{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:48:09Z","timestamp":1791460089792,"version":"4.3.4"},"reference-count":68,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hashimoto\u2019s thyroiditis (HT) is marked by self-tissue destruction as a consequence of an alteration in the adaptive immune response that entails the evasion of immune regulation. Vitamin D carries out an immunomodulatory role that appears to promote immune tolerance. The aim of this study is to elaborate a narrative review of the relationship between vitamin D status and HT and the role of vitamin D supplementation in reducing HT risk by modulating the immune system. There is extensive literature confirming that vitamin D levels are significantly lower in HT patients compared to healthy people. On the other hand, after the supplementation with cholecalciferol in patients with HT and vitamin D deficiency, thyroid autoantibody titers decreased significantly. Further knowledge of the beneficial effects of vitamin D in the prevention and treatment of autoimmune thyroid diseases requires the execution of additional randomized, double-blind, placebo-controlled trials and longer follow-up periods.<\/jats:p>","DOI":"10.3390\/ijms25063154","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T06:05:30Z","timestamp":1710137130000},"page":"3154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Autoimmune Thyroiditis and Vitamin D"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4628-2213","authenticated-orcid":false,"given":"Teodoro","family":"Dur\u00e1-Trav\u00e9","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of Navarra, 431008 Pamplona, Spain"},{"name":"Navarrabiomed (Biomedical Research Center), 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidel","family":"Gallinas-Victoriano","sequence":"additional","affiliation":[{"name":"Navarrabiomed (Biomedical Research Center), 31008 Pamplona, Spain"},{"name":"Department of Pediatrics, Navarra Hospital Complex, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bellan, M., Andreoli, L., Mele, C., Sainaghi, P.P., Rigamonti, C., Piantoni, S., De Benedittis, C., Aimaretti, G., Pirisi, M., and Marzullo, P. (2020). Pathophysiological Role and Therapeutic Implications of Vitamin D in Autoimmunity: Focus on Chronic Autoimmune Diseases. Nutrients, 12.","DOI":"10.3390\/nu12030789"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"102649","DOI":"10.1016\/j.autrev.2020.102649","article-title":"Hashimoto\u2019s Thyroiditis: An Update on Pathogenic Mechanisms, Diagnostic Protocols, Therapeutic Strategies, and Potential Malignant Transformation","volume":"19","author":"Ralli","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.mayocp.2013.05.011","article-title":"Vitamin D for health: A global perspective","volume":"88","author":"Holick","year":"2013","journal-title":"Mayo Clin. Proc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3233\/PRM-140287","article-title":"Vitamin D, bone health, and other health benefits in pediatric patients","volume":"7","author":"Palermo","year":"2014","journal-title":"J. Pediatr. Rehabil. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.3390\/nu5072502","article-title":"Vitamin D and immune function","volume":"5","author":"Prietl","year":"2013","journal-title":"Nutrients"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.3389\/fimmu.2019.02739","article-title":"Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond","volume":"10","author":"Cyprian","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mele, C., Caputo, M., Bisceglia, A., Sama, M.T., Zavattaro, M., Aimaretti, G., Pagano, L., Prodam, F., and Marzullo, P. (2020). Immunomodulatory Effects of Vitamin D in Thyroid Diseases. Nutrients, 12.","DOI":"10.3390\/nu12051444"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e210024","DOI":"10.1530\/ETJ-21-0024","article-title":"Cellular and molecular basis of thyroid autoimmunity","volume":"11","author":"Boguslawska","year":"2022","journal-title":"Eur. Thyroid. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11154-016-9405-9","article-title":"Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept","volume":"18","author":"Altieri","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/jcpt.13605","article-title":"Effects of vitamin D treatment on thyroid function and autoimmunity markers in patients with Hashimoto\u2019s thyroiditis-A meta-analysis of randomized controlled trials","volume":"47","author":"Jiang","year":"2022","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gallo, D., Baci, D., Kustrimovic, N., Lanzo, N., Patera, B., Tanda, M.L., Piantanida, E., and Mortara, L. (2023). How Does Vitamin D Affect Immune Cells Crosstalk in Autoimmune Diseases?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054689"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/03009742.2016.1151072","article-title":"Vitamin D and autoimmunity","volume":"45","author":"Rosen","year":"2016","journal-title":"Scand. J. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12020-017-1425-z","article-title":"Vitamin D deficiency affects thyroid autoimmunity and dysfunction in iodine-replete area: Korea national health and nutrition examination survey","volume":"58","author":"Kim","year":"2017","journal-title":"Endocrine"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Vieira, I.H., Rodrigues, D., and Paiva, I. (2020). Vitamin D and Autoimmune Thyroid Disease-Cause, Consequence, or a Vicious Cycle?. Nutrients, 12.","DOI":"10.3390\/nu12092791"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"574967","DOI":"10.3389\/fimmu.2021.574967","article-title":"Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Lebiedzinski, F., and Lisowska, K.A. (2023). Impact of Vitamin D on Immunopathology of Hashimoto\u2019s Thyroiditis: From Theory to Practice. Nutrients, 15.","DOI":"10.3390\/nu15143174"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s40618-020-01477-1","article-title":"An update on the pathogenesis of Hashimoto\u2019s thyroiditis","volume":"44","author":"Weetman","year":"2021","journal-title":"J. Endocrinol. Investig."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Babic Leko, M., Jure\u0161ko, I., Rozic, I., Pleic, N., Gunja\u010da, I., and Zemunik, T. (2023). Vitamin D and the Thyroid: A Critical Review of the Current Evidence. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043586"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Czarnywojtek, A., Florek, E., Pietronczyk, K., Sawicka-Gutaj, N., Rucha\u0142a, M., Ronen, O., Nixon, I.J., Shaha, A.R., Rodrigo, J.P., and Tufano, R.P. (2023). The Role of Vitamin D in utoimmune Thyroid Diseases: A Narrative Review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12041452"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"979167","DOI":"10.1155\/2015\/979167","article-title":"Immune disorders in Hashimoto\u2019s thyroiditis: What do we know so far?","volume":"2015","author":"Pyzik","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cyto.2019.01.003","article-title":"Immunological Aspects of Autoimmune Thyroid Disease\u2014Complex Interplay between Cells and Cytokines","volume":"116","author":"Luty","year":"2019","journal-title":"Cytokine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1055\/a-1023-4181","article-title":"Vitamin D Status and Thyroid Autoantibodies in Autoimmune Thyroiditis","volume":"51","author":"Koehler","year":"2019","journal-title":"Horm. Metab. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/cmi.2010.73","article-title":"Vitamin D and autoimmune thyroid diseases","volume":"8","author":"Kivity","year":"2011","journal-title":"Cell Mol. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1089\/thy.2009.0200","article-title":"Relative vitamin D insufficiency in Hashimoto\u2019s thyroiditis","volume":"21","author":"Tamer","year":"2011","journal-title":"Thyroid"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4158\/EP12376.OR","article-title":"The association between severity of vitamin D deficiency and Hashimoto\u2019s thyroiditis","volume":"19","author":"Bozkurt","year":"2013","journal-title":"Endocr. Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s40618-014-0064-y","article-title":"The association between serum 25OHD levels and hypothyroid Hashimoto\u2019s thyroiditis","volume":"37","author":"Mansournia","year":"2014","journal-title":"J. Endocrinol. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"493","DOI":"10.5114\/ceji.2014.47735","article-title":"Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis","volume":"39","author":"Unal","year":"2014","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref_29","first-page":"222","article-title":"Is vitamin D related to pathogenesis and treatment of Hashimoto\u2019s thyroiditis?","volume":"18","author":"Mazokopakis","year":"2015","journal-title":"Hell. J. Nucl. Med."},{"key":"ref_30","first-page":"385","article-title":"Low vitamin D status is associated with hypothyroid Hashimoto\u2019s thyroiditis","volume":"15","author":"Kim","year":"2016","journal-title":"Hormones"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s12020-016-0942-5","article-title":"Vitamin D receptor gene polymorphisms\/haplotypes and serum 25(OH)D3 levels in Hashimoto\u2019s thyroiditis","volume":"55","author":"Giovinazzo","year":"2016","journal-title":"Endocrine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2174\/1871530318666180406163426","article-title":"Low 25 Hydroxyvitamin D Levels are Independently Associated with Autoimmune Thyroiditis in a Cohort of Apparently Healthy Overweight and Obese Subjects","volume":"18","author":"Triggiani","year":"2018","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1055\/a-0653-7108","article-title":"The effect of gluten-free diet on thyroid autoimmunity in drug-na\u00efve women with Hashimoto\u2019s thyroiditis: A pilot study","volume":"127","author":"Krysiak","year":"2019","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1159\/000505094","article-title":"Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies","volume":"29","year":"2020","journal-title":"Med. Princ. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Appunni, S., Rubens, M., Ramamoorthy, V., Saxena, A., Tonse, R., Veledar, E., and McGranaghan, P. (2021). Association between vitamin D deficiency and hypothyroidism: Results from the National Health and Nutrition Examination Survey (NHANES) 2007\u20132012. BMC Endocr. Disord., 21.","DOI":"10.1186\/s12902-021-00897-1"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1515\/cclm-2013-0975","article-title":"High prevalence of anti-thyroid antibodies associated with a low vitamin D status in a pediatric cohort","volume":"52","author":"Zaidman","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1515\/jpem-2012-0021","article-title":"Vitamin D status in children with Hashimoto thyroiditis","volume":"25","author":"Camurdan","year":"2012","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4274\/jcrpe.2011","article-title":"Vitamin D deficiency and Hashimoto\u2019s thyroiditis in children and adolescents: A critical vitamin D level for this association?","volume":"7","author":"Evliyaoglu","year":"2015","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s40618-016-0432-x","article-title":"Vitamin D status in children and adolescents with autoimmune thyroiditis","volume":"39","author":"Metwalley","year":"2016","journal-title":"J. Endocrinol. Investig."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"611","DOI":"10.4067\/S0034-98872016000500009","article-title":"Hypovitaminosis D in children with Hashimoto\u2019s thyroiditis","volume":"144","author":"Ozer","year":"2016","journal-title":"Rev. Med. Chil."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.autrev.2014.10.008","article-title":"Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases?","volume":"14","author":"Villalta","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1507\/endocrj.EJ16-0547","article-title":"25-Hydroxyvitamin D serum level in Hashimoto\u2019s thyroiditis, but not Graves\u2019 disease is relatively deficient","volume":"64","author":"Ke","year":"2017","journal-title":"Endocr. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"809","DOI":"10.4158\/EP15934.OR","article-title":"Hashimoto thyroiditis not associated with vitamin D deficiency","volume":"22","author":"Yasmeh","year":"2016","journal-title":"Endocr. Pract."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Cvek, M., Kalicanin, D., Baric, A., Vuletic, M., Gunjac, I., Torlak Lovric, V., \u0160krabi\u0107, V., Punda, A., and Perica, V.B. (2021). Vitamin D and Hashimoto\u2019s Thyroiditis: Observations from CROHT Biobank. Nutrients, 13.","DOI":"10.3390\/nu13082793"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.3390\/nu7042485","article-title":"Meta-analysis of the association between vitamin D and autoimmune thyroid disease","volume":"7","author":"Wang","year":"2015","journal-title":"Nutrients"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00394-019-01991-w","article-title":"Serum 25-hydoxyvitamin D concentrations in relation to Hashimoto\u2019s thyroiditis: A systematic review, meta-analysis and meta-regression of observational studies","volume":"59","author":"Tokic","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Taheriniya, S., Arab, A., Hadi, A., Fadel, A., and Askari, G. (2021). Vitamin D and thyroid disorders: A systematic review and Meta-analysis of observational studies. BMC Endocr. Disord., 21.","DOI":"10.1186\/s12902-021-00831-5"},{"key":"ref_48","first-page":"e25869","article-title":"Association Between Vitamin D Deficiency and Autoimmune Thyroid Disorder: A Systematic Review","volume":"14","author":"Khozam","year":"2022","journal-title":"Cureus"},{"key":"ref_49","first-page":"e21069","article-title":"Relationship Between Vitamin D and Thyroid: An Enigma","volume":"14","author":"Ashok","year":"2022","journal-title":"Cureus"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/thy.2012.0001","article-title":"High Vitamin D Status in Younger Individuals Is Associated with Low Circulating Thyrotropin","volume":"23","author":"Chailurkit","year":"2013","journal-title":"Thyroid."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10238-014-0290-9","article-title":"TSH levels are associated with vitamin D status and seasonality in an adult population of euthyroid adults","volume":"15","author":"Barchetta","year":"2015","journal-title":"Clin. Exp. Med."},{"key":"ref_52","first-page":"343","article-title":"Immune intervention effects on the induction of experimental autoimmune thyroiditis","volume":"22","author":"Chen","year":"2002","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"ref_53","first-page":"1573","article-title":"Effects of 1,25-dihydroxyvitamin D3 in rats with experimental autoimmune thyroiditis","volume":"30","author":"Liu","year":"2010","journal-title":"J. South. Med. Univ."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1055\/s-0042-123038","article-title":"The Effect of Vitamin D on Thyroid Autoimmunity in Levothyroxine-Treated Women with Hashimoto\u2019s Thyroiditis and Normal Vitamin D Status","volume":"125","author":"Krysiak","year":"2017","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4103\/2230-8210.179997","article-title":"Vitamin D Supplementation Reduces Thyroid Peroxidase Antibody Levels in Patients with Autoimmune Thyroid Disease: An Open-Labeled Randomized Controlled Trial","volume":"20","author":"Chaudhary","year":"2016","journal-title":"Indian. J. Endocrinol. Metab."},{"key":"ref_56","first-page":"1","article-title":"A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto\u2019s Thyroiditis","volume":"71","author":"Bhakat","year":"2023","journal-title":"Assoc. Physicians India"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/1735-1995.192501","article-title":"Effects of Vitamin D treatment on thyroid autoimmunity","volume":"21","author":"Simsek","year":"2016","journal-title":"J. Res. Med. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1055\/a-0856-1044","article-title":"Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, \u00bfTSH) in Hashimoto\u2019s Thyroiditis? A Double Blind, Randomized Clinical Trial","volume":"51","author":"Chahardoli","year":"2019","journal-title":"Horm. Metab. Res."},{"key":"ref_59","first-page":"407","article-title":"The Impact of Vitamin D Supplementation on the IFN\u03b3-IP10 Axis in Women with Hashimoto\u2019s Thyroiditis Treated with Levothyroxine: A Double-blind Randomized Placebo-controlled Trial","volume":"21","author":"Mobini","year":"2022","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1111\/jcpt.13730","article-title":"The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-na\u00efve women with autoimmune thyroiditis: A pilot study","volume":"47","author":"Krysiak","year":"2022","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s12020-017-1450-y","article-title":"Physiological Serum 25-Hydroxyvitamin D Concentrations Are Associated with Improved Thyroid Function\u2014Observations from a Community-Based Program","volume":"58","author":"Mirhosseini","year":"2017","journal-title":"Endocrine"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/s41430-019-0395-z","article-title":"Effects of vitamin D supplements on frequency of CD4+ T-cell subsets in women with Hashimoto\u2019s thyroiditis: A double-blind placebo-controlled study","volume":"73","author":"Nodehi","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.33549\/physiolres.933083","article-title":"Vitamin D and thyroid diseases","volume":"64","author":"Vondra","year":"2015","journal-title":"Physiol. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1210\/js.2017-00037","article-title":"Effect of Vitamin D on Thyroid Autoimmunity: A Randomized, Double-Blind, Controlled Trial Among Ethnic Minorities","volume":"1","author":"Knutsen","year":"2017","journal-title":"J. Endocr. Soc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/jrms.JRMS_1048_16","article-title":"Effect of Vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto\u2019s thyroiditis: A double-blind randomized placebo-controlled clinical trial","volume":"22","author":"Aminorroaya","year":"2017","journal-title":"J. Res. Med. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s12020-018-1532-5","article-title":"The effect of vitamin D supplementation on thyroid autoantibody levels in the treatment of autoimmune thyroiditis: A systematic review and a meta-analysis","volume":"59","author":"Wang","year":"2018","journal-title":"Endocrine"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/03000605211060675","article-title":"Effects of Vitamin D on Thyroid Autoimmunity Markers in Hashimoto\u2019s Thyroiditis: Systematic Review and Meta-Analysis","volume":"49","author":"Zhang","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_68","first-page":"10889","article-title":"Effect of Vitamin DTherapy on Hashimoto\u2019s Thyroiditis in Children with Hypovitaminosis, D","volume":"8","author":"Aghili","year":"2020","journal-title":"Int. J. 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