{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:12:16Z","timestamp":1788361936036,"version":"build-2803163510"},"reference-count":141,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mood disorders are highly prevalent and heterogenous mental illnesses with devastating rates of mortality and treatment resistance. The molecular basis of those conditions involves complex interplay between genetic and environmental factors. Currently, there are no objective procedures for diagnosis, prognosis and personalization of patients\u2019 treatment. There is an urgent need to search for novel molecular targets for biomarkers in mood disorders. Cellular prion protein (PrPc) is infamous for its potential to convert its insoluble form, leading to neurodegeneration in Creutzfeldt-Jacob disease. Meanwhile, in its physiological state, PrPc presents neuroprotective features and regulates neurotransmission and synaptic plasticity. The aim of this study is to integrate the available knowledge about molecular mechanisms underlying the impact of PrPc on the pathophysiology of mood disorders. Our review indicates an important role of this protein in regulation of cognitive functions, emotions, sleep and biological rhythms, and its deficiency results in depressive-like behavior and cognitive impairment. PrPc plays a neuroprotective role against excitotoxicity, oxidative stress and inflammation, the main pathophysiological events in the course of mood disorders. Research indicates that PrPc may be a promising biomarker of cognitive decline. There is an urgent need of human studies to elucidate its potential utility in clinical practice.<\/jats:p>","DOI":"10.3390\/ijms25052967","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T05:31:12Z","timestamp":1709530272000},"page":"2967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New Light on Prions: Putative Role of PrPc in Pathophysiology of Mood Disorders"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-9980","authenticated-orcid":false,"given":"Adrian Andrzej","family":"Chrobak","sequence":"first","affiliation":[{"name":"Department of Adult Psychiatry, Jagiellonian University Medical College, Kopernika 21A, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8760-7494","authenticated-orcid":false,"given":"Patrycja","family":"Pa\u0144czyszyn-Trzewik","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Institute of Medical Sciences, Medical College of Rzeszow University, Kopisto 2a, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Kr\u00f3l","sequence":"additional","affiliation":[{"name":"Department of Adult Psychiatry, Jagiellonian University Medical College, Kopernika 21A, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-9022","authenticated-orcid":false,"given":"Magdalena","family":"Pawelec-B\u0105k","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders, Jagiellonian University Medical College, Kopernika 21A, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Dudek","sequence":"additional","affiliation":[{"name":"Department of Adult Psychiatry, Jagiellonian University Medical College, Kopernika 21A, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-1895","authenticated-orcid":false,"given":"Marcin","family":"Siwek","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders, Jagiellonian University Medical College, Kopernika 21A, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"ref_1","first-page":"497","article-title":"Substance Use and Mood Disorders","volume":"Volume 1","author":"Baker","year":"2013","journal-title":"Principles of Addiction: Comprehensive Addictive Behaviors and Disorders"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders: DSM-5, American Psychiatric Association. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/2045125318769235","article-title":"Epidemiology and Risk Factors for Bipolar Disorder","volume":"8","author":"Rowland","year":"2018","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref_4","unstructured":"World Health Organization (WHO) (2024, January 14). Depression. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0006-3223(03)00420-7","article-title":"Social and Economic Burden of Mood Disorders","volume":"54","author":"Simon","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1590\/1516-4446-2020-1627","article-title":"Treatment-Resistant Bipolar Depression: Concepts and Challenges for Novel Interventions","volume":"44","author":"Diaz","year":"2022","journal-title":"Braz. J. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.31887\/DCNS.2015.17.2\/dionescu","article-title":"Pharmacological Approaches to the Challenge of Treatment-Resistant Depression","volume":"17","author":"Ionescu","year":"2015","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/wps.21078","article-title":"Candidate Biomarkers in Psychiatric Disorders: State of the Field","volume":"22","author":"Moeller","year":"2023","journal-title":"World Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5114\/fn.2014.41739","article-title":"New Light on Prions: Putative Role of Co-Operation of PrPcand A\u03b2 Proteins in Cognition","volume":"52","author":"Chrobak","year":"2014","journal-title":"Folia Neuropathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.bbadis.2007.02.011","article-title":"The Cellular Prion Protein (PrPC): Its Physiological Function and Role in Disease","volume":"1772","author":"Westergard","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"762918","DOI":"10.3389\/fnmol.2021.762918","article-title":"PrPC as a Transducer of Physiological and Pathological Signals","volume":"14","author":"Panes","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.2353\/ajpath.2010.091006","article-title":"PrPC, the Cellular Isoform of the Human Prion Protein, is a Novel Biomarker of HIV-Associated Neurocognitive Impairment and Mediates Neuroinflammation","volume":"177","author":"Roberts","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"134866","DOI":"10.1016\/j.neulet.2020.134866","article-title":"Plasma Exosomal Prion Protein Levels Are Correlated with Cognitive Decline in PD Patients","volume":"723","author":"Leng","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuroscience.2015.04.020","article-title":"Low Levels of Cobalamin, Epidermal Growth Factor, and Normal Prions in Multiple Sclerosis Spinal Cord","volume":"298","author":"Scalabrino","year":"2015","journal-title":"Neuroscience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1080\/02699052.2021.1900602","article-title":"Plasma PrPC and ADAM-10 as Novel Biomarkers for Traumatic Brain Injury and Concussion: A Pilot Study","volume":"35","author":"Persad","year":"2021","journal-title":"Brain Inj."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3389\/fpsyt.2020.00432","article-title":"Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality","volume":"11","author":"Navarrete","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jaclp.2021.01.006","article-title":"Case Reports\/Case Series with Literature Review Psychiatric Presentations of Creutzfeldt-Jakob Disease: A Case Report","volume":"62","author":"Harrington","year":"2021","journal-title":"J. Acad. Consult. Liaison Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1176\/appi.ajp.2013.12111460","article-title":"Behavioral and Psychiatric Symptoms in Prion Disease","volume":"171","author":"Thompson","year":"2014","journal-title":"Am. J. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1007\/s12035-018-1293-4","article-title":"The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis","volume":"56","author":"Peggion","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19420889.2015.1063753","article-title":"Prion Protein as a Mediator of Synaptic Transmission","volume":"8","author":"Steinert","year":"2015","journal-title":"Commun. Integr. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00441-007-0565-5","article-title":"Cellular Prion Protein Electron Microscopy: Attempts\/Limits and Clues to a Synaptic Trait. Implications in Neurodegeneration Process","volume":"332","author":"Fournier","year":"2008","journal-title":"Cell Tissue Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s41467-019-09562-7","article-title":"Lower Synaptic Density Is Associated with Depression Severity and Network Alterations","volume":"10","author":"Holmes","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Koshy, S.M., Kincaid, A.E., and Bartz, J.C. (2022). Transport of Prions in the Peripheral Nervous System: Pathways, Cell Types, and Mechanisms. Viruses, 14.","DOI":"10.3390\/v14030630"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Shafiq, M., Da Vela, S., Amin, L., Younas, N., Harris, D.A., Zerr, I., Altmeppen, H.C., Svergun, D., and Glatzel, M. (2022). The Prion Protein and Its Ligands: Insights into Structure-Function Relationships. Biochim. Biophys. Acta (BBA)-Mol. Cell Res., 1869.","DOI":"10.1016\/j.bbamcr.2022.119240"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fnagi.2017.00120","article-title":"The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases","volume":"9","author":"Shah","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.biochi.2014.06.009","article-title":"PrPC Signalling in Neurons: From Basics to Clinical Challenges","volume":"104","author":"Hirsch","year":"2014","journal-title":"Biochimie"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Zou, D., Li, Y., Gu, S., Dong, J., Ma, X., Xu, S., Wang, F., and Huang, J.H. (2022). Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders. Pharmaceuticals, 15.","DOI":"10.3390\/ph15101203"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"988648","DOI":"10.3389\/fphar.2022.988648","article-title":"The Treatment of Depression\u2014Searching for New Ideas","volume":"13","author":"Stachowicz","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"20488","DOI":"10.1074\/jbc.M115.666156","article-title":"Prion Protein Modulates Monoaminergic Systems and Depressive-like Behavior in Mice","volume":"290","author":"Beckman","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_30","first-page":"12","article-title":"Dopamine Induces the Accumulation of Insoluble Prion Protein and Affects Autophagic Flux","volume":"9","author":"Peres","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1111\/ejn.12600","article-title":"Cellular Prion Protein Is Present in Dopaminergic Neurons and Modulates the Dopaminergic System","volume":"40","author":"Rial","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"ref_32","first-page":"81","article-title":"Methamphetamine Increases Prion Protein and Induces Dopamine-Dependent Expression of Protease Resistant PrPsc","volume":"155","author":"Ferrucci","year":"2017","journal-title":"Arch. Ital. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bpsgos.2022.02.007","article-title":"Dysfunction of Glutamatergic Synaptic Transmission in Depression: Focus on AMPA Receptor Trafficking","volume":"3","author":"He","year":"2023","journal-title":"Biol. Psychiatry Glob. Open Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"886918","DOI":"10.3389\/fpsyt.2022.886918","article-title":"Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization","volume":"13","author":"Khoodoruth","year":"2022","journal-title":"Front. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3892\/etm.2023.11810","article-title":"Esketamine for Treatment resistant Depression: A Review of Clinical Evidence (Review)","volume":"25","author":"Vasiliu","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1080\/13543784.2022.2113376","article-title":"New Investigational Agents for the Treatment of Major Depressive Disorder","volume":"31","author":"Pochwat","year":"2022","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1007\/s12035-019-1505-6","article-title":"Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-Symptomatic and Terminal Stages of Prion Diseases","volume":"56","author":"Meneghetti","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13041-021-00828-0","article-title":"Mutation of Copper Binding Sites on Cellular Prion Protein Abolishes Its Inhibitory Action on NMDA Receptors in Mouse Hippocampal Neurons","volume":"14","author":"Huang","year":"2021","journal-title":"Mol. Brain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13041-018-0406-3","article-title":"Differential Modulation of NMDA and AMPA Receptors by Cellular Prion Protein and Copper Ions","volume":"11","author":"Huang","year":"2018","journal-title":"Mol. Brain"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Fang, C., Wu, B., Le, N.T.T., Imberdis, T., Mercer, R.C.C., and Harris, D.A. (2018). Prions Activate a P38 MAPK Synaptotoxic Signaling Pathway. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1007283"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2147\/NDT.S199746","article-title":"Cognitive Impairment in Depression: Recent Advances and Novel Treatments","volume":"15","author":"Perini","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10571-020-00834-1","article-title":"NMDA Receptor and L-Type Calcium Channel Modulate Prion Formation","volume":"41","author":"Zattoni","year":"2021","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1083\/jcb.200711002","article-title":"Prion Protein Attenuates Excitotoxicity by Inhibiting NMDA Receptors","volume":"181","author":"Khosravani","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/jnr.21215","article-title":"Enhanced Susceptibility of Prnp-Deficient Mice to Kainate-Induced Seizures, Neuronal Apoptosis, and Death: Role of AMPA\/Kainate Receptors","volume":"85","author":"Rangel","year":"2007","journal-title":"Proc. J. Neurosci. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/ncomms2135","article-title":"Prion Protein Facilitates Uptake of Zinc into Neuronal Cells","volume":"3","author":"Watt","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ghirardini, E., Restelli, E., Morini, R., Bertani, I., Ortolan, D., Perrucci, F., Pozzi, D., Matteoli, M., and Chiesa, R. (2020). Mutant Prion Proteins Increase Calcium Permeability of AMPA Receptors, Exacerbating Excitotoxicity. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1009174"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ojeda-Ju\u00e1rez, D., Lawrence, J.A., Soldau, K., Pizzo, D.P., Wheeler, E., Aguilar-Calvo, P., Khuu, H., Chen, J., Malik, A., and Funk, G. (2022). Prions Induce an Early Arc Response and a Subsequent Reduction in MGluR5 in the Hippocampus. Neurobiol. Dis., 172.","DOI":"10.1016\/j.nbd.2022.105834"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1242\/jcs.196972","article-title":"The Prion Protein Regulates Glutamate-Mediated Ca2+ Entry and Mitochondrial Ca2+ Accumulation in Neurons","volume":"130","author":"Peggion","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.bbrc.2020.02.102","article-title":"Prion Protein Interacts with the Metabotropic Glutamate Receptor 1 and Regulates the Organization of Ca2+ Signaling","volume":"525","author":"Matsubara","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Goniotaki, D., Lakkaraju, A.K.K., Shrivastava, A.N., Bakirci, P., Sorce, S., Senatore, A., Marpakwar, R., Hornemann, S., Gasparini, F., and Triller, A. (2017). Inhibition of Group-I Metabotropic Glutamate Receptors Protects against Prion Toxicity. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006733"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"28460","DOI":"10.1074\/jbc.M114.584342","article-title":"Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (MGluR5)","volume":"289","author":"Haas","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neulet.2006.09.084","article-title":"Group I MGluR Signaling in BSE-Infected Bovine-PrP Transgenic Mice","volume":"410","author":"Albasanz","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pharmtox-021821-091747","article-title":"Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer\u2019s disease","volume":"62","author":"Ferguson","year":"2022","journal-title":"Annu. Rev. Pharmacol. Toxicol. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3389\/fncel.2019.00339","article-title":"Cellular Prion Protein as a Receptor of Toxic Amyloid-\u039242 Oligomers Is Important for Alzheimer\u2019s Disease","volume":"13","author":"Zhang","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"eabm3720","DOI":"10.1126\/scisignal.abm3720","article-title":"M1 Muscarinic Receptor Activation Reduces the Molecular Pathology and Slows the Progression of Prion-Mediated Neurodegenerative Disease","volume":"15","author":"Dwomoh","year":"2022","journal-title":"Sci. Signal."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e2107389118","DOI":"10.1073\/pnas.2107389118","article-title":"Biased M1 Muscarinic Receptor Mutant Mice Show Accelerated Progression of Prion Neurodegenerative Disease","volume":"118","author":"Scarpa","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1172\/JCI87526","article-title":"M1 Muscarinic Allosteric Modulators Slow Prion Neurodegeneration and Restore Memory Loss","volume":"127","author":"Bradley","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"24660","DOI":"10.18632\/oncotarget.4953","article-title":"Neuroprotective Effect of Cellular Prion Protein (PrPC) Is Related with Activation of Alpha7 Nicotinic Acetylcholine Receptor (A7nAchR)-Mediated Autophagy Flux","volume":"6","author":"Jeong","year":"2015","journal-title":"Oncotarget"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"36542","DOI":"10.1074\/jbc.M110.157263","article-title":"Role of A7 Nicotinic Acetylcholine Receptor in Calcium Signaling Induced by Prion Protein Interaction with Stress-Inducible Protein","volume":"285","author":"Beraldo","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bbrc.2016.02.122","article-title":"The Prion Protein Selectively Binds to and Modulates the Content of Purinergic Receptor P2X4R","volume":"472","author":"Carneiro","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Wulf, M.A., Senatore, A., and Aguzzi, A. (2017). The Biological Function of the Cellular Prion Protein: An Update. BMC Biol., 15.","DOI":"10.1186\/s12915-017-0375-5"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2174\/1874609812666190111100205","article-title":"Oxidative and Inflammatory Events in Prion Diseases: Can They Be Therapeutic Targets?","volume":"11","author":"Prasad","year":"2019","journal-title":"Curr. Aging Sci."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Abramov, A.Y., Potapova, E.V., Dremin, V.V., and Dunaev, A.V. (2020). Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration. Life, 10.","DOI":"10.3390\/life10070101"},{"key":"ref_64","first-page":"4881","article-title":"A PrPC -Caveolin-Lyn Complex Negatively Controls Neuronal GSK3\u03b2 and Serotonin 1B Receptor","volume":"4","author":"Hirsch","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1089\/ars.2014.6032","article-title":"Prion Protein and Copper Cooperatively Protect Neurons by Modulating NMDA Receptor through S-Nitrosylation","volume":"22","author":"Gasperini","year":"2015","journal-title":"Antioxid. Redox Signal"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/brain\/awv356","article-title":"Metabotropic Glutamate Receptor 5 Couples Cellular Prion Protein to Intracellular Signalling in Alzheimer\u2019s Disease","volume":"139","author":"Haas","year":"2016","journal-title":"Brain"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nn.2238","article-title":"Olfactory Behavior and Physiology Are Disrupted in Prion Protein Knockout Mice","volume":"12","author":"Valley","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1365-2869.1999.00006.x","article-title":"Prion Protein: A Role in Sleep Regulation?","volume":"1","author":"Huber","year":"1999","journal-title":"Eur. Sleep Res. Soc."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1600-0404.2008.01075.x","article-title":"Striatal [123I] FP-CIT SPECT Demonstrates Dopaminergic Deficit in a Sporadic Case of Creutzfeldt-Jakob Disease","volume":"119","author":"Ragno","year":"2009","journal-title":"Acta Neurol. Scand."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1097\/NEN.0b013e3181abdae8","article-title":"The Nigrostriatal Pathway in Creutzfeldt-Jakob Disease","volume":"68","author":"Vital","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbr.2011.03.012","article-title":"Depressive-like Behaviour of Mice Lacking Cellular Prion Protein","volume":"227","author":"Gadotti","year":"2012","journal-title":"Behav. Brain Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbr.2008.06.006","article-title":"Cellular Prion Protein Modulates Defensive Attention and Innate Fear-Induced Behaviour Evoked in Transgenic Mice Submitted to an Agonistic Encounter with the Tropical Coral Snake Oxyrhopus guibei","volume":"194","author":"Walz","year":"2008","journal-title":"Behav. Brain Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4161\/19336896.2014.983746","article-title":"Behavioral Abnormalities in Prion Protein Knockout Mice and the Potential Relevance of PrPC for the Cytoskeleton","volume":"8","author":"Schmitz","year":"2014","journal-title":"Prion"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.nbd.2005.01.001","article-title":"Mice Devoid of Prion Protein Have Cognitive Deficits That Are Rescued by Reconstitution of PrP in Neurons","volume":"19","author":"Criado","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s004240100523","article-title":"Dose-Dependent, Prion Protein (PrP)-Mediated Facilitation of Excitatory Synaptic Transmission in the Mouse Hippocampus","volume":"442","author":"Carleton","year":"2001","journal-title":"Pflug. Arch."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuroscience.2012.04.034","article-title":"Overexpression of Cellular Prion Protein (PrPC) Prevents Cognitive Dysfunction and Apoptotic Neuronal Cell Death Induced by Amyloid-\u03b2 (A\u03b2 1-40) Administration in Mice","volume":"215","author":"Rial","year":"2012","journal-title":"Neuroscience"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.neuroscience.2009.09.005","article-title":"Cellular Prion Protein Modulates Age-Related Behavioral and Neurochemical Alterations in Mice","volume":"164","author":"Rial","year":"2009","journal-title":"Neuroscience"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/bpa.12503","article-title":"Cerebellar Compartmentation of Prion Pathogenesis","volume":"28","author":"Ragagnin","year":"2018","journal-title":"Brain Pathol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"775308","DOI":"10.3389\/fpsyg.2021.775308","article-title":"Cerebellar Functional Lateralization from the Perspective of Clinical Neuropsychology","volume":"12","author":"Prochwicz","year":"2021","journal-title":"Front. Psychol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/jnp.12093","article-title":"The Visuospatial Functions in Children after Cerebellar Low-Grade Astrocytoma Surgery: A Contribution to the Pediatric Neuropsychology of the Cerebellum","volume":"11","author":"Chrobak","year":"2017","journal-title":"J. Neuropsychol."},{"key":"ref_81","first-page":"661","article-title":"Rola Mozduku w Regulacji Funkcji Jezykowych","volume":"51","author":"Chrobak","year":"2017","journal-title":"Psychiatr. Pol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1080\/09297049.2019.1657391","article-title":"Cerebellar Lesions after Low-Grade Tumor Resection Can Induce Memory Impairment in Children, Similar to That Observed in Patients with Frontal Lesions","volume":"26","author":"Chrobak","year":"2020","journal-title":"Child Neuropsychol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Chrobak, A.A., Soltys, Z., Dudek, D., and Siwek, M. (2023). Neurological and Cerebellar Soft Signs in Bipolar Disorder: The Role of Staging, Type and History of Psychotic Symptoms. Prog. Neuropsychopharmacol. Biol. Psychiatry, 121.","DOI":"10.1016\/j.pnpbp.2022.110673"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.12740\/PP\/28726","article-title":"Convergence Insufficiency with Unilateral Exophoria at near in Schizophrenia and Bipolar Disorder\u2014A Preliminary Study","volume":"48","author":"Chrobak","year":"2014","journal-title":"Psychiatr. Pol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jad.2014.11.043","article-title":"Implicit Motor Learning in Bipolar Disorder","volume":"174","author":"Chrobak","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.biopsych.2004.02.020","article-title":"Cerebellar dysfunction in neuroleptic naive schizophrenia patients: Clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs","volume":"55","author":"Ho","year":"2004","journal-title":"Biol. Psychiatry."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pnpbp.2017.06.025","article-title":"Disrupted Implicit Motor Sequence Learning in Schizophrenia and Bipolar Disorder Revealed with Ambidextrous Serial Reaction Time Task","volume":"79","author":"Chrobak","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Chrobak, A.A., Siuda-Krzywicka, K., So\u0142tys, Z., Siwek, G.P., Bohaterewicz, B., Sobczak, A.M., Ceglarek, A., Tereszko, A., Starowicz-Filip, A., and F\u0105frowicz, M. (2021). Relationship between Neurological and Cerebellar Soft Signs, and Implicit Motor Learning in Schizophrenia and Bipolar Disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry, 111.","DOI":"10.1016\/j.pnpbp.2020.110137"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"467","DOI":"10.12740\/PP\/OnlineFirst\/105229","article-title":"Vergence Eye Movements in Bipolar Disorder","volume":"54","author":"Chrobak","year":"2020","journal-title":"Psychiatr. Pol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jpsychires.2022.10.042","article-title":"Vergence Eye Movements Impairments in Schizophrenia and Bipolar Disorder","volume":"156","author":"Chrobak","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Hirano, T. (2013). Long-Term Depression and Other Synaptic Plasticity in the Cerebellum. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci., 89.","DOI":"10.2183\/pjab.89.183"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1101\/lm.3.6.445","article-title":"The cerebellum, LTD, and memory: Alternative views","volume":"3","author":"Lang","year":"1997","journal-title":"Learn. Mem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"15900","DOI":"10.1038\/s41598-020-72753-6","article-title":"Impairment of Cerebellar Long-Term Depression and GABAergic Transmission in Prion Protein Deficient Mice Ectopically Expressing PrPLP\/Dpl","volume":"10","author":"Kishimoto","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4161\/pri.5.3.16894","article-title":"Insoluble Cellular Prion Protein and Its Association with Prion and Alzheimer Diseases","volume":"5","author":"Zou","year":"2011","journal-title":"Prion"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/j.1471-4159.2005.03469.x","article-title":"Recombinant Prion Protein Induces Rapid Polarization and Development of Synapses in Embryonic Rat Hippocampal Neurons in Vitro","volume":"95","author":"Kanaani","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0304-3940(96)12596-9","article-title":"Hippocampal Slices from Prion Protein Null Mice: Disrupted Ca2+-activated K+ currents","volume":"209","author":"Colling","year":"1996","journal-title":"Neurosci. Lett."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/370295a0","article-title":"Prion Protein Is Necessary for Normal Synaptic Function","volume":"370","author":"Collinge","year":"1994","journal-title":"Nature"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tins.2011.10.002","article-title":"Prion Protein at the Crossroads of Physiology and Disease","volume":"35","author":"Biasini","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4615-0123-7_1","article-title":"Excitatory amino acid neurotoxicity","volume":"513","author":"Gillessen","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrn1886","article-title":"Ageing and Neuronal Vulnerability","volume":"7","author":"Mattson","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.neubiorev.2009.10.005","article-title":"Motor Control and Aging: Links to Age-Related Brain Structural, Functional, and Biochemical Effects","volume":"34","author":"Seidler","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_102","first-page":"1375","article-title":"Cellular Prion Protein Ablation Impairs Behavior as a Function of Age","volume":"14","author":"Coitinho","year":"2003","journal-title":"Neuroreport"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2006.04.056","article-title":"Role of Cellular Prion Protein on LTP Expression in Aged Mice","volume":"1097","author":"Maglio","year":"2006","journal-title":"Brain Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.physbeh.2013.06.006","article-title":"Altered Behavioral Aspects of Aged Mice Lacking the Cellular Prion Protein","volume":"119","author":"Massimino","year":"2013","journal-title":"Physiol. Behav."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.bbadis.2007.04.004","article-title":"Motor Behavioral and Neuropathological Deficits in Mice Deficient for Normal Prion Protein Expression","volume":"1772","author":"Nazor","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"100384","DOI":"10.1016\/j.jadr.2022.100384","article-title":"Circadian Neuromarkers of Mood Disorders","volume":"10","author":"Claudio","year":"2022","journal-title":"J. Affect. Disord. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/07420528.2016.1236806","article-title":"Morningness-Eveningness and Affective Temperaments Assessed by the Temperament Evaluation of Memphis, Pisa and San Diego-Autoquestionnaire (TEMPS-A)","volume":"34","author":"Chrobak","year":"2017","journal-title":"Chronobiol. Int."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jad.2018.02.017","article-title":"The Role of Affective Temperaments Assessed by the Temperament Evaluation of Memphis, Pisa and San Diego-Autoquestionnaire (TEMPS-A) in the Relationship between Morningness-Eveningness and Bipolarity","volume":"232","author":"Chrobak","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000458527","article-title":"A Study of Biological Rhythm Disturbances in Polish Remitted Bipolar Patients Using the BRIAN, CSM, and SWPAQ Scales","volume":"74","author":"Dopierala","year":"2017","journal-title":"Neuropsychobiology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1590\/1516-4446-2016-2021","article-title":"The Biological Rhythms Interview of Assessment in Neuropsychiatry in Patients with Bipolar Disorder: Correlation with Affective Temperaments and Schizotypy","volume":"38","author":"Dopierala","year":"2016","journal-title":"Rev. Bras. Psiquiatr."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainres.2007.05.010","article-title":"Contributions of Neuronal Prion Protein on Sleep Recovery and Stress Response Following Sleep Deprivation","volume":"1158","author":"Conti","year":"2007","journal-title":"Brain Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/jnc.14960","article-title":"Sleep Deprivation Regulates Availability of PrPC and A\u03b2 Peptides Which Can Impair Interaction between PrPC and Laminin and Neuronal Plasticity","volume":"153","author":"Pino","year":"2020","journal-title":"J. Neurochem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s11910-017-0743-0","article-title":"Fatal Familial Insomnia: Clinical Aspects and Molecular Alterations","volume":"17","author":"Llorens","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_114","first-page":"1075","article-title":"Progressive Disruption of the Circadian Rhythm of Melatonin in Fatal Familial Insomnia","volume":"78","author":"Portaluppi","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.5664\/jcsm.5944","article-title":"Sleep Pathology in Creutzfeldt-Jakob Disease","volume":"12","author":"Kang","year":"2016","journal-title":"J. Clin. Sleep. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/jsr.12405","article-title":"Early Pathology in Sleep Studies of Patients with Familial Creutzfeldt\u2013Jakob Disease","volume":"25","author":"Givaty","year":"2016","journal-title":"J. Sleep Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0013-4694(84)90090-7","article-title":"Experimental Scrapie in Rats: First Electrophysiological Observations","volume":"57","author":"Bassant","year":"1984","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0013-4694(78)90161-X","article-title":"Experimental kuru in the rhesus monkey: A study of eeg modifications in the waking state and during sleep","volume":"45","author":"Bert","year":"1978","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1073\/pnas.0610779104","article-title":"The Power of Automated High-Resolution Behavior Analysis Revealed by Its Application to Mouse Models of Huntington\u2019s and Prion Diseases","volume":"104","author":"Steele","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10286-004-0140-z","article-title":"Normal Sleep-Wake and Circadian Rhythms in a Case of Gerstmann-Str\u00e4ussler-Sheinker (GSS) Disease","volume":"14","author":"Pierangeli","year":"2004","journal-title":"Clin. Auton. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.sleep.2008.03.004","article-title":"Sleep and Temperature Rhythms in Two Sisters with P102L Gerstmann-Str\u00e4ussler-Scheinker (GSS) Disease","volume":"10","author":"Provini","year":"2009","journal-title":"Sleep. Med."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Roguski, A., and Gill, A.C. (2017). The Role of the Mammalian Prion Protein in the Control of Sleep. Pathogens, 6.","DOI":"10.3390\/pathogens6040058"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/380639a0","article-title":"Altered Circadian Activity Rhythms and Sleep in Mice Devoid of Prion Protein","volume":"380","author":"Tobler","year":"1996","journal-title":"Nature"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00702-007-0013-4","article-title":"Expression of Cellular Prion Protein (PrPc) in Schizophrenia, Bipolar Disorder, and Depression","volume":"115","author":"Weis","year":"2008","journal-title":"J. Neural Transm."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4161\/pri.19639","article-title":"Unraveling the Neuroprotective Mechanisms of PrPC in Excitotoxicity","volume":"6","author":"Llorens","year":"2012","journal-title":"Prion"},{"key":"ref_126","first-page":"8042","article-title":"Cellular Prion Protein (PrPC) and Its Role in Stress Responses","volume":"8","author":"Zeng","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2353\/ajpath.2008.071062","article-title":"Absence of the Cellular Prion Protein Exacerbates and Prolongs Neuroinflammation in Experimental Autoimmune Encephalomyelitis","volume":"173","author":"Tsutsui","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4049\/jimmunol.2100412","article-title":"A Soluble PrPC Derivative and Membrane-Anchored PrPC in Extracellular Vesicles Attenuate Innate Immunity by Engaging the NMDA-R\/LRP1 Receptor Complex","volume":"208","author":"Mantuano","year":"2022","journal-title":"J. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Haapakoski, R., Ebmeier, K.P., Alenius, H., and Kivim\u00e4ki, M. (2016). Innate and Adaptive Immunity in the Development of Depression: An Update on Current Knowledge and Technological Advances. Prog. Neuropsychopharmacol. Biol. Psychiatry, 66.","DOI":"10.1016\/j.pnpbp.2015.11.012"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/S1734-1140(13)71517-2","article-title":"Oxidative Stress Markers in Affective Disorders","volume":"65","author":"Siwek","year":"2013","journal-title":"Pharmacol. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1007\/s12035-016-0124-8","article-title":"Associations of Serum Cytokine Receptor Levels with Melancholia, Staging of Illness, Depressive and Manic Phases, and Severity of Depression in Bipolar Disorder","volume":"54","author":"Siwek","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.exger.2012.08.001","article-title":"Association of Prion Protein with Cognitive Functioning in Humans","volume":"47","author":"Breitling","year":"2012","journal-title":"Exp. Gerontol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/bmc-2015-0033","article-title":"Physiological and Pathological Roles of Exosomes in the Nervous System","volume":"7","author":"Yuyama","year":"2016","journal-title":"Biomol. Concepts"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"250180","DOI":"10.3389\/fnins.2017.00194","article-title":"Exosomes and the Prion Protein: More than One Truth","volume":"11","author":"Hartmann","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.vetimm.2008.04.002","article-title":"Enrichment of Prion Protein in Exosomes Derived from Ovine Cerebral Spinal Fluid","volume":"124","author":"Vella","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/nn.4648","article-title":"\u03b1-Synuclein Interacts with PrPC to Induce Cognitive Impairment through MGluR5 and NMDAR2B","volume":"20","author":"Ferreira","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/19336896.2017.1423186","article-title":"The Role of the Prion Protein in the Internalization of \u03b1-Synuclein Amyloids","volume":"12","author":"Legname","year":"2018","journal-title":"Prion"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Pa\u0144czyszyn-Trzewik, P., Czechowska, E., Stachowicz, K., and Sowa-Ku\u0107ma, M. (2023). The Importance of \u03b1-Klotho in Depression and Cognitive Impairment and Its Connection to Glutamate Neurotransmission\u2014An Up-to-Date Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015268"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mehy.2018.07.012","article-title":"Role of Copper in Depression. Relationship with Ketamine Treatment","volume":"119","author":"Wiglusz","year":"2018","journal-title":"Med. Hypotheses"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1113\/jphysiol.2011.225276","article-title":"Copper-Dependent Regulation of NMDA Receptors by Cellular Prion Protein: Implications for Neurodegenerative Disorders","volume":"590","author":"Stys","year":"2012","journal-title":"J. Physiol."},{"key":"ref_141","first-page":"911","article-title":"The Role of Copper and Magnesium in the Pathogenesis and Treatment of Affective Disorders","volume":"39","author":"Siwek","year":"2005","journal-title":"Psychiatr. Pol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/2967\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:08:51Z","timestamp":1760105331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/2967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,4]]},"references-count":141,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25052967"],"URL":"https:\/\/doi.org\/10.3390\/ijms25052967","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,4]]}}}