{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:07:52Z","timestamp":1792040872560,"version":"4.4.0"},"reference-count":141,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009687","name":"WROCLAW MEDICAL UNIVERSITY","doi-asserted-by":"publisher","award":["SUBK.A080.22.049"],"award-info":[{"award-number":["SUBK.A080.22.049"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cornelian cherry (Cornus mas L.) fruits, abundant in iridoids and anthocyanins, are natural products with proven beneficial impacts on the functions of the cardiovascular system and the liver. This study aims to assess and compare whether and to what extent two different doses of resin-purified cornelian cherry extract (10 mg\/kg b.w. or 50 mg\/kg b.w.) applied in a cholesterol-rich diet rabbit model affect the levels of sterol regulatory element-binding protein 1c (SREBP-1c) and CCAAT\/enhancer binding protein \u03b1 (C\/EBP\u03b1), and various liver X receptor-\u03b1 (LXR-\u03b1), peroxisome proliferator-activated receptor-\u03b1 (PPAR-\u03b1), and peroxisome proliferator-activated receptor-\u03b3 (PPAR-\u03b3) target genes. Moreover, the aim is to evaluate the resistive index (RI) of common carotid arteries (CCAs) and aortas, and histopathological changes in CCAs. For this purpose, the levels of SREBP-1c, C\/EBP\u03b1, ATP-binding cassette transporter A1 (ABCA1), ATP-binding cassette transporter G1 (ABCG1), fatty acid synthase (FAS), endothelial lipase (LIPG), carnitine palmitoyltransferase 1A (CPT1A), and adiponectin receptor 2 (AdipoR2) in liver tissue were measured. Also, the levels of lipoprotein lipase (LPL), visceral adipose tissue-derived serine protease inhibitor (Vaspin), and retinol-binding protein 4 (RBP4) in visceral adipose tissue were measured. The RI of CCAs and aortas, and histopathological changes in CCAs, were indicated. The oral administration of the cornelian cherry extract decreased the SREBP-1c and C\/EBP\u03b1 in both doses. The dose of 10 mg\/kg b.w. increased ABCA1 and decreased FAS, CPT1A, and RBP4, and the dose of 50 mg\/kg b.w. enhanced ABCG1 and AdipoR2. Mitigations in atheromatous changes in rabbits\u2019 CCAs were also observed. The obtained outcomes were compared to the results of our previous works. The beneficial results confirm that cornelian cherry fruit extract may constitute a potentially effective product in the prevention and treatment of obesity-related disorders.<\/jats:p>","DOI":"10.3390\/ijms25021199","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T11:28:46Z","timestamp":1705577326000},"page":"1199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cornelian Cherry (Cornus mas L.) Fruit Extract Lowers SREBP-1c and C\/EBP\u03b1 in Liver and Alters Various PPAR-\u03b1, PPAR-\u03b3, LXR-\u03b1 Target Genes in Cholesterol-Rich Diet Rabbit Model"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-5747","authenticated-orcid":false,"given":"Maciej","family":"Danielewski","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-0287","authenticated-orcid":false,"given":"Andrzej","family":"Rapak","sequence":"additional","affiliation":[{"name":"Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Kruszy\u0144ska","sequence":"additional","affiliation":[{"name":"Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Ma\u0142odobra-Mazur","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Division of Molecular Techniques, Wroclaw Medical University, M. Sklodowskiej-Curie 52, 50-369 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Oleszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Diagnostics II, Lower Silesian Center of Oncology, Pulmonology and Hematology, Grabiszynska 105, 53-439 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7203-2392","authenticated-orcid":false,"given":"Stanis\u0142aw","family":"Dzimira","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50-375 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-0408","authenticated-orcid":false,"given":"Alicja Z.","family":"Kucharska","sequence":"additional","affiliation":[{"name":"Department of Fruit, Vegetable, and Plant Nutraceutical Technology, Wroclaw University of Environmental and Life Sciences, J. Chelmonskiego 37, 51-630 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0833-7711","authenticated-orcid":false,"given":"Wojciech","family":"S\u0142upski","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1082-0793","authenticated-orcid":false,"given":"Agnieszka","family":"Matuszewska","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0014-6344","authenticated-orcid":false,"given":"Beata","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Szel\u0105g","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narcyz","family":"Pi\u00f3recki","sequence":"additional","affiliation":[{"name":"Bolestraszyce Arboretum and Institute of Physiography, Bolestraszyce 130, 37-722 Wyszatyce, Poland"},{"name":"Institute of Physical Culture Sciences, Medical College, University of Rzeszow, Cicha 2A, 35-326 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Zaleska-Dorobisz","sequence":"additional","affiliation":[{"name":"Department of General and Pediatric Radiology, Wroclaw Medical University, M. Sklodowskiej-Curie 50\/52, 50-369 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-3190","authenticated-orcid":false,"given":"Tomasz","family":"Soza\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Preclinical Sciences, Pharmacology and Medical Diagnostics, Faculty of Medicine, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.3390\/nu15122749","article-title":"Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review","volume":"15","year":"2023","journal-title":"Nutrients"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.2147\/DMSO.S216791","article-title":"How Western Diet and Lifestyle Drive the Pandemic of Obesity and Civilization Diseases","volume":"12","author":"Kopp","year":"2019","journal-title":"Diabetes Metab. 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