{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:46:34Z","timestamp":1768718794209,"version":"3.49.0"},"reference-count":23,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Research indicates compelling evidence of SARS-CoV-2 vertical transmission as a result of placental pathology. This study offers an approach to histopathological and immunohistochemical placental observations from SARS-CoV-2-positive mothers compared to negative ones. Out of the 44 examined placentas, 24 were collected from patients with a SARS-CoV-2 infection during pregnancy and 20 were collected from patients without infection. The disease group showed strong SARS-CoV-2 positivity of the membranes, trophoblasts, and fetal villous macrophages. Most infections occurred during the third trimester of pregnancy (66.6%). Pathology revealed areas consistent with avascular villi (AV) and thrombi in the chorionic vessels and umbilical cord in the positive group, suggesting fetal vascular malperfusion (FVM). This study shows SARS-CoV-2 has an impact on coagulation, demonstrated by fetal thrombotic vasculopathy (p = 0.01) and fibrin deposition (p = 0.01). Other observed features included infarction (17%), perivillous fibrin deposition (29%), intervillous fibrin (25%), delayed placental maturation (8.3%), chorangiosis (13%), chorioamnionitis (8.3%), and meconium (21%). The negative control group revealed only one case of placental infarction (5%), intervillous fibrin (5%), delayed placental maturation (5%), and chorioamnionitis (5%) and two cases of meconium (19%). Our study sheds light on the changes and differences that occurred in placentas from SARS-CoV-2-infected mothers and the control group. Further research is necessary to definitively establish whether SARS-CoV-2 is the primary culprit behind these intricate complications.<\/jats:p>","DOI":"10.3390\/ijms25031836","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T05:22:44Z","timestamp":1707110564000},"page":"1836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prompt Placental Histopathological and Immunohistochemical Assessment after SARS-CoV-2 Infection during Pregnancy\u2014Our Perspective of a Small Group"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4986-8025","authenticated-orcid":false,"given":"Daniela Eugenia","family":"Popescu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u015foara, Romania"},{"name":"Department of Neonatology, Premiere Hospital, Regina Maria Health Network, Calea Aradului, No. 113, 300645 Timi\u015foara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4629-5820","authenticated-orcid":false,"given":"Ioana","family":"Ro\u0219ca","sequence":"additional","affiliation":[{"name":"Faculty of Midwifery and Nursery, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria Cristina","family":"Jura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u015foara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Cioca","sequence":"additional","affiliation":[{"name":"Department of Pathology, Premiere Hospital, Regina Maria Health Network, Calea Aradului, No. 113, 300645 Timi\u015foara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-4561","authenticated-orcid":false,"given":"Ovidiu","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, University of Oradea, Universit\u0103\u021bii Street, No. 1, 410087 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoleta","family":"Lungu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u015foara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran-Lauren\u021biu","family":"Popa","sequence":"additional","affiliation":[{"name":"Department XII Obstetrics and Gynecology\u2014Obstetrics and Gynecology III, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u015foara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Ra\u021biu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timi\u015foara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u0103rioara","family":"Boia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. 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