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Cannabinoids may modulate neuronal development and brain plasticity, but further investigation is needed to better describe their implication as a neurorestorative therapy after neonatal HI. The cannabinoid URB447, a CB1 antagonist\/CB2 agonist, has previously been shown to reduce brain injury after HI, but it is not clear whether sex may affect its neuroprotective and\/or neurorestorative effect. Here, URB447 strongly reduced brain infarct, improved neuropathological score, and augmented proliferative capacity and neurogenic response in the damaged hemisphere. When analyzing these effects by sex, URB447 ameliorated brain damage in both males and females, and enhanced cell proliferation and the number of neuroblasts only in females, thus suggesting a neuroprotective effect in males and a double neuroprotective\/neurorestorative effect in females.<\/jats:p>","DOI":"10.3390\/ijms25031607","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:57:07Z","timestamp":1706504227000},"page":"1607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["URB447 Is Neuroprotective in Both Male and Female Rats after Neonatal Hypoxia\u2013Ischemia and Enhances Neurogenesis in Females"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0163-8853","authenticated-orcid":false,"given":"Gorane","family":"Beldarrain","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV\/EHU), 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2204-0439","authenticated-orcid":false,"given":"Marc","family":"Chillida","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV\/EHU), 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Hilario","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV\/EHU), 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5988-1795","authenticated-orcid":false,"given":"Borja","family":"Herrero de la Parte","sequence":"additional","affiliation":[{"name":"Department of Surgery and Radiology and Physical Medicine, Faculty of Medicine and Nursing, University of the Basque Country (UPV\/EHU), 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV\/EHU), 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Alonso-Alconada","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV\/EHU), 48940 Leioa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2000-9293","article-title":"Hypoxic-ischemic encephalopathy","volume":"17","author":"Vannucci","year":"2000","journal-title":"Am. 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