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The adverse effects and mortality\/morbidity rates associated with these NDDs are a cause of many healthcare concerns. The pathologic alterations of NDDs are related to mitochondrial dysfunction, oxidative stress, and inflammation, which further stimulate the progression of NDDs. Recently, long non-coding RNAs (lncRNAs) have attracted ample attention as critical mediators in the pathology of NDDs. However, there is a significant gap in understanding the biological function, molecular mechanisms, and potential importance of lncRNAs in NDDs. This review documents the current research on lncRNAs and their implications in NDDs. We further summarize the potential implication of lncRNAs to serve as novel therapeutic targets and biomarkers for patients with NDDs.<\/jats:p>","DOI":"10.3390\/ijms25042268","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T06:59:26Z","timestamp":1707893966000},"page":"2268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Long Non-Coding RNAs: New Insights in Neurodegenerative Diseases"],"prefix":"10.3390","volume":"25","author":[{"given":"Adithya K.","family":"Anilkumar","sequence":"first","affiliation":[{"name":"Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"},{"name":"South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Vij","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, St. John\u2019s University, Queens, NY 11439, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Lopez","sequence":"additional","affiliation":[{"name":"Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"},{"name":"South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia M.","family":"Leslie","sequence":"additional","affiliation":[{"name":"Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"},{"name":"South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Doxtater","sequence":"additional","affiliation":[{"name":"Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"},{"name":"South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-294X","authenticated-orcid":false,"given":"Mohammad Moshahid","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-8828","authenticated-orcid":false,"given":"Murali M.","family":"Yallapu","sequence":"additional","affiliation":[{"name":"Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"},{"name":"South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash C.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"},{"name":"South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys E.","family":"Maestre","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78550, USA"},{"name":"South Texas Alzheimer\u2019s Disease Research Center, School of Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish K.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"},{"name":"South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18923","DOI":"10.1038\/s41598-020-75014-8","article-title":"Genealogy of the neurodegenerative diseases based on a meta-analysis of age-stratified incidence data","volume":"10","author":"Gerovska","year":"2020","journal-title":"Sci. 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