{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:32:39Z","timestamp":1784161959270,"version":"3.55.0"},"reference-count":76,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BIOCODEX MICROBIOTA FOUNDATION: National Research Grant Russia 2019"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Our aim was to study the association of endothelial dysfunction biomarkers with cirrhosis manifestations, bacterial translocation, and gut microbiota taxa. The fecal microbiome was assessed using 16S rRNA gene sequencing. Plasma levels of nitrite, big endothelin-1, asymmetric dimethylarginine (ADMA), presepsin, and claudin were measured as biomarkers of endothelial dysfunction, bacterial translocation, and intestinal barrier dysfunction. An echocardiography with simultaneous determination of blood pressure and heart rate was performed to evaluate hemodynamic parameters. Presepsin, claudin 3, nitrite, and ADMA levels were higher in cirrhosis patients than in controls. Elevated nitrite levels were associated with high levels of presepsin and claudin 3, the development of hemodynamic circulation, hypoalbuminemia, grade 2\u20133 ascites, overt hepatic encephalopathy, high mean pulmonary artery pressure, increased abundance of Proteobacteria and Erysipelatoclostridium, and decreased abundance of Oscillospiraceae, Subdoligranulum, Rikenellaceae, Acidaminococcaceae, Christensenellaceae, and Anaerovoracaceae. Elevated ADMA levels were associated with higher Child\u2013Pugh scores, lower serum sodium levels, hypoalbuminemia, grade 2\u20133 ascites, milder esophageal varices, overt hepatic encephalopathy, lower mean pulmonary artery pressure, and low abundance of Erysipelotrichia and Erysipelatoclostridiaceae. High big endothelin-1 levels were associated with high levels of presepsin and sodium, low levels of fibrinogen and cholesterol, hypocoagulation, increased Bilophila and Coprobacillus abundances, and decreased Alloprevotella abundance.<\/jats:p>","DOI":"10.3390\/ijms25041988","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T12:38:24Z","timestamp":1707223104000},"page":"1988","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gut Microbiota and Biomarkers of Endothelial Dysfunction in Cirrhosis"],"prefix":"10.3390","volume":"25","author":[{"given":"Irina","family":"Efremova","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Pogodinskaya Str. 1-1, 119435 Moscow, 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Pogodinskaya Str. 1-1, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8942-4851","authenticated-orcid":false,"given":"Oleg","family":"Medvedev","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Lomonosov Moscow State University, Leninskie Gori 1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-8207","authenticated-orcid":false,"given":"Anna","family":"Kudryavtseva","sequence":"additional","affiliation":[{"name":"Post-Genomic Research Laboratory, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6493-8378","authenticated-orcid":false,"given":"George","family":"Krasnov","sequence":"additional","affiliation":[{"name":"Post-Genomic Research Laboratory, Engelhardt 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Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salekh","family":"Aliev","sequence":"additional","affiliation":[{"name":"Consultative and Diagnostic Center 2 of the Moscow Health Department, Millionnaya Str. 6, 107564 Moscow, Russia"},{"name":"First Hospital Surgery Department, Pirogov Russian National Research Medical University, Ostrovityanova Str. 1-7, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Sedova","sequence":"additional","affiliation":[{"name":"Consultative and Diagnostic Center 2 of the Moscow Health Department, Millionnaya Str. 6, 107564 Moscow, Russia"},{"name":"Department of Clinical Laboratory Diagnostics, FGBOU DPO \u201cRussian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation\u201d, Barricadnaya Str. 2\/1-2, 125993 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kuropatkina","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Lomonosov Moscow State University, Leninskie Gori 1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Lomonosov Moscow State University, Leninskie Gori 1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-1032","authenticated-orcid":false,"given":"Maria","family":"Zharkova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Pogodinskaya Str. 1-1, 119435 Moscow, 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the Study of the Liver (2018). EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J. Hepatol., 69, 406\u2013460.","DOI":"10.1016\/j.jhep.2018.08.009"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jhep.2020.12.008","article-title":"New concepts and perspectives in decompensated cirrhosis","volume":"75","author":"Jalan","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.22416\/1382-4376-2021-31-4-70-99","article-title":"Clinical Recommendations of the Russian Scientific Liver Society and Russian Gastroenterological Association on Diagnosis and Treatment of Liver Fibrosis, Cirrhosis and Their Complications","volume":"31","author":"Ivashkin","year":"2021","journal-title":"Russ. J. Gastroenterol. Hepatol. Coloproctology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.suc.2021.09.005","article-title":"Management of Decompensated Cirrhosis and Associated Syndromes","volume":"102","author":"Chandna","year":"2022","journal-title":"Surg. Clin. North Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.3748\/wjg.v20.i18.5442","article-title":"Cirrhosis and its complications: Evidence based treatment","volume":"20","author":"Nusrat","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9320","DOI":"10.12998\/wjcc.v9.i31.9320","article-title":"Gut-liver axis in cirrhosis: Are hemodynamic changes a missing link?","volume":"9","author":"Maslennikov","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"121685","DOI":"10.1016\/j.lfs.2023.121685","article-title":"Gut microbiome as a therapeutic target for liver diseases","volume":"322","author":"Singh","year":"2023","journal-title":"Life Sci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Lee, N.Y., and Suk, K.T. (2020). The Role of the Gut Microbiome in Liver Cirrhosis Treatment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010199"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3748\/wjg.v29.i1.144","article-title":"Role of gut microbiota in the pathogenesis and therapeutics of minimal hepatic encephalopathy via the gut-liver-brain axis","volume":"29","author":"Luo","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.cmet.2022.09.017","article-title":"Gut-liver axis: Pathophysiological concepts and clinical implications","volume":"34","author":"Tilg","year":"2022","journal-title":"Cell Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s12072-023-10496-y","article-title":"Bacterial translocation occurs early in cirrhosis and triggers a selective inflammatory response","volume":"17","author":"Simbrunner","year":"2023","journal-title":"Hepatol. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.3748\/wjg.v25.i39.5897","article-title":"Gut-liver axis signaling in portal hypertension","volume":"25","author":"Simbrunner","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s12072-017-9798-x","article-title":"Gut-liver axis, cirrhosis and portal hypertension: The chicken and the egg","volume":"12","author":"Arab","year":"2018","journal-title":"Hepatol. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.3748\/wjg.v25.i33.4814","article-title":"Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation","volume":"25","author":"Nicoletti","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4254\/wjh.v7.i3.443","article-title":"Endothelial dysfunction in cirrhosis: Role of inflammation and oxidative stress","volume":"7","author":"Vairappan","year":"2015","journal-title":"World J. Hepatol."},{"key":"ref_16","first-page":"471","article-title":"Endothelial and microvascular function in liver cirrhosis: An old concept that needs re-evaluation?","volume":"35","author":"Papagiouvanni","year":"2022","journal-title":"Ann. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.3748\/wjg.v20.i10.2555","article-title":"Splanchnic vasodilation and hyperdynamic circulatory syndrome in cirrhosis","volume":"20","author":"Bolognesi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1478-3231.2011.02579.x","article-title":"Endothelial dysfunction in the regulation of cirrhosis and portal hypertension","volume":"32","author":"Iwakiri","year":"2012","journal-title":"Liver Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100527","DOI":"10.1016\/j.jhepr.2022.100527","article-title":"Hepatopulmonary syndrome","volume":"4","author":"Raevens","year":"2022","journal-title":"JHEP Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.12998\/wjcc.v10.i17.5531","article-title":"Pulmonary complications of portal hypertension: The overlooked decompensation","volume":"10","author":"Craciun","year":"2022","journal-title":"World J. Clin. Cases"},{"key":"ref_21","first-page":"237","article-title":"Pulmonary manifestations of chronic liver disease: A comprehensive review","volume":"33","author":"Soulaidopoulos","year":"2020","journal-title":"Ann. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2478\/jtim-2020-0024","article-title":"Pulmonary Complications in Patients with Liver Cirrhosis","volume":"8","author":"Benz","year":"2020","journal-title":"J. Transl. Int. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3350\/cmh.2023.0024","article-title":"Hepatorenal Syndrome: Current Concepts and Future Perspectives","volume":"29","author":"Jung","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.12998\/wjcc.v11.i6.1261","article-title":"Clinical and pathophysiological understanding of the hepatorenal syndrome: Still wrong or still not exactly right?","volume":"11","author":"Wilde","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"17562848221102679","DOI":"10.1177\/17562848221102679","article-title":"Management of hepatorenal syndrome in liver cirrhosis: A recent update","volume":"15","author":"Bera","year":"2022","journal-title":"Therap. Adv. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jhep.2013.12.019","article-title":"Altered profile of human gut microbiome is associated with cirrhosis and its complications","volume":"60","author":"Bajaj","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.4254\/wjh.v13.i5.557","article-title":"Gut dysbiosis is associated with poorer long-term prognosis in cirrhosis","volume":"13","author":"Maslennikov","year":"2021","journal-title":"World J. Hepatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"964","DOI":"10.5152\/tjg.2019.18551","article-title":"Is small intestinal bacterial overgrowth a cause of hyperdynamic circulation in cirrhosis?","volume":"30","author":"Maslennikov","year":"2019","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Efremova, I., Maslennikov, R., Poluektova, E., Zharkova, M., Kudryavtseva, A., Krasnov, G., Fedorova, M., Shirokova, E., Kozlov, E., and Levshina, A. (2023). Gut Dysbiosis and Hemodynamic Changes as Links of the Pathogenesis of Complications of Cirrhosis. Microorganisms, 11.","DOI":"10.3390\/microorganisms11092202"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/hep.1840180520","article-title":"Increased serum nitrite and nitrate levels in patients with cirrhosis: Relationship to endotoxemia","volume":"18","author":"Guarner","year":"1993","journal-title":"Hepatology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1572-0241.1999.00790.x","article-title":"Interleukin-6, nitric oxide, and the clinical and hemodynamic alterations of patients with liver cirrhosis","volume":"94","author":"Genesca","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1055\/s-2002-35413","article-title":"Elevated nitric oxide levels in patients with chronic liver disease and cirrhosis correlate with disease stage and parameters of hyperdynamic circulation","volume":"40","author":"Arkenau","year":"2002","journal-title":"Z. Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.biopha.2018.12.124","article-title":"Presepsin: A promising biomarker for the detection of bacterial infections","volume":"111","author":"Memar","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1001\/jamapediatrics.2022.1647","article-title":"Presepsin for the Diagnosis of Neonatal Early-Onset Sepsis: A Systematic Review and Meta-analysis","volume":"176","author":"Poggi","year":"2022","journal-title":"JAMA Pediatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5847\/wjem.j.issn.1920-8642.2014.01.002","article-title":"Presepsin as a novel sepsis biomarker","volume":"5","author":"Zou","year":"2014","journal-title":"World J. Emerg. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yang, H.S., Hur, M., Yi, A., Kim, H., Lee, S., and Kim, S.N. (2018). Prognostic value of presepsin in adult patients with sepsis: Systematic review and meta-analysis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191486"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cca.2016.11.003","article-title":"Diagnostic accuracy of presepsin (sCD14-ST) as a biomarker of infection and sepsis in the emergency department","volume":"464","author":"Torrella","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Igna, R., G\u00eerleanu, I., Cojocariu, C., Muz\u00eeca, C., Huiban, L., Sfarti, C., Cuciureanu, T., Chiriac, S., S\u00eengeap, A.M., and Petrea, O.C. (2022). The Role of Presepsin in Diagnosing Infections in Patients with Liver Cirrhosis and Overt Hepatic Encephalopathy. Diagnostics, 12.","DOI":"10.3390\/diagnostics12092077"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jhep.2021.01.016","article-title":"Presepsin as a biomarker of inflammation and prognosis in decompensated liver disease","volume":"75","author":"Ferrarese","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1515\/cclm-2020-1212","article-title":"Diagnostic and prognostic role of presepsin in patients with cirrhosis and bacterial infection","volume":"59","author":"Ferrarese","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.dld.2019.05.025","article-title":"Are presepsin and resistin better markers for bacterial infection in patients with decompensated liver cirrhosis?","volume":"51","author":"Fischer","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"ref_42","first-page":"604","article-title":"Presepsin levels in cirrhotic patients with bacterial infections and\/or portal hypertension-related bleeding, presenting with or without acute kidney injury","volume":"31","author":"Elefsiniotis","year":"2018","journal-title":"Ann. Gastroenterol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9172","DOI":"10.3748\/wjg.v22.i41.9172","article-title":"Presepsin teardown\u2014Pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis","volume":"22","author":"Papp","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.clinre.2018.11.014","article-title":"Plasma claudin-3 is associated with tumor necrosis factor-alpha-induced intestinal endotoxemia in liver disease","volume":"43","author":"Wang","year":"2019","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/nyas.13360","article-title":"Intestinal epithelial claudins: Expression and regulation in homeostasis and inflammation","volume":"1397","author":"Quiros","year":"2017","journal-title":"Ann. NY Acad. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1152\/physrev.00003.2008","article-title":"Zonulin and its regulation of intestinal barrier function: The biological door to inflammation, autoimmunity, and cancer","volume":"91","author":"Fasano","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e1251384","DOI":"10.1080\/21688370.2016.1251384","article-title":"Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases","volume":"4","author":"Sturgeon","year":"2016","journal-title":"Tissue Barriers"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1242\/jcs.113.24.4435","article-title":"Human zonulin, a potential modulator of intestinal tight junctions","volume":"113","author":"Wang","year":"2000","journal-title":"J. Cell Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/liv.14106","article-title":"Faecal microbiota from patients with cirrhosis has a low capacity to ferment non-digestible carbohydrates into short-chain fatty acids","volume":"39","author":"Jin","year":"2019","journal-title":"Liver Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/jvh.13216","article-title":"Gut microbiota dysbiosis in patients with hepatitis B virus-induced chronic liver disease covering chronic hepatitis, liver cirrhosis and hepatocellular carcinoma","volume":"27","author":"Zeng","year":"2020","journal-title":"J. Viral Hepat."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1002\/cam4.3045","article-title":"Liver cirrhosis contributes to the disorder of gut microbiota in patients with hepatocellular carcinoma","volume":"9","author":"Zheng","year":"2020","journal-title":"Cancer Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejphar.2019.03.055","article-title":"Asymmetric dimethylarginine: An crucial regulator in tissue fibrosis","volume":"854","author":"Zhao","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2842S","DOI":"10.1093\/jn\/134.10.2842S","article-title":"Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the L-arginine paradox and acts as a novel cardiovascular risk factor","volume":"134","year":"2004","journal-title":"J. Nutr."},{"key":"ref_54","first-page":"1467","article-title":"Association of asymmetric dimethylarginine and endothelial dysfunction","volume":"41","year":"2003","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2174\/1568026611313020007","article-title":"Asymmetric Dimethylarginine (ADMA): A promising biomarker for cardiovascular disease?","volume":"13","author":"Bouras","year":"2013","journal-title":"Curr. Top Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"11288","DOI":"10.3390\/ijms130911288","article-title":"Asymmetric dimethylarginine, endothelial dysfunction and renal disease","volume":"13","author":"Andrade","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/hep.20968","article-title":"A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis","volume":"42","author":"Laleman","year":"2005","journal-title":"Hepatology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2362.2007.01814.x","article-title":"ADMA correlates with portal pressure in patients with compensated cirrhosis","volume":"37","author":"Vizzutti","year":"2007","journal-title":"Eur. J. Clin. Invest."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"9466","DOI":"10.3748\/wjg.v21.i32.9466","article-title":"Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis","volume":"21","author":"Lluch","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"791","DOI":"10.7754\/Clin.Lab.2013.130534","article-title":"Does asymmetric dimethylarginine (ADMA) plasma concentration predict esophageal varices in patients with cirrhosis?","volume":"60","author":"Rolla","year":"2014","journal-title":"Clin. Lab."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1157\/13072475","article-title":"Relaci\u00f3n de los valores plasm\u00e1ticos de big endotelina-1 con NT-proBNP y la funci\u00f3n ventricular de pacientes con insuficiencia card\u00edaca Plasma concentration of big endothelin-1 and its relation with plasma NT-proBNP and ventricular function in heart failure patients","volume":"58","author":"Rivera","year":"2005","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/HYPERTENSIONAHA.119.12105","article-title":"Endothelin: 30 Years From Discovery to Therapy","volume":"74","author":"Barton","year":"2019","journal-title":"Hypertension"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cca.2020.03.008","article-title":"The endothelin system as target for therapeutic interventions in cardiovascular and renal disease","volume":"506","author":"Eroglu","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.peptides.2018.10.002","article-title":"Endothelin and the heart in health and diseases","volume":"111","author":"Miyauchi","year":"2019","journal-title":"Peptides"},{"key":"ref_65","first-page":"389","article-title":"Endothelin-1 level as a predictor of hepatopulmonary syndrome in liver cirrhosis","volume":"17","author":"Darmadi","year":"2020","journal-title":"Med. Glas. (Zenica)"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/gut.52.9.1355","article-title":"Portopulmonary hypertension in decompensated cirrhosis with refractory ascites","volume":"52","author":"Benjaminov","year":"2003","journal-title":"Gut"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1136\/gut.2005.088633","article-title":"Role of endothelin in systemic and portal resistance in cirrhosis","volume":"55","author":"Angus","year":"2006","journal-title":"Gut"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1177\/0003319710369101","article-title":"Plasma cytokines and portopulmonary hypertension in patients with cirrhosis waiting for orthotopic liver transplantation","volume":"61","author":"Pellicelli","year":"2010","journal-title":"Angiology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1499-3872(11)60066-0","article-title":"Portopulmonary hypertension and serum endothelin levels in hospitalized patients with cirrhosis","volume":"10","author":"Tsiakalos","year":"2011","journal-title":"Hepatobiliary Pancreat Dis. Int."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/jcla.20074","article-title":"Plasma nitrate\/nitrite and endothelin-1 in patients with liver cirrhosis","volume":"19","author":"Curgunlu","year":"2005","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_71","first-page":"149","article-title":"Plasma endothelin-1 concentrations in children with cirrhosis and their relationship to renal function and the severity of portal hypertension","volume":"35","author":"Bakr","year":"2002","journal-title":"J. Pediatr. Gastroenterol Nutr."},{"key":"ref_72","first-page":"596","article-title":"Serum endothelin and atrial natriuretic peptide in cirrhotic patients with ascites and hepatorenal syndrome","volume":"61","author":"Lo","year":"1998","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0168-8278(96)80025-0","article-title":"Plasma endothelin-1 and -3 in cirrhosis: Relationship with systemic hemodynamics, renal function and neurohumoral systems","volume":"24","author":"Bernardi","year":"1996","journal-title":"J. Hepatol."},{"key":"ref_74","first-page":"91","article-title":"Alternation of the level of plasma calcitonin gene related peptide and endothelin-1 in liver cirrhosis","volume":"38","author":"Zhan","year":"1999","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00004836-199310000-00011","article-title":"Increased plasma endothelin-1 levels in patients with cirrhosis and esophageal varices","volume":"17","author":"Isobe","year":"1993","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1053\/jlts.2000.9735","article-title":"Hepatic localization of endothelin-1 in patients with idiopathic portal hypertension and cirrhosis of the liver","volume":"6","author":"Kamath","year":"2000","journal-title":"Liver Transpl."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/4\/1988\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:56:05Z","timestamp":1760104565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/4\/1988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":76,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["ijms25041988"],"URL":"https:\/\/doi.org\/10.3390\/ijms25041988","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]}}}