{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:41:08Z","timestamp":1760143268946,"version":"build-2065373602"},"reference-count":165,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["CF-2023-2206","1008755","854550"],"award-info":[{"award-number":["CF-2023-2206","1008755","854550"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Student\u2019s scholarships","award":["CF-2023-2206","1008755","854550"],"award-info":[{"award-number":["CF-2023-2206","1008755","854550"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disorder and the predominant form of dementia globally. No reliable diagnostic, predictive techniques, or curative interventions are available. MicroRNAs (miRNAs) are vital to controlling gene expression, making them valuable biomarkers for diagnosis and prognosis. This study examines the transcriptome of olfactory ecto-mesenchymal stem cells (MSCs) derived from individuals with the PSEN1(A431E) mutation (Jalisco mutation). The aim is to determine whether this mutation affects the transcriptome and expression profile of miRNAs and their target genes at different stages of asymptomatic, presymptomatic, and symptomatic conditions. Expression microarrays compare the MSCs from mutation carriers with those from healthy donors. The results indicate a distinct variation in the expression of miRNAs and mRNAs among different symptomatologic groups and between individuals with the mutation. Using bioinformatics tools allows us to identify target genes for miRNAs, which in turn affect various biological processes and pathways. These include the cell cycle, senescence, transcription, and pathways involved in regulating the pluripotency of stem cells. These processes are closely linked to inter- and intracellular communication, vital for cellular functioning. These findings can enhance our comprehension and monitoring of the disease\u2019s physiological processes, identify new disorder indicators, and develop innovative treatments and diagnostic tools for preventing or treating AD.<\/jats:p>","DOI":"10.3390\/ijms25031580","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:57:07Z","timestamp":1706504227000},"page":"1580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mesenchymal Stem Cells from Familial Alzheimer\u2019s Patients Express MicroRNA Differently"],"prefix":"10.3390","volume":"25","author":[{"given":"Lory J.","family":"Roch\u00edn-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lory S.","family":"Roch\u00edn-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayte L.","family":"Padilla-Cristerna","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Duarte-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Jim\u00e9nez-Acosta","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda P.","family":"Figueroa-Corona","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-8117","authenticated-orcid":false,"given":"Marco A.","family":"Meraz-R\u00edos","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"ref_1","unstructured":"Prince, M.J. (2020, July 23). World Alzheimer Report 2015: The Global Impact of Dementia. 25 August 2015. Available online: https:\/\/www.alz.co.uk\/research\/world-report-2015."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/B978-0-12-800149-3.00005-6","article-title":"Genetics of Alzheimer\u2019s Disease","volume":"Volume 87","author":"Chouraki","year":"2014","journal-title":"Advances in Genetics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15056","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer\u2019s disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neulet.2017.07.046","article-title":"A novel PSEN1 (S230N) mutation causing early-onset Alzheimer\u2019s Disease associated with prosopagnosia, hoarding, and Parkinsonism","volume":"657","author":"Ringman","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/WAD.0b013e3181732399","article-title":"Early Onset Familial Alzheimer\u2019s Disease with Spastic Paraparesis, Dysarthria, and Seizures and N135S Mutation in PSEN1","volume":"22","author":"Rudzinski","year":"2008","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neurobiolaging.2016.07.030","article-title":"Widespread white matter and conduction defects in PSEN1- related spastic paraparesis","volume":"47","author":"Soosman","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10048-006-0043-3","article-title":"Founder effect for the Ala431Glu mutation of the presenilin 1 gene causing early-onset Alzheimer\u2019s disease in Mexican families","volume":"7","author":"Yescas","year":"2006","journal-title":"Neurogenetics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"860529","DOI":"10.3389\/fnagi.2022.860529","article-title":"PSEN1 c.1292C<A Variant and Early-Onset Alzheimer\u2019s Disease: A Scoping Review","volume":"14","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Panizza, E. (2023). DeepOmicsAE: Representing Signaling Modules in Alzheimer\u2019s Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data. J. Vis. Exp. JoVE, 202.","DOI":"10.3791\/65910"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Subramanian, I., Verma, S., Kumar, S., Jere, A., and Anamika, K. (2020). Multi-omics Data Integration, Interpretation, and Its Application. Bioinform. Biol. Insights, 14.","DOI":"10.1177\/1177932219899051"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1038\/s41467-019-10101-7","article-title":"Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer\u2019s disease pathology and cognitive symptoms","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3389\/fgene.2018.00579","article-title":"The Epigenetics of Alzheimer\u2019s Disease: Factors and Therapeutic Implications","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/CIRCRESAHA.113.301865","article-title":"Decoding noncoding RNA: The long and short of it","volume":"113","author":"Sandberg","year":"2013","journal-title":"Circ. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target Recognition and Regulatory Functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.cell.2018.07.040","article-title":"SnapShot: Unconventional miRNA Functions","volume":"174","author":"Dragomir","year":"2018","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.jalz.2019.06.4952","article-title":"Differential expression of microRNAs in Alzheimer\u2019s disease brain, blood, and cerebrospinal fluid","volume":"15","author":"Takousis","year":"2019","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1007\/s11011-018-0279-2","article-title":"Comparative study of microRNA profiling in one Chinese Family with PSEN1 G378E mutation","volume":"33","author":"Lv","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"P184","DOI":"10.1016\/j.jalz.2015.07.156","article-title":"O2-05-03: Familial Alzheimer\u2019s disease PSEN2 mutations regulate inflammatory microRNAs in microglia","volume":"11","author":"Fung","year":"2015","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fphar.2013.00077","article-title":"Modeling Alzheimer\u2019s Disease: From Past to Future","volume":"4","author":"Saraceno","year":"2013","journal-title":"Front. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Miya Shaik, M., Tamargo, I.A., Abubakar, M.B., Kamal, M.A., Greig, N.H., and Gan, S.H. (2018). The Role of microRNAs in Alzheimer\u2019s Disease and Their Therapeutic Potentials. Genes, 9.","DOI":"10.3390\/genes9040174"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s12031-018-1223-y","article-title":"Amyloid Beta 1\u201342 Alters the Expression of miRNAs in Cortical Neurons","volume":"67","author":"Dursun","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12974-023-02745-6","article-title":"Microglia specific deletion of miR-155 in Alzheimer\u2019s disease mouse models reduces amyloid-\u03b2 pathology but causes hyperexcitability and seizures","volume":"20","author":"Aloi","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneumeth.2011.07.009","article-title":"A non-invasive method to isolate the neuronal linage from the nasal epithelium from schizophrenic and bipolar diseases","volume":"201","author":"Riquelme","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Veron, A.D., Bienboire-Frosini, C., Feron, F., Codecasa, E., Deveze, A., Royer, D., Watelet, P., Asproni, P., Sadelli, K., and Chabaud, C. (2018). Isolation and characterization of olfactory ecto-mesenchymal stem cells from eight mammalian genera. BMC Vet. Res., 14.","DOI":"10.1186\/s12917-018-1342-2"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1089\/scd.2009.0267","article-title":"The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties","volume":"19","author":"Delorme","year":"2010","journal-title":"Stem Cells Dev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1007\/s12035-017-0500-z","article-title":"Exfoliated Human Olfactory Neuroepithelium: A Source of Neural Progenitor Cells","volume":"55","author":"Ruiz","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_28","first-page":"299","article-title":"Mini-Review: Mesenchymal stem cells. New alternatives for nervous system disorders","volume":"17","author":"Cristerna","year":"2022","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101416","DOI":"10.1016\/j.arr.2021.101416","article-title":"Olfactory dysfunction in aging and neurodegenerative diseases","volume":"70","author":"Dan","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Kotecha, A., Corr\u00eaa, A., Fisher, K., and Rushworth, J. (2018). Olfactory Dysfunction as a Global Biomarker for Sniffing out Alzheimer\u2019s Disease: A Meta-Analysis. Biosensors, 8.","DOI":"10.3390\/bios8020041"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/337736a0","article-title":"Pathological changes in olfactory neurons in patients with Alzheimer\u2019s disease","volume":"337","author":"Talamo","year":"1989","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00001756-200102120-00021","article-title":"Olfactory centres in Alzheimer\u2019s disease: Olfactory bulb is involved in early Braak\u2019s stages","volume":"12","author":"Cairns","year":"2001","journal-title":"Neuroreport"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41418-019-0409-3","article-title":"Impaired adult neurogenesis is an early event in Alzheimer\u2019s disease neurodegeneration mediated by intracellular A\u03b2 oligomers","volume":"27","author":"Scopa","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Roch\u00edn-Hern\u00e1ndez, L.J., Jim\u00e9nez-Acosta, M.A., Ram\u00edrez-Reyes, L., Figueroa-Corona, M.d.P., S\u00e1nchez-Gonz\u00e1lez, V.J., Orozco-Barajas, M., and Meraz-R\u00edos, M.A. (2023). The Proteome Profile of Olfactory Ecto-Mesenchymal Stem Cells-Derived from Patients with Familial Alzheimer\u2019s Disease Reveals New Insights for AD Study. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612606"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1042\/BST20130044","article-title":"miRNAs in development and pathogenesis of the nervous system","volume":"41","author":"Nowak","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10565-022-09761-x","article-title":"The role of microRNAs in neurodegenerative diseases: A review","volume":"39","author":"Li","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.bbagen.2009.03.028","article-title":"The impact of noncoding RNA on the biochemical and molecular mechanisms of aging","volume":"1790","author":"Bates","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Liu, S., Fan, M., Zheng, Q., Hao, S., Yang, L., Xia, Q., Qi, C., and Ge, J. (2022). MicroRNAs in Alzheimer\u2019s disease: Potential diagnostic markers and therapeutic targets. Biomed. Pharmacother., 148.","DOI":"10.1016\/j.biopha.2022.112681"},{"key":"ref_39","unstructured":"Martin, C.R., and Preedy, V.R. (2020). Genetics, Neurology, Behavior, and Diet in Dementia, Academic Press."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Wang, L., Shui, X., Diao, Y., Chen, D., Zhou, Y., and Lee, T.H. (2023). Potential Implications of miRNAs in the Pathogenesis, Diagnosis, and Therapeutics of Alzheimer\u2019s Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216259"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"155007","DOI":"10.1016\/j.prp.2023.155007","article-title":"Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Alzheimer\u2019s disease","volume":"253","author":"Abdelmaksoud","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"ref_42","first-page":"e12251","article-title":"Plasma microRNA vary in association with the progression of Alzheimer\u2019s disease","volume":"14","author":"Tsui","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1007\/s12035-016-0088-8","article-title":"Plasma miR-34a-5p and miR-545-3p as Early Biomarkers of Alzheimer\u2019s Disease: Potential and Limitations","volume":"54","author":"Antonell","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1007\/s12035-020-02013-1","article-title":"Extracellular Vesicles of Alzheimer\u2019s Disease Patients as a Biomarker for Disease Progression","volume":"57","author":"Aharon","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Visconte, C., Fenoglio, C., Serpente, M., Muti, P., Sacconi, A., Rigoni, M., Arighi, A., Borracci, V., Arcaro, M., and Arosio, B. (2023). Altered Extracellular Vesicle miRNA Profile in Prodromal Alzheimer\u2019s Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914749"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"16122","DOI":"10.18632\/oncotarget.15109","article-title":"Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer\u2019s disease patients from non-demented subjects","volume":"8","author":"Nagaraj","year":"2017","journal-title":"Oncotarget"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Liang, T., Guo, L., and Liu, C. (2012). Genome-wide analysis of mir-548 gene family reveals evolutionary and functional implications. J. Biomed. Biotechnol., 2012.","DOI":"10.1155\/2012\/679563"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.3892\/ol.2017.5870","article-title":"MicroRNA-548c-3p inhibits T98G glioma cell proliferation and migration by downregulating c-Myb","volume":"13","author":"Lu","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_49","first-page":"189","article-title":"miR-548b Suppresses Melanoma Cell Growth, Migration, and Invasion by Negatively Regulating Its Target Gene HMGB1","volume":"36","author":"Feng","year":"2021","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/jb\/mvaa033","article-title":"MicroRNA-548-3p overexpression inhibits proliferation, migration and invasion in osteoblast-like cells by targeting STAT1 and MAFB","volume":"168","author":"Almeraya","year":"2020","journal-title":"J. Biochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/npp.2013.263","article-title":"STAT1 Negatively Regulates Spatial Memory Formation and Mediates the Memory-Impairing Effect of A\u03b2","volume":"39","author":"Hsu","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"100263","DOI":"10.1016\/j.xgen.2023.100263","article-title":"Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer\u2019s disease-specific cis-regulatory elements","volume":"3","author":"Anderson","year":"2023","journal-title":"Cell Genom."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s12031-017-0991-0","article-title":"C-myb Plays an Essential Role in the Protective Function of IGF-1 on Cytotoxicity Induced by A\u03b225\u201335 via the PI3K\/Akt Pathway","volume":"63","author":"Zhang","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e068747","DOI":"10.1002\/alz.068747","article-title":"HMGB1-Mediated Senescence and Brain Inflammation Contributes to Cognitive Dysfunctions","volume":"18","author":"Gaikwad","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e1816","DOI":"10.1002\/cnr2.1816","article-title":"MiR-548\u2009K regulatory effect on the ABCG2 gene expression in MDR breast cancer cells","volume":"6","author":"Saberiyan","year":"2023","journal-title":"Cancer Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3233\/JAD-170639","article-title":"ABC Transporters Are Key Players in Alzheimer\u2019s Disease","volume":"61","author":"Pereira","year":"2018","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_57","first-page":"198","article-title":"Exploring Potential Biomarkers Underlying the Pathogenesis of Alzheimer\u2019s Disease by Bioinformatics Gene Analysis","volume":"51","author":"Ma","year":"2021","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neurobiolaging.2019.06.005","article-title":"miR-146a and miR-181a are involved in the progression of mild cognitive impairment to Alzheimer\u2019s disease","volume":"82","author":"Ansari","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Burgos, K., Malenica, I., Metpally, R., Courtright, A., Rakela, B., Beach, T., Shill, H., Adler, C., Sabbagh, M., and Villa, S. (2014). Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer\u2019s and Parkinson\u2019s Diseases Correlate with Disease Status and Features of Pathology. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094839"},{"key":"ref_60","first-page":"1229","article-title":"Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice","volume":"42","author":"LaFerla","year":"2014","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1074\/jbc.M807530200","article-title":"MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1","volume":"284","author":"Boissonneault","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3109\/1354750X.2013.814073","article-title":"MicroRNA in Alzheimer\u2019s disease: An exploratory study in brain, cerebrospinal fluid and plasma","volume":"18","author":"Bekris","year":"2013","journal-title":"Biomarkers"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"136531","DOI":"10.1016\/j.neulet.2022.136531","article-title":"Circular RNA AXL increases neuron injury and inflammation through targeting microRNA-328 mediated BACE1 in Alzheimer\u2019s disease","volume":"776","author":"Li","year":"2022","journal-title":"Neurosci. Lett."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/emmm.201201974","article-title":"Alteration of the microRNA network during the progression of Alzheimer\u2019s disease","volume":"5","author":"Lau","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Cao, Z., Xu, J., Huang, H., Shen, P., You, L., Zhou, L., Zheng, L., Zhang, T., and Zhao, Y. (2015). MiR-1178 promotes the proliferation, G1\/S transition, migration and invasion of pancreatic cancer cells by targeting CHIP. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0116934"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e19807","DOI":"10.1016\/j.heliyon.2023.e19807","article-title":"Hsa_circ_0043603 promotes the progression of esophageal squamous cell carcinoma by sponging miR-1178\u20133p and regulating AADAC expression","volume":"9","author":"Wang","year":"2023","journal-title":"Heliyon"},{"key":"ref_67","first-page":"321","article-title":"MiR-1178-3p promotes the proliferation, migration and invasion of nasopharyngeal carcinoma Sune-1 cells by targeting STK4","volume":"33","author":"Wang","year":"2019","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12943-019-1060-9","article-title":"Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p\/p21 axis and acts as a prognostic factor of recurrence","volume":"18","author":"Bi","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.canlet.2018.05.010","article-title":"LncRNA n335586\/miR-924\/CKMT1A axis contributes to cell migration and invasion in hepatocellular carcinoma cells","volume":"429","author":"Fan","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e24116","DOI":"10.1002\/jcla.24116","article-title":"Circ_0000463 contributes to the progression and glutamine metabolism of non-small-cell lung cancer by targeting miR-924\/SLC1A5 signaling","volume":"36","author":"Liu","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1186\/s12935-020-01516-0","article-title":"MiR-924 as a tumor suppressor inhibits non-small cell lung cancer by inhibiting RHBDD1\/Wnt\/\u03b2-catenin signaling pathway","volume":"20","author":"Wang","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s10571-022-01200-z","article-title":"Roles of the miR-155 in Neuroinflammation and Neurological Disorders: A Potent Biological and Therapeutic Target","volume":"43","author":"Shahba","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.1093\/hmg\/ddu348","article-title":"Early miR-155 upregulation contributes to neuroinflammation in Alzheimer\u2019s disease triple transgenic mouse model","volume":"23","author":"Guedes","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13024-018-0285-1","article-title":"Deregulation of neuronal miRNAs induced by amyloid-\u03b2 or TAU pathology","volume":"13","author":"Sierksma","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.celrep.2014.09.037","article-title":"Sorting Nexin 27 Regulates A\u03b2 Production through Modulating \u03b3-Secretase Activity","volume":"9","author":"Wang","year":"2014","journal-title":"Cell Rep."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Garcia, G., Pinto, S., Ferreira, S., Lopes, D., Serrador, M.J., Fernandes, A., Vaz, A.R., Mendon\u00e7a, A.D., Edenhofer, F., and Malm, T. (2022). Emerging Role of miR-21-5p in Neuron-Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer\u2019s Disease. Cells, 11.","DOI":"10.3390\/cells11213377"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.stem.2014.04.021","article-title":"Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-\u03baB-dependent manner","volume":"15","author":"Wang","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.stemcr.2023.05.018","article-title":"Familial Alzheimer\u2019s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling","volume":"18","author":"Hurley","year":"2023","journal-title":"Stem Cell Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1755-5949.2012.00344.x","article-title":"MicroRNA-21 Expression is regulated by \u03b2-catenin\/STAT3 Pathway and Promotes Glioma Cell Invasion by Direct Targeting RECK","volume":"18","author":"Han","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40035-019-0169-5","article-title":"Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer\u2019s disease and dementia with Lewy bodies","volume":"8","author":"Campdelacreu","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Garcia, G., Pinto, S., Cunha, M., Fernandes, A., Koistinaho, J., and Brites, D. (2021). Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor. Cells, 10.","DOI":"10.3390\/cells10092424"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2014.04.026","article-title":"MicroRNA-135a and -200b, potential Biomarkers for Alzheimer\u05f3s disease, regulate \u03b2 secretase and amyloid precursor protein","volume":"1583","author":"Liu","year":"2014","journal-title":"Brain Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.3892\/mmr.2014.2484","article-title":"MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer\u2019s disease","volume":"10","author":"Liu","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3389\/fnins.2020.00438","article-title":"Differential Expression of Plasma Exo-miRNA in Neurodegenerative Diseases by Next-Generation Sequencing","volume":"14","author":"Nie","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_85","first-page":"87","article-title":"The Serum Exosome Derived MicroRNA-135a, -193b, and -384 Were Potential Alzheimer\u2019s Disease Biomarkers","volume":"31","author":"Yang","year":"2018","journal-title":"Biomed. Environ. Sci. BES"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/JAD-170592","article-title":"microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer\u2019s Disease","volume":"61","author":"Manzine","year":"2018","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13195-023-01366-8","article-title":"miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer\u2019s disease","volume":"16","author":"Han","year":"2024","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Kuthethur, R., Adiga, D., Kandettu, A., Jerome, M.S., Mallya, S., Mumbrekar, K.D., Kabekkodu, S.P., and Chakrabarty, S. (2023). MiR-4521 perturbs FOXM1-mediated DNA damage response in breast cancer. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1131433"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jare.2021.05.003","article-title":"MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK\/AKT pathway via targeting FAM129A","volume":"36","author":"Ayesha","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbrc.2019.05.182","article-title":"CircSAMD4A accelerates cell proliferation of osteosarcoma by sponging miR-1244 and regulating MDM2 mRNA expression","volume":"516","author":"Yanbin","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11010-019-03647-z","article-title":"Long non-coding RNA LINC00504 regulates the Warburg effect in ovarian cancer through inhibition of miR-1244","volume":"464","author":"Liu","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Xie, W., Liu, L.U., He, C., Zhao, M., Ni, R., Zhang, Z., and Shui, C. (2021). Circ_0002711 knockdown suppresses cell growth and aerobic glycolysis by modulating miR-1244\/ROCK1 axis in ovarian cancer. J. Biosci., 46.","DOI":"10.1007\/s12038-020-00136-0"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.15252\/embj.201387576","article-title":"MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer\u2019s disease","volume":"33","author":"Benito","year":"2014","journal-title":"EMBO J."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Lugli, G., Cohen, A.M., Bennett, D.A., Shah, R.C., Fields, C.J., Hernandez, A.G., and Smalheiser, N.R. (2015). Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139233"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nn.3599","article-title":"Identification of a unique TGF-\u03b2\u2013dependent molecular and functional signature in microglia","volume":"17","author":"Butovsky","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA Changes in Alzheimer\u2019s Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neulet.2009.04.052","article-title":"Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer\u2019s disease temporal lobe neocortex","volume":"459","author":"Sethi","year":"2009","journal-title":"Neurosci. Lett."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1007\/s12035-021-02323-y","article-title":"Profiling of Serum Exosome MiRNA Reveals the Potential of a MiRNA Panel as Diagnostic Biomarker for Alzheimer\u2019s Disease","volume":"58","author":"Dong","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"8826","DOI":"10.1007\/s12035-018-1032-x","article-title":"MicroRNA Expression Levels Are Altered in the Cerebrospinal Fluid of Patients with Young-Onset Alzheimer\u2019s Disease","volume":"55","author":"McKeever","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_100","first-page":"7","article-title":"MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer\u2019s disease","volume":"3","author":"Guedes","year":"2016","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"9902","DOI":"10.1080\/21655979.2021.1969195","article-title":"MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-\u03b1-induced protein 3)","volume":"12","author":"Li","year":"2021","journal-title":"Bioengineered"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5114\/fn.2022.119302","article-title":"Long non-coding RNA LINC01128 affects proliferation, migration, and invasion of glioma cells by regulating miR-27b-3p","volume":"60","author":"Zhang","year":"2022","journal-title":"Folia Neuropathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"111812","DOI":"10.1016\/j.exger.2022.111812","article-title":"MicroRNA modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid \u03b2eta oligomer induced Alzheimer\u2019s like rat model","volume":"164","author":"Bazrgar","year":"2022","journal-title":"Exp. Gerontol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.omtn.2022.04.008","article-title":"miR-23b-3p rescues cognition in Alzheimer\u2019s disease by reducing tau phosphorylation and apoptosis via GSK-3\u03b2 signaling pathways","volume":"28","author":"Jiang","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbr.2016.09.020","article-title":"miR-23b improves cognitive impairments in traumatic brain injury by targeting ATG12-mediated neuronal autophagy","volume":"340","author":"Sun","year":"2018","journal-title":"Behav. Brain Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.3892\/etm.2017.4977","article-title":"Overexpression of let-7a increases neurotoxicity in a PC12 cell model of Alzheimer\u2019s disease via regulating autophagy","volume":"14","author":"Gu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_107","first-page":"33","article-title":"Identification of microRNAs involved in Alzheimer\u2019s progression using a rabbit model of the disease","volume":"3","author":"Liu","year":"2014","journal-title":"Am. J. Neurodegener. Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3389\/fnins.2018.00333","article-title":"MicroRNA Let-7f-5p Promotes Bone Marrow Mesenchymal Stem Cells Survival by Targeting Caspase-3 in Alzheimer Disease Model","volume":"12","author":"Han","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1007\/s11064-022-03563-7","article-title":"CircAXL Knockdown Alleviates A\u03b21-42-Induced Neurotoxicity in Alzheimer\u2019s Disease via Repressing PDE4A by Releasing miR-1306-5p","volume":"47","author":"Meng","year":"2022","journal-title":"Neurochem. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neuroscience.2020.02.044","article-title":"Profile of Pathogenic Proteins and MicroRNAs in Plasma-derived Extracellular Vesicles in Alzheimer\u2019s Disease: A Pilot Study","volume":"432","author":"Li","year":"2020","journal-title":"Neuroscience"},{"key":"ref_111","first-page":"335","article-title":"A Study of Small RNAs from Cerebral Neocortex of Pathology-Verified Alzheimer\u2019s Disease, Dementia with Lewy Bodies, Hippocampal Sclerosis, Frontotemporal Lobar Dementia, and Non-Demented Human Controls","volume":"35","author":"Wang","year":"2013","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Serpente, M., Fenoglio, C., D\u2019Anca, M., Arcaro, M., Sorrentino, F., Visconte, C., Arighi, A., Fumagalli, G.G., Porretti, L., and Cattaneo, A. (2020). MiRNA Profiling in Plasma Neural-Derived Small Extracellular Vesicles from Patients with Alzheimer\u2019s Disease. Cells, 9.","DOI":"10.3390\/cells9061443"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4137\/BMI.S25132","article-title":"MicroRNA-Seq Data Analysis Pipeline to Identify Blood Biomarkers for Alzheimer\u2019s Disease from Public Data","volume":"10","author":"Satoh","year":"2015","journal-title":"Biomark. Insights"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fnagi.2015.00210","article-title":"MicroRNAs 99b-5p\/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies","volume":"7","author":"Ye","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"147884","DOI":"10.1016\/j.brainres.2022.147884","article-title":"LncRNA RMRP accelerates autophagy-mediated neurons apoptosis through miR-3142\/TRIB3 signaling axis in alzheimer\u2019s disease","volume":"1785","author":"Tang","year":"2022","journal-title":"Brain Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"597","DOI":"10.7754\/Clin.Lab.2018.180925","article-title":"Serum miR-3142 could be Used as a Potential Biomarker to Screen Cervical Cancer Patients from Healthy Controls","volume":"65","author":"Luo","year":"2019","journal-title":"Clin. Lab."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10495-022-01805-1","article-title":"circTAB2 inhibits lung cancer proliferation, migration and invasion by sponging miR-3142 to upregulate GLIS2","volume":"28","author":"Man","year":"2023","journal-title":"Apoptosis"},{"key":"ref_118","first-page":"1443","article-title":"MicroRNA expression profile in stage IA lung adenocarcinoma and miR-940 target prediction","volume":"12","author":"Zhu","year":"2019","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e13454","DOI":"10.1111\/acel.13454","article-title":"microRNA-425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies","volume":"20","author":"Hu","year":"2021","journal-title":"Aging Cell"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00702-019-02134-5","article-title":"MicroRNA-425-5p promotes tau phosphorylation and cell apoptosis in Alzheimer\u2019s disease by targeting heat shock protein B8","volume":"127","author":"Yuan","year":"2020","journal-title":"J. Neural Transm."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e00170-19","DOI":"10.1128\/MCB.00170-19","article-title":"MicroRNA 7 Impairs Insulin Signaling and Regulates A\u03b2 Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway","volume":"39","author":"Goedeke","year":"2019","journal-title":"Mol. Cell. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Frutos, M.F., Pardo-Marqu\u00e9s, V., Torrecilla-Parra, M., Rada, P., P\u00e9rez-Garc\u00eda, A., Mart\u00edn-Mart\u00edn, Y., de la Pe\u00f1a, G., G\u00f3mez, A., Toledano-Zaragoza, A., and G\u00f3mez-Coronado, D. (2023). MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression. Biochim. Biophys. Acta. Gene Regul. Mech., 1866.","DOI":"10.1016\/j.bbagrm.2023.194938"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Sempere, L.F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., and Ambros, V. (2004). Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol., 5.","DOI":"10.1186\/gb-2004-5-3-r13"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1261\/rna.783108","article-title":"MicroRNA expression in the adult mouse central nervous system","volume":"14","author":"Bak","year":"2008","journal-title":"RNA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1073\/pnas.1314341111","article-title":"miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma","volume":"111","author":"Mathew","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/ame2.12175","article-title":"Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer\u2019s disease","volume":"4","author":"Song","year":"2021","journal-title":"Anim. Models Exp. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2174\/0929866530666230302150750","article-title":"(R)-9bMS Inhibited the Protein Synthesis and Autophagy of Triple Negative Breast Cancer Cells via Regulating miR-4660\/mTOR Axis","volume":"30","author":"Bai","year":"2023","journal-title":"Protein Pept. Lett."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41419-021-04021-y","article-title":"miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3892\/etm.2020.9288","article-title":"miR-132 improves the cognitive function of rats with Alzheimer\u2019s disease by inhibiting the MAPK1 signal pathway","volume":"20","author":"Deng","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1016\/j.ygeno.2021.08.011","article-title":"Up-regulated microRNA-132 reduces the cognition-damaging effect of sevoflurane on Alzheimer\u2019s disease rats by inhibiting FOXA1","volume":"113","author":"Cong","year":"2021","journal-title":"Genomics"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.brainresbull.2018.04.007","article-title":"MicroRNA-132 is associated with the cognition improvement following voluntary exercise in SAMP8 mice","volume":"140","author":"Dong","year":"2018","journal-title":"Brain Res. Bull."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.3389\/fnins.2019.01208","article-title":"miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer\u2019s Patients","volume":"13","author":"Cha","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Denk, J., Boelmans, K., Siegismund, C., Lassner, D., Arlt, S., and Jahn, H. (2015). MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer\u2019s Disease. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126423"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/WNR.0000000000001878","article-title":"Profiling microRNA from peripheral blood mononuclear cells in early-onset familial Alzheimer\u2019s disease","volume":"34","author":"Li","year":"2023","journal-title":"Neuroreport"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Yu, Y., Chang, Z., Han, C., Zhuang, L., Zhou, C., Qi, X., and Peng, Z. (2020). Long non-coding RNA MINCR aggravates colon cancer via regulating miR-708-5p-mediated Wnt\/\u03b2-catenin pathway. Biomed. Pharmacother., 129.","DOI":"10.1016\/j.biopha.2020.110292"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.3892\/mmr.2015.4339","article-title":"Downregulated microRNA-222 is correlated with increased p27Kip1 expression in a double transgenic mouse model of Alzheimer\u2019s disease","volume":"12","author":"Wang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"15891","DOI":"10.1002\/jcb.28861","article-title":"MicroRNA-25 aggravates A\u03b21-42-induced hippocampal neuron injury in Alzheimer\u2019s disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model","volume":"120","author":"Duan","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/gtc.12009","article-title":"Micro RNA 9 regulates neural stem cell differentiation by controlling H es1 expression dynamics in the developing brain","volume":"17","author":"Tan","year":"2012","journal-title":"Genes Cells"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1515\/revneuro-2022-0039","article-title":"The role of microRNA-485 in neurodegenerative diseases","volume":"34","author":"Ryu","year":"2023","journal-title":"Rev. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"14717","DOI":"10.1523\/JNEUROSCI.2053-15.2015","article-title":"microRNA-33 Regulates ApoE Lipidation and Amyloid-\u03b2 Metabolism in the Brain","volume":"35","author":"Kim","year":"2015","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_141","first-page":"e921026","article-title":"Downregulation of miR-33 Has Protective Effect Against A\u03b225\u201335-Induced Injury in SH-SH-SY5Y Cells","volume":"26","author":"Wang","year":"2020","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Li, W., and Zheng, Y. (2023). MicroRNAs in Extracellular Vesicles of Alzheimer\u2019s Disease. Cells, 12.","DOI":"10.3390\/cells12101378"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3389\/fnins.2020.00564","article-title":"Therapeutic Effects of Transplanted Exosomes Containing miR-29b to a Rat Model of Alzheimer\u2019s Disease","volume":"14","author":"Jahangard","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fncel.2016.00051","article-title":"miRNAs Plasma Profiles in Vascular Dementia: Biomolecular Data and Biomedical Implications","volume":"10","author":"Ragusa","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jns.2013.12.017","article-title":"Screening of microRNAs associated with Alzheimer\u2019s disease using oxidative stress cell model and different strains of senescence accelerated mice","volume":"338","author":"Zhang","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"38951","DOI":"10.1074\/jbc.M110.178848","article-title":"Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-\u03baB in Stressed Human Astroglial Cells and in Alzheimer Disease","volume":"285","author":"Cui","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.nrl.2020.12.006","article-title":"miR-146a aggravates cognitive impairment and Alzheimer disease-like pathology by triggering oxidative stress through MAPK signaling","volume":"38","author":"Chi","year":"2023","journal-title":"Neurologia"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"653881","DOI":"10.3389\/fncel.2021.653881","article-title":"NF-\u03baB-Induced Upregulation of miR-146a-5p Promoted Hippocampal Neuronal Oxidative Stress and Pyroptosis via TIGAR in a Model of Alzheimer\u2019s Disease","volume":"15","author":"Lei","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neurobiolaging.2013.07.005","article-title":"MicroRNAs in Alzheimer\u2019s disease: Differential expression in hippocampus and cell-free cerebrospinal fluid","volume":"35","author":"Kuiperij","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2016.05.026","article-title":"Expression of microRNA-34a in Alzheimer\u2019s disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity","volume":"1646","author":"Sarkar","year":"2016","journal-title":"Brain Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5114\/fn.2020.94002","article-title":"miR-143-3p inhibition promotes neuronal survival in an Alzheimer\u2019s disease cell model by targeting neuregulin-1","volume":"58","author":"Sun","year":"2020","journal-title":"Folia Neuropathol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3233\/JAD-2001-3205","article-title":"Constitutive Wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration","volume":"3","author":"Tomashevski","year":"2001","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"9620","DOI":"10.1073\/pnas.95.16.9620","article-title":"Expression profiles of multiple genes in single neurons of Alzheimer\u2019s disease","volume":"95","author":"Chow","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/ng1296-482","article-title":"Identification of BTG2, an antiproliferative p53\u2013dependent component of the DNA damage cellular response pathway","volume":"14","author":"Rouault","year":"1996","journal-title":"Nat. Genet."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1002\/jcp.27407","article-title":"Tumor suppressors BTG1 and BTG2: Beyond growth control","volume":"234","author":"Yuniati","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1474-9726.2010.00601.x","article-title":"BTG2 antagonizes Pin1 in response to mitogens and telomere disruption during replicative senescence","volume":"9","author":"Wheaton","year":"2010","journal-title":"Aging Cell"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1007\/s12035-020-02036-8","article-title":"Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer\u2019s Disease Via A\u03b242-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2","volume":"57","author":"Wang","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"118891","DOI":"10.1016\/j.bbamcr.2020.118891","article-title":"TAZ negatively regulates the novel tumor suppressor ANKRD52 and promotes PAK1 dephosphorylation in lung adenocarcinomas","volume":"1868","author":"Lee","year":"2021","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Res."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Matsuda, S., Nakagawa, Y., Tsuji, A., Kitagishi, Y., Nakanishi, A., and Murai, T. (2018). Implications of PI3K\/AKT\/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer\u2019s Disease. Diseases, 6.","DOI":"10.3390\/diseases6020028"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1242\/jcs.015230","article-title":"New insights into PTEN","volume":"120","author":"Tamguney","year":"2007","journal-title":"J. Cell Sci."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Moreira, N.C.D.S., Tamarozzi, E.R., Lima, J.E.B.D.F., Piassi, L.D.O., Carvalho, I., Passos, G.A., and Sakamoto-Hojo, E.T. (2022). Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN\/AKT Pathway in Alzheimer\u2019s Disease Model. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314788"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"18501","DOI":"10.18632\/aging.103819","article-title":"D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway","volume":"12","author":"Xu","year":"2020","journal-title":"Aging"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates A\u03b2-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer\u2019s disease model","volume":"22","author":"Zhang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.neurobiolaging.2014.09.025","article-title":"Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer\u2019s disease brain","volume":"36","author":"Kuhla","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/jnen\/61.8.678","article-title":"Cyclin D1 and Cyclin E Are Co-Localized with Cyclo-Oxygenase 2 (COX-2) in Pyramidal Neurons in Alzheimer Disease Temporal Cortex","volume":"61","author":"Hoozemans","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/3\/1580\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:50:13Z","timestamp":1760104213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/3\/1580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,27]]},"references-count":165,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["ijms25031580"],"URL":"https:\/\/doi.org\/10.3390\/ijms25031580","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2024,1,27]]}}}