{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:50:19Z","timestamp":1792461019820,"version":"4.5.0"},"reference-count":156,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021R1F1A1062787"],"award-info":[{"award-number":["NRF-2021R1F1A1062787"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is a chronic inflammatory skin disease characterized by the rapid abnormal growth of skin cells in the epidermis, driven by an overactive immune system. Consequently, a complex interplay among epidermal cells, immune cells, and sensory neurons contributes to the development and progression of psoriasis. In these cellular contexts, various ion channels, such as acetylcholine receptors, TRP channels, Ca2+ release-activated channels, chloride channels, and potassium channels, each serve specific functions to maintain the homeostasis of the skin. The dysregulation of ion channels plays a major role in the pathophysiology of psoriasis, affecting various aspects of epidermal cells, immune responses, and sensory neuron signaling. Impaired function of ion channels can lead to altered calcium signaling, inflammation, proliferation, and sensory signaling, all of which are central features of psoriasis. This overview summarizes the pathophysiological roles of ion channels in epidermal cells, immune cells, and sensory neurons during early and late psoriatic processes, thereby contributing to a deeper understanding of ion channel involvement in the interplay of psoriasis and making a crucial advance toward more precise and personalized approaches for psoriasis treatment.<\/jats:p>","DOI":"10.3390\/ijms25052756","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T11:52:55Z","timestamp":1709034775000},"page":"2756","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pathophysiological Roles of Ion Channels in Epidermal Cells, Immune Cells, and Sensory Neurons in Psoriasis"],"prefix":"10.3390","volume":"25","author":[{"given":"Hyungsup","family":"Kim","sequence":"first","affiliation":[{"name":"Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ran","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory Animal Research Center, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Ho","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Pocheon 11160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1574-9009","authenticated-orcid":false,"given":"Yongwoo","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine, Hanyang University, Seoul 04736, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Duk","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Pocheon 11160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/acr.23743","article-title":"Trends in the Prevalence and Incidence of Psoriasis and Psoriatic Arthritis in Ontario, Canada: A Population-Based Study","volume":"71","author":"Eder","year":"2019","journal-title":"Arthritis Care Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"m1590","DOI":"10.1136\/bmj.m1590","article-title":"National, regional, and worldwide epidemiology of psoriasis: Systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41420-022-00943-4","article-title":"Alpha-7 nicotinic acetylcholine receptor agonist alleviates psoriasis-like inflammation through inhibition of the STAT3 and NF-\u03baB signaling pathway","volume":"8","author":"Chen","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jaci.2018.05.031","article-title":"Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice","volume":"142","author":"Lee","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_6","unstructured":"Hille, B. (2001). Ion Channels of Excitable Membranes, Sinauer Associates, Inc.. [3rd ed.]."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000495291","article-title":"Psoriasis: Keratinocytes or Immune Cells\u2014Which Is the Trigger?","volume":"235","author":"Benhadou","year":"2019","journal-title":"Dermatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12974-020-1703-1","article-title":"Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception","volume":"17","author":"Jang","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Choi, M.R., Kim, H.D., Cho, S., Jeon, S.H., Kim, D.H., Wee, J., and Yang, Y.D. (2021). Anoctamin1 Induces Hyperproliferation of HaCaT Keratinocytes and Triggers Imiquimod-Induced Psoriasis-Like Skin Injury in Mice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137145"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3109\/08916934.2016.1166214","article-title":"New insights into the role of T cells in pathogenesis of psoriasis and psoriatic arthritis","volume":"49","author":"Karczewski","year":"2016","journal-title":"Autoimmunity"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1016\/j.jid.2022.04.014","article-title":"CHRNA5 Is Overexpressed in Patients with Psoriasis and Promotes Psoriasis-Like Inflammation in Mouse Models","volume":"142","author":"Wang","year":"2022","journal-title":"J. Investig. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/exd.13024","article-title":"Baicalein increases keratin 1 and 10 expression in HaCaT keratinocytes via TRPV4 receptor activation","volume":"25","author":"Huang","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jid.2017.12.029","article-title":"The Genetics of Chronic Itch: Gene Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with Severe Itch","volume":"138","author":"Nattkemper","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jdermsci.2018.11.009","article-title":"TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice","volume":"92","author":"Zhou","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1111\/jcmm.14392","article-title":"Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice","volume":"23","author":"Zhou","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.3009","article-title":"The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells","volume":"15","author":"Bertin","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.jid.2018.02.040","article-title":"TRPA1 Acts in a Protective Manner in Imiquimod-Induced Psoriasiform Dermatitis in Mice","volume":"138","author":"Kodji","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1113\/jphysiol.2007.146258","article-title":"Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels","volume":"586","author":"Mignen","year":"2008","journal-title":"J. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/B978-0-12-407870-3.00006-8","article-title":"The ARC channel--an endogenous store-independent Orai channel","volume":"71","author":"Thompson","year":"2013","journal-title":"Curr. Top. Membr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41467-021-21242-z","article-title":"Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation","volume":"12","author":"Ye","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lozano-Gerona, J., Oliv\u00e1n-Viguera, A., Delgado-Wicke, P., Singh, V., Brown, B.M., Tapia-Casellas, E., Pueyo, E., Valero, M.S., Garcia-Ot\u00edn, \u00c1.L., and Giraldo, P. (2020). Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0222619"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1002\/art.23987","article-title":"Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor","volume":"58","author":"Waldburger","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1365-3083.2009.02266.x","article-title":"Cell specific synovial expression of nicotinic alpha 7 acetylcholine receptor in rheumatoid arthritis and psoriatic arthritis","volume":"70","author":"Westman","year":"2009","journal-title":"Scand. J. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"110063","DOI":"10.1016\/j.intimp.2023.110063","article-title":"Nerve growth factor mediates activation of transient receptor potential vanilloid 1 in neurogenic pruritus of psoriasis","volume":"118","author":"Shang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jid.2022.08.034","article-title":"miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4","volume":"143","author":"Maglie","year":"2023","journal-title":"J. Investig. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zappia, K.J., Garrison, S.R., Palygin, O., Weyer, A.D., Barabas, M.E., Lawlor, M.W., Staruschenko, A., and Stucky, C.L. (2016). Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine Keratinocytes. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151602"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1177\/0960327121991911","article-title":"Gene expression profiles of transient receptor potential (TRP) channels in the peripheral blood mononuclear cells of psoriasis patients","volume":"40","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Yamanoi, Y., Lei, J., Takayama, Y., Hosogi, S., Marunaka, Y., and Tominaga, M. (2023). TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes. Commun. Biol., 6.","DOI":"10.1038\/s42003-023-04482-1"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jid.2020.06.035","article-title":"Genotype-Phenotype Correlation of TRPV3-Related Olmsted Syndrome","volume":"141","author":"Zhong","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1750-1172-8-79","article-title":"Olmsted syndrome: Exploration of the immunological phenotype","volume":"8","author":"Zhang","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/j.jid.2023.05.009","article-title":"TRPV4 Regulates the Development of Psoriasis by Controlling Adenosine Triphosphate Expression in Keratinocytes and the Neuroimmune System","volume":"143","author":"Amalia","year":"2023","journal-title":"J. Investig. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1097\/j.pain.0000000000000674","article-title":"Mouse model of imiquimod-induced psoriatic itch","volume":"157","author":"Sakai","year":"2016","journal-title":"Pain"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jid.2018.10.044","article-title":"Gain-of-Function Mutations in TRPM4 Activation Gate Cause Progressive Symmetric Erythrokeratodermia","volume":"139","author":"Wang","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1025499","DOI":"10.3389\/fimmu.2022.1025499","article-title":"Gain-of-function of TRPM4 predisposes mice to psoriasiform dermatitis","volume":"13","author":"Yamada","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Leuner, K., Kraus, M., Woelfle, U., Beschmann, H., Harteneck, C., Boehncke, W.H., Schempp, C.M., and M\u00fcller, W.E. (2011). Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0014716"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3892\/ijmm.2016.2718","article-title":"Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement","volume":"38","author":"Cubillos","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Li, Y., Zhou, L., Yuan, X., Wang, Y., Deng, Q., Deng, Z., Xu, S., Wang, Q., and Xie, H. (2022). Nav1.8 in keratinocytes contributes to ROS-mediated inflammation in inflammatory skin diseases. Redox Biol., 55.","DOI":"10.1016\/j.redox.2022.102427"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1016\/j.bbadis.2018.07.036","article-title":"Polycystin-1 downregulation induces ERK-dependent mTOR pathway activation in a cellular model of psoriasis","volume":"1864","author":"Gargalionis","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/jid.2010.245","article-title":"The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model","volume":"131","author":"Gilhar","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2014.07.003","article-title":"Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model","volume":"55","author":"Chen","year":"2014","journal-title":"J. Autoimmun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1083\/jcb.200206096","article-title":"Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium","volume":"159","author":"Arredondo","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/S0024-3205(03)00084-5","article-title":"Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis","volume":"72","author":"Arredondo","year":"2003","journal-title":"Life Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jdermsci.2021.07.001","article-title":"Nicotine affects tight junction barriers via alpha7 nicotine-like acetylcholine receptor in keratinocytes","volume":"103","author":"Nagata","year":"2021","journal-title":"J. Dermatol. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1177\/00220345000790040901","article-title":"Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia","volume":"79","author":"Nguyen","year":"2000","journal-title":"J. Dent. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0002-9440(10)64651-2","article-title":"Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity","volume":"157","author":"Nguyen","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/labinvest.3780379","article-title":"A receptor-mediated mechanism of nicotine toxicity in oral keratinocytes","volume":"81","author":"Arredondo","year":"2001","journal-title":"Lab. Investig."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/j.lfs.2007.01.045","article-title":"The cutaneous non-neuronal cholinergic system and smoking related dermatoses: Studies of the psoriasis variant palmoplantar pustulosis","volume":"80","author":"Hagforsen","year":"2007","journal-title":"Life Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/art.37809","article-title":"Tropisetron suppresses collagen synthesis in skin fibroblasts via \u03b17 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model","volume":"65","author":"Stegemann","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kim, H., Kim, M., and Jang, Y. (2023). Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors. Biomol. Ther.","DOI":"10.4062\/biomolther.2023.118"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"134149","DOI":"10.1016\/j.snb.2023.134149","article-title":"Rapid quantitative analysis of tobacco smoking in saliva using a TRPA1 ion channel-mediated bioelectronic tongue inspired by the human sensory system","volume":"393","author":"Kim","year":"2023","journal-title":"Sens. Actuators B Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00232-023-00277-x","article-title":"Research Progress on TRPA1 in Diseases","volume":"256","author":"Li","year":"2023","journal-title":"J. Membr. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/jid.2009.58","article-title":"Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin","volume":"129","author":"Atoyan","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/jid.2010.33","article-title":"Exposure to low temperature induces elevation of intracellular calcium in cultured human keratinocytes","volume":"130","author":"Tsutsumi","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e55439","DOI":"10.15252\/embr.202255439","article-title":"Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures","volume":"24","author":"Nanba","year":"2023","journal-title":"EMBO Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1073\/pnas.90.15.7391","article-title":"Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa","volume":"90","author":"Kobayashi","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Luostarinen, S., H\u00e4m\u00e4l\u00e4inen, M., and Moilanen, E. (2021). Transient Receptor Potential Ankyrin 1 (TRPA1)-An Inflammation-Induced Factor in Human HaCaT Keratinocytes. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073322"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1039\/C4FO00407H","article-title":"Resveratrol prevents cigarette smoke-induced keratinocytes damage","volume":"5","author":"Sticozzi","year":"2014","journal-title":"Food Funct."},{"key":"ref_58","first-page":"S50","article-title":"TRPV1 Ion Channel: Structural Features, Activity Modulators, and Therapeutic Potential","volume":"86","author":"Gladkikh","year":"2021","journal-title":"Biochemistry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1460-9568.2007.05743.x","article-title":"Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons","volume":"26","author":"Koo","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s12272-012-1016-8","article-title":"Quantitative analysis of TRP channel genes in mouse organs","volume":"35","author":"Jang","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3390\/cells3030914","article-title":"TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision","volume":"3","author":"Ryskamp","year":"2014","journal-title":"Cells"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/jid.2010.421","article-title":"Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1","volume":"131","author":"Dobrosi","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.jid.2018.01.034","article-title":"Major Role for TRPV1 and InsP3R in PAR2-Elicited Inflammatory Mediator Production in Differentiated Human Keratinocytes","volume":"138","author":"Gouin","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nature00882","article-title":"TRPV3 is a calcium-permeable temperature-sensitive cation channel","volume":"418","author":"Xu","year":"2002","journal-title":"Nature"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"adv4463","DOI":"10.2340\/actadv.v103.4463","article-title":"Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch","volume":"103","author":"Nattkemper","year":"2023","journal-title":"Acta Derm. Venereol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Um, J.Y., Kim, H.B., Kim, J.C., Park, J.S., Lee, S.Y., Chung, B.Y., Park, C.W., and Kim, H.O. (2022). TRPV3 and Itch: The Role of TRPV3 in Chronic Pruritus according to Clinical and Experimental Evidence. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314962"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.jid.2020.01.012","article-title":"PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes","volume":"140","author":"Zhao","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10565-020-09536-2","article-title":"TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways","volume":"37","author":"Wang","year":"2021","journal-title":"Cell Biol. Toxicol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/bs.ctm.2022.07.004","article-title":"Chapter Nine\u2014Role of TRPV4 in skeletal function and its mutant-mediated skeletal disorders","volume":"Volume 89","author":"Sonkusare","year":"2022","journal-title":"Current Topics in Membranes"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"6014","DOI":"10.1074\/jbc.M111.316315","article-title":"Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth","volume":"287","author":"Jang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"730982","DOI":"10.3389\/fimmu.2021.730982","article-title":"TRPing on Cell Swelling\u2014TRPV4 Senses It","volume":"12","author":"MacAulay","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1365-2133.2005.06538.x","article-title":"Plaque psoriasis vs. atopic dermatitis and lichen planus: A comparison for lesional T-cell subsets, epidermal proliferation and differentiation","volume":"153","author":"Bovenschen","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1152\/physrev.1989.69.4.1316","article-title":"Structure, function, and differentiation of the keratinocyte","volume":"69","author":"Eckert","year":"1989","journal-title":"Physiol. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: A model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"102429","DOI":"10.1016\/j.ceca.2021.102429","article-title":"Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4","volume":"97","author":"Yan","year":"2021","journal-title":"Cell Calcium"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1038\/sj.jid.5700352","article-title":"TRPC7 is a receptor-operated DAG-activated channel in human keratinocytes","volume":"126","author":"Beck","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ceca.2007.08.005","article-title":"TRPC channels determine human keratinocyte differentiation: New insight into basal cell carcinoma","volume":"43","author":"Beck","year":"2008","journal-title":"Cell Calcium"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"33942","DOI":"10.1074\/jbc.M801844200","article-title":"Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation","volume":"283","author":"Essin","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1086\/515518","article-title":"The molecular pathology of progressive symmetric erythrokeratoderma: A frameshift mutation in the loricrin gene and perturbations in the cornified cell envelope","volume":"61","author":"McGrath","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archderm.1991.01680010067010","article-title":"Ultrastructural localization of calcium in psoriatic and normal human epidermis","volume":"127","author":"Menon","year":"1991","journal-title":"Arch. Dermatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(80)90406-7","article-title":"Calcium regulation of growth and differentiation of mouse epidermal cells in culture","volume":"19","author":"Hennings","year":"1980","journal-title":"Cell"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jcp.1041340208","article-title":"Biochemical and morphological characterization of growth and differentiation of normal human neonatal keratinocytes in a serum-free medium","volume":"134","author":"Pillai","year":"1988","journal-title":"J. Cell Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1046\/j.1523-1747.2000.00926.x","article-title":"Psoriasis and altered calcium metabolism: Downregulated capacitative calcium influx and defective calcium-mediated cell signaling in cultured psoriatic keratinocytes","volume":"114","author":"Karvonen","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nature05637","article-title":"The molecular choreography of a store-operated calcium channel","volume":"446","author":"Lewis","year":"2007","journal-title":"Nature"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.cub.2005.05.055","article-title":"STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx","volume":"15","author":"Liou","year":"2005","journal-title":"Curr. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1046\/j.1523-1747.1999.00698.x","article-title":"Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes","volume":"113","author":"Tu","year":"1999","journal-title":"J. Investig. Dermatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"41079","DOI":"10.1074\/jbc.M107122200","article-title":"The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes","volume":"276","author":"Tu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/sj.jid.5700633","article-title":"The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes","volume":"127","author":"Tu","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ceca.2003.10.019","article-title":"The role of the calcium-sensing receptor in epidermal differentiation","volume":"35","author":"Tu","year":"2004","journal-title":"Cell Calcium"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1242\/jcs.115980","article-title":"Role of STIM1- and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation","volume":"126","author":"Putney","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1074\/jbc.M806726200","article-title":"STIM1- and Orai1-dependent store-operated calcium entry regulates human myoblast differentiation","volume":"284","author":"Darbellay","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1083\/jcb.200604015","article-title":"The elementary unit of store-operated Ca2+ entry: Local activation of CRAC channels by STIM1 at ER-plasma membrane junctions","volume":"174","author":"Luik","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1146\/annurev.physiol.67.032003.154341","article-title":"Calcium-activated chloride channels","volume":"67","author":"Hartzell","year":"2005","journal-title":"Annu. Rev. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/nature07313","article-title":"TMEM16A confers receptor-activated calcium-dependent chloride conductance","volume":"455","author":"Yang","year":"2008","journal-title":"Nature"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/nn.3111","article-title":"The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons","volume":"15","author":"Cho","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ceca.2014.02.006","article-title":"Anoctamin 1 in secretory epithelia","volume":"55","author":"Jang","year":"2014","journal-title":"Cell Calcium"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s00424-014-1603-2","article-title":"Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium","volume":"467","author":"Lee","year":"2015","journal-title":"Pflugers Arch."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"658","DOI":"10.5607\/en.2019.28.6.658","article-title":"EF-hand like Region in the N-terminus of Anoctamin 1 Modulates Channel Activity by Ca2+ and Voltage","volume":"28","author":"Tak","year":"2019","journal-title":"Exp. Neurobiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1097\/j.pain.0000000000002611","article-title":"Anoctamin 1\/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor-dependent itch","volume":"163","author":"Kim","year":"2022","journal-title":"Pain"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0733-8635(02)00094-3","article-title":"Imiquimod","volume":"21","author":"Skinner","year":"2003","journal-title":"Dermatol. Clin."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1517\/14656566.2.5.877","article-title":"A review of the applications of imiquimod: A novel immune response modifier","volume":"2","author":"Syed","year":"2001","journal-title":"Expert. Opin. Pharmacother."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/jcp.24931","article-title":"Dynamically Regulated CFTR Expression and Its Functional Role in Cutaneous Wound Healing","volume":"230","author":"Dong","year":"2015","journal-title":"J. Cell Physiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1159\/000447919","article-title":"Epidermal CFTR Suppresses MAPK\/NF-\u03baB to Promote Cutaneous Wound Healing","volume":"39","author":"Chen","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/exd.13789","article-title":"Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume-regulated anion channels","volume":"27","author":"Trothe","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"173881","DOI":"10.1016\/j.ejphar.2021.173881","article-title":"Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells","volume":"895","author":"Yoshimoto","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/pr.57.4.4","article-title":"International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pain.2008.03.016","article-title":"Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: Evidence for a role in pain","volume":"139","author":"Zhao","year":"2008","journal-title":"Pain"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Lakom\u00e1, J., Rimondini, R., Donadio, V., Liguori, R., and Caprini, M. (2014). Pain related channels are differentially expressed in neuronal and non-neuronal cells of glabrous skin of fabry knockout male mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108641"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/exd.14709","article-title":"Characteristics and pathogenesis of Koebner phenomenon","volume":"32","author":"Zhang","year":"2023","journal-title":"Exp. Dermatol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1113\/jphysiol.2014.271346","article-title":"Polycystins and partners: Proposed role in mechanosensitivity","volume":"592","author":"Retailleau","year":"2014","journal-title":"J. Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e65987","DOI":"10.7554\/eLife.65987","article-title":"Keratinocyte PIEZO1 modulates cutaneous mechanosensation","volume":"11","author":"Mikesell","year":"2022","journal-title":"Elife"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/0019-5154.123499","article-title":"mTOR Signaling Cascade in Psoriatic Disease: Double Kinase mTOR Inhibitor a Novel Therapeutic Target","volume":"59","author":"Raychaudhuri","year":"2014","journal-title":"Indian. J. Dermatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/978-3-540-34891-7_26","article-title":"TRP channels in lymphocytes","volume":"179","author":"Schwarz","year":"2007","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/exd.13403","article-title":"Imiquimod-applied Interleukin-10 deficient mice better reflects severe and persistent psoriasis with systemic inflammatory state","volume":"27","author":"Jin","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1136\/gutjnl-2015-310710","article-title":"The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1","volume":"66","author":"Bertin","year":"2017","journal-title":"Gut"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nrrheum.2010.157","article-title":"Psoriasis: What we have learned from mouse models","volume":"6","author":"Wagner","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1096\/fj.14-265215","article-title":"Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin","volume":"29","author":"Steinckwich","year":"2015","journal-title":"FASEB J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1111798","DOI":"10.3389\/fphar.2023.1111798","article-title":"Celastrol inhibits store operated calcium entry and suppresses psoriasis","volume":"14","author":"Yuan","year":"2023","journal-title":"Front. Pharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Kong, X., Wang, F., Chen, Y., Liang, X., Yin, Y., Liu, H., Luo, G., Li, Y., Liang, S., and Wang, Y. (2023). Molecular action mechanisms of two novel and selective calcium release-activated calcium channel antagonists. Int. J. Biol. Macromol., 253.","DOI":"10.1016\/j.ijbiomac.2023.126937"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.jid.2018.02.003","article-title":"Bioactive Lipid Mediator Profiles in Human Psoriasis Skin and Blood","volume":"138","author":"Sorokin","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1158\/1541-7786.MCR-13-0541","article-title":"Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers","volume":"12","author":"Schaal","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"642071","DOI":"10.3389\/fimmu.2021.642071","article-title":"Stimulation of \u03b17 Nicotinic Acetylcholine Receptor by Nicotine Suppresses Decidual M1 Macrophage Polarization Against Inflammation in Lipopolysaccharide-Induced Preeclampsia-Like Mouse Model","volume":"12","author":"Han","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ni1229","article-title":"Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway","volume":"6","author":"The","year":"2005","journal-title":"Nat. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00418-011-0798-y","article-title":"Nicotinic acetylcholine receptor \u03b17 subunit is time-dependently expressed in distinct cell types during skin wound healing in mice","volume":"135","author":"Fan","year":"2011","journal-title":"Histochem. Cell Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1600-0625.2011.01283.x","article-title":"The cholinergic system in guttate psoriasis with special reference to mast cells","volume":"20","author":"Radosa","year":"2011","journal-title":"Exp. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/sj.jid.5700717","article-title":"Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis","volume":"127","author":"Azam","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1002\/cne.22393","article-title":"Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons","volume":"518","author":"Gazula","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0896-6273(03)00844-4","article-title":"Kv1.3 channel gene-targeted deletion produces \u201cSuper-Smeller Mice\u201d with altered glomeruli, interacting scaffolding proteins, and biophysics","volume":"41","author":"Fadool","year":"2004","journal-title":"Neuron"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.neuroscience.2007.02.068","article-title":"Expression of the vesicular glutamate transporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury","volume":"147","author":"Brumovsky","year":"2007","journal-title":"Neuroscience"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.neuron.2010.09.008","article-title":"VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch","volume":"68","author":"Liu","year":"2010","journal-title":"Neuron"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3940(99)00701-6","article-title":"Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin","volume":"274","author":"Shu","year":"1999","journal-title":"Neurosci. Lett."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1098\/rstb.1996.0039","article-title":"NGF as a mediator of inflammatory pain","volume":"351","author":"McMahon","year":"1996","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/ALN.0b013e31821b1ac5","article-title":"Antagonism of nerve growth factor-TrkA signaling and the relief of pain","volume":"115","author":"Mantyh","year":"2011","journal-title":"Anesthesiology"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature06029","article-title":"A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord","volume":"448","author":"Sun","year":"2007","journal-title":"Nature"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/j.pain.0000000000000861","article-title":"Spinal cord interneurons expressing the gastrin-releasing peptide receptor convey itch through VGLUT2-mediated signaling","volume":"158","author":"Aresh","year":"2017","journal-title":"Pain"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1126\/science.aac8653","article-title":"Gate control of mechanical itch by a subpopulation of spinal cord interneurons","volume":"350","author":"Bourane","year":"2015","journal-title":"Science"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.1233765","article-title":"The cells and circuitry for itch responses in mice","volume":"340","author":"Mishra","year":"2013","journal-title":"Science"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jgr.2015.01.004","article-title":"Red ginseng extract blocks histamine-dependent itch by inhibition of H1R\/TRPV1 pathway in sensory neurons","volume":"39","author":"Jang","year":"2015","journal-title":"J. Ginseng Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/039463201402700103","article-title":"Nerve growth factor interactions with mast cells","volume":"27","author":"Kritas","year":"2014","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"12067","DOI":"10.1523\/JNEUROSCI.0496-07.2007","article-title":"Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: A novel pathway for heat hyperalgesia","volume":"27","author":"Zhang","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.freeradbiomed.2007.05.018","article-title":"Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury","volume":"43","author":"Gazzieri","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.it.2012.11.005","article-title":"The IL-23\/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses","volume":"34","author":"Lowes","year":"2013","journal-title":"Trends Immunol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"Mourits","year":"2009","journal-title":"J. Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature13199","article-title":"Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation","volume":"510","author":"Perro","year":"2014","journal-title":"Nature"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"743675","DOI":"10.3389\/fimmu.2021.743675","article-title":"Nociceptive Sensory Fibers Drive Interleukin-23 Production in a Murine Model of Psoriasis via Calcitonin Gene-Related Peptide","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_147","unstructured":"Zuzana Sevcikova, T. (2022). Ion Transporters, IntechOpen."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0190-9622(86)70201-6","article-title":"Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris","volume":"15","author":"Bernstein","year":"1986","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Chan, T.C., Lee, M.S., Huang, W.C., Chang, W.Y., Krueger, J.G., and Tsai, T.F. (2021). Capsaicin attenuates imiquimod-induced epidermal hyperplasia and cutaneous inflammation in a murine model of psoriasis. Biomed. Pharmacother., 141.","DOI":"10.1016\/j.biopha.2021.111950"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1111\/ejn.16119","article-title":"Mechanisms involved in the antinociceptive and anti-inflammatory effects of xanthotoxin","volume":"58","author":"Zhu","year":"2023","journal-title":"Eur. J. Neurosci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"12111","DOI":"10.7150\/thno.52135","article-title":"Resolvin D3 controls mouse and human TRPV1-positive neurons and preclinical progression of psoriasis","volume":"10","author":"Lee","year":"2020","journal-title":"Theranostics"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/j.jid.2020.03.959","article-title":"Sensory Neuron-Expressed TRPC4 Is a Target for the Relief of Psoriasiform Itch and Skin Inflammation in Mice","volume":"140","author":"Lee","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"115247","DOI":"10.1016\/j.taap.2020.115247","article-title":"Thymol activates TRPM8-mediated Ca2+ influx for its antipruritic effects and alleviates inflammatory response in Imiquimod-induced mice","volume":"407","author":"Wang","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/can.2018.0057","article-title":"Anandamide Is Related to Clinical and Cardiorespiratory Benefits of Aerobic Exercise Training in Migraine Patients: A Randomized Controlled Clinical Trial","volume":"4","author":"Oliveira","year":"2019","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0923-1811(98)00064-4","article-title":"Psoralen photobiology and photochemotherapy: 50 years of science and medicine","volume":"19","author":"Bethea","year":"1999","journal-title":"J. Dermatol. Sci."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Tarcha, E.J., Olsen, C.M., Probst, P., Peckham, D., Mu\u00f1oz-El\u00edas, E.J., Kruger, J.G., and Iadonato, S.P. (2017). Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180762"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/2756\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:05:51Z","timestamp":1760105151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/2756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,27]]},"references-count":156,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25052756"],"URL":"https:\/\/doi.org\/10.3390\/ijms25052756","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,27]]}}}