{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:33:42Z","timestamp":1770496422562,"version":"3.49.0"},"reference-count":73,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005916","name":"Universidad de La Frontera","doi-asserted-by":"publisher","award":["DI22\u20130007"],"award-info":[{"award-number":["DI22\u20130007"]}],"id":[{"id":"10.13039\/501100005916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005916","name":"Universidad de La Frontera","doi-asserted-by":"publisher","award":["PDT22-0001"],"award-info":[{"award-number":["PDT22-0001"]}],"id":[{"id":"10.13039\/501100005916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alcohol is believed to harm acinar cells, pancreatic ductal epithelium, and pancreatic stellate cells. After giving ethanol and\/or \u03b2-carotene to C57BL\/6 mice, our goal was to evaluate their biochemistry, histology, and morpho-quantitative features. There were six groups of C57BL\/6 mice: 1. Group C (control), 2. Group LA (low-dose alcohol), 3. Group MA (moderate-dose alcohol), 4. Group B (\u03b2-carotene), 5. Group LA + B (low-dose alcohol combined with \u03b2-carotene), and 6. Group MA + B (moderate-dose alcohol combined with \u03b2-carotene). After the animals were euthanized on day 28, each specimen\u2019s pancreatic tissue was taken. Lipase, uric acid, and amylase were assessed using biochemical assessment. Furthermore, the examination of the pancreatic structure was conducted using Ammann\u2019s fibrosis scoring system. Finally, the morpho-quantitative characteristics of the pancreatic islets and acinar cells were determined. In the serum of the MA + B group, there were higher amounts of total amylase (825.953 \u00b1 193.412 U\/L) and lower amounts of lipase (47.139 \u00b1 6.099 U\/L) (p &lt; 0.05). Furthermore, Ammann\u2019s fibrosis punctuation in the pancreas revealed significant variations between the groups (p &lt; 0.001). Finally, the stereological analysis of pancreatic islets showed that the groups were different (p &lt; 0.001). These findings suggest that antioxidant treatments might help decrease the negative effects of ethanol exposure in animal models.<\/jats:p>","DOI":"10.3390\/ijms25021219","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T03:33:41Z","timestamp":1705635221000},"page":"1219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["\u03b2-Carotene Supplementation Improves Pancreas Function during Moderate Ethanol Consumption: Initial Characterization from a Morphological Overview"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3184-6482","authenticated-orcid":false,"given":"Cristian","family":"Sandoval","sequence":"first","affiliation":[{"name":"Escuela de Tecnolog\u00eda M\u00e9dica, Facultad de Salud, Universidad Santo Tom\u00e1s, Los Carreras 753, Osorno 5310431, Chile"},{"name":"Departamento de Ingenier\u00eda Qu\u00edmica, Facultad de Ingenier\u00eda y Ciencias, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeles","family":"Vera","sequence":"additional","affiliation":[{"name":"Carrera de Tecnolog\u00eda M\u00e9dica, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Birditt","sequence":"additional","affiliation":[{"name":"Physiology Development and Neuroscience Department, University of Cambridge, Cambridge CB2 1TN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Godoy","sequence":"additional","affiliation":[{"name":"N\u00facleo Cient\u00edfico y Tecnol\u00f3gico en Biorecursos (BIOREN), Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Carmine","sequence":"additional","affiliation":[{"name":"Carrera de Medicina, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Caama\u00f1o","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Laboratorio de Inmunohematolog\u00eda y Medicina Transfusional, Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-9603","authenticated-orcid":false,"given":"Jorge","family":"Far\u00edas","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica, Facultad de Ingenier\u00eda y Ciencias, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/2050640614554155","article-title":"Survey of digestive health across Europe: Final report. Part 2: The economic impact and burden of digestive disorders","volume":"2","author":"Anderson","year":"2014","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000497290","article-title":"Risk Stratification and Early Conservative Treatment of Acute Pancreatitis","volume":"35","author":"Beyer","year":"2019","journal-title":"Visc. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s10620-017-4621-z","article-title":"Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group","volume":"62","author":"Conwell","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(14)60649-8","article-title":"Acute pancreatitis","volume":"386","author":"Lankisch","year":"2015","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/ng.2466","article-title":"Alzheimer\u2019s Disease Genetics Consortium. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis","volume":"44","author":"Whitcomb","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1530-0277.2010.01408.x","article-title":"Investigating the pathobiology of alcoholic pancreatitis","volume":"35","author":"Pandol","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1053\/j.gastro.2018.01.032","article-title":"American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis","volume":"154","author":"Crockett","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S2468-1253(16)30004-8","article-title":"Global incidence and mortality of pancreatic diseases: A systematic review, meta-analysis, and meta-regression of population-based cohort studies","volume":"1","author":"Xiao","year":"2016","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.gastro.2021.09.043","article-title":"Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis","volume":"162","author":"Iannuzzi","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/ajg.2013.218","article-title":"American College of Gastroenterology guideline: Management of acute pancreatitis","volume":"108","author":"Tenner","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/MPA.0000000000000668","article-title":"Reassessing the Risk of Pancreatitis with Alcohol","volume":"45","author":"Yadav","year":"2016","journal-title":"Pancreas"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1053\/j.gastro.2014.11.002","article-title":"Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis","volume":"148","author":"Pallagi","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1053\/j.gastro.2012.11.037","article-title":"A starring role for stellate cells in the pancreatic cancer microenvironment","volume":"144","author":"Apte","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1053\/j.gastro.2010.11.038","article-title":"Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage","volume":"140","author":"Lugea","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.pan.2015.01.011","article-title":"Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response","volume":"15","author":"Lugea","year":"2015","journal-title":"Pancreatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4067\/S0717-95022017000300024","article-title":"Ethanol intake and toxicity: In search of new treatments","volume":"35","author":"Sandoval","year":"2017","journal-title":"Int. J. Morphol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4067\/S0717-95022018000100367","article-title":"Role of Alcohol Consumption and Antioxidants on Global Methylation of DNA and Cancer","volume":"36","author":"Sandoval","year":"2018","journal-title":"Int. J. Morphol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.taap.2006.05.003","article-title":"Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 Cells: Role of nonoxidative metabolism","volume":"216","author":"Wu","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1046\/j.1440-1746.2002.02670.x","article-title":"Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis","volume":"17","author":"Frenzer","year":"2002","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00006676-200311000-00007","article-title":"Role of Alcohol Metabolism in Alcoholic Pancreatitis","volume":"27","author":"Wilson","year":"2003","journal-title":"Pancreas"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1136\/gut.36.2.287","article-title":"Effects of ethanol and protein deficiency on pancreatic digestive and lysosomal enzymes","volume":"36","author":"Apte","year":"1995","journal-title":"Gut"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Sandoval, C., Far\u00edas, J., Zamorano, M., and Herrera, C. (2022). Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption?. An Updated Review. Antioxidants, 11.","DOI":"10.37247\/PAB.1.22.12"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Sandoval, C., Mella, L., Godoy, K., Adeli, K., and Far\u00edas, J. (2022). \u03b2-Carotene Increases Activity of Cytochrome P450 2E1 during Ethanol Consumption. Antioxidants, 11.","DOI":"10.3390\/antiox11051033"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41556-018-0124-1","article-title":"The multifaceted contributions of mitochondria to cellular metabolism","volume":"20","author":"Spinelli","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1053\/j.gastro.2012.10.037","article-title":"Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis","volume":"144","author":"Shalbueva","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ncb2979","article-title":"Cargo recognition and trafficking in selective autophagy","volume":"16","author":"Stolz","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fphys.2012.00060","article-title":"Protein kinase d regulates cell death pathways in experimental pancreatitis","volume":"3","author":"Yuan","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1053\/j.gastro.2009.04.003","article-title":"Impaired autolysosome formation correlates with Lamp-2 depletion: Role of apoptosis, autophagy, and necrosis in pancreatitis","volume":"137","author":"Fortunato","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jcmgh.2015.07.006","article-title":"Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis","volume":"1","author":"Mareninova","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"13047","DOI":"10.1074\/jbc.M611132200","article-title":"Alcohol\/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C \u03b1 phosphorylation of Munc18c","volume":"282","author":"Lam","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1053\/j.gastro.2012.12.043","article-title":"Models of acute and chronic pancreatitis","volume":"144","author":"Lerch","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/gutjnl-2011-300771","article-title":"Tumour necrosis factor \u03b1 secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice","volume":"62","author":"Sendler","year":"2013","journal-title":"Gut"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1136\/gut.2004.039263","article-title":"Cigarette smoking accelerates progression of alcoholic chronic pancreatitis","volume":"54","author":"Maisonneuve","year":"2005","journal-title":"Gut"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2169\/internalmedicine.40.368","article-title":"The natural history of alcoholic chronic pancreatitis","volume":"40","author":"Ammann","year":"2001","journal-title":"Intern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1053\/gast.2001.22586","article-title":"Chronic pancreatitis: Diagnosis, classification, and new genetic developments","volume":"120","author":"Etemad","year":"2001","journal-title":"Gastroenterology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.3748\/wjg.v11.i46.7261","article-title":"Clinical value of rapid urine trypsinogen-2 test strip, urinary trypsinogen activation peptide, and serum and urinary activation peptide of carboxypeptidase B in acute pancreatitis","volume":"11","author":"Trigo","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.clinbiochem.2017.07.003","article-title":"Lipase or amylase for the diagnosis of acute pancreatitis?","volume":"50","author":"Ismail","year":"2017","journal-title":"Clin. Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1136\/jcp.2002.002923","article-title":"Biochemical markers of acute pancreatitis","volume":"59","author":"Matull","year":"2006","journal-title":"J. Clin. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.4240\/wjgs.v14.i11.1179","article-title":"Diagnosis, severity stratification and management of adult acute pancreatitis-current evidence and controversies","volume":"14","author":"Chan","year":"2022","journal-title":"World J. Gastrointest. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1053\/j.gastro.2007.03.065","article-title":"AGA Institute technical review on acute pancreatitis","volume":"132","author":"Forsmark","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_41","first-page":"e35618","article-title":"Serum Lipase Amylase Ratio as an Indicator to Differentiate Alcoholic From Non-alcoholic Acute Pancreatitis: A Systematic Review and Meta-Analysis","volume":"15","author":"Ekka","year":"2023","journal-title":"Cureus"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/0016-5085(91)90089-4","article-title":"Lipase\/amylase ratio. A new index that distinguishes acute episodes of alcoholic from nonalcoholic acute pancreatitis","volume":"101","author":"Gumaste","year":"1991","journal-title":"Gastroenterology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.pan.2020.04.009","article-title":"Working group for the International (IAP\u2014APA\u2014JPS\u2014EPC) Consensus Guidelines for Chronic Pancreatitis. Guidelines on the histopathology of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and the European Pancreatic Club","volume":"20","author":"Esposito","year":"2020","journal-title":"Pancreatology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000077608","article-title":"Non-oxidative metabolism of ethanol by rat pancreatic acini","volume":"4","author":"Haber","year":"2004","journal-title":"Pancreatology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0022-2143(98)90042-7","article-title":"Metabolism of ethanol by rat pancreatic acinar cells","volume":"132","author":"Haber","year":"1998","journal-title":"J. Lab. Clin. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1053\/gast.2002.30302","article-title":"Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats","volume":"122","author":"Gukovskaya","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_47","first-page":"48","article-title":"Role of alcohol metabolism in chronic pancreatitis","volume":"30","author":"Vonlaufen","year":"2007","journal-title":"Alcohol Res. Health"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1530-0277.1993.tb00725.x","article-title":"Determinants of ethanol and acetaldehyde metabolism in chronic alcoholics","volume":"17","author":"Panes","year":"1993","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"285","DOI":"10.17576\/jsm-2022-5101-23","article-title":"Oral supplementation of \u03b2-carotene benefits the hepatic structure and metabolism in mice exposed to chronic ethanol consumption","volume":"51","author":"Sandoval","year":"2022","journal-title":"Sains Malays."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0741-8329(97)00073-6","article-title":"Influence of chronic alcohol abuse and liver disease on hepatic aldehyde dehydrogenase activity","volume":"15","author":"Vidal","year":"1998","journal-title":"Alcohol"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/gast.1996.v111.pm8698203","article-title":"Course of alcoholic chronic pancreatitis: A prospective clinicomorphological long-term study","volume":"111","author":"Ammann","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cgh.2011.07.022","article-title":"Oktoberfest binge drinking and acute pancreatitis: Is there really no relationship?","volume":"9","author":"DiMagno","year":"2011","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1152\/ajpendo.00011.2008","article-title":"Alcohol and lipid metabolism","volume":"295","author":"Sozio","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_54","first-page":"1713","article-title":"Morphoquantitative effects of oral \u03b2-carotene supplementation on liver of C57BL\/6 mice exposed to ethanol consumption","volume":"12","author":"Sandoval","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"310","DOI":"10.21037\/atm.2020.02.129","article-title":"Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance","volume":"8","author":"Yang","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Aggarwal, B.B., Sung, B., and Gupta, S.C. (2014). Inflammation and Cancer, Springer.","DOI":"10.1007\/978-3-0348-0837-8"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.pan.2022.09.243","article-title":"Progressive reduction in circulating levels of carotenoids and other micronutrients in patients with chronic pancreatitis","volume":"22","author":"Zhang","year":"2022","journal-title":"Pancreatology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1080\/09637486.2016.1197892","article-title":"Association between intake of antioxidants pancreatic cancer risk: A meta-analysis","volume":"67","author":"Chen","year":"2016","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1365-2168.2000.01375.x","article-title":"Relationship of carotenoid and vitamins A and E with the acute inflammatory response in acute pancreatitis","volume":"87","author":"Curran","year":"2000","journal-title":"Br. J. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1097\/00006676-200408000-00018","article-title":"Natural beta-carotene for the prevention of post-ERCP pancreatitis","volume":"29","author":"Lavy","year":"2004","journal-title":"Pancreas"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.12852.1","article-title":"Chronic pancreatitis: Review and update of etiology, risk factors, and management","volume":"7","author":"Pham","year":"2018","journal-title":"F1000Research"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000452544","article-title":"Scoparone protects against pancreatic fibrosis via TGF-\u03b2\/Smad signaling in rats","volume":"40","author":"Xu","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1159\/000430204","article-title":"Eruberin A, a natural flavanol glycoside, exerts anti-fibrotic action on pancreatic stellate cells","volume":"36","author":"Tsang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/MPA.0b013e31821b59c6","article-title":"Comparison of antioxidative and antifibrotic effects of alpha-tocopherol with those of tocotrienol-rich fraction in a rat model of chronic pancreatitis","volume":"40","author":"Jiang","year":"2011","journal-title":"Pancreas"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J. Nutr."},{"key":"ref_67","unstructured":"(2011). Guide for the Care and Use of Laboratory Animals, The National Academies Press. [8th ed.]."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1590\/S0100-879X2003000100017","article-title":"Low ethanol consumption increases insulin sensitivity in Wistar rats","volume":"36","author":"Furuya","year":"2003","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_69","first-page":"132","article-title":"The antiapoptotic effects of different doses of \u03b2-carotene in chronic ethanol-fed rats","volume":"2","author":"Peng","year":"2013","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"13128","DOI":"10.18632\/aging.103401","article-title":"Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice","volume":"12","author":"Diao","year":"2020","journal-title":"Aging"},{"key":"ref_71","first-page":"57","article-title":"A simple method for volumetry of organs in quantitative stereology","volume":"26","author":"Scherle","year":"1970","journal-title":"Mikroskopie"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.4067\/S0717-95022017000401482","article-title":"Tips for studies with quantitative morphology (morphometry and stereology)","volume":"35","year":"2017","journal-title":"Int. J. Morphol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2818.1986.tb02764.x","article-title":"Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson","volume":"143","author":"Gundersen","year":"1986","journal-title":"J. Microsc."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/2\/1219\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:45:46Z","timestamp":1760103946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/2\/1219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,19]]},"references-count":73,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25021219"],"URL":"https:\/\/doi.org\/10.3390\/ijms25021219","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,19]]}}}