{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:29:38Z","timestamp":1790188178386,"version":"4.1.0"},"reference-count":21,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MAECI Science and Technology Cooperation Italy-South Korea Grant Years 2023\u20132025 by the Italian Ministry of Foreign Affairs and International Cooperation","award":["CUP project: J53C23000300003"],"award-info":[{"award-number":["CUP project: J53C23000300003"]}]},{"name":"Italian Ministry of Health, Ricerca","award":["grant"],"award-info":[{"award-number":["grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The Second International StemNet (Federation of Stem Cell Research Associations) meeting took place on 18\u201320 October 2023 in Brescia (Italy), with the support of the University of Brescia and the Zooprophylactic Institute of Lombardy and Emilia Romagna. The program of the meeting was articulated in nine sections: (1) Biomedical Communication in Italy: Critical Aspects; (2) StemNet Next Generation Session; (3) Cell-Free Therapies; (4) Tips and Tricks of Research Valorisation; (5) Stem Cells and Cancer; (6) Stem Cells in Veterinary Applications; (7) Stem Cells in Clinical Applications; (8) Organoids and 3D Systems; (9) induced pluripotent stem cells (iPCS) and Gene Therapy. National and International speakers presented their scientific works, inspiring debates and discussions among the attendees. The participation in the meeting was high, especially because of the young researchers who animated all the sessions and the rich poster session.<\/jats:p>","DOI":"10.3390\/ijms25042221","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T04:09:21Z","timestamp":1707797361000},"page":"2221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["State of the Art and New Trends from the Second International StemNet Meeting"],"prefix":"10.3390","volume":"25","author":[{"given":"Ivana","family":"Ferrero","sequence":"first","affiliation":[{"name":"Stem Cell Transplantation and Cellular Therapy Laboratory, Paediatric Onco-Haematology Division, Regina Margherita Childrens\u2019 Hospital, City of Health and Science of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0371-7782","authenticated-orcid":false,"given":"Filippo","family":"Piccinini","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u2018\u2018Dino Amadori\u201d, 47014 Meldola, Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6644-5828","authenticated-orcid":false,"given":"Pasquale","family":"Marrazzo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3587-1768","authenticated-orcid":false,"given":"Manuela","family":"Monti","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u2018\u2018Dino Amadori\u201d, 47014 Meldola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-8686","authenticated-orcid":false,"given":"Caterina","family":"Pipino","sequence":"additional","affiliation":[{"name":"StemTeCh Group, Center for Advanced Studies and Technology-CAST, Department of Medical, Oral and Biotechnological Sciences, University G. D\u2019Annunzio Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia Santa Giovanna","family":"Banche Niclot","sequence":"additional","affiliation":[{"name":"Department of Public Health and Paediatrics, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla Francesca","family":"Proto","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation and Cellular Therapy Laboratory, Paediatric Onco-Haematology Division, Regina Margherita Childrens\u2019 Hospital, City of Health and Science of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-7417","authenticated-orcid":false,"given":"Enrico","family":"Ragni","sequence":"additional","affiliation":[{"name":"Laboratorio di Biotecnologie Applicate all\u2019Ortopedia, IRCCS Istituto Ortopedico Galeazzi, Via Cristina Belgioioso 173, 20157 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2481-7547","authenticated-orcid":false,"given":"Ralf","family":"Hass","sequence":"additional","affiliation":[{"name":"Biochemistry and Tumour Biology Laboratory, Department of Obstetrics and Gynecology, Hannover Medical School, D-30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Maria","family":"Stella","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, 27000 Pavia, Italy"},{"name":"Unit of Respiratory Diseases, Cardiothoracic and Vascular Department, IRCCS San Matteo Hospital Foundation, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0463-0611","authenticated-orcid":false,"given":"Priscilla","family":"Berni","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Parma, 43121 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-6882","authenticated-orcid":false,"given":"Ana","family":"Ivanovska","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Institute (REMEDI), University of Galway, H91 TK33 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-0394","authenticated-orcid":false,"given":"Katia","family":"Mareschi","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation and Cellular Therapy Laboratory, Paediatric Onco-Haematology Division, Regina Margherita Childrens\u2019 Hospital, City of Health and Science of Turin, 10126 Turin, Italy"},{"name":"Department of Public Health and Paediatrics, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tassone, F., Protic, D., Allen, E.G., Archibald, A.D., Baud, A., Brown, T.W., Budimirovic, D.B., Cohen, J., Dufour, B., and Eiges, R. (2023). Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on FMR1 Premutation. Cells, 12.","DOI":"10.3390\/cells12182330"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.freeradbiomed.2022.03.020","article-title":"Contraceptive Drug, Nestorone, Enhances Stem Cell-Mediated Remodeling of the Stroke Brain by Dampening Inflammation and Rescuing Mitochondria","volume":"183","author":"Lee","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pipino, C., Bernab\u00e9-Garc\u00eda, \u00c1., Cappellacci, I., Stelling-F\u00e9rez, J., Di Tomo, P., Santalucia, M., Naval\u00f3n, C., Pandolfi, A., and Nicol\u00e1s, F.J. (2022). Effect of the Human Amniotic Membrane on the Umbilical Vein Endothelial Cells of Gestational Diabetic Mothers: New Insight on Inflammation and Angiogenesis. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.854845"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Di Minin, G., Holzner, M., Grison, A., Dumeau, C.E., Chan, W., Monfort, A., Jerome-Majewska, L.A., Roelink, H., and Wutz, A. (2022). TMED2 Binding Restricts SMO to the ER and Golgi Compartments. PLoS Biol., 20.","DOI":"10.1371\/journal.pbio.3001596"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bergese, P., Hamad-Schifferli, K., and Montis, C. (2021). Biogenic, Hybrid and Synthetic Vesicles. Biochim. Biophys. Acta Gen. Subj., 1865.","DOI":"10.1016\/j.bbagen.2020.129779"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"750604","DOI":"10.3389\/fcvm.2021.750604","article-title":"Reawakening the Intrinsic Cardiac Regenerative Potential: Molecular Strategies to Boost Dedifferentiation and Proliferation of Endogenous Cardiomyocytes","volume":"8","author":"Bongiovanni","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Ragni, E., De Luca, P., Valli, F., Zagra, L., and de Girolamo, L. (2023). Inflammatory Treatment Used to Mimic Osteoarthritis and Patients\u2019 Synovial Fluid Have Divergent Molecular Impact on Chondrocytes In Vitro. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032625"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ceccotti, E., Saccu, G., Herrera Sanchez, M.B., and Bruno, S. (2023). Na\u00efve or Engineered Extracellular Vesicles from Different Cell Sources: Therapeutic Tools for Kidney Diseases. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15061715"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1478-811X-9-12","article-title":"Different Populations and Sources of Human Mesenchymal Stem Cells (MSC): A Comparison of Adult and Neonatal Tissue-Derived MSC","volume":"9","author":"Hass","year":"2011","journal-title":"Cell Commun. Signal"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1089\/scd.2013.0249","article-title":"Mesenchymal Stem Cells Directly Interact with Breast Cancer Cells and Promote Tumor Cell Growth in Vitro and in Vivo","volume":"22","author":"Mandel","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Hass, R. (2020). Role of MSC in the Tumor Microenvironment. Cancers, 12.","DOI":"10.3390\/cancers12082107"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pessina, A., Bonomi, A., Cocc\u00e8, V., Invernici, G., Navone, S., Cavicchini, L., Sisto, F., Ferrari, M., Vigan\u00f2, L., and Locatelli, A. (2011). Mesenchymal Stromal Cells Primed with Paclitaxel Provide a New Approach for Cancer Therapy. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028321"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Xu, L.-L., Yang, Y., Wang, Z., Wang, X.-J., Tong, Z.-H., and Shi, H.-Z. (2018). Malignant Pleural Mesothelioma: Diagnostic Value of Medical Thoracoscopy and Long-Term Prognostic Analysis. BMC Pulm. Med., 18.","DOI":"10.1186\/s12890-018-0619-3"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lisini, D., Nava, S., Frigerio, S., Pogliani, S., Maronati, G., Marcianti, A., Cocc\u00e8, V., Bondiolotti, G., Cavicchini, L., and Paino, F. (2020). Automated Large-Scale Production of Paclitaxel Loaded Mesenchymal Stromal Cells for Cell Therapy Applications. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12050411"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ferrara, B., Pignatelli, C., Cossutta, M., Citro, A., Courty, J., and Piemonti, L. (2021). The Extracellular Matrix in Pancreatic Cancer: Description of a Complex Network and Promising Therapeutic Options. Cancers, 13.","DOI":"10.3390\/cancers13174442"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Melzer, C., Rehn, V., Yang, Y., B\u00e4hre, H., von der Ohe, J., and Hass, R. (2019). Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells. Cancers, 11.","DOI":"10.3390\/cancers11060798"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cveq.2023.06.005","article-title":"Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions","volume":"39","author":"Pezzanite","year":"2023","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"897150","DOI":"10.3389\/fvets.2022.897150","article-title":"Manufacturing Mesenchymal Stromal Cells for the Treatment of Osteoarthritis in Canine Patients: Challenges and Recommendations","volume":"9","author":"Ivanovska","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mousaei Ghasroldasht, M., Seok, J., Park, H.-S., Liakath Ali, F.B., and Al-Hendy, A. (2022). Stem Cell Therapy: From Idea to Clinical Practice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052850"},{"key":"ref_20","unstructured":"(2024, January 25). EUR-Lex Regulation (EC) No 1394\/2007 of the European Parliament and of the Council of 13 November 2007 on Advanced Therapy Medicinal Pproducts and Amending Directive 2001\/83\/EC and Regulation (EC) No 726\/2004. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/en\/ALL\/?uri=CELEX%3A32007R1394."},{"key":"ref_21","unstructured":"(2024, January 25). Regulation (EU) No 536\/2014 of the European Parliament and of the Council of on Clinical Trials on Medicinal Products for Human Use, and Repealing Directive 2001\/20\/EC Text with EEA Relevance. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=celex%3A32014R0536."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/4\/2221\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:59:06Z","timestamp":1760104746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/4\/2221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["ijms25042221"],"URL":"https:\/\/doi.org\/10.3390\/ijms25042221","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]}}}