{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:06:21Z","timestamp":1792789581864,"version":"4.5.0"},"reference-count":49,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NSTC 112-2314-B-039-021","award":["NSTC 112-2314-B-039-021"],"award-info":[{"award-number":["NSTC 112-2314-B-039-021"]}]},{"name":"NSTC 112-2314-B-039-021","award":["CMUHCH-DRM-112-011"],"award-info":[{"award-number":["CMUHCH-DRM-112-011"]}]},{"name":"CMUHCH-DRM-112-011","award":["NSTC 112-2314-B-039-021"],"award-info":[{"award-number":["NSTC 112-2314-B-039-021"]}]},{"name":"CMUHCH-DRM-112-011","award":["CMUHCH-DRM-112-011"],"award-info":[{"award-number":["CMUHCH-DRM-112-011"]}]},{"name":"Chinese Medicine Research Center, China Medical University","award":["NSTC 112-2314-B-039-021"],"award-info":[{"award-number":["NSTC 112-2314-B-039-021"]}]},{"name":"Chinese Medicine Research Center, China Medical University","award":["CMUHCH-DRM-112-011"],"award-info":[{"award-number":["CMUHCH-DRM-112-011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pain is an unpleasant sensory and emotional experience accompanied by tissue injury. Often, an individual\u2019s experience can be influenced by different physiological, psychological, and social factors. Fibromyalgia, one of the most difficult-to-treat types of pain, is characterized by general muscle pain accompanied by obesity, fatigue, sleep, and memory and psychological concerns. Fibromyalgia increases nociceptive sensations via central sensitization in the brain and spinal cord level. We used intermittent cold stress to create a mouse fibromyalgia pain model via a von Frey test (day 0: 3.69 \u00b1 0.14 g; day 5: 2.13 \u00b1 0.12 g). Mechanical pain could be reversed by eicosapentaenoic acid (EPA) administration (day 0: 3.72 \u00b1 0.14 g; day 5: 3.69 \u00b1 0.13 g). A similar trend could also be observed for thermal hyperalgesia. The levels of elements in the transient receptor potential V1 (TRPV1) signaling pathway were increased in the ascending pain pathway, including the thalamus, medial prefrontal cortex, somatosensory cortex, anterior cingulate cortex, and cerebellum. EPA intake significantly attenuated this overexpression. A novel chemogenetics method was used to inhibit SSC and ACC activities, which presented an analgesic effect through the TRPV1 downstream pathway. The present results provide insights into the role of the TRPV1 signaling pathway for fibromyalgia and its potential as a clinical target.<\/jats:p>","DOI":"10.3390\/ijms25052901","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T11:19:24Z","timestamp":1709291964000},"page":"2901","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model"],"prefix":"10.3390","volume":"25","author":[{"given":"Hsien-Yin","family":"Liao","sequence":"first","affiliation":[{"name":"College of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ming","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 42743, Taiwan"},{"name":"School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Han","family":"Hsiao","sequence":"additional","affiliation":[{"name":"College of Chinese Medicine, School of Medicine, China Medical University, Taichung 404328, Taiwan"},{"name":"Department of Neurosurgery, China Medical University Hospital, Taichung 404332, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Cheng","family":"Hsu","sequence":"additional","affiliation":[{"name":"College of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 40402, Taiwan"},{"name":"Department of Traditional Chinese Medicine, China Medical University Hsinchu Hospital, Hsinchu 302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-8837","authenticated-orcid":false,"given":"Yi-Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Chinese Medicine, Graduate Institute of Acupuncture Science, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan"},{"name":"Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gyorfi, M., Rupp, A., and Abd-Elsayed, A. 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