{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:19:12Z","timestamp":1793830752520,"version":"4.6.1"},"reference-count":186,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["NIH R01AR081337 (GWA)"],"award-info":[{"award-number":["NIH R01AR081337 (GWA)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Innate lymphoid cells (ILCs) are a diverse population of lymphocytes classified into natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and ILCregs, broadly following the cytokine secretion and transcription factor profiles of classical T cell subsets. Nonetheless, the ILC lineage does not have rearranged antigen-specific receptors and possesses distinct characteristics. ILCs are found in barrier tissues such as the skin, lungs, and intestines, where they play a role between acquired immune cells and myeloid cells. Within the skin, ILCs are activated by the microbiota and, in turn, may influence the microbiome composition and modulate immune function through cytokine secretion or direct cellular interactions. In particular, ILC3s provide epithelial protection against extracellular bacteria. However, the mechanism by which these cells modulate skin health and homeostasis in response to microbiome changes is unclear. To better understand how ILC3s function against microbiota perturbations in the skin, we propose a role for these cells in response to Cutibacterium acnes, a predominant commensal bacterium linked to the inflammatory skin condition, acne vulgaris. In this article, we review current evidence describing the role of ILC3s in the skin and suggest functional roles by drawing parallels with ILC3s from other organs. We emphasize the limited understanding and knowledge gaps of ILC3s in the skin and discuss the potential impact of ILC3-microbiota crosstalk in select skin diseases. Exploring the dialogue between the microbiota and ILC3s may lead to novel strategies to ameliorate skin immunity.<\/jats:p>","DOI":"10.3390\/ijms25042021","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T06:12:58Z","timestamp":1707286378000},"page":"2021","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7630-0913","authenticated-orcid":false,"given":"Thao Tam","family":"To","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of California (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Chizara","family":"Oparaugo","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of California (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Kheshvadjian","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of California (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Penn State University College of Medicine, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-9864","authenticated-orcid":false,"given":"George W.","family":"Agak","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of California (UCLA), Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nagasawa, M., Spits, H., and Ros, X.R. (2018). Innate Lymphoid Cells (ILCs): Cytokine Hubs Regulating Immunity and Tissue Homeostasis. Cold Spring Harb. Perspect. Biol., 10.","DOI":"10.1101\/cshperspect.a030304"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.it.2022.04.009","article-title":"Transcription factor-driven regulation of ILC1 and ILC3","volume":"43","author":"Schroeder","year":"2022","journal-title":"Trends Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"aaa6566","DOI":"10.1126\/science.aaa6566","article-title":"Innate lymphoid cells. Innate lymphoid cells: A new paradigm in immunology","volume":"348","author":"Eberl","year":"2015","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.imlet.2013.11.003","article-title":"Innate lymphoid cells: New paradigm in immunology of inflammation","volume":"157","author":"Kumar","year":"2014","journal-title":"Immunol. Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nri3855","article-title":"Transcriptional regulation of innate lymphoid cell fate","volume":"15","author":"Serafini","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12835","DOI":"10.1073\/pnas.1406908111","article-title":"Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses","volume":"111","author":"Chappaz","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Elemam, N.M., Hannawi, S., and Maghazachi, A.A. (2017). Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules. Toxins, 9.","DOI":"10.3390\/toxins9120398"},{"key":"ref_8","first-page":"37","article-title":"Development, Homeostasis, and Heterogeneity of NK Cells and ILC1","volume":"395","author":"Seillet","year":"2016","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/ijc.2910160205","article-title":"Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells","volume":"16","author":"Herberman","year":"1975","journal-title":"Int. J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/eji.1830050209","article-title":"\u201cNatural\u201d killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell","volume":"5","author":"Kiessling","year":"1975","journal-title":"Eur. J. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"101284","DOI":"10.1016\/j.smim.2019.101284","article-title":"ILC regulation of T cell responses in inflammatory diseases and cancer","volume":"41","author":"Warner","year":"2019","journal-title":"Semin. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate Lymphoid Cells: 10 Years on","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41563-020-0783-8","article-title":"ILC1 drive intestinal epithelial and matrix remodelling","volume":"20","author":"Jowett","year":"2021","journal-title":"Nat. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2249.2010.04250.x","article-title":"Interfering with interferon-gamma signalling in intestinal epithelial cells: Selective inhibition of apoptosis-maintained secretion of anti-inflammatory interleukin-18 binding protein","volume":"163","author":"Schuhmann","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1172\/JCI124884","article-title":"IFN-gamma drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption","volume":"129","author":"Langer","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1126\/science.aac9593","article-title":"Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs","volume":"350","author":"Gasteiger","year":"2015","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/imr.12706","article-title":"The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms","volume":"286","author":"Kabata","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"Price","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12931-023-02422-5","article-title":"Dysbiosis of the intestinal fungal microbiota increases lung resident group 2 innate lymphoid cells and is associated with enhanced asthma severity in mice and humans","volume":"24","author":"Kanj","year":"2023","journal-title":"Respir. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/all.14318","article-title":"Type 2 immunity in the skin and lungs","volume":"75","author":"Akdis","year":"2020","journal-title":"Allergy"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cell.2017.07.027","article-title":"Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation","volume":"171","author":"Wang","year":"2017","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.3389\/fimmu.2018.01522","article-title":"Commentary: Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation","volume":"9","author":"Zeng","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41419-019-1540-2","article-title":"ILC3 function as a double-edged sword in inflammatory bowel diseases","volume":"10","author":"Zeng","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fimmu.2012.00072","article-title":"Functional Differences between Human NKp44\u2212 and NKp44+ RORC+ Innate Lymphoid Cells","volume":"3","author":"Hoorweg","year":"2012","journal-title":"Front. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chan, L., Mehrani, Y., Minott, J.A., Bridle, B.W., and Karimi, K. (2023). The Potential of Dendritic-Cell-Based Vaccines to Modulate Type 3 Innate Lymphoid Cell Populations. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032403"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.cell.2018.12.031","article-title":"Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium","volume":"176","author":"Kobayashi","year":"2019","journal-title":"Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.it.2019.12.004","article-title":"Skin-Resident Innate Lymphoid Cells-Cutaneous Innate Guardians and Regulators","volume":"41","author":"Kobayashi","year":"2020","journal-title":"Trends Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/jdv.18616","article-title":"Evolution of the facial skin microbiome during puberty in normal and acne skin","volume":"37","author":"Schneider","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jid.2017.07.842","article-title":"Phenotype and Antimicrobial Activity of Th17 Cells Induced by Propionibacterium acnes Strains Associated with Healthy and Acne Skin","volume":"138","author":"Agak","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"eabq1551","DOI":"10.1126\/sciadv.abq1551","article-title":"Identification of the niche and mobilization mechanism for tissue-protective multipotential bone marrow ILC progenitors","volume":"8","author":"Liu","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jaci.2021.07.025","article-title":"Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis","volume":"149","author":"Alkon","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jid.2023.07.011","article-title":"In-depth proteomic map of innate lymphoid cells from healthy human skin and blood","volume":"144","author":"Teunissen","year":"2023","journal-title":"J. Investig. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/eji.201646837","article-title":"CD69: From activation marker to metabolic gatekeeper","volume":"47","author":"Cibrian","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.4049\/jimmunol.150.3.1122","article-title":"Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells","volume":"150","author":"Picker","year":"1993","journal-title":"J. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.jid.2016.07.017","article-title":"In Situ Mapping of Innate Lymphoid Cells in Human Skin: Evidence for Remarkable Differences between Normal and Inflamed Skin","volume":"136","author":"Bruggen","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1002\/art.39261","article-title":"Brief report: Enrichment of activated group 3 innate lymphoid cells in psoriatic arthritis synovial fluid","volume":"67","author":"Leijten","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/jid.2013.477","article-title":"Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis","volume":"134","author":"Villanova","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.immuni.2010.10.017","article-title":"Regulated expression of nuclear receptor ROR\u03b3t confers distinct functional fates to NK cell receptor-expressing ROR\u03b3t+ innate lymphocytes","volume":"33","author":"Vonarbourg","year":"2010","journal-title":"Immunity"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e2016963118","DOI":"10.1073\/pnas.2016963118","article-title":"Chronic UV radiation-induced ROR\u03b3t+ IL-22-producing lymphoid cells are associated with mutant KC clonal expansion","volume":"118","author":"Lewis","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"C1757","DOI":"10.1152\/ajpcell.00147.2022","article-title":"Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides","volume":"323","author":"Slominski","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nrmicro2537","article-title":"The skin microbiome","volume":"9","author":"Grice","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/jid.2011.417","article-title":"Skin microbiome: Looking back to move forward","volume":"132","author":"Kong","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1615\/CritRevImmunol.v28.i6.10","article-title":"lnterleukin-16: The ins and outs of regulating T-cell activation","volume":"28","author":"Cruikshank","year":"2008","journal-title":"Crit. Rev. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.1243364","article-title":"Nonredundant function of soluble LTalpha3 produced by innate lymphoid cells in intestinal homeostasis","volume":"342","author":"Kruglov","year":"2013","journal-title":"Science"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.aaa4812","article-title":"Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells","volume":"348","author":"Hepworth","year":"2015","journal-title":"Science"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41586-022-05141-x","article-title":"ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut","volume":"610","author":"Lyu","year":"2022","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.4049\/jimmunol.1601554","article-title":"IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-kappaB","volume":"199","author":"Victor","year":"2017","journal-title":"J. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1084\/jem.20100348","article-title":"Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells","volume":"207","author":"Bachem","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chom.2011.06.002","article-title":"Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge","volume":"10","author":"Tumanov","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Singh, T.P., Carvalho, A.M., Sacramento, L.A., Grice, E.A., and Scott, P. (2021). Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis. PLoS Pathog., 17.","DOI":"10.1101\/2021.06.08.447514"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"11394","DOI":"10.1038\/ncomms11394","article-title":"Epidermal Notch1 recruits ROR\u03b3+ group 3 innate lymphoid cells to orchestrate normal skin repair","volume":"7","author":"Li","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1249288","DOI":"10.1126\/science.1249288","article-title":"Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis","volume":"343","author":"Mortha","year":"2014","journal-title":"Science"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"eabo2787","DOI":"10.1126\/sciimmunol.abo2787","article-title":"TREM2 macrophages induced by human lipids drive inflammation in acne lesions","volume":"7","author":"Do","year":"2022","journal-title":"Sci. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.immuni.2021.05.007","article-title":"GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair","volume":"54","author":"Wang","year":"2021","journal-title":"Immunity"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Yang, D., Li, Y., Liu, T., Yang, L., He, L., Huang, T., Zhang, L., Luo, J., and Liu, C. (2023). IL-1beta promotes IL-17A production of ILC3s to aggravate neutrophilic airway inflammation in mice. Immunology.","DOI":"10.1111\/imm.13644"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.jid.2016.04.029","article-title":"Expanding the List of Dysregulated Immunosuppressive Cells in Psoriasis","volume":"136","author":"Soler","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e12916","DOI":"10.1111\/dth.12916","article-title":"Biologics for psoriasis: What is new?","volume":"32","author":"Ozyurt","year":"2019","journal-title":"Dermatol. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"9444","DOI":"10.4081\/dr.2022.9444","article-title":"Immunohistochemical expression of interleukin 1 beta in papule biopsies from patients with acne vulgaris","volume":"14","author":"Thanh","year":"2022","journal-title":"Dermatol. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/jid.2013.309","article-title":"Propionibacterium acnes Induces IL-1beta secretion via the NLRP3 inflammasome in human monocytes","volume":"134","author":"Qin","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.abd.2023.02.007","article-title":"IL-1beta and IL-17 in cutaneous lupus erythematous skin biopsies: Could immunohistochemicals indicate a tendency towards systemic involvement?","volume":"99","author":"Lovato","year":"2024","journal-title":"An. Bras. Dermatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/ni.2830","article-title":"Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells","volume":"15","author":"Magri","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s41423-023-01041-w","article-title":"Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells","volume":"20","author":"Lv","year":"2023","journal-title":"Cell Mol. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.cell.2016.04.008","article-title":"Temporal Stability of the Human Skin Microbiome","volume":"165","author":"Oh","year":"2016","journal-title":"Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/exd.14158","article-title":"Dialog between skin and its microbiota: Emergence of \u201cCutaneous Bacterial Endocrinology\u201d","volume":"29","author":"Racine","year":"2020","journal-title":"Exp. Dermatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/jid.2013.21","article-title":"Propionibacterium acnes strain populations in the human skin microbiome associated with acne","volume":"133","author":"Tomida","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.jid.2018.01.022","article-title":"Methicillin-Resistant Staphylococcus aureus Colonization Is Associated with Decreased Skin Commensal Bacteria in Atopic Dermatitis","volume":"138","author":"Shi","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"eaah4680","DOI":"10.1126\/scitranslmed.aah4680","article-title":"Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis","volume":"9","author":"Nakatsuji","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1038\/jid.2011.182","article-title":"Microbial symbiosis with the innate immune defense system of the skin","volume":"131","author":"Gallo","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Shu, M., Wang, Y., Yu, J., Kuo, S., Coda, A., Jiang, Y., Gallo, R.L., and Huang, C.M. (2013). Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055380"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Cogen, A.L., Yamasaki, K., Muto, J., Sanchez, K.M., Crotty Alexander, L., Tanios, J., Lai, Y., Kim, J.E., Nizet, V., and Gallo, R.L. (2010). Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0008557"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e141594","DOI":"10.1172\/JCI141594","article-title":"Extracellular traps released by antimicrobial TH17 cells contribute to host defense","volume":"131","author":"Agak","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.chom.2017.10.008","article-title":"Staphylococcus aureus Virulent PSMalpha Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation","volume":"22","author":"Nakagawa","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1194597","article-title":"Lineage relationship analysis of ROR\u03b3t+ innate lymphoid cells","volume":"330","author":"Sawa","year":"2010","journal-title":"Science"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Dunphy, S., and Gardiner, C.M. (2011). NK cells and psoriasis. J. Biomed. Biotechnol., 2011.","DOI":"10.1155\/2011\/248317"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/eji.200535503","article-title":"IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis","volume":"36","author":"Wolk","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/apm.13221","article-title":"Role of IL-22 in homeostasis and diseases of the skin","volume":"130","author":"Lopez","year":"2022","journal-title":"APMIS"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/jid.2013.334","article-title":"Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D","volume":"134","author":"Agak","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00281-009-0188-x","article-title":"Biology of interleukin-22","volume":"32","author":"Wolk","year":"2010","journal-title":"Semin. Immunopathol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"900634","DOI":"10.3389\/fimmu.2022.900634","article-title":"T Cell Extracellular Traps: Tipping the Balance between Skin Health and Disease","volume":"13","author":"Ouyang","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/jid.2014.290","article-title":"Propionibacterium acnes promotes Th17 and Th17\/Th1 responses in acne patients","volume":"135","author":"Kistowska","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Kelhala, H.L., Palatsi, R., Fyhrquist, N., Lehtimaki, S., Vayrynen, J.P., Kallioinen, M., Kubin, M.E., Greco, D., Tasanen, K., and Alenius, H. (2014). IL-17\/Th17 pathway is activated in acne lesions. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105238"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Firlej, E., Kowalska, W., Szymaszek, K., Rolinski, J., and Bartosinska, J. (2022). The Role of Skin Immune System in Acne. J. Clin. Med., 11.","DOI":"10.3390\/jcm11061579"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.jid.2016.05.125","article-title":"Antimicrobial Activity of Sebocytes against Propionibacterium acnes via Toll-Like Receptor 2 and Lysosomal Pathway","volume":"136","author":"Hisaw","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mib.2017.10.024","article-title":"Host-microbe interactions: Malassezia and human skin","volume":"40","author":"Grice","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1087-0024.2005.10119.x","article-title":"Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity","volume":"10","author":"DeAngelis","year":"2005","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.chom.2019.02.002","article-title":"The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation","volume":"25","author":"Sparber","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4049\/jimmunol.1202924","article-title":"Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection","volume":"190","author":"Gladiator","year":"2013","journal-title":"J. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"De Luca, A., Carvalho, A., Cunha, C., Iannitti, R.G., Pitzurra, L., Giovannini, G., Mencacci, A., Bartolommei, L., Moretti, S., and Massi-Benedetti, C. (2013). IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003486"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Johnson, C.J., Cabezas-Olcoz, J., Kernien, J.F., Wang, S.X., Beebe, D.J., Huttenlocher, A., Ansari, H., and Nett, J.E. (2016). The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005884"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1038\/s41396-021-00901-5","article-title":"Priority effects dictate community structure and alter virulence of fungal-bacterial biofilms","volume":"15","author":"Cheong","year":"2021","journal-title":"ISME J."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Carolus, H., Van Dyck, K., and Van Dijck, P. (2019). Candida albicans and Staphylococcus Species: A Threatening Twosome. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02162"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"748851","DOI":"10.3389\/fimmu.2021.748851","article-title":"Type 3 Innate Lymphoid Cells as Regulators of the Host-Pathogen Interaction","volume":"12","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.4049\/jimmunol.1303281","article-title":"Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection","volume":"192","author":"Jie","year":"2014","journal-title":"J. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1042\/CS20180482","article-title":"Type 3 innate lymphoid cell: A new player in liver fibrosis progression","volume":"132","author":"Wang","year":"2018","journal-title":"Clin. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ouyang, K., Zheng, D.X., and Agak, G.W. (2022). T-Cell Mediated Immunity in Merkel Cell Carcinoma. Cancers, 14.","DOI":"10.3390\/cancers14246058"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e2959","DOI":"10.7717\/peerj.2959","article-title":"Evolutionary and functional implications of hypervariable loci within the skin virome","volume":"5","author":"Hannigan","year":"2017","journal-title":"PeerJ"},{"key":"ref_98","first-page":"637","article-title":"Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review)","volume":"52","author":"Boda","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jaad.2017.12.001","article-title":"Merkel cell carcinoma: An update and review: Pathogenesis, diagnosis, and staging","volume":"78","author":"Coggshall","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Nguyen, A.V., and Soulika, A.M. (2019). The Dynamics of the Skin\u2019s Immune System. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081811"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"17011","DOI":"10.1038\/nrdp.2017.11","article-title":"Alopecia areata","volume":"3","author":"Pratt","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2017.04.1141","article-title":"Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis","volume":"78","author":"Strazzulla","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nm.3645","article-title":"Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition","volume":"20","author":"Xing","year":"2014","journal-title":"Nat. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/j.immuni.2021.09.001","article-title":"Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction","volume":"54","author":"Sakamoto","year":"2021","journal-title":"Immunity"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Rendon, A., and Schakel, K. (2019). Psoriasis Pathogenesis and Treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061475"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Gao, Y., Bian, Z., Xue, W., Li, Q., Zeng, Y., Wang, Y., Tang, L., Tang, T., Gao, X., and Guo, W. (2019). Human IL-23R Cytokine-Binding Homology Region-Fc Fusion Protein Ameliorates Psoriasis via the Decrease of Systemic Th17 and ILC3 Cell Responses. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174170"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mucimm.2023.01.001","article-title":"CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation","volume":"16","author":"Linley","year":"2023","journal-title":"Mucosal Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"916701","DOI":"10.3389\/fimmu.2022.916701","article-title":"Metabolic Syndrome in Psoriasis Is Associated with Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells","volume":"13","author":"Schielke","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1365-2133.1974.tb06447.x","article-title":"Staphylococcus aureus in the lesions of atopic dermatitis","volume":"90","author":"Leyden","year":"1974","journal-title":"Br. J. Dermatol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1101\/gr.131029.111","article-title":"Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis","volume":"22","author":"Kong","year":"2012","journal-title":"Genome Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.tim.2017.11.008","article-title":"Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship","volume":"26","author":"Geoghegan","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4172\/2155-9899.1000110","article-title":"Th2 Cytokines and Atopic Dermatitis","volume":"2","author":"Brandt","year":"2011","journal-title":"J. Clin. Cell Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Mazur, M., Tomczak, H., Lodyga, M., Plagens-Rotman, K., Merks, P., and Czarnecka-Operacz, M. (2023). The Intestinal and Skin Microbiome in Patients with Atopic Dermatitis and Their Influence on the Course of the Disease: A Literature Review. Healthcare, 11.","DOI":"10.3390\/healthcare11050766"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaci.2018.11.015","article-title":"The microbiome in patients with atopic dermatitis","volume":"143","author":"Paller","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/jid.2010.277","article-title":"IL-25 in atopic dermatitis: A possible link between inflammation and skin barrier dysfunction?","volume":"131","author":"Hvid","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jaci.2011.10.036","article-title":"Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity","volume":"129","author":"Kim","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jid.2019.08.447","article-title":"IL-17A-Producing Innate Lymphoid Cells Promote Skin Inflammation by Inducing IL-33-Driven Type 2 Immune Responses","volume":"140","author":"Kim","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/jdv.17095","article-title":"Full exome sequencing of 11 families with Hidradenitis suppurativa","volume":"35","author":"Loft","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1159\/000521263","article-title":"Whole-Exome Sequencing in 10 Unrelated Patients with Syndromic Hidradenitis Suppurativa: A Preliminary Step for a Genotype-Phenotype Correlation","volume":"238","author":"Marzano","year":"2022","journal-title":"Dermatology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/bjd\/ljac096","article-title":"Keratinocytes and immune cells in the epidermis are key drivers of inflammation in hidradenitis suppurativa providing a rationale for novel topical therapies","volume":"188","author":"Schell","year":"2023","journal-title":"Br. J. Dermatol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Petrasca, A., Hambly, R., Molloy, O., Kearns, S., Moran, B., Smith, C.M., Hughes, R., O\u2019Donnell, M., Zaborowski, A., and Winter, D. (2023). Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0281688"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"649348","DOI":"10.3389\/fimmu.2021.649348","article-title":"The Impact of Neutrophil Recruitment to the Skin on the Pathology Induced by Leishmania Infection","volume":"12","author":"Passelli","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1073\/pnas.0900226106","article-title":"Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps","volume":"106","author":"Nascimento","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"101014","DOI":"10.1016\/j.isci.2020.101014","article-title":"Preferential Perinatal Development of Skin-Homing NK1.1+ Innate Lymphoid Cells for Regulation of Cutaneous Microbiota Colonization","volume":"23","author":"Yang","year":"2020","journal-title":"iScience"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e20221534","DOI":"10.1084\/jem.20221534","article-title":"The cIAP ubiquitin ligases sustain type 3 gammadelta T cells and ILC during aging to promote barrier immunity","volume":"220","author":"Rizk","year":"2023","journal-title":"J. Exp. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/jid.2013.419","article-title":"Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration","volume":"134","author":"Lewis","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"108417","DOI":"10.1016\/j.celrep.2020.108417","article-title":"Keratinocyte-Macrophage Crosstalk by the Nrf2\/Ccl2\/EGF Signaling Axis Orchestrates Tissue Repair","volume":"33","author":"Tiruneh","year":"2020","journal-title":"Cell Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41536-020-0095-2","article-title":"Immune modulation of hair follicle regeneration","volume":"5","author":"Rahmani","year":"2020","journal-title":"NPJ Regen. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.jid.2018.04.010","article-title":"Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX(3)CR1- and TGF-beta1-Dependent Manner","volume":"138","author":"Rahmani","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"14091","DOI":"10.1038\/ncomms14091","article-title":"Macrophages induce AKT\/beta-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"113121","DOI":"10.1016\/j.celrep.2023.113121","article-title":"Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury","volume":"42","author":"Veniaminova","year":"2023","journal-title":"Cell Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"105805","DOI":"10.1016\/j.isci.2022.105805","article-title":"Distinct bulge stem cell populations maintain the pilosebaceous unit in a beta-catenin-dependent manner","volume":"26","author":"Han","year":"2023","journal-title":"iScience"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/wound.2020.1284","article-title":"Approaches for Regenerative Healing of Cutaneous Wound with an Emphasis on Strategies Activating the Wnt\/beta-Catenin Pathway","volume":"11","author":"Choi","year":"2022","journal-title":"Adv. Wound Care"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"8321","DOI":"10.7150\/thno.35467","article-title":"Pten loss in Lgr5+ hair follicle stem cells promotes SCC development","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Chen, H., Wang, X., Han, J., Fan, Z., Sadia, S., Zhang, R., Guo, Y., Jiang, Y., and Wu, Y. (2017). AKT and its related molecular feature in aged mice skin. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178969"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_137","first-page":"181","article-title":"The dermis as a portal for dendritic cell-targeted immunotherapy of cutaneous melanoma","volume":"351","author":"Oosterhoff","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41556-021-00670-5","article-title":"Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis","volume":"23","author":"Park","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.4049\/jimmunol.178.4.1986","article-title":"Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition","volume":"178","author":"Bos","year":"2007","journal-title":"J. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/978-1-59745-396-7_17","article-title":"Identification of pathogen receptors on dendritic cells to understand their function and to identify new drug targets","volume":"531","author":"Geijtenbeek","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"ref_141","first-page":"403","article-title":"Dendritic Cell Plasticity in Tumor-Conditioned Skin: CD14+ Cells at the Cross-Roads of Immune Activation and Suppression","volume":"4","author":"Lindenberg","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.immuni.2019.06.001","article-title":"Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells","volume":"51","author":"Pokrovskii","year":"2019","journal-title":"Immunity"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/ni.3318","article-title":"Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment","volume":"17","author":"Zhong","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nature11813","article-title":"A T-bet gradient controls the fate and function of CCR6-ROR\u03b3t+ innate lymphoid cells","volume":"494","author":"Klose","year":"2013","journal-title":"Nature"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.immuni.2018.05.013","article-title":"Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity","volume":"48","author":"Colonna","year":"2018","journal-title":"Immunity"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1146077","DOI":"10.3389\/fimmu.2023.1146077","article-title":"Transcriptional control of ILC identity","volume":"14","author":"Korchagina","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.immuni.2015.06.019","article-title":"Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria","volume":"43","author":"Bernink","year":"2015","journal-title":"Immunity"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.immuni.2013.02.010","article-title":"Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-gamma-producing cells","volume":"38","author":"Fuchs","year":"2013","journal-title":"Immunity"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.1005641107","article-title":"Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity","volume":"107","author":"Cella","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni.2534","article-title":"Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues","volume":"14","author":"Bernink","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/eji.201848075","article-title":"Suppression of Aiolos and Ikaros expression by lenalidomide reduces human ILC3-ILC1\/NK cell transdifferentiation","volume":"49","author":"Mazzurana","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"ra46","DOI":"10.1126\/scisignal.aaf2176","article-title":"Transforming growth factor-beta and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells","volume":"9","author":"Viant","year":"2016","journal-title":"Sci. Signal"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"ra45","DOI":"10.1126\/scisignal.aaf2223","article-title":"Notch signaling in group 3 innate lymphoid cells modulates their plasticity","volume":"9","author":"Chea","year":"2016","journal-title":"Sci. Signal"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bj.2020.12.004","article-title":"The Notch signaling pathway involvement in innate lymphoid cell biology","volume":"44","author":"Golub","year":"2021","journal-title":"Biomed. J."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ni.2545","article-title":"The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway","volume":"14","author":"Rankin","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/ni.3800","article-title":"Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells","volume":"18","author":"Gao","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41586-021-03188-w","article-title":"Skin-resident innate lymphoid cells converge on a pathogenic effector state","volume":"592","author":"Bielecki","year":"2021","journal-title":"Nature"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/s41590-019-0423-0","article-title":"c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies","volume":"20","author":"Bernink","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/eji.200535243","article-title":"CD56brightCD16\u2212 NK cells accumulate in psoriatic skin in response to CXCL10 and CCL5 and exacerbate skin inflammation","volume":"36","author":"Ottaviani","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2014.03.030","article-title":"Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages","volume":"157","author":"Klose","year":"2014","journal-title":"Cell"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.immuni.2011.11.016","article-title":"The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation","volume":"36","author":"Gordon","year":"2012","journal-title":"Immunity"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1084\/jem.20131560","article-title":"T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow","volume":"211","author":"Daussy","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/ni796","article-title":"In vivo developmental stages in murine natural killer cell maturation","volume":"3","author":"Kim","year":"2002","journal-title":"Nat. Immunol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2567.2009.03123.x","article-title":"Natural killer cell cytotoxicity: How do they pull the trigger?","volume":"128","author":"Topham","year":"2009","journal-title":"Immunology"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1002\/eji.1830251246","article-title":"Perforin dependence of natural killer cell-mediated tumor control in vivo","volume":"25","author":"Kagi","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1189\/jlb.0611308","article-title":"Natural killer cell-produced IFN-gamma and TNF-alpha induce target cell cytolysis through up-regulation of ICAM-1","volume":"91","author":"Wang","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1365-2249.2008.03638.x","article-title":"Possible role of natural killer cells in pemphigus vulgaris\u2014Preliminary observations","volume":"152","author":"Stern","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Younes, A.K., Hammad, R., Othman, M., and Sobhy, A. (2022). CD4, CD8 and natural killer cells are depressed in patients with alopecia areata: Their association with disease activity. BMC Immunol., 23.","DOI":"10.1186\/s12865-022-00486-4"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/sj.jid.5700527","article-title":"T helper type 2-biased natural killer cell phenotype in patients with pemphigus vulgaris","volume":"127","author":"Takahashi","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ni.3094","article-title":"Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets","volume":"16","author":"Robinette","year":"2015","journal-title":"Nat. Immunol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1038\/s41467-018-07405-5","article-title":"Memory formation and long-term maintenance of IL-7Ralpha+ ILC1s via a lymph node-liver axis","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"eabi8642","DOI":"10.1126\/sciimmunol.abi8642","article-title":"Cytotoxic granzyme C-expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity","volume":"7","author":"Nixon","year":"2022","journal-title":"Sci. Immunol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2017.09.052","article-title":"ILC1 Confer Early Host Protection at Initial Sites of Viral Infection","volume":"171","author":"Weizman","year":"2017","journal-title":"Cell"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/jid.2014.401","article-title":"Innate lymphoid cells in the skin","volume":"135","author":"Kim","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.coi.2013.07.013","article-title":"Innate lymphoid cells and allergic inflammation","volume":"25","author":"Kim","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.immuni.2012.10.002","article-title":"Striking similarity: GATA-3 regulates ILC2 and Th2 cells","volume":"37","author":"Zhou","year":"2012","journal-title":"Immunity"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"675169","DOI":"10.3389\/fimmu.2021.675169","article-title":"Role of ILC2 in Viral-Induced Lung Pathogenesis","volume":"12","author":"Fonseca","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jdermsci.2017.07.003","article-title":"Increased frequencies of basophils, type 2 innate lymphoid cells and Th2 cells in skin of patients with atopic dermatitis but not psoriasis","volume":"88","author":"Mashiko","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1084\/jem.20130351","article-title":"A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis","volume":"210","author":"Salimi","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/annrheumdis-2015-207388","article-title":"Type 2 innate lymphoid cell counts are increased in patients with systemic sclerosis and correlate with the extent of fibrosis","volume":"75","author":"Wohlfahrt","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1034\/j.1600-0625.2002.110104.x","article-title":"Intermediate or chronic cutaneous leishmaniasis: Leukocyte immunophenotypes and cytokine characterisation of the lesion","volume":"11","author":"Diaz","year":"2002","journal-title":"Exp. Dermatol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jdermsci.2014.01.009","article-title":"Immediate-type contact hypersensitivity is reduced in interleukin-33 knockout mice","volume":"74","author":"Imai","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/exd.14351","article-title":"Innate lymphoid cells in peripheral blood of patients with American Cutaneous Leishmaniasis","volume":"30","author":"Rodriguez","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/intimm\/dxv052","article-title":"Differentiation and function of group 3 innate lymphoid cells, from embryo to adult","volume":"28","author":"Vivier","year":"2016","journal-title":"Int. Immunol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/jid.2014.146","article-title":"Composition of innate lymphoid cell subsets in the human skin: Enrichment of NCR+ ILC3 in lesional skin and blood of psoriasis patients","volume":"134","author":"Teunissen","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.immuni.2018.05.010","article-title":"Innate Lymphoid Cell Development: A T Cell Perspective","volume":"48","author":"Cherrier","year":"2018","journal-title":"Immunity"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/4\/2021\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:56:26Z","timestamp":1760104586000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/4\/2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":186,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["ijms25042021"],"URL":"https:\/\/doi.org\/10.3390\/ijms25042021","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,7]]}}}