{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:28:31Z","timestamp":1789730911731,"version":"4.0.1"},"reference-count":220,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This comprehensive review delves into the multifaceted roles of mesenchymal stem cells (MSCs) in leukemia, focusing on their interactions within the bone marrow microenvironment and their impact on leukemia pathogenesis, progression, and treatment resistance. MSCs, characterized by their ability to differentiate into various cell types and modulate the immune system, are integral to the BM niche, influencing hematopoietic stem cell maintenance and functionality. This review extensively explores the intricate relationship between MSCs and leukemic cells in acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, and chronic lymphocytic leukemia. This review also addresses the potential clinical applications of MSCs in leukemia treatment. MSCs\u2019 role in hematopoietic stem cell transplantation, their antitumor effects, and strategies to disrupt chemo-resistance are discussed. Despite their therapeutic potential, the dual nature of MSCs in promoting and inhibiting tumor growth poses significant challenges. Further research is needed to understand MSCs\u2019 biological mechanisms in hematologic malignancies and develop targeted therapeutic strategies. This in-depth exploration of MSCs in leukemia provides crucial insights for advancing treatment modalities and improving patient outcomes in hematologic malignancies.<\/jats:p>","DOI":"10.3390\/ijms25052527","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T10:52:00Z","timestamp":1708512720000},"page":"2527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biology and Therapeutic Properties of Mesenchymal Stem Cells in Leukemia"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5983-6686","authenticated-orcid":false,"given":"Cheng-Hsien","family":"Wu","sequence":"first","affiliation":[{"name":"School of Medicine, National Defense Medical Center, Taipei 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-8671","authenticated-orcid":false,"given":"Te-Fu","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan"},{"name":"School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3406-4865","authenticated-orcid":false,"given":"Ju-Pi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan"},{"name":"Department of Pathology, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Hsi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan"},{"name":"School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/14653240500319234","article-title":"Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement","volume":"7","author":"Horwitz","year":"2005","journal-title":"Cytotherapy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ullah, I., Subbarao, R.B., and Rho, G.J. (2015). Human mesenchymal stem cells-current trends and future prospective. Biosci. Rep., 35.","DOI":"10.1042\/BSR20150025"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12185-017-2262-9","article-title":"Complexity of bone marrow hematopoietic stem cell niche","volume":"106","author":"Asada","year":"2017","journal-title":"Int. J. Hematol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.stem.2015.02.019","article-title":"Mesenchymal cell contributions to the stem cell niche","volume":"16","author":"Kfoury","year":"2015","journal-title":"Cell Stem Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.immuni.2018.03.024","article-title":"Niches for Hematopoietic Stem Cells and Their Progeny","volume":"48","author":"Wei","year":"2018","journal-title":"Immunity"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Barthes, J., \u00d6z\u00e7elik, H., Hindi\u00e9, M., Ndreu-Halili, A., Hasan, A., and Vrana, N.E. (2014). Cell microenvironment engineering and monitoring for tissue engineering and regenerative medicine: The recent advances. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/921905"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s13287-022-02985-y","article-title":"Mesenchymal stem cells and their microenvironment","volume":"13","author":"Liu","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/nyas.13016","article-title":"Niche heterogeneity in the bone marrow","volume":"1370","author":"Birbrair","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.gendis.2020.10.006","article-title":"Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment-specific factors involved in the regulation of MSC plasticity","volume":"9","author":"Tan","year":"2022","journal-title":"Genes. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6649314","DOI":"10.1155\/2021\/6649314","article-title":"Similarities between Tumour Immune Response and Chronic Wound Microenvironment: Influence of Mesenchymal Stromal\/Stem Cells","volume":"2021","author":"Peta","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1289\/ehp.9023","article-title":"Risk factors for acute leukemia in children: A review","volume":"115","author":"Belson","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"248","DOI":"10.20892\/j.issn.2095-3941.2016.0023","article-title":"Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang","volume":"13","author":"Zhou","year":"2016","journal-title":"Cancer Biol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1002\/ijc.26318","article-title":"Leukemia stem cells","volume":"129","author":"Buss","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/stem.2487","article-title":"Concise Review: The Malignant Hematopoietic Stem Cell Niche","volume":"35","author":"Yao","year":"2017","journal-title":"Stem Cells"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1126\/science.1164390","article-title":"Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells","volume":"322","author":"Colmone","year":"2008","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0740-2570(03)00031-5","article-title":"Classification of acute leukemias","volume":"20","author":"Brunning","year":"2003","journal-title":"Semin. Diagn. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cbi.2009.10.009","article-title":"The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: An overview with emphasis on the myeloid neoplasms","volume":"184","author":"Vardiman","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1134\/S0026893319060025","article-title":"Niches of Hematopoietic Stem Cells in Bone Marrow","volume":"53","author":"Belyavsky","year":"2019","journal-title":"Mol. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kandarakov, O., Belyavsky, A., and Semenova, E. (2022). Bone Marrow Niches of Hematopoietic Stem and Progenitor Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084462"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"114069","DOI":"10.1016\/j.addr.2021.114069","article-title":"The extracellular matrix of hematopoietic stem cell niches","volume":"181","author":"Schertl","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6854080","DOI":"10.1155\/2019\/6854080","article-title":"Emerging Role of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Pathogenesis of Haematological Malignancies","volume":"2019","author":"Cominal","year":"2019","journal-title":"Stem Cells Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1182\/blood.V78.1.55.55","article-title":"Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1","volume":"78","author":"Simmons","year":"1991","journal-title":"Blood"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3324\/haematol.2009.015065","article-title":"CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties","volume":"95","author":"Kreyenberg","year":"2010","journal-title":"Haematologica"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"Michurina","year":"2010","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","article-title":"Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment","volume":"131","author":"Sacchetti","year":"2007","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","article-title":"Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches","volume":"25","author":"Sugiyama","year":"2006","journal-title":"Immunity"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1182\/blood-2014-09-570192","article-title":"Making sense of hematopoietic stem cell niches","volume":"125","author":"Boulais","year":"2015","journal-title":"Blood"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1097\/HS9.0000000000000151","article-title":"Mesenchymal Stromal Cells: Role in the BM Niche and in the Support of Hematopoietic Stem Cell Transplantation","volume":"2","author":"Crippa","year":"2018","journal-title":"Hemasphere"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1084\/jem.20110132","article-title":"The bone marrow stem cell niche grows up: Mesenchymal stem cells and macrophages move in","volume":"208","author":"Ehninger","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s12015-011-9228-8","article-title":"Bone marrow mesenchymal stem cells: Biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation","volume":"7","author":"Pontikoglou","year":"2011","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1182\/blood-2004-06-2480","article-title":"Blood and bone: Two tissues whose fates are intertwined to create the hematopoietic stem-cell niche","volume":"105","author":"Taichman","year":"2005","journal-title":"Blood"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/stem.160007","article-title":"The role of osteoblasts in the hematopoietic microenvironment","volume":"16","author":"Taichman","year":"1998","journal-title":"Stem Cells"},{"key":"ref_37","first-page":"517","article-title":"Role of osteoblasts in the hematopoietic microenvironment of bone marrow and regulatory pathways and mechanisms","volume":"21","author":"Zhi","year":"2007","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.179.5.1677","article-title":"Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor","volume":"179","author":"Taichman","year":"1994","journal-title":"J. Exp. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1182\/blood-2003-11-4011","article-title":"Hematopoiesis is severely altered in mice with an induced osteoblast deficiency","volume":"103","author":"Visnjic","year":"2004","journal-title":"Blood"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1182\/blood-2006-08-041384","article-title":"Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells","volume":"109","author":"Zhu","year":"2007","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Batsali, A.K., Georgopoulou, A., Mavroudi, I., Matheakakis, A., Pontikoglou, C.G., and Papadaki, H.A. (2020). The Role of Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles (MSC-EVs) in Normal and Abnormal Hematopoiesis and Their Therapeutic Potential. J. Clin. Med., 9.","DOI":"10.3390\/jcm9030856"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature08099","article-title":"Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment","volume":"460","author":"Naveiras","year":"2009","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tcb.2015.01.004","article-title":"Ectosomes and exosomes: Shedding the confusion between extracellular vesicles","volume":"25","author":"Cocucci","year":"2015","journal-title":"Trends Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12964-016-0143-0","article-title":"Interaction of MSC with tumor cells","volume":"14","author":"Melzer","year":"2016","journal-title":"Cell Commun. Signal"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3324\/haematol.2017.183335","article-title":"Extracellular vesicles in the hematopoietic microenvironment","volume":"103","author":"Butler","year":"2018","journal-title":"Haematologica"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"531","DOI":"10.15171\/apb.2017.065","article-title":"The Effect of Mesenchymal Stem Cell-Derived Extracellular Vesicles on Hematopoietic Stem Cells Fate","volume":"7","author":"Timari","year":"2017","journal-title":"Adv. Pharm. Bull."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Yamamoto, Y., Xiao, Z., and Ochiya, T. (2019). The Immunomodulatory Functions of Mesenchymal Stromal\/Stem Cells Mediated via Paracrine Activity. J. Clin. Med., 8.","DOI":"10.3390\/jcm8071025"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5126156","DOI":"10.1155\/2019\/5126156","article-title":"Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics","volume":"2019","author":"Seo","year":"2019","journal-title":"Stem Cells Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s13287-019-1398-3","article-title":"Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles","volume":"10","author":"Park","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"45200","DOI":"10.18632\/oncotarget.16778","article-title":"Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis","volume":"8","author":"Gong","year":"2017","journal-title":"Oncotarget"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1038\/bcj.2016.50","article-title":"Acute myeloid leukemia: A comprehensive review and 2016 update","volume":"6","year":"2016","journal-title":"Blood Cancer J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"796","DOI":"10.21037\/tcr-22-27","article-title":"A systematic review and meta-analysis on the risk factors of acute myeloid leukemia","volume":"11","author":"Guo","year":"2022","journal-title":"Transl. Cancer Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/gcc.22756","article-title":"Clonal hematopoiesis and preleukemia-Genetics, biology, and clinical implications","volume":"58","author":"Hartmann","year":"2019","journal-title":"Genes. Chromosomes Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kosmidou, A., Tragiannidis, A., and Gavriilaki, E. (2023). Myeloid Leukemia of Down Syndrome. Cancers, 15.","DOI":"10.3390\/cancers15133265"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0889-8588(05)70340-3","article-title":"Therapy-related myeloid leukemia","volume":"10","author":"Thirman","year":"1996","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Ley","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2012.06.023","article-title":"The origin and evolution of mutations in acute myeloid leukemia","volume":"150","author":"Welch","year":"2012","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1182\/asheducation-2017.1.37","article-title":"Classification and risk assessment in AML: Integrating cytogenetics and molecular profiling","volume":"2017","author":"Moarii","year":"2017","journal-title":"Hematology Am. Soc. Hematol. Educ. Program."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.stemcr.2017.04.019","article-title":"Detailed Characterization of Mesenchymal Stem\/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment Outcomes","volume":"8","author":"Lavoie","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6720594","DOI":"10.1155\/2017\/6720594","article-title":"Mesenchymal Stem Cells in Myeloid Malignancies: A Focus on Immune Escaping and Therapeutic Implications","volume":"2017","author":"Fracchiolla","year":"2017","journal-title":"Stem Cells Int."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Brenner, A.K., Nepstad, I., and Bruserud, \u00d8. (2017). Mesenchymal Stem Cells Support Survival and Proliferation of Primary Human Acute Myeloid Leukemia Cells through Heterogeneous Molecular Mechanisms. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00106"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41375-019-0568-8","article-title":"Bone marrow mesenchymal stromal cells from acute myelogenous leukemia patients demonstrate adipogenic differentiation propensity with implications for leukemia cell support","volume":"34","author":"Azadniv","year":"2020","journal-title":"Leukemia"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Tan, Z., Kan, C., Wong, M., Sun, M., Liu, Y., Yang, F., Wang, S., and Zheng, H. (2022). Regulation of Malignant Myeloid Leukemia by Mesenchymal Stem Cells. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.857045"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s12015-017-9762-0","article-title":"Micro-RNA Profiling of Exosomes from Marrow-Derived Mesenchymal Stromal Cells in Patients with Acute Myeloid Leukemia: Implications in Leukemogenesis","volume":"13","author":"Lavoie","year":"2017","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbrc.2022.07.017","article-title":"Exosomes from bone marrow mesenchymal stem cells decrease chemosensitivity of acute myeloid leukemia cells via delivering miR-10a","volume":"622","author":"Wu","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1111\/cas.15855","article-title":"Acute myeloid leukemia (AML)-derived mesenchymal stem cells induce chemoresistance and epithelial-mesenchymal transition-like program in AML through IL-6\/JAK2\/STAT3 signaling","volume":"114","author":"Lu","year":"2023","journal-title":"Cancer Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","article-title":"Human mesenchymal stem cells modulate allogeneic immune cell responses","volume":"105","author":"Aggarwal","year":"2005","journal-title":"Blood"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Luciano, M., Krenn, P.W., and Horejs-Hoeck, J. (2022). The cytokine network in acute myeloid leukemia. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1000996"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41375-018-0373-9","article-title":"Mesenchymal stem cells in suppression or progression of hematologic malignancy: Current status and challenges","volume":"33","author":"Lee","year":"2019","journal-title":"Leukemia"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1111\/cas.13334","article-title":"Double-edged sword of mesenchymal stem cells: Cancer-promoting versus therapeutic potential","volume":"108","author":"Lee","year":"2017","journal-title":"Cancer Sci."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Yagi, H., and Kitagawa, Y. (2013). The role of mesenchymal stem cells in cancer development. Front. Genet., 4.","DOI":"10.3389\/fgene.2013.00261"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s12185-008-0030-6","article-title":"Effects of human bone marrow stromal cell line (HFCL) on the proliferation, differentiation and apoptosis of acute myeloid leukemia cell lines U937, HL-60 and HL-60\/VCR","volume":"87","author":"Liang","year":"2008","journal-title":"Int. J. Hematol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Fathi, E., Farahzadi, R., Valipour, B., and Sanaat, Z. (2019). Cytokines secreted from bone marrow derived mesenchymal stem cells promote apoptosis and change cell cycle distribution of K562 cell line as clinical agent in cell transplantation. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0215678"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/2211-5463.13352","article-title":"Bone marrow-mesenchymal stem cell-derived extracellular vesicles affect proliferation and apoptosis of leukemia cells in vitro","volume":"12","author":"Phetfong","year":"2022","journal-title":"FEBS Open Bio"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12935-021-01836-9","article-title":"Mesenchymal stem cells and cancer therapy: Insights into targeting the tumour vasculature","volume":"21","author":"Aravindhan","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1182\/asheducation-2018.1.137","article-title":"Genetics and prognosis of ALL in children vs. adults","volume":"2018","author":"Roberts","year":"2018","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e577","DOI":"10.1038\/bcj.2017.53","article-title":"Acute lymphoblastic leukemia: A comprehensive review and 2017 update","volume":"7","author":"Terwilliger","year":"2017","journal-title":"Blood Cancer J."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Tebbi, C.K. (2021). Etiology of Acute Leukemia: A Review. Cancers, 13.","DOI":"10.3390\/cancers13092256"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pcl.2014.09.004","article-title":"Biology of childhood acute lymphoblastic leukemia","volume":"62","author":"Bhojwani","year":"2015","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kakaje, A., Alhalabi, M.M., Ghareeb, A., Karam, B., Mansour, B., Zahra, B., and Hamdan, O. (2020). Rates and trends of childhood acute lymphoblastic leukaemia: An epidemiology study. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-63528-0"},{"key":"ref_82","first-page":"22869","article-title":"Global burden and trend of acute lymphoblastic leukemia from 1990 to 2017","volume":"12","author":"Yi","year":"2020","journal-title":"Aging"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhu, W., Liu, S., Shi, Y., Tang, Q., Sun, J., Bai, R., Sun, Z., and Du, Z. (2023). The epidemic of acute lymphoid leukemia in China: Current trends and future prediction. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1195065"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1200\/EDBK_200773","article-title":"The Landscape of CAR T Cells Beyond Acute Lymphoblastic Leukemia for Pediatric Solid Tumors","volume":"38","author":"DeRenzo","year":"2018","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.14634.1","article-title":"Genetics and epigenetics of pediatric leukemia in the era of precision medicine","volume":"7","author":"Ramos","year":"2018","journal-title":"F1000Res"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1182\/blood-2018-02-791350","article-title":"The rise of apoptosis: Targeting apoptosis in hematologic malignancies","volume":"132","author":"Valentin","year":"2018","journal-title":"Blood"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Fallati, A., Di Marzo, N., D\u2019Amico, G., and Dander, E. (2022). Mesenchymal Stromal Cells (MSCs): An Ally of B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells in Disease Maintenance and Progression within the Bone Marrow Hematopoietic Niche. Cancers, 14.","DOI":"10.3390\/cancers14143303"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"101669","DOI":"10.1016\/j.bonr.2023.101669","article-title":"Metabolic crosstalk between stromal and malignant cells in the bone marrow niche","volume":"18","author":"Tirado","year":"2023","journal-title":"Bone Rep."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Woods, K., and Guezguez, B. (2021). Dynamic Changes of the Bone Marrow Niche: Mesenchymal Stromal Cells and Their Progeny during Aging and Leukemia. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.714716"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.ccell.2020.04.015","article-title":"Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia","volume":"37","author":"Witkowski","year":"2020","journal-title":"Cancer Cell"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Hughes, A.M., Kuek, V., Oommen, J., Chua, G.A., van Loenhout, M., Malinge, S., Kotecha, R.S., and Cheung, L.C. (2023). Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1005494"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Chiu, M., Taurino, G., Bianchi, M.G., and Bussolati, O. (2021). The Role of Amino Acids in the Crosstalk Between Mesenchymal Stromal Cells and Neoplastic Cells in the Hematopoietic Niche. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.714755"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1182\/bloodadvances.2020004041","article-title":"ALL blasts drive primary mesenchymal stromal cells to increase asparagine availability during asparaginase treatment","volume":"5","author":"Chiu","year":"2021","journal-title":"Blood Adv."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1182\/blood-2015-03-634238","article-title":"B-cell precursor acute lymphoblastic leukemia cells use tunneling nanotubes to orchestrate their microenvironment","volume":"126","author":"Polak","year":"2015","journal-title":"Blood"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1038\/leu.2017.117","article-title":"Tunneling nanotubes facilitate autophagosome transfer in the leukemic niche","volume":"31","author":"Polak","year":"2017","journal-title":"Leukemia"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1182\/blood.2019001398","article-title":"Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress","volume":"134","author":"Burt","year":"2019","journal-title":"Blood"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s12185-020-02981-z","article-title":"Close interaction with bone marrow mesenchymal stromal cells induces the development of cancer stem cell-like immunophenotype in B cell precursor acute lymphoblastic leukemia cells","volume":"112","author":"Kihira","year":"2020","journal-title":"Int. J. Hematol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1182\/blood.V79.9.2370.2370","article-title":"Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia","volume":"79","author":"Manabe","year":"1992","journal-title":"Blood"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1182\/blood-2013-06-511527","article-title":"Reciprocal leukemia-stroma VCAM-1\/VLA-4-dependent activation of NF-\u03baB mediates chemoresistance","volume":"123","author":"Jacamo","year":"2014","journal-title":"Blood"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.celrep.2019.01.034","article-title":"Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promotes B-ALL Progression by Modulating CCL2 in Leukemia Cells","volume":"26","author":"Ma","year":"2019","journal-title":"Cell Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/s41419-022-05377-5","article-title":"Blockade of FGF2\/FGFR2 partially overcomes bone marrow mesenchymal stromal cells mediated progression of T-cell acute lymphoblastic leukaemia","volume":"13","author":"Tian","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/ijc.30848","article-title":"Mutation in the FGFR1 tyrosine kinase domain or inactivation of PTEN is associated with acquired resistance to FGFR inhibitors in FGFR1-driven leukemia\/lymphomas","volume":"141","author":"Cowell","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1038\/s41375-018-0124-y","article-title":"FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia\/lymphoma syndrome","volume":"32","author":"Hu","year":"2018","journal-title":"Leukemia"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1002\/ijc.32665","article-title":"Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia\/lymphoma syndrome","volume":"146","author":"Chong","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Ramuta, T., and Kreft, M.E. (2022). Mesenchymal Stem\/Stromal Cells May Decrease Success of Cancer Treatment by Inducing Resistance to Chemotherapy in Cancer Cells. Cancers, 14.","DOI":"10.3390\/cancers14153761"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13045-018-0554-z","article-title":"Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells","volume":"11","author":"Wang","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e2459","DOI":"10.1038\/cddis.2016.370","article-title":"ERK\/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells","volume":"7","author":"Cai","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.3324\/haematol.2017.186700","article-title":"Investigating chemoresistance to improve sensitivity of childhood T-cell acute lymphoblastic leukemia to parthenolide","volume":"103","author":"Ede","year":"2018","journal-title":"Haematologica"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Balandr\u00e1n, J.C., Purizaca, J., Enciso, J., Dozal, D., Sandoval, A., Jim\u00e9nez-Hern\u00e1ndez, E., Alem\u00e1n-Lazarini, L., Perez-Koldenkova, V., Quintela-N\u00fa\u00f1ez Del Prado, H., and Rios de Los R\u00edos, J. (2016). Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis. Front. Immunol., 7.","DOI":"10.3389\/fimmu.2016.00666"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"100825","DOI":"10.1016\/j.blre.2021.100825","article-title":"Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions","volume":"49","author":"Osman","year":"2021","journal-title":"Blood Rev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-0609.1977.tb01474.x","article-title":"The peripheral blood in chronic granulocytic leukaemia. Study of 50 untreated Philadelphia-positive cases","volume":"18","author":"Spiers","year":"1977","journal-title":"Scand. J. Haematol."},{"key":"ref_112","first-page":"1241","article-title":"Bone marrow histopathology in chronic myelogenous leukemia (CML)\u2014Evaluation of distinctive features with clinical impact","volume":"14","author":"Thiele","year":"1999","journal-title":"Histol. Histopathol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1056\/NEJM199907153410306","article-title":"The biology of chronic myeloid leukemia","volume":"341","author":"Faderl","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2147\/JBM.S382090","article-title":"Chronic Myeloid Leukemia, from Pathophysiology to Treatment-Free Remission: A Narrative Literature Review","volume":"14","author":"Rinaldi","year":"2023","journal-title":"J. Blood Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s11899-015-0248-3","article-title":"Chronic myeloid leukemia: Advances in understanding disease biology and mechanisms of resistance to tyrosine kinase inhibitors","volume":"10","author":"Eide","year":"2015","journal-title":"Curr. Hematol. Malig. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1186\/s13287-021-02659-1","article-title":"Chronic myeloid leukemia stem cells: Targeting therapeutic implications","volume":"12","author":"Mojtahedi","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12185-017-2295-0","article-title":"Treatment-free remission in patients with chronic myeloid leukemia","volume":"108","author":"Rea","year":"2018","journal-title":"Int. J. Hematol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.leukres.2006.04.013","article-title":"Bone marrow derived mesenchymal stem cells from chronic myeloid leukemia t(9;22) patients are devoid of Philadelphia chromosome and support cord blood stem cell expansion","volume":"30","author":"Jootar","year":"2006","journal-title":"Leuk. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1756-9966-30-47","article-title":"The research on the immuno-modulatory defect of mesenchymal stem cell from Chronic Myeloid Leukemia patients","volume":"30","author":"Xishan","year":"2011","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/leu.2011.291","article-title":"Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn\/CXCR4 interactions in lipid rafts","volume":"26","author":"Tabe","year":"2012","journal-title":"Leukemia"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1182\/blood-2012-02-412890","article-title":"Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-\u03b2-catenin signaling","volume":"121","author":"Zhang","year":"2013","journal-title":"Blood"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3324\/haematol.2009.017178","article-title":"Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4\/CXCL12 axis","volume":"95","author":"Vianello","year":"2010","journal-title":"Haematologica"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1158\/1535-7163.MCT-07-2331","article-title":"Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells","volume":"7","author":"Weisberg","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"12167","DOI":"10.1074\/jbc.RA119.008037","article-title":"Bone marrow-derived mesenchymal stromal cells promote resistance to tyrosine kinase inhibitors in chronic myeloid leukemia via the IL-7\/JAK1\/STAT5 pathway","volume":"294","author":"Zhang","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s41419-021-03499-w","article-title":"Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy","volume":"12","author":"Zuo","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Giallongo, C., Romano, A., Parrinello, N.L., La Cava, P., Brundo, M.V., Bramanti, V., Stagno, F., Vigneri, P., Chiarenza, A., and Palumbo, G.A. (2016). Mesenchymal Stem Cells (MSC) Regulate Activation of Granulocyte-Like Myeloid Derived Suppressor Cells (G-MDSC) in Chronic Myeloid Leukemia Patients. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158392"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/S0140-6736(18)30422-7","article-title":"Chronic lymphocytic leukaemia","volume":"391","author":"Hallek","year":"2018","journal-title":"Lancet"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.critrevonc.2016.06.003","article-title":"Chronic lymphocytic leukaemia","volume":"104","author":"Ferreri","year":"2016","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1200\/JCO.1999.17.1.399","article-title":"B-cell chronic lymphocytic leukemia: A bird of a different feather","volume":"17","author":"Hamblin","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"ref_130","first-page":"598","article-title":"Lymphocytic leukemia and exposures to benzene and other solvents in the rubber industry","volume":"25","author":"Arp","year":"1983","journal-title":"J. Occup. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/00039896.1985.10545920","article-title":"Leukemia cell types and agricultural practices in Nebraska","volume":"40","author":"Blair","year":"1985","journal-title":"Arch. Environ. Health"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/oxfordjournals.aje.a116362","article-title":"Smoking and risk of leukemia","volume":"135","author":"Brown","year":"1992","journal-title":"Am. J. Epidemiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1476-069X-9-31","article-title":"Exposure to benzene at work and the risk of leukemia: A systematic review and meta-analysis","volume":"9","author":"Khalade","year":"2010","journal-title":"Environ. Health"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/bmj.326.7383.242\/d","article-title":"Link found between Agent Orange and chronic lymphocytic leukaemia","volume":"326","author":"Marwick","year":"2003","journal-title":"BMJ"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1365-2141.2007.06843.x","article-title":"Chronic lymphocytic leukaemia and radiation: Findings among workers at five US nuclear facilities and a review of the recent literature","volume":"139","author":"Daniels","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/ijc.30814","article-title":"Occupational solvent exposure and adult chronic lymphocytic leukemia: No risk in a population-based case-control study in four Nordic countries","volume":"141","author":"Talibov","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature11309","article-title":"Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling","volume":"489","author":"Schneider","year":"2012","journal-title":"Nature"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1182\/blood-2012-01-404681","article-title":"Monoclonal B-cell lymphocytosis: Right track or red herring?","volume":"119","author":"Ghia","year":"2012","journal-title":"Blood"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.hoc.2013.01.002","article-title":"Biology of chronic lymphocytic leukemia in different microenvironments: Clinical and therapeutic implications","volume":"27","author":"Herishanu","year":"2013","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1182\/bloodadvances.2021006941","article-title":"The immune microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia","volume":"7","author":"Sun","year":"2023","journal-title":"Blood Adv."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Dubois, N., Crompot, E., Meuleman, N., Bron, D., Lagneaux, L., and Stamatopoulos, B. (2020). Importance of Crosstalk Between Chronic Lymphocytic Leukemia Cells and the Stromal Microenvironment: Direct Contact, Soluble Factors, and Extracellular Vesicles. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.01422"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Binder, M., L\u00e9chenne, B., Ummanni, R., Scharf, C., Balabanov, S., Trusch, M., Schl\u00fcter, H., Braren, I., Spillner, E., and Trepel, M. (2010). Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015992"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"42130","DOI":"10.18632\/oncotarget.6239","article-title":"Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): Implications for neoplastic cell survival","volume":"6","author":"Trimarco","year":"2015","journal-title":"Oncotarget"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s00277-011-1218-z","article-title":"Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma","volume":"90","author":"Plander","year":"2011","journal-title":"Ann. Hematol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2141.2009.07868.x","article-title":"Bi-directional activation between mesenchymal stem cells and CLL B-cells: Implication for CLL disease progression","volume":"147","author":"Ding","year":"2009","journal-title":"Br. J. Haematol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/jb\/mvaa064","article-title":"Exosomes derived from chronic lymphocytic leukaemia cells transfer miR-146a to induce the transition of mesenchymal stromal cells into cancer-associated fibroblasts","volume":"168","author":"Yang","year":"2020","journal-title":"J. Biochem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1182\/blood-2010-02-269894","article-title":"Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: Implications for an angiogenic switch","volume":"116","author":"Ding","year":"2010","journal-title":"Blood"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3727\/096368910X","article-title":"Mesenchymal stem cells","volume":"20","author":"Ding","year":"2011","journal-title":"Cell Transplant."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13287-019-1224-y","article-title":"Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies","volume":"10","author":"Noronha","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s13287-020-01855-9","article-title":"Mesenchymal stromal cell therapies: Immunomodulatory properties and clinical progress","volume":"11","author":"Wu","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/jnci\/djh299","article-title":"Mesenchymal stem cells: Potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents","volume":"96","author":"Studeny","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jconrel.2013.03.012","article-title":"Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: Effective photoinduced in vitro killing of osteosarcoma","volume":"168","author":"Duchi","year":"2013","journal-title":"J. Control Release"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jconrel.2012.07.034","article-title":"Mesenchymal stem cells as therapeutic agents and potential targeted gene delivery vehicle for brain diseases","volume":"162","author":"Huang","year":"2012","journal-title":"J. Control Release"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.nano.2012.06.003","article-title":"Mesenchymal stem cells: A potential targeted-delivery vehicle for anti-cancer drug, loaded nanoparticles","volume":"9","author":"Gao","year":"2013","journal-title":"Nanomedicine"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.addr.2010.08.010","article-title":"Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery","volume":"62","author":"Porada","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.bbmt.2011.07.023","article-title":"Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy","volume":"18","author":"Sundberg","year":"2012","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41423-023-01022-z","article-title":"Current perspectives on mesenchymal stromal cell therapy for graft versus host disease","volume":"20","author":"Kadri","year":"2023","journal-title":"Cell Mol. Immunol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13045-016-0276-z","article-title":"The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation","volume":"9","author":"Zhao","year":"2016","journal-title":"J. Hematol. Oncol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/stem.559","article-title":"Concise review: Dissecting a discrepancy in the literature: Do mesenchymal stem cells support or suppress tumor growth?","volume":"29","author":"Klopp","year":"2011","journal-title":"Stem Cells"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.exphem.2008.03.019","article-title":"Effects of plating density and culture time on bone marrow stromal cell characteristics","volume":"36","author":"Neuhuber","year":"2008","journal-title":"Exp. Hematol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/14653240802217011","article-title":"Heterogeneity of mesenchymal stromal cell preparations","volume":"10","author":"Ho","year":"2008","journal-title":"Cytotherapy"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"318098","DOI":"10.1155\/2014\/318098","article-title":"IFN-\u03b3-secreting-mesenchymal stem cells exert an antitumor effect in vivo via the TRAIL pathway","volume":"2014","author":"Yang","year":"2014","journal-title":"J. Immunol. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/hon.779","article-title":"In Vitro effect of adenovirus-mediated human Gamma Interferon gene transfer into human mesenchymal stem cells for chronic myelogenous leukemia","volume":"24","author":"Li","year":"2006","journal-title":"Hematol. Oncol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/mt.2008.3","article-title":"A tumor-selective biotherapy with prolonged impact on established metastases based on cytokine gene-engineered MSCs","volume":"16","author":"Chen","year":"2008","journal-title":"Mol. Ther."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2174\/156800913804486665","article-title":"Experimental therapy for lung cancer: Umbilical cord-derived mesenchymal stem cell-mediated interleukin-24 delivery","volume":"13","author":"Zhang","year":"2013","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2017.08.022","article-title":"Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia","volume":"264","author":"Gangadaran","year":"2017","journal-title":"J. Control Release"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Rajendran, R.L., Gangadaran, P., Bak, S.S., Oh, J.M., Kalimuthu, S., Lee, H.W., Baek, S.H., Zhu, L., Sung, Y.K., and Jeong, S.Y. (2017). Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-15505-3"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tice.2015.01.005","article-title":"Human Wharton\u2019s jelly mesenchymal stem cell secretome display antiproliferative effect on leukemia cell line and produce additive cytotoxic effect in combination with doxorubicin","volume":"47","author":"Hendijani","year":"2015","journal-title":"Tissue Cell"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1182\/blood-2003-02-0481","article-title":"Imatinib normalizes bone marrow vascularity in patients with chronic myeloid leukemia in first chronic phase","volume":"101","author":"Rumpel","year":"2003","journal-title":"Blood"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1182\/blood-2008-09-176198","article-title":"Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells","volume":"113","author":"Otsu","year":"2009","journal-title":"Blood"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1089\/ars.2005.7.1423","article-title":"Reactive oxygen species as signaling molecules in cardiovascular differentiation of embryonic stem cells and tumor-induced angiogenesis","volume":"7","author":"Sauer","year":"2005","journal-title":"Antioxid. Redox Signal"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3892\/ijmm.2015.2191","article-title":"Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia\/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant","volume":"36","author":"Song","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/sj.leu.2404489","article-title":"Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: Impact on in vivo tumor growth","volume":"21","author":"Ramasamy","year":"2007","journal-title":"Leukemia"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3892\/or.2013.2518","article-title":"Effect of bone marrow mesenchymal stem cells from blastic phase chronic myelogenous leukemia on the growth and apoptosis of leukemia cells","volume":"30","author":"Han","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_175","first-page":"209","article-title":"Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest","volume":"65","author":"Sarmadi","year":"2010","journal-title":"Med. J. Malaysia"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1756-9966-28-141","article-title":"Bone marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cells","volume":"28","author":"Wei","year":"2009","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1159\/000323973","article-title":"p38 MAPK contributes to the growth inhibition of leukemic tumor cells mediated by human umbilical cord mesenchymal stem cells","volume":"26","author":"Tian","year":"2010","journal-title":"Cell Physiol. Biochem."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature03097","article-title":"Cell-cycle checkpoints and cancer","volume":"432","author":"Kastan","year":"2004","journal-title":"Nature"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1182\/blood-2011-10-383406","article-title":"A phase 1\/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia","volume":"119","author":"Uy","year":"2012","journal-title":"Blood"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/ajh.25943","article-title":"Phase 1 study of combinatorial sorafenib, G-CSF, and plerixafor treatment in relapsed\/refractory, FLT3-ITD-mutated acute myelogenous leukemia patients","volume":"95","author":"Borthakur","year":"2020","journal-title":"Am. J. Hematol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1038\/leu.2017.87","article-title":"Combined inhibition of \u03b2-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo","volume":"31","author":"Zhou","year":"2017","journal-title":"Leukemia"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1158\/1078-0432.CCR-17-1556","article-title":"Disruption of Wnt\/\u03b2-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia","volume":"24","author":"Jiang","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1158\/0008-5472.CAN-18-0921","article-title":"An ARC-Regulated IL1\u03b2\/Cox-2\/PGE2\/\u03b2-Catenin\/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML","volume":"79","author":"Carter","year":"2019","journal-title":"Cancer Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1182\/bloodadvances.2019000757","article-title":"Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome","volume":"4","author":"Lee","year":"2020","journal-title":"Blood Adv."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.3324\/haematol.2019.231944","article-title":"CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity","volume":"106","author":"Gutjahr","year":"2021","journal-title":"Haematologica"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1182\/blood.2020006343","article-title":"CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues","volume":"138","author":"Yu","year":"2021","journal-title":"Blood"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1182\/blood.2021010721","article-title":"Phase 1\/2 study of uproleselan added to chemotherapy in patients with relapsed or refractory acute myeloid leukemia","volume":"139","author":"DeAngelo","year":"2022","journal-title":"Blood"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3324\/haematol.2014.119735","article-title":"Phase I\/II study of the combination of panobinostat and carfilzomib in patients with relapsed\/refractory multiple myeloma","volume":"100","author":"Berdeja","year":"2015","journal-title":"Haematologica"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1158\/1078-0432.CCR-18-3886","article-title":"A Phase I\/II Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib for Relapsed Refractory Acute Myeloid Leukemia","volume":"25","author":"Advani","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Wong, R.S. (2011). Mesenchymal stem cells: Angels or demons?. J. Biomed. Biotechnol., 2011.","DOI":"10.1155\/2011\/459510"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.canlet.2008.04.032","article-title":"Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling","volume":"269","author":"Qiao","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1002\/jcp.22511","article-title":"Human mesenchymal stem cells play a dual role on tumor cell growth in vitro and in vivo","volume":"226","author":"Tian","year":"2011","journal-title":"J. Cell Physiol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3109\/14653241003631815","article-title":"Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment","volume":"12","author":"Kidd","year":"2010","journal-title":"Cytotherapy"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1089\/scd.2007.0181","article-title":"Mesenchymal stem cells derived from human adipose tissues favor tumor cell growth in vivo","volume":"17","author":"Yu","year":"2008","journal-title":"Stem Cells Dev."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/pros.21140","article-title":"Effects of transplantation of adipose tissue-derived stem cells on prostate tumor","volume":"70","author":"Lin","year":"2010","journal-title":"Prostate"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3892\/mmr.2016.5389","article-title":"NR2F2 regulates bone marrow-derived mesenchymal stem cell-promoted proliferation of Reh cells","volume":"14","author":"Zhu","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/jcb.25501","article-title":"Human Umbilical Cord Wharton\u2019s Jelly Stem Cell Conditioned Medium Induces Tumoricidal Effects on Lymphoma Cells through Hydrogen Peroxide Mediation","volume":"117","author":"Lin","year":"2016","journal-title":"J. Cell Biochem."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/j.1582-4934.2007.00120.x","article-title":"Mesenchymal stem cells and neovascularization: Role of platelet-derived growth factor receptors","volume":"11","author":"Ball","year":"2007","journal-title":"J. Cell Mol. Med."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/sj.gt.3301934","article-title":"Postnatal bone marrow stromal cells elicit a potent VEGF-dependent neoangiogenic response in vivo","volume":"10","author":"Eliopoulos","year":"2003","journal-title":"Gene Ther."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.critrevonc.2008.06.004","article-title":"Bone marrow-derived cells and tumor growth: Contribution of bone marrow-derived cells to tumor micro-environments with special focus on mesenchymal stem cells","volume":"69","author":"Roorda","year":"2009","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"25007","DOI":"10.1074\/jbc.M110.213108","article-title":"Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer","volume":"286","author":"Liu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_202","first-page":"394917","article-title":"Immunoregulation by mesenchymal stem cells: Biological aspects and clinical applications","volume":"2015","author":"Montesinos","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.exphem.2007.11.007","article-title":"Mesenchymal cells recruit and regulate T regulatory cells","volume":"36","author":"Moretti","year":"2008","journal-title":"Exp. Hematol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1634\/stemcells.2004-0359","article-title":"Interactions between human mesenchymal stem cells and natural killer cells","volume":"24","author":"Sotiropoulou","year":"2006","journal-title":"Stem Cells"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/sj.bjc.6604662","article-title":"The role of endothelial-to-mesenchymal transition in cancer progression","volume":"99","author":"Potenta","year":"2008","journal-title":"Br. J. Cancer"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrc822","article-title":"Epithelial-mesenchymal transitions in tumour progression","volume":"2","author":"Thiery","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2174\/1568009615666150126154151","article-title":"Involvement of mesenchymal stem cells in cancer progression and metastases","volume":"15","author":"Chang","year":"2015","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13287-015-0003-7","article-title":"Influence of mesenchymal stem cells on metastasis development in mice in vivo","volume":"6","author":"Meleshina","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/ncomms2766","article-title":"Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis","volume":"4","author":"Jung","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/cas.12059","article-title":"Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells","volume":"104","author":"Higuchi","year":"2013","journal-title":"Cancer Sci."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Corcoran, K.E., Trzaska, K.A., Fernandes, H., Bryan, M., Taborga, M., Srinivas, V., Packman, K., Patel, P.S., and Rameshwar, P. (2008). Mesenchymal stem cells in early entry of breast cancer into bone marrow. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002563"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.critrevonc.2014.12.013","article-title":"The inherent metastasis of leukaemia and its exploitation by sonodynamic therapy","volume":"94","author":"Trendowski","year":"2015","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.canlet.2016.02.033","article-title":"Mesenchymal stem cells generate pericytes to promote tumor recurrence via vasculogenesis after stereotactic body radiation therapy","volume":"375","author":"Wang","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/sj.leu.2405090","article-title":"The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: Outcome of a pilot clinical study","volume":"22","author":"Ning","year":"2008","journal-title":"Leukemia"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s12185-016-2028-9","article-title":"High IL-7 levels in the bone marrow microenvironment mediate imatinib resistance and predict disease progression in chronic myeloid leukemia","volume":"104","author":"Zhang","year":"2016","journal-title":"Int. J. Hematol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1158\/1535-7163.MCT-07-0042","article-title":"CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells","volume":"7","author":"Jin","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"20054","DOI":"10.18632\/oncotarget.7911","article-title":"Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NF\u03baB\/IL1\u03b2 signaling network","volume":"7","author":"Carter","year":"2016","journal-title":"Oncotarget"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.leukres.2014.11.004","article-title":"c-Myc plays part in drug resistance mediated by bone marrow stromal cells in acute myeloid leukemia","volume":"39","author":"Xia","year":"2015","journal-title":"Leuk. Res."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"21713","DOI":"10.18632\/oncotarget.7964","article-title":"Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia","volume":"7","author":"Bassi","year":"2016","journal-title":"Oncotarget"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3109\/10428194.2013.811579","article-title":"Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosis in vitro and in a mesenchymal stem cell simulated drug-resistant microenvironment via Akt\/mammalian target of rapamycin and extracellular signal-related kinase signaling pathways","volume":"55","author":"Wu","year":"2014","journal-title":"Leuk. Lymphoma"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/2527\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:02:38Z","timestamp":1760104958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/2527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":220,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25052527"],"URL":"https:\/\/doi.org\/10.3390\/ijms25052527","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]}}}