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I4.1"],"award-info":[{"award-number":["351\/2022 M4C1 I4.1"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["PRID BIRD225980"],"award-info":[{"award-number":["PRID BIRD225980"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE-1954456"],"award-info":[{"award-number":["CHE-1954456"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The 3d transition metal (Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)) complexes, supported by anions of sterically demanding \u03b2-diketones, 1,3-dimesitylpropane-1,3-dione (HLMes) and 1,3-bis(3,5-bis(trifluoromethyl)phenyl)-3-hydroxyprop-2-en-1-one (HLCF3), were synthesized and evaluated for their antitumor activity. To assess the biological effects of substituents on phenyl moieties, we also synthesized and investigated the analogous metal(II) complexes of the anion of the less bulky 1,3-diphenylpropane-1,3-dione (HLPh) ligand. The compounds [Cu(LCF3)2], [Cu(LMes)2] and ([Zn(LMes)2]) were characterized by X-ray crystallography. The [Cu(LCF3)2] crystallizes with an apical molecule of solvent (THF) and features a rare square pyramidal geometry at the Cu(II) center. The copper(II) and zinc(II) complexes of diketonate ligands, derived from the deprotonated 1,3-dimesitylpropane-1,3-dione (HLMes), adopt a square planar or a tetrahedral geometry at the metal, respectively. We evaluated the antitumor properties of the newly synthesized (Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)) complexes against a series of human tumor cell lines derived from different solid tumors. Except for iron derivatives, cellular studies revealed noteworthy antitumor properties, even towards cancer cells endowed with poor sensitivity to the reference drug cisplatin.<\/jats:p>","DOI":"10.3390\/ijms25042038","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T11:03:14Z","timestamp":1707303794000},"page":"2038","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Synthesis and Investigations of the Antitumor Effects of First-Row Transition Metal(II) Complexes Supported by Two Fluorinated and Non-Fluorinated \u03b2-Diketonates"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5020-1730","authenticated-orcid":false,"given":"Maura","family":"Pellei","sequence":"first","affiliation":[{"name":"School of Science and Technology\u2014Chemistry Division, University of Camerino, Via Madonna delle Carceri (ChIP), Camerino, 62032 Macerata, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u2019","family":"Del Gobbo","sequence":"additional","affiliation":[{"name":"School of Science and Technology\u2014Chemistry Division, University of Camerino, Via Madonna delle Carceri (ChIP), Camerino, 62032 Macerata, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Caviglia","sequence":"additional","affiliation":[{"name":"School of Science and Technology\u2014Chemistry Division, University of Camerino, Via Madonna delle Carceri (ChIP), Camerino, 62032 Macerata, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0442-0670","authenticated-orcid":false,"given":"Valentina","family":"Gandin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-2596","authenticated-orcid":false,"given":"Cristina","family":"Marzano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9565-6341","authenticated-orcid":false,"given":"Deepika V.","family":"Karade","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, P.O. Box 19065, Arlington, TX 76019, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Noonikara Poyil","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, P.O. Box 19065, Arlington, TX 76019, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. V. Rasika","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Arlington, P.O. Box 19065, Arlington, TX 76019, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3942-1713","authenticated-orcid":false,"given":"Carlo","family":"Santini","sequence":"additional","affiliation":[{"name":"School of Science and Technology\u2014Chemistry Division, University of Camerino, Via Madonna delle Carceri (ChIP), Camerino, 62032 Macerata, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"ref_1","unstructured":"Constable, E.C., Parkin, G., and Que, L. (2021). Comprehensive Coordination Chemistry III, Elsevier."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12197","DOI":"10.1021\/acssuschemeng.8b02532","article-title":"Stabilizing Effect of Bulky \u03b2-Diketones on Homogeneous Mo Catalysts for Deoxydehydration","volume":"6","author":"Stalpaert","year":"2018","journal-title":"ACS Sustain. Chem. 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