{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:51Z","timestamp":1787028531619,"version":"build-2736575974"},"reference-count":129,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007388","name":"San Paolo-UNITO","doi-asserted-by":"publisher","award":["S1921_EX-POST_21_01"],"award-info":[{"award-number":["S1921_EX-POST_21_01"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Torino","award":["S1921_EX-POST_21_01"],"award-info":[{"award-number":["S1921_EX-POST_21_01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Iron overload in many brain regions is a common feature of aging and most neurodegenerative diseases. In this review, the causes, mechanisms, mathematical models, and possible therapies are summarized. Indeed, physiological and pathological conditions can be investigated using compartmental models mimicking iron trafficking across the blood\u2013brain barrier and the Cerebrospinal Fluid-Brain exchange membranes located in the choroid plexus. In silico models can investigate the alteration of iron homeostasis and simulate iron concentration in the brain environment, as well as the effects of intracerebral iron chelation, determining potential doses and timing to recover the physiological state. Novel formulations of non-toxic nanovectors with chelating capacity are already tested in organotypic brain models and could be available to move from in silico to in vivo experiments.<\/jats:p>","DOI":"10.3390\/ijms25042337","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T06:00:25Z","timestamp":1708063225000},"page":"2337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Iron Overload in Brain: Transport Mismatches, Microbleeding Events, and How Nanochelating Therapies May Counteract Their Effects"],"prefix":"10.3390","volume":"25","author":[{"given":"Eleonora","family":"Ficiar\u00e0","sequence":"first","affiliation":[{"name":"School of Pharmacy, University of Camerino, 62032 Camerino, MC, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9815-5446","authenticated-orcid":false,"given":"Ilaria","family":"Stura","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Universit\u00e0 degli Studi di Torino, 10125 Torino, TO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9748-2178","authenticated-orcid":false,"given":"Annamaria","family":"Vernone","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Universit\u00e0 degli Studi di Torino, 10125 Torino, TO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8800-9135","authenticated-orcid":false,"given":"Francesca","family":"Silvagno","sequence":"additional","affiliation":[{"name":"Department of Oncology, Universit\u00e0 degli Studi di Torino, 10126 Torino, TO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Cavalli","sequence":"additional","affiliation":[{"name":"Department of Drug Science and Technology, Universit\u00e0 degli Studi di Torino, 10125 Torino, TO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-1625","authenticated-orcid":false,"given":"Caterina","family":"Guiot","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Universit\u00e0 degli Studi di Torino, 10125 Torino, TO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3233\/JAD-201577","article-title":"Urban Air Pollution Nanoparticles from Los Angeles: Recently Decreased Neurotoxicity","volume":"82","author":"Zhang","year":"2021","journal-title":"J. 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