{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:43:32Z","timestamp":1760143412394,"version":"build-2065373602"},"reference-count":145,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cystic fibrosis (CF) is a monogenic disease with different types of mutations that mainly affect the respiratory-digestive system. Calcium (Ca), phosphorus (P), and vitamin D (Vit-D) are essential nutrients for maintaining adequate growth and development, as well as key components in crucial metabolic pathways. Proper diagnosis, treatment, and response are decisive components of precision medicine. Therefore, we conducted a cross-sectional study to evaluate Ca, P, and Vit-D levels along with health and nutritional indicators, regarding their non-skeletal functions, in a series of CF patients. Anthropometric and clinical evaluation, biochemical analysis, dietary survey, and respiratory and pancreatic status were performed. Even though the results showed that all patients had normal dietary and serum Ca levels, 47% of patients had deficient Vit-D intake, 53% of patients had hypovitaminosis D, 35% had insufficient Vit-D levels, 18% had hypophosphatemia, 76% had elevated alkaline phosphate levels, 29% had hypercalciuria, and 65% had hyperphosphaturia. There were no significant differences between homozygous and compound heterozygous patients. Ca, P, and Vit-D levels were associated with body mass index; body composition; physical activity; diet; growth hormones; and the immune, liver, and kidney systems. We suggest a periodically evaluation of Ca and P losses.<\/jats:p>","DOI":"10.3390\/ijms25031900","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T05:22:44Z","timestamp":1707110564000},"page":"1900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1295-3752","authenticated-orcid":false,"given":"Marlene Fabiola","family":"Escobedo-Monge","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Valladolid, Avenida Ram\u00f3n y Cajal, 7, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianela","family":"Marcos-Temprano","sequence":"additional","affiliation":[{"name":"Castilla y Le\u00f3n Cystic Fibrosis Unit, University Clinical Hospital of Valladolid, Avenida Ram\u00f3n y Cajal, 3, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Parodi-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Science Faculty, University of Cadiz, Paseo de Carlos III, 28, 11003 C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6318-7333","authenticated-orcid":false,"given":"Mar\u00eda Antonieta","family":"Escobedo-Monge","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Science Faculty, University of Burgos, Plaza Misael Ba\u00f1uelos s\/n, 09001 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Alonso-Vicente","sequence":"additional","affiliation":[{"name":"Department of Pediatrics of the Faculty of Medicine, University of Valladolid; Section of Gastroenterology and Pediatric Nutrition, University Clinical Hospital of Valladolid, Avenida Ram\u00f3n y Cajal, 7, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Carmen","family":"Torres-Hinojal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Valladolid, Avenida Ram\u00f3n y Cajal, 7, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7255-7578","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Marug\u00e1n-Miguelsanz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics of the Faculty of Medicine, University of Valladolid; Section of Gastroenterology and Pediatric Nutrition, University Clinical Hospital of Valladolid, Avenida Ram\u00f3n y Cajal, 7, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3389\/fphar.2017.00390","article-title":"Personalized or Precision Medicine? 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