{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:01:11Z","timestamp":1790604071992,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"COMECYT","award":["CAT-2022-0123"],"award-info":[{"award-number":["CAT-2022-0123"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The protection of the neonate against pathogens depends largely on the antibodies transferred placentally from the mother; for this reason, maternal vaccination against emerging viruses, such as SARS-CoV-2, is of vital importance. Knowing some of the immunogenic factors that could alter the placental transfer of antibodies could aid in understanding the immune response and neonatal protection after maternal vaccination. In this study, we analyzed the efficiency of the placental transfer of binding and neutralizing antibodies, as well as some factors that could alter the passive immune response, such as the trimester of gestation at the time of immunization, the number of doses received by the mother and the type of vaccine. Binding IgG antibodies were detected by ELISA, and the detection of neutralizing antibodies was carried out using flow cytometry. Our results show efficient transfer rates (&gt;1), which are higher when maternal vaccination occurs during the third trimester of gestation. Antibodies are detectable in mothers and their neonates after 12 months of maternal immunization, suggesting than the vaccination against COVID-19 before and during pregnancy in the Mexican population induces a lasting neutralizing response in mothers and their newborns.<\/jats:p>","DOI":"10.3390\/ijms25031516","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T04:05:46Z","timestamp":1706241946000},"page":"1516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Placental Transfer Efficiency of Neutralizing Antibodies on SARS-CoV-2 Vaccination before and after Pregnancy in Mexican Women"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1287-1375","authenticated-orcid":false,"given":"Rebeca","family":"Mart\u00ednez-Quezada","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, Carretera Federal M\u00e9xico-Puebla Km. 34.5, Pueblo de Zoquiapan, Ixtapaluca 56530, Mexico"},{"name":"Consejo Mexiquense de Ciencia y Tecnolog\u00eda (COMECYT), Paseo Col\u00f3n N\u00b0 112-A, Cipr\u00e9s, Toluca 50120, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Emilio","family":"Miguel-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, Carretera Federal M\u00e9xico-Puebla Km. 34.5, Pueblo de Zoquiapan, Ixtapaluca 56530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0729-0031","authenticated-orcid":false,"given":"Tito","family":"Ram\u00edrez-Lozada","sequence":"additional","affiliation":[{"name":"Unidad de Ginecolog\u00eda y Obstetricia, Hospital Regional de Alta Especialidad de Ixtapaluca, Carretera Federal M\u00e9xico-Puebla Km. 34.5, Pueblo de Zoquiapan, Ixtapaluca 56530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7239-7946","authenticated-orcid":false,"given":"Omar Esteban","family":"Valencia-Ledezma","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, Carretera Federal M\u00e9xico-Puebla Km. 34.5, Pueblo de Zoquiapan, Ixtapaluca 56530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Acosta-Altamirano","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, Carretera Federal M\u00e9xico-Puebla Km. 34.5, Pueblo de Zoquiapan, Ixtapaluca 56530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"ref_1","first-page":"189","article-title":"Pregnancy Should Be a Condition Eligible for Additional Doses of COVID-19 Messenger RNA Vaccines","volume":"138","author":"Faust","year":"2023","journal-title":"Am. 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