{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:50:02Z","timestamp":1790383802206,"version":"4.1.0"},"reference-count":134,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fu Jen Catholic University","award":["FJCU 111-A0111003"],"award-info":[{"award-number":["FJCU 111-A0111003"]}]},{"name":"Fu Jen Catholic University","award":["FJCU 112-A0112011"],"award-info":[{"award-number":["FJCU 112-A0112011"]}]},{"name":"Fu Jen Catholic University","award":["FJCU 112-48010104112"],"award-info":[{"award-number":["FJCU 112-48010104112"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This review explores the diverse applications of gold nanoparticles (AuNPs) in neurological diseases, with a specific focus on Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and stroke. The introduction highlights the pivotal role of neuroinflammation in these disorders and introduces the unique properties of AuNPs. The review\u2019s core examines the mechanisms by which AuNPs exert neuroprotection and anti-neuro-inflammatory effects, elucidating various pathways through which they manifest these properties. The potential therapeutic applications of AuNPs in AD are discussed, shedding light on promising avenues for therapy. This review also explores the prospects of utilizing AuNPs in PD interventions, presenting a hopeful outlook for future treatments. Additionally, the review delves into the potential of AuNPs in providing neuroprotection after strokes, emphasizing their significance in mitigating cerebrovascular accidents\u2019 aftermath. Experimental findings from cellular and animal models are consolidated to provide a comprehensive overview of AuNPs\u2019 effectiveness, offering insights into their impact at both the cellular and in vivo levels. This review enhances our understanding of AuNPs\u2019 applications in neurological diseases and lays the groundwork for innovative therapeutic strategies in neurology.<\/jats:p>","DOI":"10.3390\/ijms25042360","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T05:39:56Z","timestamp":1708321196000},"page":"2360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Gold Nanoparticles in Neurological Diseases: A Review of Neuroprotection"],"prefix":"10.3390","volume":"25","author":[{"given":"Ming-Chang","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Life Science, College of Science and Engineering, Fu Jen Catholic University, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-7676","authenticated-orcid":false,"given":"Yu-Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"},{"name":"Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J. B.","family":"Nicol","sequence":"additional","affiliation":[{"name":"Departments of Pathology & Molecular Medicine and Biomedical & Molecular Sciences, Cancer Biology and Genetics Division, Cancer Research Institute, Queen\u2019s University, Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Ju","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Life Science, College of Science and Engineering, Fu Jen Catholic University, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Villani, E.R., and Marzetti, E. (2023). Molecular Signals and Genetic Regulations of Neurological Disorders. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065902"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Yen, C., Lin, C.L., and Chiang, M.C. (2023). 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