{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:47:56Z","timestamp":1785494876434,"version":"3.56.0"},"reference-count":42,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UCM Research Groups","award":["951579"],"award-info":[{"award-number":["951579"]}]},{"name":"UCM Research Groups","award":["920105"],"award-info":[{"award-number":["920105"]}]},{"name":"UCM Research Groups","award":["SNEO-20222384"],"award-info":[{"award-number":["SNEO-20222384"]}]},{"name":"UCM Research Groups","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}]},{"name":"UCM Research Groups","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}]},{"name":"UCM Research Groups","award":["2022\/BMD-7223"],"award-info":[{"award-number":["2022\/BMD-7223"]}]},{"name":"UCM Research Groups","award":["PID2022-140535NB-I00"],"award-info":[{"award-number":["PID2022-140535NB-I00"]}]},{"name":"UCM Research Groups","award":["CT15\/23"],"award-info":[{"award-number":["CT15\/23"]}]},{"name":"UCM Research Groups","award":["CT63\/19-CT64\/19"],"award-info":[{"award-number":["CT63\/19-CT64\/19"]}]},{"DOI":"10.13039\/501100001872","name":"Spanish Ministry of Science, Innovation and Universities","doi-asserted-by":"publisher","award":["951579"],"award-info":[{"award-number":["951579"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001872","name":"Spanish Ministry of Science, Innovation and Universities","doi-asserted-by":"publisher","award":["920105"],"award-info":[{"award-number":["920105"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001872","name":"Spanish Ministry of Science, Innovation and Universities","doi-asserted-by":"publisher","award":["SNEO-20222384"],"award-info":[{"award-number":["SNEO-20222384"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001872","name":"Spanish Ministry of Science, Innovation and Universities","doi-asserted-by":"publisher","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001872","name":"Spanish Ministry of Science, Innovation and Universities","doi-asserted-by":"publisher","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001872","name":"Spanish Ministry of Science, Innovation and Universities","doi-asserted-by":"publisher","award":["2022\/BMD-7223"],"award-info":[{"award-number":["2022\/BMD-7223"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001872","name":"Spanish Ministry of Science, Innovation and Universities","doi-asserted-by":"publisher","award":["PID2022-140535NB-I00"],"award-info":[{"award-number":["PID2022-140535NB-I00"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001872","name":"Spanish Ministry of Science, Innovation and Universities","doi-asserted-by":"publisher","award":["CT15\/23"],"award-info":[{"award-number":["CT15\/23"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001872","name":"Spanish Ministry of Science, Innovation and Universities","doi-asserted-by":"publisher","award":["CT63\/19-CT64\/19"],"award-info":[{"award-number":["CT63\/19-CT64\/19"]}],"id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["951579"],"award-info":[{"award-number":["951579"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["920105"],"award-info":[{"award-number":["920105"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["SNEO-20222384"],"award-info":[{"award-number":["SNEO-20222384"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["2022\/BMD-7223"],"award-info":[{"award-number":["2022\/BMD-7223"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PID2022-140535NB-I00"],"award-info":[{"award-number":["PID2022-140535NB-I00"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CT15\/23"],"award-info":[{"award-number":["CT15\/23"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CT63\/19-CT64\/19"],"award-info":[{"award-number":["CT63\/19-CT64\/19"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII-RICORS2040","doi-asserted-by":"publisher","award":["951579"],"award-info":[{"award-number":["951579"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII-RICORS2040","doi-asserted-by":"publisher","award":["920105"],"award-info":[{"award-number":["920105"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII-RICORS2040","doi-asserted-by":"publisher","award":["SNEO-20222384"],"award-info":[{"award-number":["SNEO-20222384"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII-RICORS2040","doi-asserted-by":"publisher","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII-RICORS2040","doi-asserted-by":"publisher","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII-RICORS2040","doi-asserted-by":"publisher","award":["2022\/BMD-7223"],"award-info":[{"award-number":["2022\/BMD-7223"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII-RICORS2040","doi-asserted-by":"publisher","award":["PID2022-140535NB-I00"],"award-info":[{"award-number":["PID2022-140535NB-I00"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII-RICORS2040","doi-asserted-by":"publisher","award":["CT15\/23"],"award-info":[{"award-number":["CT15\/23"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII-RICORS2040","doi-asserted-by":"publisher","award":["CT63\/19-CT64\/19"],"award-info":[{"award-number":["CT63\/19-CT64\/19"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["951579"],"award-info":[{"award-number":["951579"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["920105"],"award-info":[{"award-number":["920105"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["SNEO-20222384"],"award-info":[{"award-number":["SNEO-20222384"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["2022\/BMD-7223"],"award-info":[{"award-number":["2022\/BMD-7223"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["PID2022-140535NB-I00"],"award-info":[{"award-number":["PID2022-140535NB-I00"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["CT15\/23"],"award-info":[{"award-number":["CT15\/23"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["CT63\/19-CT64\/19"],"award-info":[{"award-number":["CT63\/19-CT64\/19"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["951579"],"award-info":[{"award-number":["951579"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["920105"],"award-info":[{"award-number":["920105"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["SNEO-20222384"],"award-info":[{"award-number":["SNEO-20222384"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["2022\/BMD-7223"],"award-info":[{"award-number":["2022\/BMD-7223"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["PID2022-140535NB-I00"],"award-info":[{"award-number":["PID2022-140535NB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["CT15\/23"],"award-info":[{"award-number":["CT15\/23"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["CT63\/19-CT64\/19"],"award-info":[{"award-number":["CT63\/19-CT64\/19"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Complutense University of Madrid","award":["951579"],"award-info":[{"award-number":["951579"]}]},{"name":"Complutense University of Madrid","award":["920105"],"award-info":[{"award-number":["920105"]}]},{"name":"Complutense University of Madrid","award":["SNEO-20222384"],"award-info":[{"award-number":["SNEO-20222384"]}]},{"name":"Complutense University of Madrid","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}]},{"name":"Complutense University of Madrid","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}]},{"name":"Complutense University of Madrid","award":["2022\/BMD-7223"],"award-info":[{"award-number":["2022\/BMD-7223"]}]},{"name":"Complutense University of Madrid","award":["PID2022-140535NB-I00"],"award-info":[{"award-number":["PID2022-140535NB-I00"]}]},{"name":"Complutense University of Madrid","award":["CT15\/23"],"award-info":[{"award-number":["CT15\/23"]}]},{"name":"Complutense University of Madrid","award":["CT63\/19-CT64\/19"],"award-info":[{"award-number":["CT63\/19-CT64\/19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Glaucoma is a neurodegenerative disease that causes blindness. In this study, we aimed to evaluate the protective role of cilastatin (CIL), generally used in the treatment of nephropathologies associated with inflammation, in an experimental mouse model based on unilateral (left) laser-induced ocular hypertension (OHT). Male Swiss mice were administered CIL daily (300 mg\/kg, i.p.) two days before OHT surgery until sacrifice 3 or 7 days later. Intraocular Pressure (IOP), as well as retinal ganglion cell (RGC) survival, was registered, and the inflammatory responses of macroglial and microglial cells were studied via immunohistochemical techniques. Results from OHT eyes were compared to normotensive contralateral (CONTRA) and na\u00efve control eyes considering nine retinal areas and all retinal layers. OHT successfully increased IOP values in OHT eyes but not in CONTRA eyes; CIL did not affect IOP values. Surgery induced a higher loss of RGCs in OHT eyes than in CONTRA eyes, while CIL attenuated this loss. Similarly, surgery increased macroglial and microglial activation in OHT eyes and to a lesser extent in CONTRA eyes; CIL prevented both macroglial and microglial activation in OHT and CONTRA eyes. Therefore, CIL arises as a potential effective strategy to reduce OHT-associated damage in the retina of experimental mice.<\/jats:p>","DOI":"10.3390\/ijms25063115","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T11:33:06Z","timestamp":1709811186000},"page":"3115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cilastatin as a Potential Anti-Inflammatory and Neuroprotective Treatment in the Management of Glaucoma"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7481-2536","authenticated-orcid":false,"given":"Miguel A.","family":"Mart\u00ednez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Immunology, Ophthalmology and ORL, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Department of Physiology, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rubio-Casado","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-9947","authenticated-orcid":false,"given":"Diego","family":"San Felipe","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-1860","authenticated-orcid":false,"given":"Beatriz","family":"Mart\u00edn-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Renal Physiopathology Laboratory, Department of Nephrology, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-7996","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Fern\u00e1ndez-Albarral","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmologic Research Ram\u00f3n Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-5551","authenticated-orcid":false,"given":"Elena","family":"Salobrar-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmologic Research Ram\u00f3n Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ORL, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Health Research Institute, San Carlos Clinical Hospital (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0607-5225","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Matamoros","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmologic Research Ram\u00f3n Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ORL, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5145-5094","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Immunology, Ophthalmology and ORL, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Institute of Ophthalmologic Research Ram\u00f3n Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Health Research Institute, San Carlos Clinical Hospital (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1581-087X","authenticated-orcid":false,"given":"Rosa","family":"de Hoz","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmologic Research Ram\u00f3n Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ORL, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Health Research Institute, San Carlos Clinical Hospital (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5480-5902","authenticated-orcid":false,"given":"Juan J.","family":"Salazar","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmologic Research Ram\u00f3n Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ORL, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Health Research Institute, San Carlos Clinical Hospital (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-475X","authenticated-orcid":false,"given":"Eva M.","family":"Marco","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmologic Research Ram\u00f3n Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Department of Genetics, Microbiology and Physiology, Faculty of Biological Sciences, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2656-4723","authenticated-orcid":false,"given":"Ana I.","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmologic Research Ram\u00f3n Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ORL, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Health Research Institute, San Carlos Clinical Hospital (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-679X","authenticated-orcid":false,"given":"Alberto","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Renal Physiopathology Laboratory, Department of Nephrology, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-623X","authenticated-orcid":false,"given":"Meritxell","family":"L\u00f3pez-Gallardo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Institute of Ophthalmologic Research Ram\u00f3n Castroviejo, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global Causes of Blindness and Distance Vision Impairment 1990\u20132020: A Systematic Review and Meta-Analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040: A Systematic Review and Meta-Analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.exer.2010.05.020","article-title":"Changes in the Inner and Outer Retinal Layers after Acute Increase of the Intraocular Pressure in Adult Albino Swiss Mice","volume":"91","author":"Cuenca","year":"2010","journal-title":"Exp. Eye Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jphs.2020.12.009","article-title":"Potential Roles of Astrocytes and M\u00fcller Cells in the Pathogenesis of Glaucoma","volume":"145","author":"Shinozaki","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"M\u00e9lik Parsadaniantz, S., R\u00e9aux-le Goazigo, A., Sapienza, A., Habas, C., and Baudouin, C. (2020). Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation?. Cells, 9.","DOI":"10.3390\/cells9030535"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.brainres.2011.06.005","article-title":"Glial Cell Response and INOS Expression in the Optic Nerve Head and Retina of the Rat Following Acute High IOP Ischemia-Reperfusion","volume":"1403","author":"Cho","year":"2011","journal-title":"Brain Res."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Albarral, J.A., Salazar, J.J., de Hoz, R., Marco, E.M., Mart\u00edn-S\u00e1nchez, B., Flores-Salguero, E., Salobrar-Garc\u00eda, E., L\u00f3pez-Cuenca, I., Barrios-Sabador, V., and Avil\u00e9s-Trigueros, M. (2021). Retinal Molecular Changes Are Associated with Neuroinflammation and Loss of RGCs in an Experimental Model of Glaucoma. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042066"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e331","DOI":"10.1111\/aos.13983","article-title":"Review of Rodent Hypertensive Glaucoma Models","volume":"97","author":"Biswas","year":"2019","journal-title":"Acta Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1038\/s41598-020-61848-9","article-title":"Time Course of Bilateral Microglial Activation in a Mouse Model of Laser-Induced Glaucoma","volume":"10","author":"Rojas","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Albarral, J.A., de Hoz, R., Matamoros, J.A., Chen, L., L\u00f3pez-Cuenca, I., Salobrar-Garc\u00eda, E., S\u00e1nchez-Puebla, L., Ram\u00edrez, J.M., Trivi\u00f1o, A., and Salazar, J.J. (2022). Retinal Changes in Astrocytes and M\u00fcller Glia in a Mouse Model of Laser-Induced Glaucoma: A Time-Course Study. Biomedicines, 10.","DOI":"10.3390\/biomedicines10050939"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/0042-6989(94)90024-8","article-title":"Immunohistochemical Study of Human Retinal Astroglia","volume":"34","author":"Ramirez","year":"1994","journal-title":"Vis. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/1742-2094-8-173","article-title":"Adaptive M\u00fcller Cell Responses to Microglial Activation Mediate Neuroprotection and Coordinate Inflammation in the Retina","volume":"8","author":"Wang","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Albarral, J.A., Mart\u00ednez-L\u00f3pez, M.A., Marco, E.M., de Hoz, R., Mart\u00edn-S\u00e1nchez, B., San Felipe, D., Salobrar-Garc\u00eda, E., L\u00f3pez-Cuenca, I., Pinazo-Dur\u00e1n, M.D., and Salazar, J.J. (2021). Is Saffron Able to Prevent the Dysregulation of Retinal Cytokines Induced by Ocular Hypertension in Mice?. J. Clin. Med., 10.","DOI":"10.3390\/jcm10214801"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2174\/1570159X15666170724104305","article-title":"Neuroprotection by (Endo)Cannabinoids in Glaucoma and Retinal Neurodegenerative Diseases","volume":"16","author":"Rapino","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"27532","DOI":"10.1038\/srep27532","article-title":"Caffeine Administration Prevents Retinal Neuroinflammation and Loss of Retinal Ganglion Cells in an Animal Model of Glaucoma","volume":"6","author":"Madeira","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1167\/iovs.15-18024","article-title":"The Effect of A2A Receptor Antagonist on Microglial Activation in Experimental Glaucoma","volume":"57","author":"Liu","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"942","DOI":"10.2174\/1570159X15666170720094529","article-title":"Modulation of the Immune System for the Treatment of Glaucoma","volume":"16","author":"Bell","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1167\/iovs.07-1337","article-title":"Reduced Retina Microglial Activation and Improved Optic Nerve Integrity with Minocycline Treatment in the DBA\/2J Mouse Model of Glaucoma","volume":"49","author":"Bosco","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/archopht.124.4.520","article-title":"Minocycline Delays Death of Retinal Ganglion Cells in Experimental Glaucoma and after Optic Nerve Transection","volume":"124","author":"Melamed","year":"2006","journal-title":"Arch. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1002\/glia.22715","article-title":"Fractalkine Receptor Regulates Microglial Neurotoxicity in an Experimental Mouse Glaucoma Model","volume":"62","author":"Wang","year":"2014","journal-title":"Glia"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/tvst.10.1.22","article-title":"When Is a Control Not a Control? Reactive Microglia Occur throughout the Control Contralateral Pathway of Retinal Ganglion Cell Projections in Experimental Glaucoma","volume":"10","author":"Tribble","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/ki.2012.199","article-title":"Cilastatin Protects against Cisplatin-Induced Nephrotoxicity without Compromising Its Anticancer Efficiency in Rats","volume":"82","author":"Humanes","year":"2012","journal-title":"Kidney Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/ndt\/gfx005","article-title":"Cisplatin-Induced Renal Inflammation Is Ameliorated by Cilastatin Nephroprotection","volume":"32","author":"Humanes","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Jado, J.C., Humanes, B., Gonz\u00e1lez-Nicol\u00e1s, M.\u00c1., Cama\u00f1o, S., Lara, J.M., L\u00f3pez, B., Cercenado, E., Garc\u00eda-Bordas, J., Tejedor, A., and L\u00e1zaro, A. (2020). Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency. Antioxidants, 9.","DOI":"10.3390\/antiox9090821"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/ajhp\/zxab012","article-title":"Imipenem\/Cilastatin\/Relebactam: A New Carbapenem \u03b2-Lactamase Inhibitor Combination","volume":"78","author":"Mansour","year":"2021","journal-title":"Am. J. Health Pharm."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1080\/14740338.2020.1796967","article-title":"Cilastatin as a Protective Agent against Drug Induced Nephrotoxicity: A Literature Review","volume":"19","author":"Shayan","year":"2020","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zaballos, M., Power, M., Canal-Alonso, M.I., Gonz\u00e1lez-Nicol\u00e1s, M.\u00c1., Vasquez-Jimenez, W., Lozano-Lominchar, P., Cabrerizo-Torrente, P., Palencia-Garc\u00eda, N., Gago-Quiroga, S., and Ginel-Feito, M.D. (2021). Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031239"},{"key":"ref_29","first-page":"2578","article-title":"Functional and Morphological Effects of Laser-Induced Ocular Hypertension in Retinas of Adult Albino Swiss Mice","volume":"15","year":"2009","journal-title":"Mol. Vis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e647","DOI":"10.1097\/IJG.0000000000000242","article-title":"Vascular Endothelial Growth Factor Is Increased in Aqueous Humor of Acute Primary Angle-Closure Eyes","volume":"25","author":"Huang","year":"2016","journal-title":"J. Glaucoma"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1167\/iovs.05-0955","article-title":"Topographic and Morphologic Analyses of Retinal Ganglion Cell Loss in Old DBA\/2NNia Mice","volume":"47","author":"Filippopoulos","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"fcac251","DOI":"10.1093\/braincomms\/fcac251","article-title":"Axon Hyperexcitability in the Contralateral Projection Following Unilateral Optic Nerve Crush in Mice","volume":"4","author":"McGrady","year":"2022","journal-title":"Brain Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.exer.2005.01.012","article-title":"Long-Term Glial Reactivity in Rat Retinas Ipsilateral and Contralateral to Experimental Glaucoma","volume":"81","author":"Kanamori","year":"2005","journal-title":"Exp. Eye Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.1167\/iovs.10-5248","article-title":"Quantification of the Effect of Different Levels of IOP in the Astroglia of the Rat Retina Ipsilateral and Contralateral to Experimental Glaucoma","volume":"51","author":"Salazar","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","article-title":"Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases","volume":"53","author":"Tang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1167\/iovs.64.7.24","article-title":"Neuroprotection of Retinal Ganglion Cells Suppresses Microglia Activation in a Mouse Model of Glaucoma","volume":"64","author":"Kumar","year":"2023","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez, R., Gonz\u00e1lez-Nicol\u00e1s, M.\u00c1., Morales, M., \u00c1vila, J., L\u00e1zaro, A., and Mart\u00edn-Vasallo, P. (2022). FKBP51, AmotL2 and IQGAP1 Involvement in Cilastatin Prevention of Cisplatin-Induced Tubular Nephrotoxicity in Rats. Cells, 11.","DOI":"10.3390\/cells11091585"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuron.2012.12.023","article-title":"Microglia: New Roles for the Synaptic Stripper","volume":"77","author":"Kettenmann","year":"2013","journal-title":"Neuron"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Volland, S., Esteve-Rudd, J., Hoo, J., Yee, C., and Williams, D.S. (2015). A Comparison of Some Organizational Characteristics of the Mouse Central Retina and the Human Macula. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125631"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving Bioscience Research Reporting: The Arrive Guidelines for Reporting Animal Research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.toxlet.2017.05.023","article-title":"Cilastatin Attenuates Vancomycin-Induced Nephrotoxicity via P-Glycoprotein","volume":"277","author":"Im","year":"2017","journal-title":"Toxicol. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1167\/iovs.08-3267","article-title":"Brn3a as a Marker of Retinal Ganglion Cells: Qualitative and Quantitative Time Course Studies in Na\u00efve and Optic Nerve-Injured Retinas","volume":"50","author":"Agudo","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/6\/3115\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:10:40Z","timestamp":1760105440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/6\/3115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25063115"],"URL":"https:\/\/doi.org\/10.3390\/ijms25063115","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]}}}