{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:10:16Z","timestamp":1791544216368,"version":"4.3.4"},"reference-count":324,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute of the National Institutes of Health","doi-asserted-by":"publisher","award":["R15CA260126"],"award-info":[{"award-number":["R15CA260126"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Known as a diverse collection of neoplastic diseases, breast cancer (BC) can be hyperbolically characterized as a dynamic pseudo-organ, a living organism able to build a complex, open, hierarchically organized, self-sustainable, and self-renewable tumor system, a population, a species, a local community, a biocenosis, or an evolving dynamical ecosystem (i.e., immune or metabolic ecosystem) that emphasizes both developmental continuity and spatio-temporal change. Moreover, a cancer cell community, also known as an oncobiota, has been described as non-sexually reproducing species, as well as a migratory or invasive species that expresses intelligent behavior, or an endangered or parasite species that fights to survive, to optimize its features inside the host\u2019s ecosystem, or that is able to exploit or to disrupt its host circadian cycle for improving the own proliferation and spreading. BC tumorigenesis has also been compared with the early embryo and placenta development that may suggest new strategies for research and therapy. Furthermore, BC has also been characterized as an environmental disease or as an ecological disorder. Many mechanisms of cancer progression have been explained by principles of ecology, developmental biology, and evolutionary paradigms. Many authors have discussed ecological, developmental, and evolutionary strategies for more successful anti-cancer therapies, or for understanding the ecological, developmental, and evolutionary bases of BC exploitable vulnerabilities. Herein, we used the integrated framework of three well known ecological theories: the Bronfenbrenner\u2019s theory of human development, the Vannote\u2019s River Continuum Concept (RCC), and the Ecological Evolutionary Developmental Biology (Eco-Evo-Devo) theory, to explain and understand several eco-evo-devo-based principles that govern BC progression. Multi-omics fields, taken together as onco-breastomics, offer better opportunities to integrate, analyze, and interpret large amounts of complex heterogeneous data, such as various and big-omics data obtained by multiple investigative modalities, for understanding the eco-evo-devo-based principles that drive BC progression and treatment. These integrative eco-evo-devo theories can help clinicians better diagnose and treat BC, for example, by using non-invasive biomarkers in liquid-biopsies that have emerged from integrated omics-based data that accurately reflect the biomolecular landscape of the primary tumor in order to avoid mutilating preventive surgery, like bilateral mastectomy. From the perspective of preventive, personalized, and participatory medicine, these hypotheses may help patients to think about this disease as a process governed by natural rules, to understand the possible causes of the disease, and to gain control on their own health.<\/jats:p>","DOI":"10.3390\/ijms25031628","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:11:27Z","timestamp":1706515887000},"page":"1628","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Onco-Breastomics: An Eco-Evo-Devo Holistic Approach"],"prefix":"10.3390","volume":"25","author":[{"given":"Anca-Narcisa","family":"Neagu","sequence":"first","affiliation":[{"name":"Laboratory of Animal Histology, Faculty of Biology, \u201cAlexandru Ioan Cuza\u201d University of Ia\u0219i, Carol I bvd. 20A, 700505 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4799-8096","authenticated-orcid":false,"given":"Danielle","family":"Whitham","sequence":"additional","affiliation":[{"name":"Biochemistry & Proteomics Laboratories, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathea","family":"Bruno","sequence":"additional","affiliation":[{"name":"Biochemistry & Proteomics Laboratories, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneeta","family":"Arshad","sequence":"additional","affiliation":[{"name":"Biochemistry & Proteomics Laboratories, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Seymour","sequence":"additional","affiliation":[{"name":"Biochemistry & Proteomics Laboratories, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Morrissiey","sequence":"additional","affiliation":[{"name":"Biochemistry & Proteomics Laboratories, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angiolina I.","family":"Hukovic","sequence":"additional","affiliation":[{"name":"Biochemistry & Proteomics Laboratories, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-2311","authenticated-orcid":false,"given":"Costel C.","family":"Darie","sequence":"additional","affiliation":[{"name":"Biochemistry & Proteomics Laboratories, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40164-022-00363-1","article-title":"Breast cancer heterogeneity and its implication in personalized precision therapy","volume":"12","author":"Guo","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bennett, C., Carroll, C., Wright, C., Awad, B., Park, J.M., Farmer, M., Brown, E.B., Heatherly, A., and Woodard, S. (2022). Breast Cancer Genomics: Primary and Most Common Metastases. Cancers, 14.","DOI":"10.3390\/cancers14133046"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/j.ajpath.2017.07.011","article-title":"Next-Generation Breast Cancer Omics","volume":"187","author":"Coleman","year":"2017","journal-title":"Am. J. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nrclinonc.2010.227-c1","article-title":"P5 medicine: A plus for a personalized approach to oncology","volume":"8","author":"Gorini","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102403","DOI":"10.1016\/j.isci.2021.102403","article-title":"The many faces of cancer evolution","volume":"24","author":"Ciriello","year":"2021","journal-title":"iScience"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Feng, X.-H. (2010). The changing faces of cancer cells. Nat. Rev. Mol. Cell Biol., 11.","DOI":"10.1038\/nrm2923"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-319-12114-7_3","article-title":"The many faces of prolactin in breast cancer","volume":"Volume 846","author":"Chen","year":"2015","journal-title":"Recent Advances in Prolactin Research"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1101\/gad.342287.120","article-title":"The many facets of Notch signaling in breast cancer: Toward overcoming therapeutic resistance","volume":"34","author":"Nandi","year":"2020","journal-title":"Genes Dev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1158\/2159-8290.CD-12-0345","article-title":"Cancer Cell Metabolism: One Hallmark, Many Faces","volume":"2","author":"Cantor","year":"2012","journal-title":"Cancer Discov."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3389\/fonc.2019.00765","article-title":"The Many Faces of Obesity and Its Influence on Breast Cancer Risk","volume":"9","author":"Ross","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Lemus, E., Reyes-Gopar, H., Espinal-Enr\u00edquez, J., and Ochoa, S. (2019). The Many Faces of Gene Regulation in Cancer: A Computational Oncogenomics Outlook. Genes, 10.","DOI":"10.3390\/genes10110865"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.14348\/molcells.2021.0042","article-title":"Integrative Multi-Omics Approaches in Cancer Research: From Biological Networks to Clinical Subtypes","volume":"44","author":"Heo","year":"2021","journal-title":"Mol. Cells"},{"key":"ref_13","unstructured":"Yadav, S.P. (2007). The wholeness in suffix -omics, -omes, and the word om. J. Biomol. Tech. JBT, 18."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1586\/14789450.3.4.383","article-title":"I\u2019m an -omics, you\u2019re an -omics\u2026","volume":"3","author":"Smejkal","year":"2006","journal-title":"Expert Rev. Proteom."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"012005","DOI":"10.1088\/1742-6596\/1379\/1\/012005","article-title":"Novel multidimensional biomarkers for non-invasive medical diagnostics","volume":"1379","author":"Vonsky","year":"2019","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Neagu, A.-N., Whitham, D., Bruno, P., Morrissiey, H., Darie, C.A., and Darie, C.C. (2023). Omics-Based Investigations of Breast Cancer. Molecules, 28.","DOI":"10.3390\/molecules28124768"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s40495-017-0103-4","article-title":"Discovering Epimodifications of the Genome, Transcriptome, Proteome, and Metabolome: The Quest for Conquering the Uncharted Epi(c) Territories","volume":"3","author":"Xu","year":"2017","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1074\/mcp.M113.034751","article-title":"Environmental stress affects the activity of metabolic and growth factor signaling networks and induces autophagy markers in MCF7 breast cancer cells","volume":"13","author":"Casado","year":"2014","journal-title":"Mol. Cell. Proteom. MCP"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/path.5395","article-title":"The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis","volume":"250","author":"Nikolaou","year":"2020","journal-title":"J. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1038\/s41467-023-39241-7","article-title":"Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation","volume":"14","author":"Rodina","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e2019918118","DOI":"10.1073\/pnas.2019918118","article-title":"The intracellular environment affects protein\u2013protein interactions","volume":"118","author":"Speer","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"eabf3066","DOI":"10.1126\/science.abf3066","article-title":"A protein interaction landscape of breast cancer","volume":"374","author":"Kim","year":"2021","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/nrc2013","article-title":"Cancer as an evolutionary and ecological process","volume":"6","author":"Merlo","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Stearns, S.C., and Koella, J.C. (2007). Evolution in Health and Disease, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780199207466.001.0001"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/gm514","article-title":"Participatory medicine: A driving force for revolutionizing healthcare","volume":"5","author":"Hood","year":"2013","journal-title":"Genome Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1109\/TKDE.2017.2720168","article-title":"Theory-Guided Data Science: A New Paradigm for Scientific Discovery from Data","volume":"29","author":"Karpatne","year":"2017","journal-title":"IEEE Trans. Knowl. Data Eng."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1200\/JCO.2009.27.4944","article-title":"Clinical implications of the cancer genome","volume":"28","author":"Macconaill","year":"2010","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gerstung, M., Jolly, C., Leshchiner, I., Dentro, S.C., Gonzalez, S., Rosebrock, D., Mitchell, T.J., Rubanova, Y., Anur, P., and Yu, K. (2017). The evolutionary history of 2658 cancers. bioRxiv.","DOI":"10.1101\/161562"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ostrow, S.L., Barshir, R., DeGregori, J., Yeger-Lotem, E., and Hershberg, R. (2014). Cancer evolution is associated with pervasive positive selection on globally expressed genes. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004239"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e2837","DOI":"10.6061\/clinics\/2021\/e2837","article-title":"Germline and Somatic mutations in postmenopausal breast cancer patients","volume":"76","author":"Nagy","year":"2021","journal-title":"Clinics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1087432","DOI":"10.3389\/fgene.2023.1087432","article-title":"Delineating intra-tumoral heterogeneity and tumor evolution in breast cancer using precision-based approaches","volume":"14","author":"Xulu","year":"2023","journal-title":"Front. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e02869","DOI":"10.7554\/eLife.02869","article-title":"Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia","volume":"3","author":"Wang","year":"2014","journal-title":"eLife"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Testa, U., Castelli, G., and Pelosi, E. (2020). Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments. Med. Sci., 8.","DOI":"10.3390\/medsci8010018"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1297180","DOI":"10.3389\/fimmu.2023.1297180","article-title":"Multi-omics analyses unravel DNA damage repair-related clusters in breast cancer with experimental validation","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1148861","DOI":"10.3389\/fonc.2023.1148861","article-title":"Molecular mechanisms of multi-omic regulation in breast cancer","volume":"13","author":"Ochoa","year":"2023","journal-title":"Front. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cancergen.2022.11.001","article-title":"Multi-omics inference of differential breast cancer-related transcriptional regulatory network gene hubs between young Black and White patients","volume":"270\u2013271","author":"Aguilar","year":"2023","journal-title":"Cancer Genet."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Voskarides, K., and Giannopoulou, N. (2023). The Role of TP53 in Adaptation and Evolution. Cells, 12.","DOI":"10.3390\/cells12030512"},{"key":"ref_38","first-page":"293","article-title":"The Evolution, Functions and Applications of the Breast Cancer Genes BRCA1 and BRCA2","volume":"14","author":"Pfeffer","year":"2017","journal-title":"Cancer Genom. Proteom."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s41065-018-0073-5","article-title":"Unique divergence of the breast cancer 2 (BRCA2) gene in Neanderthals","volume":"155","author":"Michalak","year":"2018","journal-title":"Hereditas"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e202101263","DOI":"10.26508\/lsa.202101263","article-title":"Human BRCA pathogenic variants were originated during recent human history","volume":"5","author":"Li","year":"2022","journal-title":"Life Sci. Alliance"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/hmg\/11.7.841","article-title":"Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations","volume":"11","author":"Warren","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Lou, D.I., McBee, R.M., Le, U.Q., Stone, A.C., Wilkerson, G.K., Demogines, A.M., and Sawyer, S.L. (2014). Rapid evolution of BRCA1 and BRCA2 in humans and other primates. BMC Evol. Biol., 14.","DOI":"10.1186\/1471-2148-14-155"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Fu, X., Tan, W., Song, Q., Pei, H., and Li, J. (2022). BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.813457"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Bartas, M., Br\u00e1zda, V., Voln\u00e1, A., \u010cerve\u0148, J., Pe\u010dinka, P., and Zawacka-Pankau, J.E. (2021). The Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in Longevity. Int. J. Mol. Sci., 22.","DOI":"10.1101\/2020.05.06.080200"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2147\/OTT.S342292","article-title":"Role of Reactivating Mutant p53 Protein in Suppressing Growth and Metastasis of Triple-Negative Breast Cancer","volume":"15","author":"Berke","year":"2022","journal-title":"Onco Targets Ther."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e11994","DOI":"10.7554\/eLife.11994","article-title":"TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants","volume":"5","author":"Sulak","year":"2016","journal-title":"eLife"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"zcad025","DOI":"10.1093\/narcan\/zcad025","article-title":"TP53 germline pathogenic variants in modern humans were likely originated during recent human history","volume":"5","author":"Kou","year":"2023","journal-title":"NAR Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1200\/JCO.2015.62.2126","article-title":"Comparison of the Genomic Landscape between Primary Breast Cancer in African American versus White Women and the Association of Racial Differences with Tumor Recurrence","volume":"33","author":"Keenan","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Abdelghani, E., Schieffer, K.M., Cottrell, C.E., Audino, A., Zajo, K., and Shah, N. (2023). CHEK2 Alterations in Pediatric Malignancy: A Single-Institution Experience. Cancers, 15.","DOI":"10.3390\/cancers15061649"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1752-4571.2010.00156.x","article-title":"The emergence of human-evolutionary medical genomics","volume":"4","author":"Crespi","year":"2011","journal-title":"Evol. Appl."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3389\/fgene.2020.00829","article-title":"Germline PALB2 Mutations in Cancers and Its Distinction from Somatic PALB2 Mutations in Breast Cancers","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Genet."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Chian, J.S., Li, J., and Wang, S.M. (2023). Evolutionary Origin of Human PALB2 Germline Pathogenic Variants. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411343"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10549-022-06637-w","article-title":"PIK3CA-mutations in breast cancer","volume":"196","author":"Reinhardt","year":"2022","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"872562","DOI":"10.3389\/fphys.2022.872562","article-title":"Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops with Distinct Lifespans","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13073-020-00744-3","article-title":"Ancestry-specific predisposing germline variants in cancer","volume":"12","author":"Oak","year":"2020","journal-title":"Genome Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/13102818.2022.2151376","article-title":"Incidence of ancient variants associated with oncological diseases in modern populations","volume":"37","author":"Toncheva","year":"2023","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/ijc.32176","article-title":"Germline variation in BRCA1\/2 is highly ethnic-specific: Evidence from over 30,000 Chinese hereditary breast and ovarian cancer patients","volume":"145","author":"Bhaskaran","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ccell.2018.08.019","article-title":"Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers","volume":"34","author":"Yuan","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/cam4.1120","article-title":"Predictors of BRCA1\/2 genetic testing among Black women with breast cancer: A population-based study","volume":"6","author":"Jones","year":"2017","journal-title":"Cancer Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1002\/ajmg.a.36267","article-title":"Developmental disease and cancer: Biological and clinical overlaps","volume":"161","author":"Bellacosa","year":"2013","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Costanzo, V., Bardelli, A., Siena, S., and Abrignani, S. (2018). Exploring the links between cancer and placenta development. Open Biol., 8.","DOI":"10.1098\/rsob.180081"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.redox.2015.11.005","article-title":"Breast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies","volume":"7","author":"Shapiro","year":"2016","journal-title":"Redox Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/cdd.2016.128","article-title":"The p53 family members have distinct roles during mammalian embryonic development","volume":"24","author":"Bowen","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.yexmp.2015.10.005","article-title":"GATA6 is overexpressed in breast cancer and promotes breast cancer cell epithelial\u2013mesenchymal transition by upregulating slug expression","volume":"99","author":"Song","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"11189","DOI":"10.1073\/pnas.0604604103","article-title":"A threshold of GATA4 and GATA6 expression is required for cardiovascular development","volume":"103","author":"Xin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4714781","DOI":"10.1155\/2019\/4714781","article-title":"Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway","volume":"2019","author":"Cofre","year":"2019","journal-title":"Sci. World J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12943-020-01276-5","article-title":"Wnt signaling in breast cancer: Biological mechanisms, challenges and opportunities","volume":"19","author":"Xu","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbagrm.2014.06.005","article-title":"Estrogen receptor signaling during vertebrate development","volume":"1849","author":"Bondesson","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Clusan, L., Ferri\u00e8re, F., Flouriot, G., and Pakdel, F. (2023). A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076834"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"103997","DOI":"10.1016\/j.critrevonc.2023.103997","article-title":"A review of HER2 overexpression and somatic mutations in cancers","volume":"186","author":"Galogre","year":"2023","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/s-2007-1016235","article-title":"Embryo Implantation and Tumor Metastasis: Common Pathways of Invasion and Angiogenesis","volume":"17","author":"Murray","year":"1999","journal-title":"Semin. Reprod. Endocrinol."},{"key":"ref_72","unstructured":"Ahmad, A. (2017). Introduction to Cancer Metastasis, Academic Press."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/CS20090503","article-title":"Regulation of invasive growth: Similar epigenetic mechanisms underpin tumour progression and implantation in human pregnancy","volume":"118","author":"Perry","year":"2009","journal-title":"Clin. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/19336918.2016.1170258","article-title":"Epithelial-mesenchymal transition during extravillous trophoblast differentiation","volume":"10","author":"Davies","year":"2016","journal-title":"Cell Adhes. Migr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1091\/mbc.e11-04-0306","article-title":"Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer","volume":"22","author":"Wendt","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1053\/plac.2002.0864","article-title":"The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast","volume":"23","author":"Shih","year":"2002","journal-title":"Placenta"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.placenta.2015.10.013","article-title":"Differentiation of first trimester cytotrophoblast to extravillous trophoblast involves an epithelial\u2013mesenchymal transition","volume":"36","author":"James","year":"2015","journal-title":"Placenta"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10616-020-00402-x","article-title":"Vimentin plays an important role in the promotion of breast cancer cell migration and invasion by leucine aminopeptidase 3","volume":"72","author":"Wang","year":"2020","journal-title":"Cytotechnology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.3892\/ol.2017.5896","article-title":"Fibronectin induces epithelial-mesenchymal transition in human breast cancer MCF-7 cells via activation of calpain","volume":"13","author":"Li","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.2741\/4364","article-title":"Matrix metalloproteinases as breast cancer drivers and therapeutic targets","volume":"20","author":"Radisky","year":"2015","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Manzo, G. (2019). Similarities between Embryo Development and Cancer Process Suggest New Strategies for Research and Therapy of Tumors: A New Point of View. Front. Cell Dev. Biol., 7.","DOI":"10.3389\/fcell.2019.00020"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.4252\/wjsc.v7.i9.1150","article-title":"Common stemness regulators of embryonic and cancer stem cells","volume":"7","author":"Hadjimichael","year":"2015","journal-title":"World J. Stem Cells"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.2174\/1389450116666150907102717","article-title":"Cancer: A Problem of Developmental Biology; Scientific Evidence for Reprogramming and Differentiation Therapy","volume":"17","author":"Sell","year":"2016","journal-title":"Curr. Drug Targets"},{"key":"ref_84","unstructured":"Lynn, H., Ward, D., Burton, D., Day, J., Craig, A., Parnell, M., and Dimmer, C. (2024, January 23). Breast Cancer: An Environmental Disease. The Case for Primary Prevention. Available online: https:\/\/www.env-health.org\/IMG\/pdf\/23-_Breast_Cancer_-_an_environmental_disease_the_case_for_primary_prevention.pdf."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev-publhealth-040617-014101","article-title":"Environmental Determinants of Breast Cancer","volume":"39","author":"Hiatt","year":"2018","journal-title":"Annu. Rev. Public Health"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/bjc.2015.439","article-title":"Gene-environment interaction and risk of breast cancer","volume":"114","author":"Rudolph","year":"2016","journal-title":"Br. J. Cancer"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"8538","DOI":"10.1002\/ece3.6590","article-title":"Eco-oncology: Applying ecological principles to understand and manage cancer","volume":"10","author":"Reynolds","year":"2020","journal-title":"Ecol. Evol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ijgo.14407","article-title":"Women\u2019s cancers and climate change","volume":"160","author":"Hiatt","year":"2023","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"10799","DOI":"10.2147\/CMAR.S267415","article-title":"The Association between Smartphone Use and Breast Cancer Risk Among Taiwanese Women: A Case-Control Study","volume":"12","author":"Shih","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"047011","DOI":"10.1289\/EHP1837","article-title":"Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study)","volume":"126","author":"Espinosa","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Afzal, S., Fiaz, K., Noor, A., Sindhu, A.S., Hanif, A., Bibi, A., Asad, M., Nawaz, S., Zafar, S., and Ayub, S. (2022). Interrelated Oncogenic Viruses and Breast Cancer. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.781111"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12940-020-00670-2","article-title":"Environmental chemicals, breast cancer progression and drug resistance","volume":"19","author":"Koual","year":"2020","journal-title":"Environ. Health"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gendis.2018.05.001","article-title":"Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis","volume":"5","author":"Feng","year":"2018","journal-title":"Genes Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13058-019-1168-2","article-title":"Environmental exposures during windows of susceptibility for breast cancer: A framework for prevention research","volume":"21","author":"Terry","year":"2019","journal-title":"Breast Cancer Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/eva.12497","article-title":"Ancient oncogenesis, infection and human evolution","volume":"10","author":"Rifkin","year":"2017","journal-title":"Evol. Appl."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"osad003","DOI":"10.1093\/exposome\/osad003","article-title":"Exposomics as a tool to investigate differences in health and disease by sex and gender","volume":"3","author":"Bucher","year":"2023","journal-title":"Exposome"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"105887","DOI":"10.1016\/j.envint.2020.105887","article-title":"What is new in the exposome?","volume":"143","author":"Vineis","year":"2020","journal-title":"Environ. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"12201","DOI":"10.1021\/acs.est.3c04524","article-title":"Exploring Single-Cell Exposomics by Mass Spectrometry","volume":"57","author":"Gao","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41420-021-00485-1","article-title":"Single cell RNA sequencing for breast cancer: Present and future","volume":"7","author":"Ren","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.devcel.2022.05.003","article-title":"A human breast atlas integrating single-cell proteomics and transcriptomics","volume":"57","author":"Gray","year":"2022","journal-title":"Dev. Cell"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1124\/dmd.122.001043","article-title":"Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies","volume":"51","author":"Wheeler","year":"2023","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Sellami, M., and Bragazzi, N.L. (2020). Nutrigenomics and Breast Cancer: State-of-Art, Future Perspectives and Insights for Prevention. Nutrients, 12.","DOI":"10.3390\/nu12020512"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Vahid, F., Hajizadeghan, K., and Khodabakhshi, A. (2023). Nutritional Metabolomics in Diet\u2013Breast Cancer Relations: Current Research, Challenges, and Future Directions\u2014A Review. Biomedicines, 11.","DOI":"10.3390\/biomedicines11071845"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3945\/an.113.004168","article-title":"Nutritional epigenomics: A portal to disease prevention","volume":"4","author":"Choi","year":"2013","journal-title":"Adv. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1006\/bbrc.2000.2942","article-title":"Stimulation of Cell Invasion and Migration by Alcohol in Breast Cancer Cells","volume":"273","author":"Meng","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12609-013-0114-z","article-title":"Alcohol Intake and Breast Cancer Risk: Weighing the Overall Evidence","volume":"5","author":"McDonald","year":"2013","journal-title":"Curr. Breast Cancer Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.phrs.2016.12.005","article-title":"Cellular and Molecular Mechanism Underlying Alcohol-induced Aggressiveness of Breast Cancer","volume":"115","author":"Wang","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Candelaria, N.R., Weldon, R., Muthusamy, S., Nguyen-Vu, T., Addanki, S., Yoffou, P.-H., Karaboga, H., Blessing, A.M., Bollu, L.R., and Miranda, R.C. (2015). Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0145061"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4420479","DOI":"10.1155\/2021\/4420479","article-title":"A Decade of Research on Coffee as an Anticarcinogenic Beverage","volume":"2021","author":"Nigra","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3389\/fendo.2018.00306","article-title":"Coffee Is Associated with Lower Breast Tumor Insulin-Like Growth Factor Receptor 1 Levels in Normal-Weight Patients and Improved Prognosis Following Tamoxifen or Radiotherapy Treatment","volume":"9","author":"Rosendahl","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Hayakawa, S., Ohishi, T., Miyoshi, N., Oishi, Y., Nakamura, Y., and Isemura, M. (2020). Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid. Molecules, 25.","DOI":"10.3390\/molecules25194553"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"5572630","DOI":"10.1155\/2021\/5572630","article-title":"Antitumor Effects of Freeze-Dried Robusta Coffee (Coffea canephora) Extracts on Breast Cancer Cell Lines","volume":"2021","author":"Nigra","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fgene.2019.00079","article-title":"Dietary Compounds as Epigenetic Modulating Agents in Cancer","volume":"10","author":"Marchat","year":"2019","journal-title":"Front. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3892\/or.2020.7891","article-title":"Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF-\u03baB signaling pathway","volume":"45","author":"Zeng","year":"2021","journal-title":"Oncol. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Pascua, S.M., McGahey, G.E., Ma, N., Wang, J.J., and Digman, M.A. (2020). Caffeine and Cisplatin Effectively Targets the Metabolism of a Triple-Negative Breast Cancer Cell Line Assessed via Phasor-FLIM. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072443"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s00204-016-1784-x","article-title":"Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells","volume":"91","author":"Deus","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.canlet.2014.11.017","article-title":"Piperine inhibits the growth and motility of triple-negative breast cancer cells","volume":"357","author":"Greenshields","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1158\/1055-9965.EPI-21-0837","article-title":"A Metabolomics Analysis of Circulating Carotenoids and Breast Cancer Risk","volume":"31","author":"Peng","year":"2022","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Vydra, N., Janus, P., Toma-Jonik, A., Stokowy, T., Mrowiec, K., Korfanty, J., D\u0142ugajczyk, A., Wojta\u015b, B., Gielniewski, B., and Wid\u0142ak, W. (2019). 17\u03b2-Estradiol Activates HSF1 via MAPK Signaling in ER\u03b1-Positive Breast Cancer Cells. Cancers, 11.","DOI":"10.3390\/cancers11101533"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13058-020-01275-w","article-title":"In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness","volume":"22","author":"Wormsbaecher","year":"2020","journal-title":"Breast Cancer Res. BCR"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/jat.2978","article-title":"Differential effect of methyl-, butyl- and propylparaben and 17\u03b2-estradiol on selected cell cycle and apoptosis gene and protein expression in MCF-7 breast cancer cells and MCF-10A non-malignant cells","volume":"34","author":"Gregoraszczuk","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"581388","DOI":"10.3389\/fnut.2020.581388","article-title":"Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components","volume":"7","author":"Stillwater","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/bcr3649","article-title":"Maternal exposure to diethylstilbestrol during pregnancy and increased breast cancer risk in daughters","volume":"16","year":"2014","journal-title":"Breast Cancer Res."},{"key":"ref_124","first-page":"44","article-title":"Altered blood proteome in girls with high urine concentrations of bisphenol a, genistein, mono-ethyl hexylphthalate and mono-benzyl phthalate","volume":"2","author":"Wang","year":"2015","journal-title":"MOJ Proteom. Bioinform."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"E1343","DOI":"10.1073\/pnas.1600645113","article-title":"Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals","volume":"113","author":"Williams","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1158\/1055-9965.EPI-19-0154","article-title":"Plasma Metabolomic Signatures Associated with Long-term Breast Cancer Risk in the SU.VI.MAX Prospective Cohort","volume":"28","author":"Dalle","year":"2019","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Fitzpatrick, D., Pirie, K., Reeves, G., Green, J., and Beral, V. (2023). Combined and progestagen-only hormonal contraceptives and breast cancer risk: A UK nested case-control study and meta-analysis. PLoS Med., 20.","DOI":"10.1371\/journal.pmed.1004188"},{"key":"ref_128","first-page":"4559","article-title":"Hormone Replacement Therapy with Estrogen or Estrogen plus Medroxyprogesterone Acetate Is Associated with Increased Epithelial Proliferation in the Normal-Postmenopausal Breast","volume":"84","author":"Hofseth","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1095\/biolreprod.110.090431","article-title":"Bisphenol A increases mammary cancer risk in two distinct mouse models of breast cancer","volume":"85","author":"Keri","year":"2011","journal-title":"Biol. Reprod."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3892\/ol.2020.12145","article-title":"Carcinogenic effects of bisphenol A in breast and ovarian cancers (Review)","volume":"20","author":"Dumitrascu","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Zamora-Le\u00f3n, P. (2021). Are the Effects of DES Over? A Tragic Lesson from the Past. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph181910309"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.toxlet.2011.04.031","article-title":"Gene expression profile of terminal end buds in rat mammary glands exposed to diethylstilbestrol in neonatal period","volume":"205","author":"Umekita","year":"2011","journal-title":"Toxicol. Lett."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1200\/JCO.18.02202","article-title":"Phthalate Exposure and Breast Cancer Incidence: A Danish Nationwide Cohort Study","volume":"37","author":"Ahern","year":"2019","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13058-021-01419-6","article-title":"Urinary phthalate exposures and risk of breast cancer: The Multiethnic Cohort study","volume":"23","author":"Wu","year":"2021","journal-title":"Breast Cancer Res."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Hager, E., Chen, J., and Zhao, L. (2022). Minireview: Parabens Exposure and Breast Cancer. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031873"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/EDE.0000000000001356","article-title":"A Congener-specific and Mixture Analysis of Plasma Polychlorinated Biphenyl Levels and Incident Breast Cancer","volume":"32","author":"Parada","year":"2021","journal-title":"Epidemiology"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cotox.2019.10.006","article-title":"Endocrine-disrupting mechanisms of polychlorinated biphenyls","volume":"19","author":"Antonijevic","year":"2020","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Liu, S., Li, S., and Du, Y. (2010). Polychlorinated biphenyls (PCBs) enhance metastatic properties of breast cancer cells by activating Rho-associated kinase (ROCK). PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011272"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"109516","DOI":"10.1016\/j.envres.2020.109516","article-title":"Dioxin exposure and breast cancer risk in a prospective cohort study","volume":"186","author":"VoPham","year":"2020","journal-title":"Environ. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.envint.2019.01.001","article-title":"Long-term airborne dioxin exposure and breast cancer risk in a case-control study nested within the French E3N prospective cohort","volume":"124","author":"Danjou","year":"2019","journal-title":"Environ. Int."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13058-015-0536-9","article-title":"Estimated dietary dioxin exposure and breast cancer risk among women from the French E3N prospective cohort","volume":"17","author":"Danjou","year":"2015","journal-title":"Breast Cancer Res."},{"key":"ref_142","first-page":"e116516","article-title":"Dioxins Exposure and the Risk of Breast Cancer: A Systematic Review and Meta-analysis","volume":"13","author":"Ghaedrahmat","year":"2021","journal-title":"Jundishapur J. Health Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/toxsci\/kfm125","article-title":"A Proposed Mechanism for the Protective Effect of Dioxin against Breast Cancer","volume":"98","author":"Hsu","year":"2007","journal-title":"Toxicol. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"37002","DOI":"10.1289\/EHP7102","article-title":"Aggressiveness and Metastatic Potential of Breast Cancer Cells Co-Cultured with Preadipocytes and Exposed to an Environmental Pollutant Dioxin: An in Vitro and in Vivo Zebrafish Study","volume":"129","author":"Koual","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3389\/fphar.2017.00699","article-title":"The Impacts of Genistein and Daidzein on Estrogen Conjugations in Human Breast Cancer Cells: A Targeted Metabolomics Approach","volume":"8","author":"Poschner","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.1038\/s41467-020-19263-1","article-title":"Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fendo.2019.00367","article-title":"Dietary Fructose Consumption and Triple-Negative Breast Cancer Incidence","volume":"10","author":"Strober","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e3804","DOI":"10.7717\/peerj.3804","article-title":"Increased utilization of fructose has a positive effect on the development of breast cancer","volume":"5","author":"Fan","year":"2017","journal-title":"PeerJ"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40170-020-00222-9","article-title":"Fructose contributes to the Warburg effect for cancer growth","volume":"8","author":"Nakagawa","year":"2020","journal-title":"Cancer Metab."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.3945\/ajcn.112.057760","article-title":"Dietary intake and breast cancer among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study","volume":"98","author":"Ko","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.3390\/cimb43030106","article-title":"Genistein: A Potent Anti-Breast Cancer Agent","volume":"43","author":"Bhat","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Sohel, M., Biswas, P., Al Amin, M., Hossain, M.A., Sultana, H., Dey, D., Aktar, S., Setu, A., Khan, M.S., and Paul, P. (2022). Genistein, a Potential Phytochemical against Breast Cancer Treatment-Insight into the Molecular Mechanisms. Processes, 10.","DOI":"10.3390\/pr10020415"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s43440-022-00426-4","article-title":"Alcohol and breast cancer","volume":"75","author":"Budziszewska","year":"2023","journal-title":"Pharmacol. Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.alcohol.2010.11.006","article-title":"Alcohol consumption in relation to aberrant DNA methylation in breast tumors","volume":"45","author":"Tao","year":"2011","journal-title":"Alcohol"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00394-020-02465-0","article-title":"Coffee consumption and breast cancer risk: A narrative review in the general population and in different subtypes of breast cancer","volume":"60","author":"Nehlig","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"12684","DOI":"10.1038\/s41598-019-49205-x","article-title":"Associations between Coffee Products and Breast Cancer Risk: A Case-Control study in Hong Kong Chinese Women","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/biof.1544","article-title":"Resveratrol modulates epigenetic regulators of promoter histone methylation and acetylation that restores BRCA1, p53, p21 CIP1 in human breast cancer cell lines","volume":"45","author":"Chatterjee","year":"2019","journal-title":"BioFactors"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1086\/506237","article-title":"Ecological Units: Definitions and Application","volume":"81","author":"Jax","year":"2006","journal-title":"Q. Rev. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Hirpara, A., Bloomfield, M., and Duesberg, P. (2018). Speciation Theory of Carcinogenesis Explains Karyotypic Individuality and Long Latencies of Cancers. Genes, 9.","DOI":"10.3390\/genes9080402"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3389\/fonc.2019.00718","article-title":"Editorial: Cancer Ecosystems","volume":"9","author":"Bartrons","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Edwards, J., Marusyk, A., and Basanta, D. (2020). Selection-driven tumor evolution involving non-cell growth promotion leads to patterns of clonal expansion consistent with neutrality interpretation. bioRxiv.","DOI":"10.1101\/2020.02.11.944843"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrc3712","article-title":"Turning ecology and evolution against cancer","volume":"14","author":"Korolev","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"693781","DOI":"10.3389\/fevo.2021.693781","article-title":"Starvation and Climate Change\u2014How to Constrain Cancer Cell Epigenetic Diversity and Adaptability to Enhance Treatment Efficacy","volume":"9","author":"Gregg","year":"2021","journal-title":"Front. Ecol. Evol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s13752-015-0226-y","article-title":"Cancer Ecology: Niche Construction, Keystone Species, Ecological Succession, and Ergodic Theory","volume":"10","author":"Kareva","year":"2015","journal-title":"Biol. Theory"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/cac2.12316","article-title":"The theory of tumor ecosystem","volume":"42","author":"Chen","year":"2022","journal-title":"Cancer Commun."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s00018-023-04902-9","article-title":"Breast cancers as ecosystems: A metabolic perspective","volume":"80","author":"Martino","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.cell.2019.03.005","article-title":"A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer","volume":"177","author":"Wagner","year":"2019","journal-title":"Cell"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"6796","DOI":"10.1038\/s41467-023-42504-y","article-title":"Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer","volume":"14","author":"Zhao","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1593\/tlo.08178","article-title":"Ecological therapy for cancer: Defining tumors using an ecosystem paradigm suggests new opportunities for novel cancer treatments","volume":"1","author":"Pienta","year":"2008","journal-title":"Transl. Oncol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1073274820951776","DOI":"10.1177\/1073274820951776","article-title":"Cancer Community Ecology","volume":"27","author":"Kotler","year":"2020","journal-title":"Cancer Control J. Moffitt Cancer Cent."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s13752-018-0303-0","article-title":"Rethinking Causation in Cancer with Evolutionary Developmental Biology","volume":"13","author":"Liu","year":"2018","journal-title":"Biol. Theory"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1111\/eva.12947","article-title":"The three dimensions of somatic evolution: Integrating the role of genetic damage, life-history traits, and aging in carcinogenesis","volume":"13","author":"Rozhok","year":"2020","journal-title":"Evol. Appl."},{"key":"ref_173","first-page":"e166","article-title":"A Brief History of Breast Cancer: Part I: Surgical domination reinvented","volume":"14","author":"Lakhtakia","year":"2014","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Binder, M., Roberts, C., Spencer, N., Antoine, D., and Cartwright, C. (2014). On the Antiquity of Cancer: Evidence for Metastatic Carcinoma in a Young Man from Ancient Nubia (c. 1200BC). PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090924"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Yegorov, S., and Good, S. (2012). Using Paleogenomics to Study the Evolution of Gene Families: Origin and Duplication History of the Relaxin Family Hormones and Their Receptors. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032923"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/syen.12406","article-title":"Phylogenomics\u2014Principles, opportunities and pitfalls of big-data phylogenetics","volume":"45","author":"Young","year":"2020","journal-title":"Syst. Entomol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1111\/brv.12415","article-title":"From humans to hydra: Patterns of cancer across the tree of life","volume":"93","author":"Albuquerque","year":"2018","journal-title":"Biol. Rev."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/0194262X.2022.2163451","article-title":"Analyses of the 2022 Nobel Prize in Physiology or Medicine: Paleogenomics","volume":"42","author":"Sterner","year":"2023","journal-title":"Sci. Technol. Libr."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"703541","DOI":"10.3389\/fgene.2021.703541","article-title":"Quantitative Human Paleogenetics: What can Ancient DNA Tell us About Complex Trait Evolution?","volume":"12","author":"Muktupavela","year":"2021","journal-title":"Front. Genet."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/molbev\/msz242","article-title":"Molecular Biology and Evolution of Cancer: From Discovery to Action","volume":"37","author":"Somarelli","year":"2019","journal-title":"Mol. Biol. Evol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/sysbio\/syu081","article-title":"Cancer Evolution: Mathematical Models and Computational Inference","volume":"64","author":"Beerenwinkel","year":"2014","journal-title":"Syst. Biol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21873\/anticanres.13074","article-title":"Evolution of Cancer Progression in the Context of Darwinism","volume":"39","author":"Lacina","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"661583","DOI":"10.3389\/fevo.2021.661583","article-title":"The Hallmarks of Cancer as Ecologically Driven Phenotypes","volume":"9","author":"Somarelli","year":"2021","journal-title":"Front. Ecol. Evol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"171060","DOI":"10.1098\/rsos.171060","article-title":"Sweepstake evolution revealed by population-genetic analysis of copy-number alterations in single genomes of breast cancer","volume":"4","author":"Kato","year":"2017","journal-title":"R. Soc. Open Sci."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"e108389","DOI":"10.15252\/embj.2021108389","article-title":"Cancer evolution: Darwin and beyond","volume":"40","author":"Vendramin","year":"2021","journal-title":"EMBO J."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41523-021-00230-y","article-title":"Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy","volume":"7","author":"Epstein","year":"2021","journal-title":"npj Breast Cancer"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Lineweaver, C.H., Bussey, K.J., Blackburn, A.C., and Davies, P.C.W. (2021). Cancer progression as a sequence of atavistic reversions. BioEssays News Rev. Mol. Cell. Dev. Biol., 43.","DOI":"10.1002\/bies.202000305"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"101531","DOI":"10.1016\/j.isci.2020.101531","article-title":"A Similar Speciation Process Relying on Cellular Stochasticity in Microbial and Cancer Cell Populations","volume":"23","author":"Capp","year":"2020","journal-title":"iScience"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1073\/pnas.1617743114","article-title":"Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors","volume":"114","author":"Trigos","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s12052-011-0373-y","article-title":"How cancer shapes evolution and how evolution shapes cancer","volume":"4","author":"Degregori","year":"2011","journal-title":"Evol. Educ. Outreach"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Maruki, T., Ye, Z., and Lynch, M. (2022). Evolutionary Genomics of a Subdivided Species. Mol. Biol. Evol., 39.","DOI":"10.1093\/molbev\/msac152"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1073\/pnas.0909343106","article-title":"Somatic evolutionary genomics: Mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration","volume":"107","author":"Frank","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jprot.2015.09.031","article-title":"Proteomics in evolutionary ecology","volume":"135","author":"Baer","year":"2016","journal-title":"J. Proteom."},{"key":"ref_194","first-page":"4006","article-title":"Proteomics and its applications in breast cancer","volume":"11","author":"Neagu","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s10654-022-00936-8","article-title":"The need for evolutionary theory in cancer research","volume":"38","author":"Boddy","year":"2022","journal-title":"Eur. J. Epidemiol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecolmodel.2013.02.031","article-title":"Thermodynamics-based categorization of ecosystems in a socio-ecological context","volume":"258","author":"Coscieme","year":"2013","journal-title":"Ecol. Model."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"105565","DOI":"10.1016\/j.icheatmasstransfer.2021.105565","article-title":"Predicting cancer cells progression via entropy generation based on AR and ARMA models","volume":"127","author":"Mirzaei","year":"2021","journal-title":"Int. Commun. Heat Mass Transf."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1073274820911058","DOI":"10.1177\/1073274820911058","article-title":"Cancer Cells and M2 Macrophages: Cooperative Invasive Ecosystem Engineers","volume":"27","author":"Myers","year":"2020","journal-title":"Cancer Control J. Moffitt Cancer Cent."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1006304821464","article-title":"The Impact of Developmental Biology on Cancer Research: An Overview","volume":"18","author":"Edwards","year":"1999","journal-title":"Cancer Metastasis Rev."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Zhu, X., Li, S., Xu, B., and Luo, H. (2021). Cancer evolution: A means by which tumors evade treatment. Biomed. Pharmacother., 133.","DOI":"10.1016\/j.biopha.2020.111016"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/eva.12021","article-title":"Applying ecological and evolutionary theory to cancer: A long and winding road","volume":"6","author":"Thomas","year":"2013","journal-title":"Evol. Appl."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3389\/fimmu.2020.00933","article-title":"Editorial: Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy","volume":"11","author":"Chouaib","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/eva.13190","article-title":"Identifying key questions in the ecology and evolution of cancer","volume":"14","author":"Dujon","year":"2021","journal-title":"Evol. Appl."},{"key":"ref_204","unstructured":"Tot, T. (2008). Breast Cancer: A Lobar Disease, Springer."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/1066896907302225","article-title":"The Theory of the Sick Breast Lobe and the Possible Consequences","volume":"15","author":"Tot","year":"2007","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00428-005-1274-7","article-title":"DCIS, cytokeratins, and the theory of the sick lobe","volume":"447","author":"Tot","year":"2005","journal-title":"Virchows Arch."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"611","DOI":"10.21037\/gs.2018.09.08","article-title":"The sick lobe hypothesis, field cancerisation and the new era of precision breast surgery","volume":"7","author":"Tan","year":"2018","journal-title":"Gland. Surg."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"e1495","DOI":"10.1002\/wat2.1495","article-title":"Toward catchment hydro-biogeochemical theories","volume":"8","author":"Li","year":"2021","journal-title":"WIREs Water"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"163946","DOI":"10.1016\/j.scitotenv.2023.163946","article-title":"Application of an integrated catchment-lake model approach for simulating effects of climate change on lake inputs and biogeochemistry","volume":"885","author":"Mesman","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"17184","DOI":"10.1038\/s41598-021-96215-9","article-title":"Migrations of cancer cells through the lens of phylogenetic biogeography","volume":"11","author":"Chroni","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Chroni, A., and Kumar, S. (2021). Tumors Are Evolutionary Island-Like Ecosystems. Genome Biol. Evol., 13.","DOI":"10.1093\/gbe\/evab276"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1158\/0008-5472.CAN-19-1941","article-title":"Eradicating Metastatic Cancer and the Eco-Evolutionary Dynamics of Anthropocene Extinctions","volume":"80","author":"Gatenby","year":"2020","journal-title":"Cancer Res."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"676802","DOI":"10.3389\/fevo.2021.676802","article-title":"The Evolutionary Ecology of Dormancy in Nature and in Cancer","volume":"9","author":"Miller","year":"2021","journal-title":"Front. Ecol. Evol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1073274820946804","DOI":"10.1177\/1073274820946804","article-title":"Histoecology: Applying Ecological Principles and Approaches to Describe and Predict Tumor Ecosystem Dynamics Across Space and Time","volume":"27","author":"Gatenbee","year":"2020","journal-title":"Cancer Control J. Moffitt Cancer Cent."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1158\/1541-7786.MCR-19-0262","article-title":"Treating Cancer as an Invasive Species","volume":"18","author":"Noorbakhsh","year":"2020","journal-title":"Mol. Cancer Res. MCR"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"681100","DOI":"10.3389\/fevo.2021.681100","article-title":"The Genomic Processes of Biological Invasions: From Invasive Species to Cancer Metastases and Back Again","volume":"9","author":"Neinavaie","year":"2021","journal-title":"Front. Ecol. Evol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3892\/ijo.2020.5075","article-title":"Biomarkers of tumor invasiveness in proteomics (Review)","volume":"57","author":"Pouliquen","year":"2020","journal-title":"Int. J. Oncol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12967-021-02773-x","article-title":"Multi-omics characterization and validation of invasiveness-related molecular features across multiple cancer types","volume":"19","author":"Bi","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Cort\u00e9s-Hern\u00e1ndez, L.E., Eslami-S, Z., Dujon, A.M., Giraudeau, M., Ujvari, B., Thomas, F., and Alix-Panabi\u00e8res, C. (2020). Do malignant cells sleep at night?. Genome Biol., 21.","DOI":"10.1186\/s13059-020-02179-w"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1017\/S0031182016000147","article-title":"Cancer and life-history traits: Lessons from host\u2013parasite interactions","volume":"143","author":"Arnal","year":"2016","journal-title":"Parasitology"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"a029652","DOI":"10.1101\/cshperspect.a029652","article-title":"Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks","volume":"7","author":"Fortunato","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/carcin\/24.1.1","article-title":"Cancer as an evolutionary process at the cell level: An epidemiological perspective","volume":"24","author":"Vineis","year":"2003","journal-title":"Carcinogenesis"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/eva.12015","article-title":"Riparian ecosystems in human cancers","volume":"6","author":"Alfarouk","year":"2013","journal-title":"Evol. Appl."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41576-022-00553-x","article-title":"Spatial biology of cancer evolution","volume":"24","author":"Seferbekova","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrg3982","article-title":"Eco-Evo-Devo: Developmental symbiosis and developmental plasticity as evolutionary agents","volume":"16","author":"Gilbert","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Landry, C.R., and Aubin-Horth, N. (2014). Ecological Genomics: Ecology and the Evolution of Genes and Genomes, Springer.","DOI":"10.1007\/978-94-007-7347-9"},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Nuno de la Rosa, L., and M\u00fcller, G. (2017). Evolutionary Developmental Biology: A Reference Guide, Springer International Publishing.","DOI":"10.1007\/978-3-319-33038-9"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/s41388-020-01624-1","article-title":"Onco-ontogeny recapitulates phylogeny\u2013A consideration","volume":"40","author":"Plowman","year":"2021","journal-title":"Oncogene"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"768098","DOI":"10.3389\/fimmu.2021.768098","article-title":"Cancer Evo\u2013Dev: A Theory of Inflammation-Induced Oncogenesis","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Kozlov, A.P. (2023). Carcino-Evo-Devo, A Theory of the Evolutionary Role of Hereditary Tumors. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108611"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/s41559-017-0343-z","article-title":"The importance of cancer cells for animal evolutionary ecology","volume":"1","author":"Thomas","year":"2017","journal-title":"Nat. Ecol. Evol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/jftr.12022","article-title":"Urie Bronfenbrenner\u2019s Theory of Human Development: Its Evolution from Ecology to Bioecology","volume":"5","author":"Rosa","year":"2013","journal-title":"J. Fam. Theory Rev."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1177\/0269216318757622","article-title":"A framework for complexity in palliative care: A qualitative study with patients, family carers and professionals","volume":"32","author":"Pask","year":"2018","journal-title":"Palliat. Med."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"012014","DOI":"10.1088\/1755-1315\/628\/1\/012014","article-title":"Problems of sustainable development of ecosystems","volume":"628","author":"Yeremeyev","year":"2021","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3934\/molsci.2020006","article-title":"Cell division symmetry control and cancer stem cells","volume":"7","author":"Majumdar","year":"2020","journal-title":"AIMS Mol. Sci."},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Zhang, X., Powell, K., and Li, L. (2020). Breast Cancer Stem Cells: Biomarkers, Identification and Isolation Methods, Regulating Mechanisms, Cellular Origin, and Beyond. Cancers, 12.","DOI":"10.3390\/cancers12123765"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.biocel.2018.12.017","article-title":"Self-renewal signaling pathways in breast cancer stem cells","volume":"107","author":"Nalla","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.stem.2015.02.015","article-title":"The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells?","volume":"16","author":"Plaks","year":"2015","journal-title":"Cell Stem Cell"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"14129","DOI":"10.1073\/pnas.1819408116","article-title":"Consecutive seeding and transfer of genetic diversity in metastasis","volume":"116","author":"Heyde","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41586-023-06333-9","article-title":"Evolutionary histories of breast cancer and related clones","volume":"620","author":"Nishimura","year":"2023","journal-title":"Nature"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12052-007-0016-5","article-title":"The Hierarchical Structure of Ecosystems: Connections to Evolution","volume":"1","author":"Miller","year":"2008","journal-title":"Evol. Educ. Outreach"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.7150\/thno.41647","article-title":"An evolving paradigm of cancer stem cell hierarchies: Therapeutic implications","volume":"10","author":"Cole","year":"2020","journal-title":"Theranostics"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"975091","DOI":"10.3389\/fmars.2022.975091","article-title":"Competing with each other: Fish isotopic niche in two resource availability contexts","volume":"9","author":"Pelage","year":"2022","journal-title":"Front. Mar. Sci."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"a014274","DOI":"10.1101\/cshperspect.a014274","article-title":"Socializing with MYC: Cell competition in development and as a model for premalignant cancer","volume":"4","author":"Johnston","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s10555-023-10123-0","article-title":"Is cancer an intelligent species?","volume":"42","author":"Nicolazzo","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1158\/0008-5472.CAN-22-2217","article-title":"Cell Competition in Carcinogenesis","volume":"82","author":"Madan","year":"2022","journal-title":"Cancer Res."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"jcs260835","DOI":"10.1242\/jcs.260835","article-title":"Migration speed of captured breast cancer subpopulations correlates with metastatic fitness","volume":"136","author":"Annis","year":"2023","journal-title":"J. Cell Sci."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.aecr.2019.02.001","article-title":"Chapter One\u2013Adaptive capacity in ecosystems","volume":"Volume 60","author":"Bohan","year":"2019","journal-title":"Advances in Ecological Research"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ecocom.2019.01.002","article-title":"Ecosystem spatial self-organization: Free order for nothing?","volume":"38","author":"Dong","year":"2019","journal-title":"Ecol. Complex."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13058-020-01361-z","article-title":"CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress","volume":"22","author":"Balcioglu","year":"2020","journal-title":"Breast Cancer Res."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.2217\/fon.13.92","article-title":"Role of hypoxia-inducible factors in breast cancer metastasis","volume":"9","author":"Gilkes","year":"2013","journal-title":"Future Oncol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fonc.2019.00043","article-title":"Differential Oxygenation in Tumor Microenvironment Modulates Macrophage and Cancer Cell Crosstalk: Novel Experimental Setting and Proof of Concept","volume":"9","author":"Campillo","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cmet.2018.11.018","article-title":"Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming","volume":"29","author":"Goding","year":"2019","journal-title":"Cell Metab."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"10105","DOI":"10.1038\/s41598-020-66926-6","article-title":"Determining the thermal characteristics of breast cancer based on high-resolution infrared imaging, 3D breast scans, and magnetic resonance imaging","volume":"10","author":"Lozano","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s005950300055","article-title":"Relationship between Microvessel Density and Thermographic Hot Areas in Breast Cancer","volume":"33","author":"Yahara","year":"2003","journal-title":"Surg. Today"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41416-020-01171-2","article-title":"Putting Warburg to work: How imaging of tumour acidosis could help predict metastatic potential in breast cancer","volume":"124","author":"Rolver","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1242\/jcs.195297","article-title":"Cancer cell behaviors mediated by dysregulated pH dynamics at a glance","volume":"130","author":"White","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10555-019-09787-4","article-title":"Acidosis and cancer: From mechanism to neutralization","volume":"38","author":"Estrella","year":"2019","journal-title":"Cancer Metastasis Rev."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature10762","article-title":"Clonal evolution in cancer","volume":"481","author":"Greaves","year":"2012","journal-title":"Nature"},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Li, J.J., Tsang, J.Y., and Tse, G.M. (2021). Tumor Microenvironment in Breast Cancer\u2013Updates on Therapeutic Implications and Pathologic Assessment. Cancers, 13.","DOI":"10.3390\/cancers13164233"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1038\/s41467-023-41518-w","article-title":"The tumor microenvironment shows a hierarchy of cell-cell interactions dominated by fibroblasts","volume":"14","author":"Mayer","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/cac2.12291","article-title":"Cancer-associated fibroblasts in breast cancer: Challenges and opportunities","volume":"42","author":"Hu","year":"2022","journal-title":"Cancer Commun."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2478\/tumor-2013-0001","article-title":"Cancer-associated Fibroblasts and Therapies That Interfere with Their Activity","volume":"1","author":"Takebe","year":"2013","journal-title":"Tumor Microenviron. Ther."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"668221","DOI":"10.3389\/fimmu.2021.668221","article-title":"Predator-Prey in Tumor-Immune Interactions: A Wrong Model or Just an Incomplete One?","volume":"12","author":"Kareva","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Taylor, T.B., Wass, A.V., Johnson, L.J., and Dash, P. (2017). Resource competition promotes tumour expansion in experimentally evolved cancer. BMC Evol. Biol., 17.","DOI":"10.1186\/s12862-017-1117-6"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fonc.2020.00476","article-title":"Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology","volume":"10","author":"Brown","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.meegid.2013.08.005","article-title":"Of parasites and men","volume":"20","author":"Thomas","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Song, X., Wei, C., and Li, X. (2022). The Relationship between Microbial Community and Breast Cancer. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.849022"},{"key":"ref_270","first-page":"46","article-title":"Metastatic cancer stem cells: From the concept to therapeutics","volume":"3","author":"Liao","year":"2014","journal-title":"Am. J. Stem Cells"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"e14283","DOI":"10.15252\/emmm.202114283","article-title":"Feed-forward loops between metastatic cancer cells and their microenvironment\u2013The stage of escalation","volume":"14","author":"Baumann","year":"2022","journal-title":"EMBO Mol. Med."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"e9383","DOI":"10.1002\/ece3.9383","article-title":"Linking animal migration and ecosystem processes: Data-driven simulation of propagule dispersal by migratory herbivores","volume":"12","author":"Somveille","year":"2022","journal-title":"Ecol. Evol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"100899","DOI":"10.1016\/j.tranon.2020.100899","article-title":"Plasticity of cancer cell invasion: Patterns and mechanisms","volume":"14","author":"Wu","year":"2021","journal-title":"Transl. Oncol."},{"key":"ref_274","first-page":"109","article-title":"Circulating tumor cells and epithelial, mesenchymal and stemness markers: Characterization of cell subpopulations","volume":"2","author":"Barriere","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.3892\/ol.2016.5369","article-title":"Biomarkers for EMT and MET in breast cancer: An update","volume":"12","author":"Liu","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1111\/febs.14090","article-title":"Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer","volume":"284","author":"Sciacovelli","year":"2017","journal-title":"FEBS J."},{"key":"ref_277","first-page":"75","article-title":"Salmon spawning migration: Metabolic shifts and environmental triggers","volume":"4","author":"Miller","year":"2009","journal-title":"Comp. Biochem. Physiol. Part D Genom. Proteom."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"27990","DOI":"10.18632\/oncotarget.15856","article-title":"Breast cancer subtypes predict the preferential site of distant metastases: A SEER based study","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"860932","DOI":"10.3389\/fonc.2022.860932","article-title":"Changes in Pulmonary Microenvironment Aids Lung Metastasis of Breast Cancer","volume":"12","author":"Wu","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.bpj.2018.09.028","article-title":"Chemotaxis Model for Breast Cancer Cells Based on Signal\/Noise Ratio","volume":"115","author":"Lim","year":"2018","journal-title":"Biophys. J."},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Farahani, M.K., Gharibshahian, M., Rezvani, A., and Vaez, A. (2023). Breast cancer brain metastasis: From etiology to state-of-the-art modeling. J. Biol. Eng., 17.","DOI":"10.1186\/s13036-023-00352-w"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41698-018-0047-0","article-title":"Organotropism: New insights into molecular mechanisms of breast cancer metastasis","volume":"2","author":"Chen","year":"2018","journal-title":"npj Precis. Oncol."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1158\/0008-5472.CAN-17-2310","article-title":"Mutation Profiling of Key Cancer Genes in Primary Breast Cancers and Their Distant Metastases","volume":"78","author":"Schrijver","year":"2018","journal-title":"Cancer Res."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1158\/1078-0432.CCR-13-0897","article-title":"Molecular pathways: Niches in metastatic dormancy","volume":"20","author":"Yumoto","year":"2014","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"M\u0103g\u0103lie, A., Schwartz, D.A., Lennon, J.T., and Weitz, J.S. (2023). Optimal dormancy strategies in fluctuating environments given delays in phenotypic switching. J. Theor. Biol., 561.","DOI":"10.1016\/j.jtbi.2023.111413"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11914-017-0378-8","article-title":"Hypoxia and Bone Metastatic Disease","volume":"15","author":"Johnson","year":"2017","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41523-021-00269-x","article-title":"Breast cancer dormancy: Need for clinically relevant models to address current gaps in knowledge","volume":"7","author":"Bushnell","year":"2021","journal-title":"npj Breast Cancer"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12964-018-0259-5","article-title":"Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence","volume":"16","author":"Tivari","year":"2018","journal-title":"Cell Commun. Signal."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1245\/s10434-018-6615-2","article-title":"Timing and Delays in Breast Cancer Evaluation and Treatment","volume":"25","author":"Bleicher","year":"2018","journal-title":"Ann. Surg. Oncol."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"365","DOI":"10.21037\/atm-22-918","article-title":"The natural history of breast cancer: A chronological analysis of breast cancer progression using data from the SEER database","volume":"10","author":"Wu","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1038\/s41467-020-16995-y","article-title":"Looking backward in time to define the chronology of metastasis","volume":"11","author":"Hu","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10549-015-3419-y","article-title":"Second primary breast cancer in BRCA1 and BRCA2 mutation carriers: 10-year cumulative incidence in the Breast Cancer Family Registry","volume":"151","author":"Menes","year":"2015","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1139\/f80-017","article-title":"The River Continuum Concept","volume":"37","author":"Vannote","year":"1980","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1139\/cjfas-2020-0039","article-title":"The River Continuum Concept: Lessons from the past and perspectives for the future","volume":"77","author":"Doretto","year":"2020","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Tinganelli, W., and Durante, M. (2020). Tumor Hypoxia and Circulating Tumor Cells. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249592"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/mi5010013","article-title":"The Migration of Cancer Cells in Gradually Varying Chemical Gradients and Mechanical Constraints","volume":"5","author":"Rao","year":"2014","journal-title":"Micromachines"},{"key":"ref_297","doi-asserted-by":"crossref","unstructured":"Garg, A.A., Jones, T.H., Moss, S.M., Mishra, S., Kaul, K., Ahirwar, D.K., Ferree, J., Kumar, P., Subramaniam, D., and Ganju, R.K. (2019). Electromagnetic fields alter the motility of metastatic breast cancer cells. Commun. Biol., 2.","DOI":"10.1038\/s42003-019-0550-z"},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Varennes, J., Moon, H.-R., Saha, S., Mugler, A., and Han, B. (2019). Physical constraints on accuracy and persistence during breast cancer cell chemotaxis. PLoS Comput. Biol., 15.","DOI":"10.1371\/journal.pcbi.1006961"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"9307","DOI":"10.1096\/fj.202000101RR","article-title":"Cancer cells display increased migration and deformability in pace with metastatic progression","volume":"34","author":"Liu","year":"2020","journal-title":"FASEB J."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"R976","DOI":"10.1016\/j.cub.2018.04.044","article-title":"Collective animal migration","volume":"28","author":"Couzin","year":"2018","journal-title":"Curr. Biol."},{"key":"ref_301","doi-asserted-by":"crossref","unstructured":"Amintas, S., Bedel, A., Moreau-Gaudry, F., Boutin, J., Buscail, L., Merlio, J.-P., Vendrely, V., Dabernat, S., and Buscail, E. (2020). Circulating Tumor Cell Clusters: United We Stand Divided We Fall. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072653"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tree.2021.08.010","article-title":"Animal migration to northern latitudes: Environmental changes and increasing threats","volume":"37","author":"Kubelka","year":"2022","journal-title":"Trends Ecol. Evol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-319-42023-3_5","article-title":"Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment","volume":"Volume 936","author":"Rejniak","year":"2016","journal-title":"Systems Biology of Tumor Microenvironment"},{"key":"ref_304","doi-asserted-by":"crossref","unstructured":"Bulfoni, M., Turetta, M., Del Ben, F., Di Loreto, C., Beltrami, A.P., and Cesselli, D. (2016). Dissecting the Heterogeneity of Circulating Tumor Cells in Metastatic Breast Cancer: Going Far Beyond the Needle in the Haystack. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17101775"},{"key":"ref_305","doi-asserted-by":"crossref","unstructured":"Menyailo, M.E., Tretyakova, M.S., and Denisov, E.V. (2020). Heterogeneity of Circulating Tumor Cells in Breast Cancer: Identifying Metastatic Seeds. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051696"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1158\/0008-5472.CAN-12-4140","article-title":"Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing","volume":"73","author":"Heitzer","year":"2013","journal-title":"Cancer Res."},{"key":"ref_307","doi-asserted-by":"crossref","unstructured":"Park, H.-A., Brown, S.R., and Kim, Y. (2020). Cellular Mechanisms of Circulating Tumor Cells During Breast Cancer Metastasis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145040"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12014-020-09280-z","article-title":"Identification of TUBB2A by quantitative proteomic analysis as a novel biomarker for the prediction of distant metastatic breast cancer","volume":"17","author":"Shin","year":"2020","journal-title":"Clin. Proteom."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12014-022-09362-0","article-title":"Circulating proteins as predictive and prognostic biomarkers in breast cancer","volume":"19","author":"Bidet","year":"2022","journal-title":"Clin. Proteom."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1038\/s41467-023-39287-7","article-title":"Hypoxia induced responses are reflected in the stromal proteome of breast cancer","volume":"14","author":"Finne","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nm.3886","article-title":"Subclonal diversification of primary breast cancer revealed by multiregion sequencing","volume":"21","author":"Yates","year":"2015","journal-title":"Nat. Med."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1038\/s41416-022-01962-9","article-title":"Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer","volume":"127","author":"Nteliopoulos","year":"2022","journal-title":"Br. J. Cancer"},{"key":"ref_313","doi-asserted-by":"crossref","unstructured":"Bhatia, R., Chang, J., Munoz, J.L., and Walker, N.D. (2023). Forging New Therapeutic Targets: Efforts of Tumor Derived Exosomes to Prepare the Pre-Metastatic Niche for Cancer Cell Dissemination and Dormancy. Biomedicines, 11.","DOI":"10.3390\/biomedicines11061614"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.7150\/thno.45351","article-title":"Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells","volume":"11","author":"Yuan","year":"2021","journal-title":"Theranostics"},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.3390\/cancers3021580","article-title":"Delineating an Epigenetic Continuum for Initiation, Transformation and Progression to Breast Cancer","volume":"3","author":"Chen","year":"2011","journal-title":"Cancers"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ajpath.2018.07.031","article-title":"Morphologic and Molecular Features of Breast Ductal Carcinoma in Situ","volume":"189","author":"Sanati","year":"2019","journal-title":"Am. J. Pathol."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1016\/j.devcel.2021.11.006","article-title":"Distinct contributions of partial and full EMT to breast cancer malignancy","volume":"56","author":"Sugiyama","year":"2021","journal-title":"Dev. Cell"},{"key":"ref_318","doi-asserted-by":"crossref","unstructured":"Manfioletti, G., and Fedele, M. (2023). Epithelial-Mesenchymal Transition (EMT). Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411386"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/bcr2416","article-title":"Epithelial to mesenchymal transition and breast cancer","volume":"11","author":"Thompson","year":"2009","journal-title":"Breast Cancer Res."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41467-023-36439-7","article-title":"Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer","volume":"14","author":"Wiecek","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/s41588-019-0489-5","article-title":"A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition","volume":"51","author":"Hill","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_322","unstructured":"Kamboj, V., Kamboj, N., and Sharma, A. (2020). Environmental Degradation: Causes and Remediation Strategies, Agro Environ Media, Agriculture and Environmental Science Academy."},{"key":"ref_323","doi-asserted-by":"crossref","unstructured":"Terceiro, L.E.L., Edechi, C.A., Ikeogu, N.M., Nickel, B.E., Hombach-Klonisch, S., Sharif, T., Leygue, E., and Myal, Y. (2021). The Breast Tumor Microenvironment: A Key Player in Metastatic Spread. Cancers, 13.","DOI":"10.3390\/cancers13194798"},{"key":"ref_324","doi-asserted-by":"crossref","unstructured":"Saha, T., Solomon, J., Samson, A.O., and Gil-Henn, H. (2021). Invasion and Metastasis as a Central Hallmark of Breast Cancer. J. Clin. 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