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As a drawback of these restoring strategies, reperfusion after an ischemic insult and sudden oxygen exposure lead to the exacerbated synthesis of additional reactive oxidative species and the persistence of increased oxidation levels. Attempts based on antioxidant treatment have failed to achieve an effective therapy for cardiovascular disease patients. The controversial use of vitamin C as an antioxidant in clinical practice is comprehensively systematized and discussed in this review. The dose-dependent adsorption and release kinetics mechanism of vitamin C is complex; however, this review may provide a holistic perspective on its potential as a preventive supplement and\/or for combined precise and targeted therapeutics in cardiovascular management therapy.<\/jats:p>","DOI":"10.3390\/ijms25063114","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T11:33:06Z","timestamp":1709811186000},"page":"3114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Vitamin C as Scavenger of Reactive Oxygen Species during Healing after Myocardial Infarction"],"prefix":"10.3390","volume":"25","author":[{"given":"Huabo","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care, University Hospital, Rheinisch-Westf\u00e4lische Technische Hochschule Aachen University, 52074 Aachen, Germany"},{"name":"Institute of Molecular Medicine, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark"},{"name":"Department of Histology and Embryology, Medicine and Life Sciences, Hainan Medical University, Haikou 571199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa A.","family":"Liehn","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark"},{"name":"National Institute of Pathology \u201cVictor Babes\u201d, Splaiul Independentei Nr. 99-101, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Rusu","sequence":"additional","affiliation":[{"name":"Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, Rheinisch-Westf\u00e4lische Technische Hochschule Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1093\/eurheartj\/ehaa035","article-title":"Clinical application of the 4th Universal Definition of Myocardial Infarction","volume":"41","author":"Hartikainen","year":"2020","journal-title":"Eur. 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