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A comprehensive understanding of the molecular signaling pathways and cell interactions that play a role in thrombosis is essential for the development of precise therapeutic strategies for the treatment and prevention of thrombotic diseases. Ongoing research in this field is constantly uncovering new molecular players and pathways that offer opportunities for more precise interventions in the clinical setting. These molecular insights into thrombosis form the basis for the development of targeted therapeutic approaches for the treatment and prevention of thrombotic disease. The aim of this review is to provide an overview of the pathogenesis of thrombosis and to explore new therapeutic options.<\/jats:p>","DOI":"10.3390\/ijms25052523","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T10:52:00Z","timestamp":1708512720000},"page":"2523","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Research into New Molecular Mechanisms in Thrombotic Diseases Paves the Way for Innovative Therapeutic Approaches"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3928-4173","authenticated-orcid":false,"given":"Sara","family":"Sacchetti","sequence":"first","affiliation":[{"name":"Clinical Chemistry Laboratory, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0416-6687","authenticated-orcid":false,"given":"Chiara","family":"Puricelli","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mennuni","sequence":"additional","affiliation":[{"name":"Division of Cardiology, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Department of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1927-1566","authenticated-orcid":false,"given":"Valentina","family":"Zanotti","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7921-5501","authenticated-orcid":false,"given":"Luca","family":"Giacomini","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6686-4600","authenticated-orcid":false,"given":"Mara","family":"Giordano","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Dianzani","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5404-3968","authenticated-orcid":false,"given":"Giuseppe","family":"Patti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Department of Translational Medicine, University of Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0805-8285","authenticated-orcid":false,"given":"Roberta","family":"Rolla","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, \u201cMaggiore della Carit\u00e0\u201d University Hospital, Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref_1","unstructured":"GBD 2017 Causes of Death Collaborators (2018). 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