{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:59:05Z","timestamp":1788433145948,"version":"build-2803163510"},"reference-count":83,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/01596"],"award-info":[{"award-number":["PI21\/01596"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["IDI\/2021\/000033"],"award-info":[{"award-number":["IDI\/2021\/000033"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["AYUD\/2021\/58477"],"award-info":[{"award-number":["AYUD\/2021\/58477"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["AP184182023"],"award-info":[{"award-number":["AP184182023"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI22\/00286"],"award-info":[{"award-number":["FI22\/00286"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PAPl-22-PF-17"],"award-info":[{"award-number":["PAPl-22-PF-17"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Government of the Principado de Asturias through the Fundaci\u00f3n para el Fomento en Asturias de la Investigaci\u00f3n Cient\u00edfica Aplicada y la Tecnolog\u00eda (FICYT)","award":["PI21\/01596"],"award-info":[{"award-number":["PI21\/01596"]}]},{"name":"Government of the Principado de Asturias through the Fundaci\u00f3n para el Fomento en Asturias de la Investigaci\u00f3n Cient\u00edfica Aplicada y la Tecnolog\u00eda (FICYT)","award":["IDI\/2021\/000033"],"award-info":[{"award-number":["IDI\/2021\/000033"]}]},{"name":"Government of the Principado de Asturias through the Fundaci\u00f3n para el Fomento en Asturias de la Investigaci\u00f3n Cient\u00edfica Aplicada y la Tecnolog\u00eda (FICYT)","award":["AYUD\/2021\/58477"],"award-info":[{"award-number":["AYUD\/2021\/58477"]}]},{"name":"Government of the Principado de Asturias through the Fundaci\u00f3n para el Fomento en Asturias de la Investigaci\u00f3n Cient\u00edfica Aplicada y la Tecnolog\u00eda (FICYT)","award":["AP184182023"],"award-info":[{"award-number":["AP184182023"]}]},{"name":"Government of the Principado de Asturias through the Fundaci\u00f3n para el Fomento en Asturias de la Investigaci\u00f3n Cient\u00edfica Aplicada y la Tecnolog\u00eda (FICYT)","award":["FI22\/00286"],"award-info":[{"award-number":["FI22\/00286"]}]},{"name":"Government of the Principado de Asturias through the Fundaci\u00f3n para el Fomento en Asturias de la Investigaci\u00f3n Cient\u00edfica Aplicada y la Tecnolog\u00eda (FICYT)","award":["PAPl-22-PF-17"],"award-info":[{"award-number":["PAPl-22-PF-17"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","award":["PI21\/01596"],"award-info":[{"award-number":["PI21\/01596"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","award":["IDI\/2021\/000033"],"award-info":[{"award-number":["IDI\/2021\/000033"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","award":["AYUD\/2021\/58477"],"award-info":[{"award-number":["AYUD\/2021\/58477"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","award":["AP184182023"],"award-info":[{"award-number":["AP184182023"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","award":["FI22\/00286"],"award-info":[{"award-number":["FI22\/00286"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","award":["PAPl-22-PF-17"],"award-info":[{"award-number":["PAPl-22-PF-17"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["PI21\/01596"],"award-info":[{"award-number":["PI21\/01596"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["IDI\/2021\/000033"],"award-info":[{"award-number":["IDI\/2021\/000033"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["AYUD\/2021\/58477"],"award-info":[{"award-number":["AYUD\/2021\/58477"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["AP184182023"],"award-info":[{"award-number":["AP184182023"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["FI22\/00286"],"award-info":[{"award-number":["FI22\/00286"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["PAPl-22-PF-17"],"award-info":[{"award-number":["PAPl-22-PF-17"]}]},{"name":"Instituto de Salud Carlos III (ISCIII, Spanish Ministry of Science, Innovation and Universities (MCIU))","award":["PI21\/01596"],"award-info":[{"award-number":["PI21\/01596"]}]},{"name":"Instituto de Salud Carlos III (ISCIII, Spanish Ministry of Science, Innovation and Universities (MCIU))","award":["IDI\/2021\/000033"],"award-info":[{"award-number":["IDI\/2021\/000033"]}]},{"name":"Instituto de Salud Carlos III (ISCIII, Spanish Ministry of Science, Innovation and Universities (MCIU))","award":["AYUD\/2021\/58477"],"award-info":[{"award-number":["AYUD\/2021\/58477"]}]},{"name":"Instituto de Salud Carlos III (ISCIII, Spanish Ministry of Science, Innovation and Universities (MCIU))","award":["AP184182023"],"award-info":[{"award-number":["AP184182023"]}]},{"name":"Instituto de Salud Carlos III (ISCIII, Spanish Ministry of Science, Innovation and Universities (MCIU))","award":["FI22\/00286"],"award-info":[{"award-number":["FI22\/00286"]}]},{"name":"Instituto de Salud Carlos III (ISCIII, Spanish Ministry of Science, Innovation and Universities (MCIU))","award":["PAPl-22-PF-17"],"award-info":[{"award-number":["PAPl-22-PF-17"]}]},{"name":"University of Oviedo","award":["PI21\/01596"],"award-info":[{"award-number":["PI21\/01596"]}]},{"name":"University of Oviedo","award":["IDI\/2021\/000033"],"award-info":[{"award-number":["IDI\/2021\/000033"]}]},{"name":"University of Oviedo","award":["AYUD\/2021\/58477"],"award-info":[{"award-number":["AYUD\/2021\/58477"]}]},{"name":"University of Oviedo","award":["AP184182023"],"award-info":[{"award-number":["AP184182023"]}]},{"name":"University of Oviedo","award":["FI22\/00286"],"award-info":[{"award-number":["FI22\/00286"]}]},{"name":"University of Oviedo","award":["PAPl-22-PF-17"],"award-info":[{"award-number":["PAPl-22-PF-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sarcopenia, a complex and debilitating condition characterized by progressive deterioration of skeletal muscle, is the primary cause of age-associated disability and significantly impacts healthspan in elderly patients. Despite its prevalence among the aging population, the underlying molecular mechanisms are still under investigation. The NLRP3 inflammasome is crucial in the innate immune response and has a significant impact on diseases related to inflammation and aging. Here, we investigated the expression of the NLRP3 inflammasome pathway and pro-inflammatory cytokines in skeletal muscle and peripheral blood of dependent and independent patients who underwent hip surgery. Patients were categorized into independent and dependent individuals based on their Barthel Index. The expression of NLRP3 inflammasome components was significantly upregulated in sarcopenic muscle from dependent patients, accompanied by higher levels of Caspase-1, IL-1\u03b2 and IL-6. Among older dependent individuals with sarcopenia, there was a significant increase in the MYH3\/MYH2 ratio, indicating a transcriptional shift in expression from mature to developmental myosin isoforms. Creatine kinase levels and senescence markers were also higher in dependent patients, altogether resembling dystrophic diseases and indicating muscle degeneration. In summary, we present evidence for the involvement of the NLRP3\/ASC\/NEK7\/Caspase-1 inflammasome pathway with activation of pro-inflammatory SASP in the outcome of sarcopenia in the elderly.<\/jats:p>","DOI":"10.3390\/ijms25031439","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T09:57:42Z","timestamp":1706090262000},"page":"1439","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["NLRP3 Contributes to Sarcopenia Associated to Dependency Recapitulating Inflammatory-Associated Muscle Degeneration"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-6306","authenticated-orcid":false,"given":"Eduardo","family":"Antu\u00f1a","sequence":"first","affiliation":[{"name":"Research Group OSKAR, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4687-6230","authenticated-orcid":false,"given":"Yaiza","family":"Potes","sequence":"additional","affiliation":[{"name":"Research Group OSKAR, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Baena-Huerta","sequence":"additional","affiliation":[{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7244-7862","authenticated-orcid":false,"given":"Cristina","family":"Cach\u00e1n-Vega","sequence":"additional","affiliation":[{"name":"Research Group OSKAR, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4796-4965","authenticated-orcid":false,"given":"Nerea","family":"Men\u00e9ndez-Coto","sequence":"additional","affiliation":[{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"\u00c1lvarez Darriba","sequence":"additional","affiliation":[{"name":"Geriatric Service, Monte Naranco Hospital, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Fern\u00e1ndez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Geriatric Service, Monte Naranco Hospital, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Burgos Bencosme","sequence":"additional","affiliation":[{"name":"Geriatric Service, Monte Naranco Hospital, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Research Group OSKAR, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Geriatric Service, Monte Naranco Hospital, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Mar\u00eda","family":"L\u00f3pez \u00c1lvarez","sequence":"additional","affiliation":[{"name":"Research Group OSKAR, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Geriatric Service, Monte Naranco Hospital, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Guti\u00e9rrez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Research Group OSKAR, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Geriatric Service, Monte Naranco Hospital, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Boga","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Microbiolog\u00eda Traslacional, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0242-9620","authenticated-orcid":false,"given":"Beatriz","family":"Caballero","sequence":"additional","affiliation":[{"name":"Research Group OSKAR, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Vega-Naredo","sequence":"additional","affiliation":[{"name":"Research Group OSKAR, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-6258","authenticated-orcid":false,"given":"Ana","family":"Coto-Montes","sequence":"additional","affiliation":[{"name":"Research Group OSKAR, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-230X","authenticated-orcid":false,"given":"Claudia","family":"Garcia-Gonzalez","sequence":"additional","affiliation":[{"name":"Research Group OSKAR, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fendo.2019.00255","article-title":"Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly","volume":"10","author":"Greco","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Sayer","year":"2019","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101530","DOI":"10.1016\/j.arr.2021.101530","article-title":"Biomarkers shared by frailty and sarcopenia in older adults: A systematic review and meta-analysis","volume":"73","author":"Picca","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exger.2016.09.007","article-title":"Biomarkers in sarcopenia: A multifactorial approach","volume":"85","author":"Curcio","year":"2016","journal-title":"Exp. Gerontol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: Signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101185","DOI":"10.1016\/j.arr.2020.101185","article-title":"Markers of inflammation and their association with muscle strength and mass: A systematic review and meta-analysis","volume":"64","author":"Tuttle","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"526.e9","DOI":"10.1016\/j.amjmed.2005.10.049","article-title":"Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength","volume":"119","author":"Schaap","year":"2006","journal-title":"Am. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Antu\u00f1a, E., Cach\u00e1n-Vega, C., Bermejo-Millo, J.C., Potes, Y., Caballero, B., Vega-Naredo, I., Coto-Montes, A., and Garcia-Gonzalez, C. (2022). Inflammaging: Implications in Sarcopenia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315039"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.arr.2014.10.004","article-title":"DAMPs, ageing, and cancer: The \u2018DAMP Hypothesis\u2019","volume":"24 Pt A","author":"Huang","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.arr.2015.02.005","article-title":"Innate immune perturbations, accumulating DAMPs and inflammasome dysreg-ulation: A ticking time bomb in ageing","volume":"24","author":"Kapetanovic","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","article-title":"The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases","volume":"29","author":"Davis","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chen, Y., Ye, X., Escames, G., Lei, W., Zhang, X., Li, M., Jing, T., Yao, Y., Qiu, Z., and Wang, Z. (2023). The NLRP3 inflammasome: Contributions to inflammation-related diseases. Cell Mol. Biol. Lett., 28.","DOI":"10.1186\/s11658-023-00462-9"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zeng, C., Duan, F., Hu, J., Luo, B., Huang, B., Lou, X., Sun, X., Li, H., Zhang, X., and Yin, S. (2020). NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardio-myopathy. Redox Biol., 34.","DOI":"10.1016\/j.redox.2020.101523"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e13050","DOI":"10.1111\/acel.13050","article-title":"NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice","volume":"19","author":"Lucas","year":"2020","journal-title":"Aging Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1161\/CIRCULATIONAHA.122.060860","article-title":"NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload","volume":"147","author":"Higashikuni","year":"2023","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5152\/AnatolJCardiol.2021.580","article-title":"NLRP3 inflammasome as a novel therapeutic target for heart failure","volume":"26","author":"Wang","year":"2022","journal-title":"Anatol. J. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1035709","DOI":"10.3389\/fimmu.2022.1035709","article-title":"The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40635-016-0115-0","article-title":"Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy","volume":"5","author":"Huang","year":"2017","journal-title":"Intensiv. Care Med. Exp."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"374","DOI":"10.7150\/thno.74831","article-title":"Ablation of NLRP3 inflammasome attenuates muscle atrophy via inhibiting pyroptosis, proteolysis and apoptosis following denervation","volume":"13","author":"You","year":"2023","journal-title":"Theranostics"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jorquera, G., Russell, J., Monsalves-\u00c1lvarez, M., Cruz, G., Valladares-Ide, D., Basualto-Alarc\u00f3n, C., Barrientos, G., Estrada, M., and Llanos, P. (2021). NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063254"},{"key":"ref_24","first-page":"412","article-title":"European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Baeyens","year":"2010","journal-title":"Age Ageing"},{"key":"ref_25","first-page":"40","article-title":"Impact of Sarcopenia on One-Year Mortality Among Older Hospitalized Patients with Impaired Mobility","volume":"7","author":"Pourhassan","year":"2018","journal-title":"J. Frailty Aging"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Dos Santos Barros, V., Bassi-Dibai, D., Guedes, C.L.R., Morais, D.N., Coutinho, S.M., de Oliveira Sim\u00f5es, G., Mendes, L.P., da Cunha Leal, P., and Dibai-Filho, A.V. (2022). Barthel Index is a valid and reliable tool to measure the functional independence of cancer patients in palliative care. BMC Palliat Care, 21.","DOI":"10.1186\/s12904-022-01017-z"},{"key":"ref_27","first-page":"61","article-title":"Functional evaluation: The Barthel Index","volume":"14","author":"Mahoney","year":"1965","journal-title":"Meryland State Med. J."},{"key":"ref_28","first-page":"14","article-title":"Stroke rehabilitation: Analysis of repeated Barthel index measures","volume":"60","author":"Granger","year":"1979","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/geroni\/igaa057.581","article-title":"The Impact of the Risk for Sarcopenia on Frailty Among Older Adults With Physical Functional Dependency","volume":"4","author":"Ning","year":"2020","journal-title":"Innov Aging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/jcsm.12937","article-title":"Cell interactome in sarcopenia during aging","volume":"13","author":"Solano","year":"2022","journal-title":"J. Cachex-Sarcopenia Muscle"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Cebria i Iranzo, M.A., Arnal-G\u00f3mez, A., Tortosa-Chuli\u00e1, M.A., Balasch-Bernat, M., Forcano, S., Sentandreu-Ma\u00f1\u00f3, T., Tomas, J.M., and Cez\u00f3n-Serrano, N. (2020). Functional and Clinical Characteristics for Predicting Sarcopenia in Institutionalised Older Adults: Identifying Tools for Clinical Screening. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17124483"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ryrs\u00f8, C.K., Hegelund, M.H., Dungu, A.M., Faurholt-Jepsen, D., Pedersen, B.K., Ritz, C., Krogh-Madsen, R., and Lindegaard, B. (2022). Association between Barthel Index, Grip Strength, and Physical Activity Level at Admission and Prognosis in Community-Acquired Pneumonia: A Prospective Cohort Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11216326"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"834","DOI":"10.14740\/jocmr4027","article-title":"Skeletal Muscle Index at Intensive Care Unit Admission Is a Predictor of Intensive Care Unit-Acquired Weakness in Patients With Sepsis","volume":"11","author":"Mitobe","year":"2019","journal-title":"J. Clin. Med. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/jcsm.12444","article-title":"Gait speed as a mediator of the effect of sarcopenia on dependency in activities of daily living","volume":"10","author":"Izquierdo","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40001-017-0266-9","article-title":"A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-\u03b1","volume":"22","author":"Bian","year":"2017","journal-title":"Eur. J. Med. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Rong, Y.-D., Bian, A.-L., Hu, H.-Y., Ma, Y., and Zhou, X.-Z. (2018). Study on relationship between elderly sarcopenia and inflammatory cytokine IL-6, anti-inflammatory cytokine IL-10. BMC Geriatr., 18.","DOI":"10.1186\/s12877-018-1007-9"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev.physiol.010908.163216","article-title":"Mechanisms of Muscle Degeneration, Regeneration, and Repair in the Muscular Dystrophies","volume":"71","author":"Wallace","year":"2009","journal-title":"Annu. Rev. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1093\/hmg\/ddu366","article-title":"Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients","volume":"23","author":"Hathout","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"29691","DOI":"10.1073\/pnas.2018391117","article-title":"Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by sin-gle-nucleus RNA sequencing","volume":"117","author":"Chemello","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12974-018-1235-0","article-title":"Necroptosis: A regulated inflammatory mode of cell death","volume":"15","author":"Dhuriya","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12967-018-1606-4","article-title":"RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice","volume":"16","author":"Chen","year":"2018","journal-title":"J. Transl. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00011-016-0955-9","article-title":"Red cell DAMPs and inflammation","volume":"65","author":"Silveira","year":"2016","journal-title":"Inflamm. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1016\/j.celrep.2017.11.079","article-title":"Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection","volume":"21","author":"Pons","year":"2017","journal-title":"Cell Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nature13085","article-title":"Nucleotide signalling during inflammation","volume":"509","author":"Idzko","year":"2014","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ziemkiewicz, N., Hilliard, G., Pullen, N.A., and Garg, K. (2021). The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063265"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: A new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/jb\/mvz017","article-title":"Cellular and molecular mechanisms of sterile inflammation in ischaemic stroke","volume":"165","author":"Nakamura","year":"2019","journal-title":"J. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1253\/circj.CJ-17-0261","article-title":"Sterile Inflammation and Degradation Systems in Heart Failure","volume":"81","author":"Nishida","year":"2017","journal-title":"Circ. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1161\/CIRCULATIONAHA.108.769331","article-title":"High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart","volume":"117","author":"Andrassy","year":"2008","journal-title":"Circulation"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1161\/STROKEAHA.110.598334","article-title":"Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood-Brain Barrier From Ischemia-Induced Disruption in Rats","volume":"42","author":"Zhang","year":"2011","journal-title":"Stroke"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1093\/gerona\/glz079","article-title":"Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dys-function, Favoring the Prophylactic Effect of Melatonin","volume":"74","author":"Sayed","year":"2019","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_53","first-page":"E222","article-title":"The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice","volume":"313","author":"McBride","year":"2017","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1002\/jcsm.13062","article-title":"The NLRP3 inflammasome contributes to inflammation-induced morphological and metabolic alterations in skeletal muscle","volume":"13","author":"Eggelbusch","year":"2022","journal-title":"J. Cachex- Sarcopenia Muscle"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kummer, K., Bertram, I., Zechel, S., Hoffmann, D.B., and Schmidt, J. (2023). Inflammasome in Skeletal Muscle: NLRP3 Is an Inflammatory Cell Stress Component in Inclusion Body Myositis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310675"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Moreno-Garc\u00eda, L., Miana-Mena, F.J., Moreno-Mart\u00ednez, L., de la Torre, M., Lunetta, C., Tarlarini, C., Zaragoza, P., Calvo, A.C., and Osta, R. (2021). Inflammasome in ALS Skeletal Muscle: NLRP3 as a Potential Biomarker. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052523"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e001808","DOI":"10.1136\/bmjdrc-2020-001808","article-title":"Expression of the NEK7\/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease","volume":"8","author":"Cai","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Elmadbouh, I., and Singla, D.K. (2021). BMP-7 Attenuates Inflammation-Induced Pyroptosis and Improves Cardiac Repair in Diabetic Cardiomyopathy. Cells, 10.","DOI":"10.3390\/cells10102640"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1084\/jem.20190545","article-title":"Gasdermins and their role in immunity and inflammation","volume":"216","author":"Orning","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.immuni.2023.10.004","article-title":"Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyrop-tosis","volume":"56","author":"Miao","year":"2023","journal-title":"Immunity"},{"key":"ref_63","first-page":"307","article-title":"Embryonic myosin is a regeneration marker to monitor utrophin-based therapies for DMD","volume":"28","author":"Guiraud","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13395-015-0046-6","article-title":"Developmental myosins: Expression patterns and functional significance","volume":"5","author":"Schiaffino","year":"2015","journal-title":"Skelet. Muscle"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1074\/mcp.RA120.002345","article-title":"Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy","volume":"19","author":"Johansson","year":"2020","journal-title":"Mol. Cell Proteomics"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Boursereau, R., Abou-Samra, M., Lecompte, S., Noel, L., and Brichard, S.M. (2018). Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy. BMC Biol., 16.","DOI":"10.1186\/s12915-018-0501-z"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3389\/fphys.2017.01045","article-title":"The Role of Inflammation in Age-Related Sarcopenia","volume":"8","author":"Dalle","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Luo, R., Hu, J., Jiang, L., and Zhang, M. (2016). Prognostic Value of Red Blood Cell Distribution Width in Non-Cardiovascular Critically or Acutely Patients: A Systematic Review. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167000"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1191\/0267659105pf793oa","article-title":"Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical cir-culatory assist device","volume":"20","author":"Pierce","year":"2005","journal-title":"Perfusion"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11484","DOI":"10.1038\/s41598-018-29855-z","article-title":"The Association between Red Blood Cell Distribution Width and Sarcopenia in U.S. Adults","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression","volume":"5","author":"Desprez","year":"2010","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s40478-023-01657-z","article-title":"Myopathologic trajectory in Duchenne muscular dystrophy (DMD) reveals lack of regeneration due to senescence in satellite cells","volume":"11","author":"Cardone","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"111595","DOI":"10.1016\/j.mad.2021.111595","article-title":"Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions","volume":"200","author":"Englund","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3415528","DOI":"10.1155\/2022\/3415528","article-title":"p16INK4a Plays Critical Role in Exacerbating Inflammaging in High Fat Diet Induced Skin","volume":"2022","author":"Liang","year":"2022","journal-title":"Oxidative Med. Cell Longev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41419-020-02985-x","article-title":"NLRP3 inflammasome in endothelial dysfunction","volume":"11","author":"Bai","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"102286","DOI":"10.1016\/j.jaut.2019.05.014","article-title":"Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation","volume":"103","author":"Guo","year":"2019","journal-title":"J. Autoimmun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.expneurol.2017.06.003","article-title":"RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage","volume":"295","author":"Zhou","year":"2017","journal-title":"Exp. Neurol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/eji.201242918","article-title":"The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells","volume":"43","author":"Licandro","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.bbrc.2016.06.106","article-title":"Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes","volume":"477","author":"Hasegawa","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"109333","DOI":"10.1016\/j.neuropharm.2022.109333","article-title":"Extracellular ATP: A powerful inflammatory mediator in the central nervous system","volume":"224","author":"Falzoni","year":"2023","journal-title":"Neuropharmacology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.molimm.2015.03.009","article-title":"Mechanisms that lead to the regulation of NLRP3 inflammasome expression and activation in human dental pulp fibroblasts","volume":"66","author":"Zhang","year":"2015","journal-title":"Mol. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1172\/JCI108760","article-title":"The Occurrence and Effects of Human Vitamin E Deficiency","volume":"60","author":"Farrell","year":"1977","journal-title":"J. Clin. Investig."},{"key":"ref_83","first-page":"376","article-title":"Defective adaption of erythrocytes during acute hypoxia injury in an elderly population","volume":"66","author":"Neitzert","year":"2011","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/3\/1439\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:48:38Z","timestamp":1760104118000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/3\/1439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":83,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["ijms25031439"],"URL":"https:\/\/doi.org\/10.3390\/ijms25031439","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,24]]}}}