{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:18:29Z","timestamp":1791299909379,"version":"4.1.0"},"reference-count":25,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Science and Technology Program of Guangzhou, China","award":["202103000089"],"award-info":[{"award-number":["202103000089"]}]},{"name":"the Science and Technology Program of Guangzhou, China","award":["2023"],"award-info":[{"award-number":["2023"]}]},{"name":"the Science and Technology Program of Guangzhou, China","award":["2020B1515020026"],"award-info":[{"award-number":["2020B1515020026"]}]},{"name":"Guangdong Demonstration Base for Joint Cultivation of Postgraduates","award":["202103000089"],"award-info":[{"award-number":["202103000089"]}]},{"name":"Guangdong Demonstration Base for Joint Cultivation of Postgraduates","award":["2023"],"award-info":[{"award-number":["2023"]}]},{"name":"Guangdong Demonstration Base for Joint Cultivation of Postgraduates","award":["2020B1515020026"],"award-info":[{"award-number":["2020B1515020026"]}]},{"name":"Science Foundation for Distinguished Young Scholars of Guangdong, China","award":["202103000089"],"award-info":[{"award-number":["202103000089"]}]},{"name":"Science Foundation for Distinguished Young Scholars of Guangdong, China","award":["2023"],"award-info":[{"award-number":["2023"]}]},{"name":"Science Foundation for Distinguished Young Scholars of Guangdong, China","award":["2020B1515020026"],"award-info":[{"award-number":["2020B1515020026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This article aims to develop an aspirin-loaded double-modified nano-delivery system for the treatment of hepatocellular carcinoma. In this paper, mesoporous silica nanoparticles (MSN) were prepared by the \u201cone-pot two-phase layering method\u201d, and polydopamine (PDA) was formed by the self-polymerization of dopamine as a pH-sensitive coating. Gal-modified PDA-modified nanoparticles (Gal-PDA-MSN) were synthesized by linking galactosamine (Gal) with actively targeted galactosamine (Gal) to PDA-coated MSN by a Michael addition reaction. The size, particle size distribution, surface morphology, BET surface area, mesoporous size, and pore volume of the prepared nanoparticles were characterized, and their drug load and drug release behavior in vitro were investigated. Gal-PDA-MSN is pH sensitive and targeted. MSN@Asp is different from the release curves of PDA-MSN@Asp and Gal-PDA-MSN@Asp, the drug release of PDA-MSN@Asp and Gal-PDA-MSN@Asp accelerates with increasing acidity. In vitro experiments showed that the toxicity and inhibitory effects of the three nanodrugs on human liver cancer HepG2 cells were higher than those of free Asp. This drug delivery system facilitates controlled release and targeted therapy.<\/jats:p>","DOI":"10.3390\/ijms25052525","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T10:52:00Z","timestamp":1708512720000},"page":"2525","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Mesoporous Silicon Nanoparticles with Liver-Targeting and pH-Response-Release Function Are Used for Targeted Drug Delivery in Liver Cancer Treatment"],"prefix":"10.3390","volume":"25","author":[{"given":"Jintao","family":"Wei","sequence":"first","affiliation":[{"name":"Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University, Guangzhou 510006, China"},{"name":"Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Tan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University, Guangzhou 510006, China"},{"name":"Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincan","family":"He","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-6620","authenticated-orcid":false,"given":"Zhengquan","family":"Su","sequence":"additional","affiliation":[{"name":"Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University, Guangzhou 510006, China"},{"name":"Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.urolonc.2007.03.017","article-title":"New frontiers in nanotechnology for cancer treatment","volume":"26","author":"Alexis","year":"2008","journal-title":"Urol. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s10311-018-00841-1","article-title":"Nanocarriers for drug delivery applications","volume":"17","author":"Chamundeeswari","year":"2019","journal-title":"Environ. Chem. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1021\/acs.accounts.0c00280","article-title":"Silica-Based Nanoparticles for Biomedical Applications: From Nanocarri ers to Biomodulators","volume":"53","author":"Yang","year":"2020","journal-title":"ACC Chem. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"13850","DOI":"10.1002\/chem.201500578","article-title":"Mesoporous-Silica-Functionalized Nanoparticles for Drug Delivery","volume":"21","author":"Giret","year":"2015","journal-title":"Chemistry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jcis.2011.07.022","article-title":"Facile synthesis of 3D cubic mesoporous silica microspheres with a con trollable pore size and their application for improved delivery of a w ater-insoluble drug","volume":"363","author":"Hu","year":"2011","journal-title":"J. Colloid. Interface Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/17425247.2019.1575806","article-title":"Mesoporous silica nanoparticles: Synthesis, classification, drug loadi ng, pharmacokinetics, biocompatibility, and application in drug delive ry","volume":"16","author":"Li","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/adma.201104763","article-title":"Mesoporous silica nanoparticles: Synthesis, biocompatibility and drug delivery","volume":"24","author":"Tang","year":"2012","journal-title":"Adv. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"727123","DOI":"10.3389\/fchem.2021.727123","article-title":"Research Progress on Polydopamine Nanoparticles for Tissue Engineering","volume":"9","author":"Tang","year":"2021","journal-title":"Front. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lei, W., Sun, C., Jiang, T., Gao, Y., Yang, Y., Zhao, Q., and Wang, S. (2019). Polydopamine-coated mesoporous silica nanoparticles for multi-responsi ve drug delivery and combined chemo-photothermal therapy. Mater. Sci. Eng. C Mater. Biol. Appl., 105.","DOI":"10.1016\/j.msec.2019.110103"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11671","DOI":"10.1021\/acs.langmuir.5b02757","article-title":"Oxidative Self-Polymerization of Dopamine in an Acidic Environment","volume":"31","author":"Zheng","year":"2015","journal-title":"Langmuir"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1126\/science.1147241","article-title":"Mussel-inspired surface chemistry for multifunctional coatings","volume":"318","author":"Lee","year":"2007","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jconrel.2018.10.009","article-title":"Application of polydopamine in tumor targeted drug delivery system and its drug release behavior","volume":"290","author":"Wang","year":"2018","journal-title":"J. Control Release"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"He, X., Obeng, E., Sun, X., Kwon, N., Shen, J., and Yoon, J. (2022). Polydopamine, harness of the antibacterial potentials\u2014A review. Mater. Today Bio, 15.","DOI":"10.1016\/j.mtbio.2022.100329"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17150","DOI":"10.1039\/C6NR05502H","article-title":"Indocyanine green-loaded polydopamine-iron ions coordination nanoparti cles for photoacoustic\/magnetic resonance dual-modal imaging-guided ca ncer photothermal therapy","volume":"8","author":"Hu","year":"2016","journal-title":"Nanoscale"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jcis.2014.06.025","article-title":"Role of surfactants in the control of dopamine-eumelanin particle size and in the inhibition of film deposition at solid-liquid interfaces","volume":"431","author":"Ponzio","year":"2014","journal-title":"J. Colloid. Interface Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.2147\/IJN.S132270","article-title":"Mn2+-coordinated PDA@DOX\/PLGA nanoparticles as a smart ther anostic agent for synergistic chemo-photothermal tumor therapy","volume":"12","author":"Xi","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3109\/07388551.2014.930017","article-title":"Liver cell-targeted delivery of therapeutic molecules","volume":"36","author":"Kang","year":"2016","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jconrel.2015.02.022","article-title":"Asialoglycoprotein receptor mediated hepatocyte targeting\u2014Strategies and applications","volume":"203","author":"Devarajan","year":"2015","journal-title":"J. Control Release"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.nano.2015.12.381","article-title":"Drug delivery system targeting advanced hepatocellular carcinoma: Curr ent and future","volume":"12","author":"Zhang","year":"2016","journal-title":"Nanomedicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1002\/jps.20443","article-title":"Effect of galactose density on asialoglycoprotein receptor-mediated up take of galactosylated liposomes","volume":"94","author":"Managit","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev-med-051019-102940","article-title":"Aspirin in the Prevention of Cardiovascular Disease and Cancer","volume":"72","author":"Ricciotti","year":"2021","journal-title":"Annu. Rev. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1158\/0008-5472.CAN-21-0758","article-title":"Aspirin in Hepatocellular Carcinoma","volume":"81","author":"Ricciotti","year":"2021","journal-title":"Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2019.07.047","article-title":"Uncovering the mechanism of action of aspirin in HCC chemoprevention","volume":"46","author":"Roehlen","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/hep.31481","article-title":"Multiple Roles for Hepatitis B and C Viruses and the Host in the Devel opment of Hepatocellular Carcinoma","volume":"73","author":"Wangensteen","year":"2021","journal-title":"Hepatology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1021\/acsami.8b18107","article-title":"Polydopamine Coating Enhances Mucopenetration and Cell Uptake of Nanop articles","volume":"11","author":"Poinard","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/2525\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:02:36Z","timestamp":1760104956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/2525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25052525"],"URL":"https:\/\/doi.org\/10.3390\/ijms25052525","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]}}}