{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:38:44Z","timestamp":1775633924068,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The main aims of the present study were to explore the relationship of the OPRM1 gene rs1074287 polymorphism in alcohol-dependent women with their personality traits and to try to find out whether any specific features may influence alcohol cravings and be a prognostic for alcohol dependency and treatment in AUD women. Our study found a notable correlation between openness and the interaction of the ORIM1 gene and AUD. The alcohol use disorder subjects with genotype AG showed a higher level of openness compared to the control group with genotypes AG (p = 0.0001) and AA (p = 0.0125). The alcohol use disorder subjects with the AA genotype displayed higher levels of openness than the control group with genotype AG (p = 0.0271). However, the alcohol use disorder subjects with the AA genotype displayed lower levels of openness than the control group with genotype GG (p = 0.0212). Our study indicates that openness as a personality trait is correlated with the OPRM1 gene rs1074287 polymorphism in alcohol-dependent women. These are the first data and results exploring such a relationship between opioid and alcohol pathways and the mental construction of AUD women. Personality traits such as openness to experience and neuroticism might play major roles in the addiction mechanism, especially in genetically predisposed females, independent of the reward system involved in the emotional disturbances that coexist with anxiety and depression.<\/jats:p>","DOI":"10.3390\/ijms25053067","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T08:43:14Z","timestamp":1709714594000},"page":"3067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3574-5726","authenticated-orcid":false,"given":"Agnieszka","family":"Boro\u0144","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Biochemistry, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wielkopolskich 72 St., 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7137-1429","authenticated-orcid":false,"given":"Aleksandra","family":"Suchanecka","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wielkopolskich 72 St., 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4254-5466","authenticated-orcid":false,"given":"Krzysztof","family":"Chmielowiec","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona G\u00f3ra, 28 Zyty St., 65-045 Zielona G\u00f3ra, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"\u015amiarowska","sequence":"additional","affiliation":[{"name":"Individual Specialized Medical Practice, Swaro\u017cyca 3\/6 St., 71-601 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3285-5313","authenticated-orcid":false,"given":"Jolanta","family":"Chmielowiec","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona G\u00f3ra, 28 Zyty St., 65-045 Zielona G\u00f3ra, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6564-2141","authenticated-orcid":false,"given":"Aleksandra","family":"Stro\u0144ska-Pluta","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wielkopolskich 72 St., 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7841-821X","authenticated-orcid":false,"given":"Remigiusz","family":"Rec\u0142aw","sequence":"additional","affiliation":[{"name":"Foundation Strong in the Spirit, 60 Sienkiewicza St., 90-058 \u0141\u00f3d\u017a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Grzywacz","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wielkopolskich 72 St., 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1517\/14622416.5.8.1037","article-title":"Alcoholism: Genes and Mechanisms","volume":"5","author":"Oroszi","year":"2004","journal-title":"Pharmacogenomics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pbb.2013.10.018","article-title":"Pharmacogenetics of OPRM1","volume":"123","author":"Crist","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_3","first-page":"304","article-title":"Influence of the Endogenous Opioid System on High Alcohol Consumption and Genetic Predisposition to Alcoholism","volume":"26","author":"Gianoulakis","year":"2001","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.mp.4002147","article-title":"Genotype Patterns That Contribute to Increased Risk for or Protection from Developing Heroin Addiction","volume":"13","author":"Nielsen","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7333","DOI":"10.2174\/138161281942140105160625","article-title":"Opioid Receptor Interacting Proteins and the Control of Opioid Signaling","volume":"19","author":"Lamberts","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1177\/0269881121991992","article-title":"Association of the OPRM1 A118G Polymorphism and Pavlovian-to-Instrumental Transfer: Clinical Relevance for Alcohol Dependence","volume":"35","author":"Sebold","year":"2021","journal-title":"J. Psychopharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"E116","DOI":"10.1111\/j.1530-0277.2012.01916.x","article-title":"Subjective Response to Alcohol among Alcohol Dependent Individuals: Effects of the Mu-Opioid Receptor (OPRM1) Gene and Alcoholism Severity","volume":"37","author":"Ray","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/acer.13384","article-title":"Independent and Interactive Effects of OPRM1 and DAT1 Polymorphisms on Alcohol Consumption and Subjective Responses in Social Drinkers","volume":"41","author":"Weerts","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s002130100919","article-title":"Naltrexone Decreases Craving and Alcohol Self-Administration in Alcohol-Dependent Subjects and Activates the Hypothalamo-Pituitary-Adrenocortical Axis","volume":"160","author":"Farren","year":"2002","journal-title":"Psychopharmacology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/jhg.2012.139","article-title":"OPRM1 Genetic Polymorphisms Are Associated with the Plasma Nicotine Metabolite Cotinine Concentration in Methadone Maintenance Patients: A Cross Sectional Study","volume":"58","author":"Chen","year":"2013","journal-title":"J. Hum. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.euroneuro.2012.02.002","article-title":"Genetic Polymorphisms in the Opioid Receptor Mu1 Gene Are Associated with Changes in Libido and Insomnia in Methadone Maintenance Patients","volume":"22","author":"Wang","year":"2012","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1001\/archpsyc.1992.01820110040006","article-title":"Naltrexone in the Treatment of Alcohol Dependence","volume":"49","author":"Volpicelli","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1530-0277.2012.01897.x","article-title":"Preliminary Evidence for a Gene-Environment Interaction in Predicting Alcohol Use Disorders in Adolescents","volume":"37","author":"Miranda","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41386-021-00974-y","article-title":"Increased Functional Coupling of the Mu Opioid Receptor in the Anterior Insula of Depressed Individuals","volume":"46","author":"Lutz","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/archinte.1977.03630190041012","article-title":"Morbidity in Alcoholics. Evidence for Accelerated Development of Physical Disease in Women","volume":"137","author":"Ashley","year":"1977","journal-title":"Arch. Intern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1001\/archpsyc.1985.01790340028004","article-title":"Psychopathology in Hospitalized Alcoholics","volume":"42","author":"Hesselbrock","year":"1985","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1124\/pharmrev.121.000361","article-title":"Sex\/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect","volume":"75","author":"Towers","year":"2023","journal-title":"Pharmacol. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/sj.npp.1300389","article-title":"Sex Differences in the Behavioral Effects of 24-h\/Day Access to Cocaine under a Discrete Trial Procedure","volume":"29","author":"Lynch","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00213-018-5091-5","article-title":"Sex Differences in Incentive-Sensitization Produced by Intermittent Access Cocaine Self-Administration","volume":"236","author":"Kawa","year":"2019","journal-title":"Psychopharmacology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s00213-021-05846-3","article-title":"Females Develop Features of an Addiction-like Phenotype Sooner during Withdrawal than Males","volume":"238","author":"Towers","year":"2021","journal-title":"Psychopharmacology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.15288\/jsa.1999.60.252","article-title":"Telescoping of Landmark Events Associated with Drinking: A Gender Comparison","volume":"60","author":"Randall","year":"1999","journal-title":"J. Stud. Alcohol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1081\/JA-200042281","article-title":"Telescoping of Drinking-Related Behaviors: Gender, Racial\/Ethnic, and Age Comparisons","volume":"40","author":"Johnson","year":"2005","journal-title":"Subst. Use Misuse"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00406-007-0737-z","article-title":"Alcoholism in Women: Is It Different in Onset and Outcome Compared to Men?","volume":"257","author":"Diehl","year":"2007","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/j.1530-0277.1992.tb00698.x","article-title":"Do Women Develop Alcoholic Brain Damage More Readily Than Men?","volume":"16","author":"Mann","year":"1992","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.drugalcdep.2004.02.001","article-title":"Opioid-, Cannabis- and Alcohol-Dependent Women Show More Rapid Progression to Substance Abuse Treatment","volume":"74","author":"Rounsaville","year":"2004","journal-title":"Drug Alcohol Depend."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/acer.12228","article-title":"Characterizing Gender Differences in Treatment Seekers","volume":"38","author":"Lewis","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.psc.2010.01.004","article-title":"Substance Abuse in Women","volume":"33","author":"Greenfield","year":"2010","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.3109\/00365528708996472","article-title":"Increased Susceptibility to Liver Disease in Relation to Alcohol Consumption in Women","volume":"22","author":"Loft","year":"1987","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1176\/appi.ajp.158.2.198","article-title":"Evidence for a Gender-Related Effect of Alcoholism on Brain Volumes","volume":"158","author":"Hommer","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/01.ALC.0000164376.69978.6B","article-title":"Neuroimaging of Gender Differences in Alcohol Dependence: Are Women More Vulnerable?","volume":"29","author":"Mann","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0002-9149(97)00399-8","article-title":"Comparison of Alcoholic Cardiomyopathy in Women Versus Men","volume":"80","author":"Estruch","year":"1997","journal-title":"Am. J. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1001\/jama.1995.03530020067034","article-title":"The Greater Risk of Alcoholic Cardiomyopathy and Myopathy in Women Compared with Men","volume":"274","author":"Estruch","year":"1995","journal-title":"JAMA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.drugalcdep.2015.03.008","article-title":"Personality and Alcohol Consumption: Pooled Analysis of 72,949 Adults from Eight Cohort Studies","volume":"151","author":"Hakulinen","year":"2015","journal-title":"Drug Alcohol Depend."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.biopsych.2003.08.006","article-title":"Serotonin Transporter and GABA(A) Alpha 6 Receptor Variants Are Associated with Neuroticism","volume":"55","author":"Sen","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/13548506.2017.1338737","article-title":"Genetic Polymorphisms of Alcohol-Metabolizing Enzymes and Their Association with Alcoholism Risk, Personality and Anthropometric Traits among Malaysian University Students","volume":"23","author":"Ong","year":"2018","journal-title":"Psychol. Health Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1471-4159.2009.06472.x","article-title":"Single-Nucleotide Polymorphism (A118G) in Exon 1 of OPRM1 Gene Causes Alteration in Downstream Signaling by Mu-Opioid Receptor and May Contribute to the Genetic Risk for Addiction","volume":"112","author":"Deb","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.biopsych.2013.04.012","article-title":"ELK1 Transcription Factor Linked to Dysregulated Striatal Mu Opioid Receptor Signaling Network and OPRM1 Polymorphism in Human Heroin Abusers","volume":"74","author":"Sillivan","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1073\/pnas.0600871103","article-title":"\u03bc Opioid Receptor A118G Polymorphism in Association with Striatal Opioid Neuropeptide Gene Expression in Heroin Abusers","volume":"103","author":"Drakenberg","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1176\/appi.ajp.2018.18030352","article-title":"Molecular Genetics and New Medication Strategies for Opioid Addiction","volume":"175","author":"Hurd","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neulet.2013.02.018","article-title":"Low Frequency Genetic Variants in the \u03bc-Opioid Receptor (OPRM1) Affect Risk for Addiction to Heroin and Cocaine","volume":"542","author":"Clarke","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1093\/hmg\/9.19.2895","article-title":"Sequence Variability and Candidate Gene Analysis in Complex Disease: Association of \u00b5 Opioid Receptor Gene Variation with Substance Dependence","volume":"9","author":"Hoehe","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1369-1600.2010.00265.x","article-title":"A C17T Polymorphism in the Mu Opiate Receptor Is Associated with Quantitative Measures of Drug Use in African American Women","volume":"17","author":"Crystal","year":"2012","journal-title":"Addict. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00041444-200309000-00006","article-title":"A Genetic Association Study of the Mu Opioid Receptor and Severe Opioid Dependence","volume":"13","author":"Crowley","year":"2003","journal-title":"Psychiatr. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/hmg\/ddn439","article-title":"Expansion of the Human \u03bc-Opioid Receptor Gene Architecture: Novel Functional Variants","volume":"18","author":"Shabalina","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/ajmg.b.30701","article-title":"Multiple OPR Genes Influence Personality Traits in Substance Dependent and Healthy Subjects in Two American Populations","volume":"147","author":"Luo","year":"2008","journal-title":"Am. J. Med. Genet. Part B Neuropsychiatr. Genet."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1001\/archpsyc.1981.01780330019001","article-title":"Inheritance of Alcohol Abuse. Cross-Fostering Analysis of Adopted Men","volume":"38","author":"Cloninger","year":"1981","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_47","first-page":"18","article-title":"Type I and Type II Alcoholism: An Update","volume":"20","author":"Cloninger","year":"1996","journal-title":"Alcohol. Health Res. World"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1521\/pedi.2008.22.5.525","article-title":"Drinking motives as mediators in the relation between personality disorder symptoms and alcohol use disorder","volume":"22","author":"Tragesser","year":"2008","journal-title":"J. Pers. Disord."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1126\/science.2882604","article-title":"Neurogenetic Adaptive Mechanisms in Alcoholism","volume":"236","author":"Cloninger","year":"1987","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1001\/archpsyc.1987.01800180093014","article-title":"A Systematic Method for Clinical Description and Classification of Personality Variants. A Proposal","volume":"44","author":"Cloninger","year":"1987","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Peltier, M.R., Verplaetse, T.L., Mineur, Y.S., Petrakis, I.L., Cosgrove, K.P., Picciotto, M.R., and McKee, S.A. (2019). Sex Differences in Stress-Related Alcohol Use. Neurobiol. Stress, 10.","DOI":"10.1016\/j.ynstr.2019.100149"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1037\/pha0000598","article-title":"Cluster-b Personality Disorder Traits and Impulsivity: Indirect Associations with Alcohol Use Severity through Positive Alcohol Expectancies","volume":"31","author":"Guillot","year":"2023","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Chmielowiec, J., Chmielowiec, K., Masiak, J., \u015amiarowska, M., Stro\u0144ska-Pluta, A., Dziedziejko, V., and Grzywacz, A. (2022). Association between Polymorphism Rs1799732 of DRD2 Dopamine Receptor Gene and Personality Traits among Cannabis Dependency. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph191710915"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/3067\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:09:54Z","timestamp":1760105394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/5\/3067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,6]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25053067"],"URL":"https:\/\/doi.org\/10.3390\/ijms25053067","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,6]]}}}