{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:12:04Z","timestamp":1789589524005,"version":"build-2803163510"},"reference-count":108,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2014Next Generation EU\u2014NRRP M6C2\u2014Investment 2.1 Enhancement and Strengthening of Biomedical Research in the NHS","award":["PNRR-MR1-2022-12376699"],"award-info":[{"award-number":["PNRR-MR1-2022-12376699"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Aortic aneurysms are a serious health concern as their rupture leads to high morbidity and mortality. Abdominal aortic aneurysms (AAAs) and thoracic aortic aneurysms (TAAs) exhibit differences and similarities in their pathophysiological and pathogenetic features. AAA is a multifactorial disease, mainly associated with atherosclerosis, characterized by a relevant inflammatory response and calcification. TAA is rarely associated with atherosclerosis and in some cases is associated with genetic mutations such as Marfan syndrome (MFS) and bicuspid aortic valve (BAV). MFS-related and non-genetic or sporadic TAA share aortic degeneration with endothelial-to-mesenchymal transition (End-Mt) and fibrosis, whereas in BAV TAA, aortic degeneration with calcification prevails. microRNA (miRNAs) contribute to the regulation of aneurysmatic aortic remodeling. miRNAs are a class of non-coding RNAs, which post-transcriptionally regulate gene expression. In this review, we report the involvement of deregulated miRNAs in the different aortic remodeling characterizing AAAs and TAAs. In AAA, miRNA deregulation appears to be involved in parietal inflammatory response, smooth muscle cell (SMC) apoptosis and aortic wall calcification. In sporadic and MFS-related TAA, miRNA deregulation promotes End-Mt, SMC myofibroblastic phenotypic switching and fibrosis with glycosaminoglycan accumulation. In BAV TAA, miRNA deregulation sustains aortic calcification. Those differences may support the development of more personalized therapeutic approaches.<\/jats:p>","DOI":"10.3390\/ijms25052641","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T06:50:23Z","timestamp":1708930223000},"page":"2641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["miRNA Regulation of Cell Phenotype and Parietal Remodeling in Atherosclerotic and Non-Atherosclerotic Aortic Aneurysms: Differences and Similarities"],"prefix":"10.3390","volume":"25","author":[{"given":"Sonia","family":"Terriaca","sequence":"first","affiliation":[{"name":"Anatomic Pathology, Policlinico Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Ferlosio","sequence":"additional","affiliation":[{"name":"Anatomic Pathology, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8458-4108","authenticated-orcid":false,"given":"Maria Giovanna","family":"Scioli","sequence":"additional","affiliation":[{"name":"Anatomic Pathology, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Coppa","sequence":"additional","affiliation":[{"name":"Anatomic Pathology, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bertoldo","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Surgery, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-1965","authenticated-orcid":false,"given":"Calogera","family":"Pisano","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Surgery, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9668-0925","authenticated-orcid":false,"given":"Beatrice","family":"Belmonte","sequence":"additional","affiliation":[{"name":"Tumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy"},{"name":"Azienda sanitaria Provinciale di Catania (ASP), 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-1007","authenticated-orcid":false,"given":"Carmela Rita","family":"Balistreri","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Laboratory, Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, 90134 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-5854","authenticated-orcid":false,"given":"Augusto","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Anatomic Pathology, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Qian, G., Adeyanju, O., Olajuyin, A., and Guo, X. (2022). Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells. Life, 12.","DOI":"10.3390\/life12020191"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/CIRCRESAHA.118.313187","article-title":"Cellular Mechanisms of Aortic Aneurysm Formation","volume":"124","author":"Quintana","year":"2019","journal-title":"Circ. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1196\/annals.1383.013","article-title":"Pathogenesis of thoracic and abdominal aortic aneurysms","volume":"1085","author":"Guo","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1161\/ATVBAHA.121.316237","article-title":"Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms","volume":"42","author":"Jauhiainen","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.carpath.2014.04.007","article-title":"Aortopathy in Marfan syndrome: An update","volume":"23","author":"Romaniello","year":"2014","journal-title":"Cardiovasc. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.hjc.2022.09.009","article-title":"The genetic basis of thoracic aortic disease: The future of aneurysm classification?","volume":"69","author":"Salmasi","year":"2023","journal-title":"Hell. J. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Terriaca, S., Scioli, M.G., Pisano, C., Ruvolo, G., Ferlosio, A., and Orlandi, A. (2023). miR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015133"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Pisano, C., Terriaca, S., Scioli, M.G., Nardi, P., Altieri, C., Orlandi, A., Ruvolo, G., and Balistreri, C.R. (2022). The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A Preliminary Study. Int. J. Mol. Sci., 23.","DOI":"10.20944\/preprints202208.0030.v1"},{"key":"ref_9","first-page":"1199","article-title":"Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response","volume":"137","author":"Koch","year":"1990","journal-title":"Am. J. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1083\/jcb.201412052","article-title":"Recent insights into the cellular biology of atherosclerosis","volume":"209","author":"Tabas","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.ATV.0000214999.12921.4f","article-title":"Inflammation and cellular immune responses in abdominal aortic aneurysms","volume":"26","author":"Shimizu","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.ajpath.2011.05.049","article-title":"Prolonged infusion of angiotensin II in apoE(\u2212\/\u2212) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm","volume":"179","author":"Rateri","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1161\/ATVBAHA.113.301280","article-title":"Natural regulatory T cells limit angiotensin II-induced aneurysm formation and rupture in mice","volume":"33","author":"Wang","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"I288","DOI":"10.1161\/hc37t1.094596","article-title":"Plasma levels of metalloproteinases-3 and -9 as markers of successful abdominal aortic aneurysm exclusion after endovascular graft treatment","volume":"104","author":"Sangiorgi","year":"2001","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1749-6632.1996.tb33307.x","article-title":"Role of matrix metalloproteinases in abdominal aortic aneurysms","volume":"800","author":"Thompson","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejvs.2015.09.006","article-title":"Abdominal Aortic Aneurysm Genetic Associations: Mostly False? A Systematic Review and Meta-analysis","volume":"51","author":"Bradley","year":"2016","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/01.ATV.20.4.1123","article-title":"Aging influences development and progression of early aortic atherosclerotic lesions in cholesterol-fed rabbits","volume":"20","author":"Orlandi","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.atherosclerosis.2006.01.018","article-title":"Aging, smooth muscle cells and vascular pathobiology: Implications for atherosclerosis","volume":"188","author":"Orlandi","year":"2006","journal-title":"Atherosclerosis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.atherosclerosis.2012.07.016","article-title":"Age-related increase of stem marker expression influences vascular smooth muscle cell properties","volume":"224","author":"Ferlosio","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/ncpcardio0937","article-title":"Etiology, pathogenesis and management of thoracic aortic aneurysm","volume":"4","author":"Ince","year":"2007","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"D\u2019Amico, F., Doldo, E., Pisano, C., Scioli, M.G., Centofanti, F., Proietti, G., Falconi, M., Sangiuolo, F., Ferlosio, A., and Ruvolo, G. (2020). Specific miRNA and Gene Deregulation Characterize the Increased Angiogenic Remodeling of Thoracic Aneurysmatic Aortopathy in Marfan Syndrome. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186886"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/eurheartj\/ehac771","article-title":"The emerging role of endothelial cells in the pathogenesis of thoracic aortic aneurysm and dissection","volume":"44","author":"Verstraeten","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/cvr\/cvx253","article-title":"Endothelial-mesenchymal transition in atherosclerosis","volume":"114","author":"Souilhol","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s13239-018-0363-0","article-title":"The Roles of Matrix Stiffness and \u00df-Catenin Signaling in Endothelial-to-Mesenchymal Transition of Aortic Valve Endothelial Cells","volume":"9","author":"Zhong","year":"2018","journal-title":"Cardiovasc. Eng. Technol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13644","DOI":"10.1038\/s41598-018-28968-9","article-title":"Inhibition of Wnt\/\u03b2-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis","volume":"8","author":"Cao","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fphys.2017.00536","article-title":"Mechanisms of Smooth Muscle Cell Differentiation Are Distinctly Altered in Thoracic Aortic Aneurysms Associated with Bicuspid or Tricuspid Aortic Valves","volume":"8","author":"Ignatieva","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"13834","DOI":"10.1038\/s41598-018-32170-2","article-title":"Deregulation of Notch1 pathway and circulating endothelial progenitor cell (EPC) number in patients with bicuspid aortic valve with and without ascending aorta aneurysm","volume":"8","author":"Balistreri","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"677977","DOI":"10.3389\/fcvm.2021.677977","article-title":"Molecular and Mechanical Mechanisms of Calcification Pathology Induced by Bicuspid Aortic Valve Abnormalities","volume":"8","author":"Kazik","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/bs.apha.2017.08.002","article-title":"Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease","volume":"81","author":"Wang","year":"2018","journal-title":"Adv. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1095757","DOI":"10.3389\/fphar.2022.1095757","article-title":"Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Vartak, T., Kumaresan, S., and Brennan, E. (2022). Decoding microRNA drivers in atherosclerosis. Biosci. Rep., 42.","DOI":"10.1042\/BSR20212355"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12967-017-1176-x","article-title":"Specific circulating microRNA signature of bicuspid aortic valve disease","volume":"15","author":"Baiges","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1101\/gr.2722704","article-title":"Identification of mammalian microRNA host genes and transcription units","volume":"14","author":"Rodriguez","year":"2004","journal-title":"Genome Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"R259","DOI":"10.1530\/REP-17-0603","article-title":"MicroRNAs: Crucial regulators of placental development","volume":"155","author":"Hayder","year":"2018","journal-title":"Reproduction"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00018-023-04793-w","article-title":"MicroRNA regulation of phenotypic transformations in vascular smooth muscle: Relevance to vascular remodeling","volume":"80","author":"Wang","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/aps.2018.30","article-title":"miRNAS in cardiovascular diseases: Potential biomarkers, therapeutic targets and challenges","volume":"39","author":"Zhou","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.celrep.2012.10.021","article-title":"FGF regulates TGF-\u03b2 signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression","volume":"2","author":"Chen","year":"2012","journal-title":"Cell Rep."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Nagai, T., Kanasaki, M., Srivastava, S.P., Nakamura, Y., Ishigaki, Y., Kitada, M., Shi, S., Kanasaki, K., and Koya, D. (2014). N-acetyl-seryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/696475"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/heartjnl-2013-305402","article-title":"MicroRNAs in cardiovascular disease: An introduction for clinicians","volume":"101","author":"Romaine","year":"2015","journal-title":"Heart"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"599415","DOI":"10.3389\/fimmu.2020.599415","article-title":"Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation","volume":"11","author":"Sorokin","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10180","DOI":"10.1038\/srep10180","article-title":"SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model","volume":"5","author":"Dai","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.0959-9673.2004.00377.x","article-title":"Smad3 as a mediator of the fibrotic response","volume":"85","author":"Flanders","year":"2004","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/CIRCRESAHA.115.304361","article-title":"Role of miR-195 in aortic aneurysmal disease","volume":"115","author":"Zampetaki","year":"2014","journal-title":"Circ. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e12286","DOI":"10.1111\/1755-5922.12286","article-title":"MiR-195 promotes abdominal aortic aneurysm media remodeling by targeting Smad3","volume":"35","author":"Liang","year":"2017","journal-title":"Cardiovasc. Ther."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.acra.2015.08.017","article-title":"Risk Factors for the Development and Progression of Thoracic Aorta Calcification: The Multi-Ethnic Study of Atherosclerosis","volume":"22","author":"Youssef","year":"2015","journal-title":"Acad. Radiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.omtn.2021.12.028","article-title":"miR-424\/322 protects against abdominal aortic aneurysm formation by modulating the Smad2\/3\/runt-related transcription factor 2 axis","volume":"27","author":"Tsai","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/cvr\/cvx187","article-title":"MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1","volume":"114","author":"Baptista","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.117.032184","article-title":"H19 Induces Abdominal Aortic Aneurysm Development and Progression","volume":"138","author":"Li","year":"2018","journal-title":"Circulation"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Prins, P.A., Hill, M.F., Airey, D., Nwosu, S., Perati, P.R., Tavori, H., Linton, M.F., Kon, V., Fazio, S., and Sampson, U.K. (2014). Angiotensin-induced abdominal aortic aneurysms in hypercholesterolemic mice: Role of serum cholesterol and temporal effects of exposure. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0084517"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Jebari-Benslaiman, S., Galicia-Garc\u00eda, U., Larrea-Sebal, A., Olaetxea, J.R., Alloza, I., Vandenbroeck, K., Vicente, A.B., and Mart\u00edn, C. (2022). Pathophysiology of Atherosclerosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063346"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1161\/ATVBAHA.117.309768","article-title":"Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways","volume":"37","author":"Nakao","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11984","DOI":"10.1038\/s41598-022-16017-5","article-title":"Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways","volume":"12","author":"Yamasaki","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/0267659119850685","article-title":"miR-33-5p knockdown attenuates abdominal aortic aneurysm progression via promoting target adenosine triphosphate-binding cassette transporter A1 expression and activating the PI3K\/Akt signaling pathway","volume":"35","author":"Zhao","year":"2020","journal-title":"Perfusion"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chen, W.M., Sheu, W.H., Tseng, P.C., Lee, T.S., Lee, W.J., Chang, P.J., and Chiang, A.N. (2016). Modulation of microRNA Expression in Subjects with Metabolic Syndrome and Decrease of Cholesterol Efflux from Macrophages via microRNA-33-Mediated Attenuation of ATP-Binding Cassette Transporter A1 Expression by Statins. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0154672"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yexcr.2015.05.023","article-title":"MicroRNA-101 overexpression by IL-6 and TNF-\u03b1 inhibits cholesterol efflux by suppressing ATP-binding cassette transporter A1 expression","volume":"336","author":"Zhang","year":"2015","journal-title":"Exp. Cell Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/ATVBAHA.117.310507","article-title":"LAL (Lysosomal Acid Lipase) Promotes Reverse Cholesterol Transport In Vitro and In Vivo","volume":"38","author":"Bowden","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/cvr\/cvy077","article-title":"Identification of miR-9-5p as direct regulator of ABCA1 and HDL-driven reverse cholesterol transport in circulating CD14+ cells of patients with metabolic syndrome","volume":"114","author":"Cariello","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"32336","DOI":"10.1074\/jbc.M109.047472","article-title":"The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor","volume":"284","author":"Tang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3892\/ijmm.2021.4923","article-title":"Dexmedetomidine suppresses the development of abdominal aortic aneurysm by downregulating the mircoRNA-21\/PDCD 4 axis","volume":"47","author":"Yu","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jclinane.2017.04.003","article-title":"The protective effects of dexmedetomidine on ischemic brain injury: A meta-analysis","volume":"40","author":"Jiang","year":"2017","journal-title":"J. Clin. Anesth."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fimmu.2015.00019","article-title":"Turning 21: Induction of miR-21 as a Key Switch in the Inflammatory Response","volume":"6","author":"Sheedy","year":"2015","journal-title":"Front. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.3171\/2015.11.JNS151841","article-title":"MicroRNA and gene expression changes in unruptured human cerebral aneurysms","volume":"125","author":"Bekelis","year":"2016","journal-title":"J. Neurosurg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"122ra22","DOI":"10.1126\/scitranslmed.3003441","article-title":"MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion","volume":"4","author":"Maegdefessel","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e001081","DOI":"10.1136\/bmjdrc-2019-001081","article-title":"PDCD4 deficiency ameliorates left ventricular remodeling and insulin resistance in a rat model of type 2 diabetic cardiomyopathy","volume":"8","author":"Zhang","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jtcvs.2008.07.023","article-title":"Ascending thoracic aortic aneurysms are associated with compositional remodeling and vessel stiffening but not weakening in age-matched subjects","volume":"137","author":"Iliopoulos","year":"2009","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/CIRCRESAHA.115.306361","article-title":"Vascular Smooth Muscle Cells in Atherosclerosis","volume":"118","author":"Bennett","year":"2016","journal-title":"Circ. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e13697","DOI":"10.1111\/eci.13697","article-title":"The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections","volume":"52","author":"Rombouts","year":"2022","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.yexcr.2005.10.008","article-title":"Phenotypic heterogeneity influences the behavior of rat aortic smooth muscle cells in collagen lattice","volume":"311","author":"Orlandi","year":"2005","journal-title":"Exp. Cell Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.actbio.2019.07.030","article-title":"Substrate stiffness directs diverging vascular fates","volume":"96","author":"Wong","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e2201483","DOI":"10.1002\/advs.202201483","article-title":"Stiffening Matrix Induces Age-Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions","volume":"9","author":"Schnellmann","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3724\/abbs.2022081","article-title":"miR-335-5p regulates the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection by directly regulating SP1","volume":"54","author":"Ma","year":"2022","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.omtn.2019.02.021","article-title":"MicroRNA-134-5p Regulates Media Degeneration through Inhibiting VSMC Phenotypic Switch and Migration in Thoracic Aortic Dissection","volume":"16","author":"Wang","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cytogfr.2004.03.003","article-title":"PDGF signaling in cells and mice","volume":"15","author":"Tallquist","year":"2004","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1006\/excr.1994.1290","article-title":"Proliferative activity and alpha-smooth muscle actin expression in cultured rat aortic smooth muscle cells are differently modulated by transforming growth factor-beta 1 and heparin","volume":"214","author":"Orlandi","year":"1994","journal-title":"Exp. Cell Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1161\/CIRCRESAHA.111.255737","article-title":"MicroRNA-29 in aortic dilation: Implications for aneurysm formation","volume":"109","author":"Boon","year":"2011","journal-title":"Circ. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/CIRCRESAHA.108.183749","article-title":"Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: Prevention by oxygen-regulated protein 150 expression","volume":"104","author":"Sanson","year":"2009","journal-title":"Circ. Res."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Wang, Y.I., Bettaieb, A., Sun, C., De Verse, J.S., Radecke, C.E., Mathew, S., Edwards, C.M., Haj, F.G., Passerini, A.G., and Simon, S.I. (2013). Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078322"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.molcel.2014.03.022","article-title":"VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress","volume":"54","author":"Karali","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"C1117","DOI":"10.1152\/ajpcell.00061.2013","article-title":"Endoplasmic reticulum stress signaling: The microRNA connection","volume":"304","author":"Maurel","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"12565","DOI":"10.1038\/ncomms12565","article-title":"Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1","volume":"7","author":"Vikram","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhang, L., Huang, G., Li, X., Zhang, Y., Jiang, Y., Shen, J., Liu, J., Wang, Q., Zhu, J., and Feng, X. (2013). Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1\u03b1 in hepatocellular carcinoma. BMC Cancer, 13.","DOI":"10.1186\/1471-2407-13-108"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9308","DOI":"10.1038\/s41598-017-06721-y","article-title":"MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1","volume":"7","author":"Kassan","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.athoracsur.2016.03.061","article-title":"Unbiased Profile of MicroRNA Expression in Ascending Aortic Aneurysm Tissue Appoints Molecular Pathways Contributing to the Pathology","volume":"102","author":"Licholai","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Gasiul\u0117, S., Stankevi\u010dius, V., Patamsyt\u0117, V., Ra\u017eanskas, R., \u017dukovas, G., Kapustina, Z., \u017daliaduonyt\u0117, D., Benetis, R., Lesauskait\u0117, V., and Vilkaitis, G. (2019). Tissue-Specific miRNAs Regulate the Development of Thoracic Aortic Aneurysm: The Emerging Role of KLF4 Network. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101609"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1055\/s-0038-1639612","article-title":"Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2018 Update and Clinical Implications","volume":"6","author":"Brownstein","year":"2018","journal-title":"Aorta"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3389\/fphys.2017.00687","article-title":"Pathogenic Mechanisms of Bicuspid Aortic Valve Aortopathy","volume":"8","author":"Yassine","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3389\/fphys.2017.00400","article-title":"Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor","volume":"8","author":"Gillis","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Ma, M., Li, Z., Mohamed, M.A., Liu, L., and Wei, X. (2021). Aortic root aortopathy in bicuspid aortic valve associated with high genetic risk. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-021-02215-y"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Junco-Vicente, A., Del R\u00edo-Garc\u00eda, \u00c1., Mart\u00edn, M., and Rodr\u00edguez, I. (2021). Update in Biomolecular and Genetic Bases of Bicuspid Aortopathy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115694"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"759035","DOI":"10.3389\/fphys.2021.759035","article-title":"Plasma Exosomal Mir-423-5p Is Involved in the Occurrence and Development of Bicuspid Aortopathy via TGF-\u03b2\/SMAD2 Pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/joim.12833","article-title":"The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves","volume":"285","author":"Maleki","year":"2019","journal-title":"J. Intern. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ijc.27708","article-title":"ZEB\/miR-200 feedback loop: At the crossroads of signal transduction in cancer","volume":"132","author":"Hill","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/embor.2010.117","article-title":"The ZEB\/miR-200 feedback loop\u2014A motor of cellular plasticity in development and cancer?","volume":"11","author":"Brabletz","year":"2010","journal-title":"EMBO Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ajmg.c.30068","article-title":"Recent progress towards a molecular understanding of Marfan syndrome","volume":"139","author":"Dietz","year":"2005","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41572-021-00298-7","article-title":"Marfan syndrome","volume":"7","author":"Milewicz","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/CIRCRESAHA.111.253740","article-title":"miR-29b participates in early aneurysm development in Marfan syndrome","volume":"110","author":"Merk","year":"2012","journal-title":"Circ. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis","volume":"105","author":"Sutherland","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.1038\/sj.onc.1210436","article-title":"mir-29 regulates Mcl-1 protein expression and apoptosis","volume":"26","author":"Mott","year":"2007","journal-title":"Oncogene"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1096\/fj.10-174904","article-title":"OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2\/MMP-9 genes: A novel mechanism for cardiovascular diseases","volume":"25","author":"Chen","year":"2011","journal-title":"FASEB J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/jcb.22630","article-title":"Transcriptional suppression of mir-29b-1\/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB","volume":"110","author":"Mott","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"ref_105","first-page":"e21598","article-title":"The fibrillin-1 RGD motif posttranscriptionally regulates ERK1\/2 signaling and fibroblast proliferation via miR-1208","volume":"35","author":"Zhang","year":"2021","journal-title":"FASEB J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jmb.2018.11.021","article-title":"Corrigendum to \u201cThe Fibrillin-1 RGD Integrin Binding Site Regulates Gene Expression and Cell Function Through microRNAs\u201d","volume":"431","author":"Zeyer","year":"2019","journal-title":"J. Mol. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s00018-022-04337-8","article-title":"Fibrillin-1-regulated miR-122 has a critical role in thoracic aortic aneurysm formation","volume":"79","author":"Zhang","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"24686","DOI":"10.1074\/jbc.M109.094847","article-title":"DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype","volume":"285","author":"Mitra","year":"2010","journal-title":"J. Biol. Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/2641\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:04:13Z","timestamp":1760105053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/2641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,24]]},"references-count":108,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25052641"],"URL":"https:\/\/doi.org\/10.3390\/ijms25052641","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,24]]}}}