science Foundation of Gansu Province","award":["21JR7RA097"],"award-info":[{"award-number":["21JR7RA097"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mitochondria are double-membrane organelles that are involved in energy production, apoptosis, and signaling in eukaryotic cells. Several studies conducted over the past decades have correlated mitochondrial dysfunction with various diseases, including cerebral ischemia, myocardial ischemia-reperfusion, and cancer. Mitochondrial transplantation entails importing intact mitochondria from healthy tissues into diseased tissues with damaged mitochondria to rescue the injured cells. In this review, the different mitochondrial transplantation techniques and their clinical applications have been discussed. In addition, the challenges and future directions pertaining to mitochondrial transplantation and its potential in the treatment of diseases with defective mitochondria have been summarized.<\/jats:p>","DOI":"10.3390\/ijms25021175","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T03:50:56Z","timestamp":1705549856000},"page":"1175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Research Progress of Mitochondrial Transplantation in the Treatment of Mitochondrial Defective Diseases"],"prefix":"10.3390","volume":"25","author":[{"given":"Cuilan","family":"Hu","sequence":"first","affiliation":[{"name":"Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1048-2758","authenticated-orcid":false,"given":"Xiongxiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-3142","authenticated-orcid":false,"given":"Chao","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/bj2800561","article-title":"Control of mitochondrial ATP synthesis in the heart","volume":"280","author":"Harris","year":"1991","journal-title":"Biochem. 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