{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:09:03Z","timestamp":1792382943676,"version":"4.4.0"},"reference-count":82,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["DK081423"],"award-info":[{"award-number":["DK081423"]}]},{"name":"National Institutes of Health","award":["DK115703"],"award-info":[{"award-number":["DK115703"]}]},{"name":"National Institutes of Health","award":["DK091392"],"award-info":[{"award-number":["DK091392"]}]},{"name":"National Institutes of Health","award":["DK092461"],"award-info":[{"award-number":["DK092461"]}]},{"name":"Charles Pak Foundation","award":["DK081423"],"award-info":[{"award-number":["DK081423"]}]},{"name":"Charles Pak Foundation","award":["DK115703"],"award-info":[{"award-number":["DK115703"]}]},{"name":"Charles Pak Foundation","award":["DK091392"],"award-info":[{"award-number":["DK091392"]}]},{"name":"Charles Pak Foundation","award":["DK092461"],"award-info":[{"award-number":["DK092461"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A variety of changes in mineral metabolism aiming to restore acid\u2013base balance occur in acid loading and metabolic acidosis. Phosphate plays a key role in defense against metabolic acidosis, both as an intracellular and extracellular buffer, as well as in the renal excretion of excess acid in the form of urinary titratable acid. The skeleton acts as an extracellular buffer in states of metabolic acidosis, as the bone matrix demineralizes, leading to bone apatite dissolution and the release of phosphate, calcium, carbonate, and citrate into the circulation. The renal handling of calcium, phosphate and citrate is also affected, with resultant hypercalciuria, hyperphosphaturia and hypocitraturia.<\/jats:p>","DOI":"10.3390\/ijms25042081","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T09:00:02Z","timestamp":1707382802000},"page":"2081","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Effects of Acid on Calcium and Phosphate Metabolism"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-2239","authenticated-orcid":false,"given":"Juan D.","family":"Salcedo-Betancourt","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orson W.","family":"Moe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"},{"name":"Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"},{"name":"Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.12968\/bjon.2007.16.16.27082","article-title":"Short-term regulation of acid-base homeostasis of body fluids","volume":"16","author":"Clancy","year":"2007","journal-title":"Br. 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