{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:35Z","timestamp":1790899235086,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["FGFZ-2022-0035"],"award-info":[{"award-number":["FGFZ-2022-0035"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Dichlorodiphenyltrichloroethane (DDT) is a wide-spread systemic pollutant with endocrine disrupting properties. Prenatal exposure to low doses of DDT has been shown to affect adrenal medulla growth and function. The role of postnatal exposure to DDT in developmental disorders remains unclear. The aim of the present investigation is to assess growth parameters and the expression of factors mediating the function and renewal of chromaffin cells in the adult adrenal medulla of male Wistar rats exposed to the endocrine disruptor o,p\u2019-DDT since birth until sexual maturation. The DDT-exposed rats exhibited normal growth of the adrenal medulla but significantly decreased tyrosine hydroxylase production by chromaffin cells during postnatal period. Unlike the control, the exposed rats showed enhanced proliferation and reduced expression of nuclear \u03b2-catenin, transcription factor Oct4, and ligand of Sonic hedgehog after termination of the adrenal growth period. No expression of pluripotency marker Sox2 and absence of Ascl 1-positive progenitors were found in the adrenal medulla during postnatal ontogeny of the exposed and the control rats. The present findings indicate that an increase in proliferative activity and inhibition of the formation of reserve for chromaffin cell renewal, two main mechanisms for cell maintenance in adrenal medulla, in the adult DDT-exposed rats may reflect a compensatory reaction aimed at the restoration of catecholamine production levels. The increased proliferation of chromaffin cells in adults suggests excessive growth of the adrenal medulla. Thus, postnatal exposure to DDT alters cell physiology and increases the risk of functional insufficiency and hyperplasia of the adrenal medulla.<\/jats:p>","DOI":"10.3390\/ijms25031494","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T08:44:07Z","timestamp":1706172247000},"page":"1494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Postnatal Exposure to the Endocrine Disruptor Dichlorodiphenyltrichloroethane Affects Adrenomedullary Chromaffin Cell Physiology and Alters the Balance of Mechanisms Underlying Cell Renewal"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-5039","authenticated-orcid":false,"given":"Nataliya V.","family":"Yaglova","sequence":"first","affiliation":[{"name":"Laboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey S.","family":"Obernikhin","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana V.","family":"Nazimova","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibakhan A.","family":"Tsomartova","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d, 119991 Moscow, Russia"},{"name":"Department of Human Anatomy and Histology, Federal State Funded Educational Unlike the Control Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-1488","authenticated-orcid":false,"given":"Ekaterina P.","family":"Timokhina","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin V.","family":"Yaglov","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina S.","family":"Tsomartova","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d, 119991 Moscow, Russia"},{"name":"Department of Human Anatomy and Histology, Federal State Funded Educational Unlike the Control Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-6336","authenticated-orcid":false,"given":"Elizaveta V.","family":"Chereshneva","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology, Federal State Funded Educational Unlike the Control Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Y.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology, Federal State Funded Educational Unlike the Control Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana A.","family":"Lomanovskaya","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology, Federal State Funded Educational Unlike the Control Institution of Higher Education, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"ref_1","first-page":"715","article-title":"Research needs for the risk assessment of health and environmental effects of endocrine disruptors: A report of the U.S. EPA-sponsored workshop","volume":"104","author":"Kavlock","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1289\/ehp.1002727","article-title":"Environmental chemicals in pregnant women in the United States: NHANES 2003-2004","volume":"119","author":"Woodruff","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1038\/s41598-019-41134-z","article-title":"Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation","volume":"9","author":"Kelley","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112031","DOI":"10.1016\/j.mce.2023.112031","article-title":"Exposure to endocrine disrupting chemicals impacts immunological and metabolic status of women during pregnancy","volume":"577","author":"Merrill","year":"2023","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"110749","DOI":"10.1016\/j.envres.2021.110749","article-title":"Prenatal exposure to endocrine disrupting chemical mixtures and infant birth weight: A Bayesian analysis using kernel machine regression","volume":"195","author":"Hu","year":"2021","journal-title":"Environ. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"116705","DOI":"10.1016\/j.envpol.2021.116705","article-title":"Prenatal exposure to mixtures of persistent endocrine disrupting chemicals and early menarche in a population-based cohort of British girls","volume":"276","author":"Marks","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11036","DOI":"10.1038\/s41598-021-89846-5","article-title":"Prenatal exposures to mixtures of endocrine disrupting chemicals and children\u2019s weight trajectory up to age 5.5 in the SELMA study","volume":"11","author":"Svensson","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Yaglova, N.V., Obernikhin, S.S., Tsomartova, E.S., Yaglov, V.V., Nazimova, S.V., Tsomartova, D.A., Timokhina, E.P., Chereshneva, E.V., Ivanova, M.Y., and Payushina, O.V. (2022). Developmental Exposure to Endocrine Disrupter DDT Interferes with Age-Related Involution of Thymus. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126678"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/humupd\/dmw036","article-title":"The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: A systematic review and meta-analysis","volume":"23","author":"Bonde","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s42000-019-00170-0","article-title":"The effects of postnatal exposure of endocrine disruptors on testicular function: A systematic review and a meta-analysis","volume":"19","author":"Bliatka","year":"2020","journal-title":"Hormones"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/humupd\/dmac013","article-title":"Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: A systematic review and meta-analysis","volume":"28","author":"Uldbjerg","year":"2022","journal-title":"Hum. Reprod. Update"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"140626","DOI":"10.1016\/j.chemosphere.2023.140626","article-title":"Association of postnatal exposure to mixture of bisphenol A, Di-n-butyl phthalate and Di-(2-ethylhexyl) phthalate with Children\u2019s IQ at 5 Years of age: Mothers and Children\u2019s environmental health (MOCEH) study","volume":"347","author":"Ham","year":"2024","journal-title":"Chemosphere"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"116156","DOI":"10.1016\/j.envpol.2020.116156","article-title":"Human exposure to organochlorine, pyrethroid and neonicotinoid pesticides: Comparison between urban and semi-urban regions of India","volume":"270","author":"Anand","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_14","unstructured":"World Health Organization (2019). Pesticide Residues in Food\u20142018. Toxicological Evaluations, Food and Agriculture Organization."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"111569","DOI":"10.1016\/j.marpolbul.2020.111569","article-title":"Spatial distribution, ecological and health risk assessment and source identification of atrazine in Shadegan international wetland, Iran","volume":"160","author":"Almasi","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.metabol.2018.03.022","article-title":"Endocrine disruptors and testicular function","volume":"86","author":"Lymperi","year":"2018","journal-title":"Metabolism"},{"key":"ref_17","unstructured":"World Health Organization (2011). The Use of DDT in Malaria Vector Control, WHO."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/j.ecoenv.2009.04.009","article-title":"Simulation of the transfer and fate of HCHs since the 1950s in Lanzhou, China","volume":"72","author":"Dong","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110942","DOI":"10.1016\/j.marpolbul.2020.110942","article-title":"Distribution, sources and ecological risks of organochlorine compounds (DDTs, HCHs and PCBs) in surface sediments from the Pearl River Estuary, China","volume":"152","author":"Tang","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Yu, R., Zhou, Y., Xu, S., Jing, J., Zhang, H., and Huang, Y. (2023). Distribution, Transfer, and Health Risk of Organochlorine Pesticides in Soil and Water of the Huangshui River Basin. Toxics, 11.","DOI":"10.3390\/toxics11121024"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.envres.2009.02.003","article-title":"Association between thyroid hormone levels and 4,40-DDE concentrations in pregnant women (Valencia, Spain)","volume":"109","author":"Vizcaino","year":"2009","journal-title":"Environ. Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Calsolaro, V., Pasqualetti, G., Niccolai, F., Caraccio, N., and Monzani, F. (2017). Thyroid disrupting chemicals. Int. J. Mol. Sci., 18.","DOI":"10.20944\/preprints201711.0026.v1"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1134\/S1990750818010122","article-title":"Differences in production of adrenal steroid hormones in pubertal rats exposed to low doses of the endocrine disrupter DDT during prenatal and postnatal development","volume":"12","author":"Yaglova","year":"2018","journal-title":"Biochem. Mosc. Suppl. Ser. B Biomed. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Yaglova, N.V., Tsomartova, D.A., Obernikhin, S.S., Yaglov, V.V., Nazimova, S.V., Tsomartova, E.S., Chereshneva, E.V., Ivanova, M.Y., and Lomanovskaya, T.A. (2021). Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063155"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Yaglova, N.V., Obernikhin, S.S., Tsomartova, D.A., Nazimova, S.V., Yaglov, V.V., Tsomartova, E.S., Chereshneva, E.V., Ivanova, M.Y., and Lomanovskaya, T.A. (2021). Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126324"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1007\/s10517-021-05132-4","article-title":"Low-Dose Exposure to Endocrine Disrupter Dichlorodiphenyltrichloroethane (DDT) Affects Transcriptional Regulation of Adrenal Zona Reticularis in Male Rats","volume":"170","author":"Yaglova","year":"2021","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s10517-017-3819-6","article-title":"Effect of prenatal and postnatal exposure to low doses of DDT on catecholamine secretion in rats in different period of ontogeny","volume":"163","author":"Yaglova","year":"2017","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Yaglova, N.V., Obernikhin, S.S., Tsomartova, D.A., Yaglov, V.V., Nazimova, S.V., Tsomartova, E.S., Timokhina, E.P., Chereshneva, E.V., Ivanova, M.Y., and Lomanovskaya, T.A. (2022). Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094912"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yaglova, N.V., Nazimova, S.V., Obernikhin, S.S., Tsomartova, D.A., Yaglov, V.V., Timokhina, E.P., Tsomartova, E.S., Chereshneva, E.V., Ivanova, M.Y., and Lomanovskaya, T.A. (2023). Developmental Exposure to DDT Disrupts Transcriptional Regulation of Postnatal Growth and Cell Renewal of Adrenal Medulla. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032774"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.stem.2013.01.019","article-title":"Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog","volume":"12","author":"Sirko","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1242\/dev.083691","article-title":"Roles for Hedgehog signaling in adult organ homeostasis and repair","volume":"141","author":"Petrova","year":"2014","journal-title":"Development"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10517-023-05903-1","article-title":"Regulation of Morphogenetic Processes during Postnatal Development and Physiological Regeneration of the Adrenal Medulla","volume":"175","author":"Obernikhin","year":"2023","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0736-5748(89)90004-X","article-title":"Chromaffin cell proliferation in the adult rat adrenal medulla","volume":"7","author":"Tischler","year":"1989","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_34","first-page":"315","article-title":"Kinetics of adrenal medullary cells","volume":"183","author":"Verhofstad","year":"1993","journal-title":"J. Anat."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1002\/stem.180","article-title":"Isolation of neural crest derived chromaffin progenitors from adult adrenal medulla","volume":"27","author":"Chung","year":"2009","journal-title":"Stem. Cells"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/stem.2002","article-title":"Multipotent glia-like stem cells mediate stress adaptation","volume":"33","author":"Wittig","year":"2015","journal-title":"Stem. Cells"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"783","DOI":"10.5966\/sctm.2012-0022","article-title":"Isolation, Characterization, and Differentiation of Progenitor Cells from Human Adult Adrenal Medulla","volume":"1","author":"Santana","year":"2012","journal-title":"Stem. Cells Transl. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrn874","article-title":"Proneural genes and the specification of neural cell types","volume":"3","author":"Bertrand","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(03)00365-9","article-title":"Basic helix\u2013loop\u2013helix factors in cortical development","volume":"39","author":"Ross","year":"2003","journal-title":"Neuron"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1101\/gad.627811","article-title":"A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets","volume":"25","author":"Castro","year":"2011","journal-title":"Genes Dev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neo.2018.01.009","article-title":"Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma","volume":"20","author":"Szemes","year":"2018","journal-title":"Neoplasia"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41556-018-0067-6","article-title":"Deconstructing the pluripotency gene regulatory network","volume":"20","author":"Li","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1101\/gad.350113.122","article-title":"Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells","volume":"36","author":"Lo","year":"2022","journal-title":"Genes Dev."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Santambrogio, A., Kemkem, Y., Willis, T., Berger, I., Kastriti, M., Faure, L., Russell, J., Lodge, E., Yianni, V., and Oakey, R. (2023). SOX2+ 1 sustentacular cells are stem cells of the postnatal adrenal medulla. bioRxiv.","DOI":"10.1101\/2023.10.28.564519"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.stem.2013.12.001","article-title":"In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer\u2019s disease model","volume":"14","author":"Guo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature01611","article-title":"Wnt proteins are lipid-modified and can act as stem cell growth factors","volume":"423","author":"Willert","year":"2003","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1101\/sqb.2008.73.035","article-title":"Wnt signaling and stem cell control","volume":"73","author":"Nusse","year":"2008","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.stem.2008.08.017","article-title":"Periodic activation of Wnt\/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion","volume":"3","author":"Lluis","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_51","unstructured":"Cheremisinoff, N.P., and Rosenfeld, P.E. (2010). Handbook of Pollution Prevention and Cleaner Production: Best Practices in the Agrochemical Industry, Elsevier."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1677\/joe.1.06972","article-title":"Adrenarche in the rat","volume":"191","author":"Pignatelli","year":"2006","journal-title":"J. Endocrinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1248\/jhs.56.566","article-title":"Human blood concentrations of dichlorodiphenyltrichloroethane (DDT) extrapolated from metabolism in rats and humans and physiologically based pharmacokinetic modeling","volume":"56","author":"Yamazaki","year":"2010","journal-title":"J. Health Sci."},{"key":"ref_54","unstructured":"(2023, December 27). Technical Regulation of the Customs Union TR CU 021\/2011 Concerning Safety of Food Products. St. Petersburg. Available online: https:\/\/www.rustandard.com\/images\/CU_TR\/TR_CU_021.2011_Safety_of_Food_Products.pdf."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/BJ20121284","article-title":"Wnt\/\u03b2-catenin signalling: From plasma membrane to nucleus","volume":"450","author":"Kim","year":"2013","journal-title":"Biochem. J."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/3\/1494\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:49:18Z","timestamp":1760104158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/3\/1494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":55,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["ijms25031494"],"URL":"https:\/\/doi.org\/10.3390\/ijms25031494","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]}}}