{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:22:25Z","timestamp":1789647745742,"version":"4.0.0"},"reference-count":141,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["2786937"],"award-info":[{"award-number":["2786937"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The present investigation was designed based on the evidence that, in neurodegenerative disorders, such as Alzheimer\u2019s dementia (AD) and Parkinson\u2019s disease (PD), damage to the locus coeruleus (LC) arising norepinephrine (NE) axons (LC-NE) is documented and hypothesized to foster the onset and progression of neurodegeneration within target regions. Specifically, the present experiments were designed to assess whether selective damage to LC-NE axons may alter key proteins involved in neurodegeneration within specific limbic regions, such as the hippocampus and piriform cortex, compared with the dorsal striatum. To achieve this, a loss of LC-NE axons was induced by the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) in C57 Black mice, as assessed by a loss of NE and dopamine-beta-hydroxylase within target regions. In these experimental conditions, the amount of alpha-synuclein (alpha-syn) protein levels were increased along with alpha-syn expressing neurons within the hippocampus and piriform cortex. Similar findings were obtained concerning phospho-Tau immunoblotting. In contrast, a decrease in inducible HSP70-expressing neurons and a loss of sequestosome (p62)-expressing cells, along with a loss of these proteins at immunoblotting, were reported. The present data provide further evidence to understand why a loss of LC-NE axons may foster limbic neurodegeneration in AD and limbic engagement during PD.<\/jats:p>","DOI":"10.3390\/ijms25063159","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T06:05:30Z","timestamp":1710137130000},"page":"3159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-4889","authenticated-orcid":false,"given":"Francesca","family":"Biagioni","sequence":"first","affiliation":[{"name":"IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzili, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1446-715X","authenticated-orcid":false,"given":"Michela","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Human Anatomy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Lazzeri","sequence":"additional","affiliation":[{"name":"Human Anatomy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Scioli","sequence":"additional","affiliation":[{"name":"IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzili, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Frati","sequence":"additional","affiliation":[{"name":"IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzili, Italy"},{"name":"Neurosurgery Division, Human Neurosciences Department, Sapienza University, 00135 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Puglisi-Allegra","sequence":"additional","affiliation":[{"name":"IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzili, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-5084","authenticated-orcid":false,"given":"Francesco","family":"Fornai","sequence":"additional","affiliation":[{"name":"IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzili, Italy"},{"name":"Neurosurgery Division, Human Neurosciences Department, Sapienza University, 00135 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fnana.2017.00098","article-title":"Systematic Morphometry of Catecholamine Nuclei in the Brainstem","volume":"11","author":"Bucci","year":"2017","journal-title":"Front. Neuroanat."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.274.5290.1211","article-title":"Neuronal gene expression in the waking state: A role for the locus coeruleus","volume":"274","author":"Cirelli","year":"1996","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1016\/j.cub.2023.09.074","article-title":"Noradrenaline tracks emotional modulation of attention in human amygdala","volume":"33","author":"Bang","year":"2023","journal-title":"Curr. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Le, L., Feidler, A.M., Li, H., Kara-Pabani, K., Lamantia, C., O\u2019Banion, M.K., and Majewska, K.A. (2023). Noradrenergic signaling controls Alzheimer\u2019s disease pathology via activation of microglial \u03b22 adrenergic receptors. bioRxiv.","DOI":"10.1101\/2023.12.01.569564"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1342622","DOI":"10.3389\/fnmol.2024.1342622","article-title":"Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus","volume":"17","author":"Grella","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"26331055241227220","DOI":"10.1177\/26331055241227220","article-title":"Let\u2019s Shape Learning Into Lasting Memories","volume":"19","author":"Vanneste","year":"2024","journal-title":"Neurosci. Insights"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1138624","DOI":"10.3389\/fncel.2023.1138624","article-title":"Locus coeruleus ablation in mice: Protocol optimization, stereology and behavioral impact","volume":"17","author":"Markussen","year":"2023","journal-title":"Front. Cell Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"bqad178","DOI":"10.1210\/endocr\/bqad178","article-title":"Hindbrain Adrenergic\/Noradrenergic Control of Integrated Endocrine and Autonomic Stress Responses","volume":"165","author":"Pace","year":"2023","journal-title":"Endocrinology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"eadh0980","DOI":"10.1126\/sciadv.adh0980","article-title":"The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1","volume":"9","author":"Fortin","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"RP89267","DOI":"10.7554\/eLife.89267.3","article-title":"Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats","volume":"12","author":"Lui","year":"2024","journal-title":"elife"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0047-6374(83)90100-8","article-title":"The locus coeruleus and its possible role in ageing and degenerative disease of the human central nervous system","volume":"23","author":"Mann","year":"1983","journal-title":"Mech. Ageing Dev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/ana.410320510","article-title":"Disease-specific patterns of locus coeruleus cell loss","volume":"32","author":"German","year":"1992","journal-title":"Ann. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0149-7634(00)00028-2","article-title":"The role of the locus coeruleus in the development of Parkinson\u2019s disease","volume":"24","author":"Gesi","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainresrev.2004.02.002","article-title":"Noradrenergic mechanisms in neurodegenerative diseases: A theory","volume":"45","author":"Marien","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0165-0270(94)00163-B","article-title":"N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) has differential efficacy for causing central noradrenergic lesions in two different rat strains: Comparison between Long-Evans and Sprague-Dawley rats","volume":"58","author":"Schuerger","year":"1995","journal-title":"J. Neurosci. Methods"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fphar.2020.593822","article-title":"The Noradrenergic System in Parkinson\u2019s Disease","volume":"11","author":"Miguelez","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neuro.2020.06.001","article-title":"Adrenergic \u03b2 receptor activation reduces amyloid \u03b21-42-mediated intracellular Zn2+ toxicity in dentate granule cells followed by rescuing impair-ment of dentate gyrus LTP","volume":"79","author":"Tamano","year":"2020","journal-title":"Neurotoxicology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"eabj2511","DOI":"10.1126\/scitranslmed.abj2511","article-title":"In vivo and neuropa-thology data support locus coeruleus integrity as indicator of Alzheimer\u2019s disease pathology and cognitive decline","volume":"13","author":"Jacobs","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"607566","DOI":"10.3389\/fneur.2020.607566","article-title":"The Human Brain Representation of Odor Identification in Amnestic Mild Cognitive Impairment and Alzheimer\u2019s Dementia of Mild Degree","volume":"11","author":"Kjelvik","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00401-020-02248-1","article-title":"The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer\u2019s disease","volume":"141","author":"Murray","year":"2021","journal-title":"Acta Neuropathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/s41386-022-01293-6","article-title":"Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer\u2019s disease","volume":"47","author":"Cassidy","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00401-022-02477-6","article-title":"Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging","volume":"144","author":"Gilvesy","year":"2022","journal-title":"Acta Neuropathol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez, I.L., Dello Russo, C., Novellino, F., Caso, J.R., Garc\u00eda-Bueno, B., Leza, J.C., and Madrigal, J.L.M. (2022). Noradrenaline in Alzheimer\u2019s Disease: A New Potential Therapeutic Target. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116143"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/WCO.0000000000001042","article-title":"The role of the locus coeruleus\/norepinephrine system in the pathogenesis of neurodegenerative disorders: An update","volume":"35","author":"Malatt","year":"2022","journal-title":"Curr. Opin. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1002\/hbm.26324","article-title":"Characterization of an automated method to segment the human locus coeruleus","volume":"44","author":"Sibahi","year":"2023","journal-title":"Hum. Brain Mapp."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"10985","DOI":"10.1523\/JNEUROSCI.19-24-10985.1999","article-title":"Norepinephrine-deficient mice have increased susceptibility to seizure-inducing stimuli","volume":"19","author":"Szot","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1046\/j.1460-9568.2003.02692.x","article-title":"A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus","volume":"17","author":"Giorgi","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.neubiorev.2004.06.008","article-title":"The role of norepinephrine in epilepsy: From the bench to the bedside","volume":"28","author":"Giorgi","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1528-1167.2006.00872.x","article-title":"Locus coeruleus and neuronal plasticity in a model of focal limbic epilepsy","volume":"47","author":"Giorgi","year":"2006","journal-title":"Epilepsia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1111\/j.1528-1167.2008.01972.x","article-title":"Lack of alpha 1b-adrenergic receptor protects against epileptic seizures","volume":"50","author":"Pizzanelli","year":"2009","journal-title":"Epilepsia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1111\/j.1460-9568.2011.07707.x","article-title":"The role of locus coeruleus in the antiepileptic activity induced by vagus nerve stimulation","volume":"33","author":"Fornai","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.2174\/1570159X20666220327213615","article-title":"Noradrenaline and Seizures: A Perspective on the Role of Adrenergic Receptors in Limbic Seizures","volume":"21","author":"Biagioni","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Larsen, L.E., Caestecker, S., Stevens, L., van Mierlo, P., Carrette, E., Boon, P., Vonck, K., and Raedt, R. (2023). Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus. Neurobiol. Dis., 189.","DOI":"10.1016\/j.nbd.2023.106355"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0306-4522(91)90300-D","article-title":"DSP4 treatment worsens hippocampal pyramidal cell damage after transient ischemia","volume":"43","author":"Nishino","year":"1991","journal-title":"Neuroscience"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1038\/s41467-019-10795-9","article-title":"Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12975-019-00718-7","article-title":"Central Noradrenergic Agonists in the Treatment of Ischemic Stroke-an Overview","volume":"11","author":"Sternberg","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0014-2999(93)90489-5","article-title":"Noradrenaline depletion exacerbates MPTP-induced striatal dopamine loss in mice","volume":"236","author":"Marien","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1471-4159.1995.65020704.x","article-title":"Clonidine suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced reductions of striatal dopamine and tyrosine hydroxylase activity in mice","volume":"65","author":"Fornai","year":"1995","journal-title":"J. Neurochem."},{"key":"ref_39","first-page":"100","article-title":"Effects of noradrenergic lesions on MPTP\/MPP+ kinetics and MPTP-induced nigrostriatal dopamine depletions","volume":"283","author":"Fornai","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0306-4522(91)90345-O","article-title":"Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: A possible role for the locus coeruleus in the progression of Parkinson\u2019s disease","volume":"41","author":"Mavridis","year":"1991","journal-title":"Neuroscience"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/cne.902870308","article-title":"Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson\u2019s disease with and without dementia and depression","volume":"287","author":"Asan","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ana.410250612","article-title":"Parkinsonism and neurofibrillary tangle pathology in pigmented nuclei","volume":"25","author":"Rajput","year":"1989","journal-title":"Ann. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1001\/archneur.63.12.1724","article-title":"Inverse relationship between brain noradrenaline level and dopamine loss in Parkinson disease: A possible neuroprotective role for noradrenaline","volume":"63","author":"Tong","year":"2006","journal-title":"Arch. Neurol."},{"key":"ref_44","first-page":"99","article-title":"Morphological changes in Alzheimer\u2019s disease-senile dementia: Ultrastructural changes and quantitative studies","volume":"57","author":"Terry","year":"1979","journal-title":"Res. Publ. Assoc. Res. Nerv. Ment. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1192\/bjp.136.6.533","article-title":"Changes in the monoamine containing neurones of the human CNS in senile dementia","volume":"136","author":"Mann","year":"1980","journal-title":"Br. J. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0140-6736(81)92657-X","article-title":"Selective loss of neurones of origin of adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia","volume":"1","author":"Bondareff","year":"1981","journal-title":"Lancet"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF00697178","article-title":"Synaptic morphology in the human locus ceruleus","volume":"53","author":"Forno","year":"1981","journal-title":"Acta Neuropathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0022-510X(81)90031-9","article-title":"Cell loss in the locus coeruleus in senile dementia of Alzheimer type","volume":"49","author":"Tomlinson","year":"1981","journal-title":"J. Neurol. Sci."},{"key":"ref_49","first-page":"97","article-title":"The human locus coeruleus in neurology and psychiatry. (Parkinson\u2019s, Lewy body, Hallervorden-Spatz, Alzheimer\u2019s and Korsakoff\u2019s disease, (pre)senile dementia, schizophrenia, affective disorders, psychosis)","volume":"17","year":"1981","journal-title":"Prog. Neurobiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0079-6123(08)63839-X","article-title":"Alterations in the locus coeruleus in dementias of Alzheimer\u2019s and Parkinson\u2019s disease","volume":"88","year":"1991","journal-title":"Prog. Brain Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/jnnp.45.2.113","article-title":"The noradrenergic system in Alzheimer and multi-infarct dementias","volume":"45","author":"Mann","year":"1982","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0304-3940(86)90336-8","article-title":"Loss of nerve cells from locus coeruleus in Alzheimer\u2019s disease is topographically arranged","volume":"64","author":"Marcyniuk","year":"1986","journal-title":"Neurosci. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Banwinkler, M., Theis, H., Prange, S., and van Eimeren, T. (2022). Imaging the Limbic System in Parkinson\u2019s Disease-A Review of Limbic Pathology and Clinical Symptoms. Brain Sci., 12.","DOI":"10.3390\/brainsci12091248"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Jellinger, K.A. (2023). Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010498"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"824","DOI":"10.21037\/qims-23-919","article-title":"Hippocampal volume and resting-state functional connectivity on magnetic resonance imaging in patients with Parkinson and depression","volume":"14","author":"Liang","year":"2024","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e14480","DOI":"10.1111\/cns.14480","article-title":"Fine-grained features characterize hippocampal and amygdaloid change pattern in Parkinson\u2019s disease and discriminate cognitive-deficit subtype","volume":"30","author":"Zhang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/01677063.2018.1497630","article-title":"Noradrenergic gating of long-lasting synaptic potentiation in the hippocampus: From neurobiology to translational biomedicine","volume":"32","author":"Nguyen","year":"2018","journal-title":"J. Neurogenet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.3389\/fphar.2019.01000","article-title":"Salmeterol, a \u03b22 Adrenergic Agonist, Promotes Adult Hippocampal Neurogenesis in a Region-Specific Manner","volume":"10","author":"Bortolotto","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1111\/ejn.15045","article-title":"Locus coeruleus in memory formation and Alzheimer\u2019s disease","volume":"54","author":"James","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12974-020-02054-2","article-title":"Comparisons of neuroinflammation, microglial activation, and degeneration of the locus coeruleus-norepinephrine system in APP\/PS1 and aging mice","volume":"18","author":"Cao","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1523\/JNEUROSCI.0119-21.2021","article-title":"Heightened Hippocampal \u03b2-Adrenergic Receptor Function Drives Synaptic Potentiation and Supports Learning and Memory in the TgF344-AD Rat Model during Prodromal Alzheimer\u2019s Disease","volume":"41","author":"Goodman","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"667244","DOI":"10.3389\/fnbeh.2021.667244","article-title":"The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory","volume":"15","author":"Titulaer","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40478-023-01546-5","article-title":"Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer\u2019s disease","volume":"11","author":"Khan","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neurobiolaging.2024.01.011","article-title":"Long-term olfactory enrichment promotes non-olfactory cognition, noradrenergic plasticity and remodeling of brain functional connectivity in older mice","volume":"136","author":"Terrier","year":"2024","journal-title":"Neurobiol. Aging"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/cne.901800309","article-title":"Catecholamine innervation of the basal forebrain. III. Olfactory bulb, anterior olfactory nuclei, olfactory tubercle and piriform cortex","volume":"180","author":"Fallon","year":"1978","journal-title":"J. Comp. Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0006-8993(95)01279-6","article-title":"Catecholamine innervation of the piriform cortex: A tracing and immunohistochemical study in the rat","volume":"710","author":"Datiche","year":"1996","journal-title":"Brain Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8438","DOI":"10.1007\/s12035-018-1004-1","article-title":"\u03b12A- and \u03b12C-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands","volume":"55","author":"Yano","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ejrad.2013.11.024","article-title":"Imaging of olfactory bulb and gray matter volumes in brain areas associated with olfactory function in patients with Parkinson\u2019s disease and multiple system atrophy","volume":"83","author":"Chen","year":"2014","journal-title":"Eur. J. Radiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/mds.25829","article-title":"Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson\u2019s disease","volume":"29","author":"Lee","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3389\/fncel.2018.00479","article-title":"Structural Changes Observed in the Piriform Cortex in a Rat Model of Pre-motor Parkinson\u2019s Disease","volume":"12","author":"Sancandi","year":"2018","journal-title":"Front. Cell Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neuroscience.2019.09.006","article-title":"Lesion of the Locus Coeruleus Damages Learning and Memory Performance in Paraquat and Maneb-induced Mouse Parkinson\u2019s Disease Model","volume":"419","author":"Hou","year":"2019","journal-title":"Neuroscience"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Hummel, T., Haehner, A., Thaploo, D., Georgiopoulos, C., Falkenburger, B., and Whitcroft, K. (2021). Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study. Medicina, 57.","DOI":"10.3390\/medicina57111183"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/jon.12911","article-title":"Hippocampal volume is related to olfactory impairment in Parkinson\u2019s disease","volume":"31","author":"Roh","year":"2021","journal-title":"J. Neuroimaging"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"908758","DOI":"10.3389\/fncel.2022.908758","article-title":"Noradrenergic Modulation of the Piriform Cortex: A Possible Avenue for Understanding Pre-Clinical Alzheimer\u2019s Disease Pathogenesis","volume":"16","author":"Rajani","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/ejn.15899","article-title":"Hippocampal, basal ganglia and olfactory connectivity contribute to cognitive impairments in Parkinson\u2019s disease","volume":"57","author":"Wylie","year":"2023","journal-title":"Eur. J. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.4103\/1673-5374.386406","article-title":"Amyloid-beta and tau protein beyond Alzheimer\u2019s disease","volume":"19","author":"Abyadeh","year":"2024","journal-title":"Neural Regen Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41582-023-00905-z","article-title":"A multiple hits hypothesis for memory dysfunction in Parkinson disease","volume":"20","author":"Citro","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4103\/1673-5374.380875","article-title":"Olfactory dysfunction and its related molecular mechanisms in Parkinson\u2019s disease","volume":"19","author":"Gu","year":"2024","journal-title":"Neural Regen Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/bs.irn.2023.12.001","article-title":"Executive dysfunction and cognitive decline, a non-motor symptom of Parkinson\u2019s disease captured in animal models","volume":"174","author":"Iravani","year":"2024","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40035-024-00400-5","article-title":"Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"13","author":"Lin","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"ENEURO.0247-22.2022","DOI":"10.1523\/ENEURO.0247-22.2022","article-title":"Increase in Tau Pathology in P290S Knock-In Mice Crossed with AppNL-G-F Mice","volume":"9","author":"Huang","year":"2022","journal-title":"eNeuro"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3233\/JAD-220694","article-title":"Altered Odor-Evoked Electrophysiological Responses in the Anterior Piriform Cortex of Conscious APP\/PS1 Mice","volume":"90","author":"Shen","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"964336","DOI":"10.3389\/fnagi.2022.964336","article-title":"Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer\u2019s disease","volume":"14","author":"Tsui","year":"2022","journal-title":"Front Aging Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"112325","DOI":"10.1016\/j.exger.2023.112325","article-title":"Smaller grey matter volume in the central olfactory system in mild cognitive impairment","volume":"183","author":"Jobin","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1093\/brain\/awac318","article-title":"Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model","volume":"146","author":"Ponnusamy","year":"2023","journal-title":"Brain"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1002\/hbm.26274","article-title":"Alzheimer\u2019s Disease Neuroimaging Initiative. Automatic and manual segmentation of the piriform cortex: Method development and validation in patients with temporal lobe epilepsy and Alzheimer\u2019s disease","volume":"44","author":"Steinbart","year":"2023","journal-title":"Hum. Brain Mapp."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neurobiolaging.2022.09.007","article-title":"Amyloid \u03b2 oligomers disrupt piriform cortical output via a serotonergic pathway","volume":"121","author":"Wang","year":"2023","journal-title":"Neurobiol. Aging"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neulet.2009.02.006","article-title":"Regional differences in the severity of Lewy body pathology across the olfactory cortex","volume":"453","author":"Holton","year":"2009","journal-title":"Neurosci. Lett."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00401-010-0687-9","article-title":"alpha-Synucleinopathy in the human olfactory system in Parkinson\u2019s disease: Involvement of calcium-binding protein- and substance P-positive cells","volume":"119","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00429-011-0347-4","article-title":"\u03b1-Synuclein in the olfactory system of a mouse model of Parkinson\u2019s disease: Correlation with olfactory projections","volume":"217","year":"2012","journal-title":"Brain Struct. Funct."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13024-016-0113-4","article-title":"Transmission of \u03b1-synucleinopathy from olfactory structures deep into the temporal lobe","volume":"11","author":"Mason","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40478-019-0713-7","article-title":"Neurodegeneration and contralateral \u03b1-synuclein induction after intracerebral \u03b1-synuclein injections in the anterior olfactory nucleus of a Parkinson\u2019s disease A53T mouse model","volume":"7","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9242","DOI":"10.1038\/s41598-020-66201-8","article-title":"Deficits in olfactory sensitivity in a mouse model of Parkinson\u2019s disease revealed by plethysmography of odor-evoked sniffing","volume":"10","author":"Johnson","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"ENEURO.0009-20.2020","DOI":"10.1523\/ENEURO.0009-20.2020","article-title":"Chronic \u03b1-Synuclein Accumulation in Rat Hippocampus Induces Lewy Bodies Formation and Specific Cognitive Impairments","volume":"7","author":"Kasongo","year":"2020","journal-title":"eNeuro"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00401-012-1048-7","article-title":"Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion","volume":"125","author":"Bieniek","year":"2013","journal-title":"Acta Neuropathol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00401-013-1161-2","article-title":"Progressive amnestic dementia, hippocampal sclerosis, and mutation in C9ORF72","volume":"126","author":"Murray","year":"2013","journal-title":"Acta Neuropathol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0169-328X(01)00199-1","article-title":"Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration","volume":"93","author":"Akbar","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neuroscience.2013.09.050","article-title":"Reduction in heat shock protein 90 correlates to neuronal vulnerability in the rat piriform cortex following status epilepticus","volume":"255","author":"Kim","year":"2013","journal-title":"Neuroscience"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.neurobiolaging.2015.02.011","article-title":"Heat shock protein defenses in the neocortex and allocortex of the telencephalon","volume":"36","author":"Posimo","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"9480398","DOI":"10.1155\/2022\/9480398","article-title":"HSPA1A, HSPA2, and HSPA8 Are Potential Molecular Biomarkers for Prognosis among HSP70 Family in Alzheimer\u2019s Disease","volume":"2022","author":"Dong","year":"2022","journal-title":"Dis. Markers"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"196","DOI":"10.5607\/en22019","article-title":"The Change in Circadian Rhythms in P301S Transgenic Mice is Linked to Variability in Hsp70-related Tau Disaggregation","volume":"31","author":"Han","year":"2022","journal-title":"Exp. Neurobiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1038\/s41467-022-31396-z","article-title":"Hsp multichaperone complex buffers pathologically modified Tau","volume":"13","author":"Moll","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"14068","DOI":"10.1038\/s41598-023-41188-0","article-title":"The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease proteins","volume":"13","author":"Babazadeh","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Chang, Y.L., Yang, C.C., Huang, Y.Y., Chen, Y.A., Yang, C.W., Liao, C.Y., Li, H., Wu, C.S., Lin, C.H., and Teng, S.C. (2023). The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation. BMC Biol., 21.","DOI":"10.1186\/s12915-023-01798-6"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"55859","DOI":"10.15252\/embr.202255859","article-title":"UBQLN2 and HSP70 participate in Parkin- mediated mitophagy by facilitating outer mitochondrial membrane rupture","volume":"24","author":"Ma","year":"2023","journal-title":"EMBO Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1211141","DOI":"10.3389\/fnagi.2023.1211141","article-title":"Implication of the cooking oil-peroxidation product \u201ehydroxynonenal\u201d for Alzheimer\u2019s disease","volume":"15","author":"Yamashima","year":"2023","journal-title":"Front Aging Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/neur.1996.0032","article-title":"Region-and neurotransmitter-dependent species and strain differences in DSP-4-induced monoamine depletion in rodents","volume":"5","author":"Fornai","year":"1996","journal-title":"Neurodegeneration"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3233\/JAD-180487","article-title":"Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-\u03b2 Pathology in Female Rhesus Macaques (Macaca Mulatta)","volume":"68","author":"Duffy","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Pozzi, N.G., Bolzoni, F., Biella, G.E.M., Pezzoli, G., Ip, C.W., Volkmann, J., Cavallari, P., Asan, E., and Isaias, I.U. (2023). Brain Noradrenergic Innervation Supports the Development of Parkinson\u2019s Tremor: A Study in a Reserpinized Rat Model. Cells, 12.","DOI":"10.3390\/cells12212529"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0006-8993(96)00891-8","article-title":"Norepinephrine loss selectively enhances chronic nigrostriatal dopamine depletion in mice and rats","volume":"735","author":"Fornai","year":"1996","journal-title":"Brain Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"ENEURO.0483-22.2022","DOI":"10.1523\/ENEURO.0483-22.2022","article-title":"The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease","volume":"10","author":"Iannitelli","year":"2023","journal-title":"eNeuro"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/alzrt175","article-title":"Targeting norepinephrine in mild cognitive impairment and Alzheimer\u2019s disease","volume":"5","author":"Chalermpalanupap","year":"2013","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1093\/brain\/awz193","article-title":"Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases","volume":"142","author":"Betts","year":"2019","journal-title":"Brain"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Giorgi, F.S., Biagioni, F., Galgani, A., Pavese, N., Lazzeri, G., and Fornai, F. (2020). Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228630"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.semcdb.2021.05.013","article-title":"Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer\u2019s disease?","volume":"116","author":"Mather","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Mercan, D., and Heneka, M.T. (2022). The Contribution of the Locus Coeruleus-Noradrenaline System Degeneration during the Progression of Alzheimer\u2019s Disease. Biology, 11.","DOI":"10.3390\/biology11121822"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1471-4159.2007.05145.x","article-title":"Genetic or pharmacological blockade of noradrenaline synthesis enhances the neurochemical, behavioral, and neurotoxic effects of methamphetamine","volume":"105","author":"Weinshenker","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_118","first-page":"80","article-title":"The effects of locus coeruleus and norepinephrine in methamphetamine toxicity","volume":"11","author":"Ferrucci","year":"2013","journal-title":"Curr. Neuropharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Lazzeri, G., Busceti, C.L., Biagioni, F., Fabrizi, C., Morucci, G., Giorgi, F.S., Ferrucci, M., Lenzi, P., Puglisi-Allegra, S., and Fornai, F. (2021). Norepinephrine Protects against Methamphetamine Toxicity through \u03b22-Adrenergic Receptors Promoting LC3 Compartmentalization. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137232"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s11011-018-0263-x","article-title":"The locus coeruleus neurotoxin, DSP4, and\/or a high sugar diet induce behavioral and biochemical alterations in wild-type mice consistent with Alzheimers related pathology","volume":"33","author":"Choudhary","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3233\/JPD-202241","article-title":"Perturbation of in vivo Neural Activity Following \u03b1-Synuclein Seeding in the Olfactory Bulb","volume":"10","author":"Kulkarni","year":"2020","journal-title":"J. Parkinsons Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neubiorev.2021.11.009","article-title":"A potential biomarker of preclinical Alzheimer\u2019s disease: The olfactory dysfunction and its pathogenesis-based neural circuitry impairments","volume":"132","author":"Yan","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3233\/JAD-221163","article-title":"Characteristics of Odor Identification and Hedonics and Their Association with Piriform Cortex-Based Resting-State Functional Connectivity in Amnestic Mild Cognitive Impairment","volume":"94","author":"Tu","year":"2023","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/archneur.55.1.84","article-title":"Olfaction in neurodegenerative disease: A meta-analysis of olfactory functioning in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"55","author":"Mesholam","year":"1998","journal-title":"Arch. Neurol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jchemneu.2010.12.002","article-title":"The chemical neuroanatomy of vagus nerve stimulation","volume":"42","author":"Ruffoli","year":"2011","journal-title":"J. Chem. Neuroanat."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.nbd.2008.02.008","article-title":"Activation of brain metabolism and fos during limbic seizures: The role of locus coeruleus","volume":"30","author":"Giorgi","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.nlm.2010.07.002","article-title":"Central noradrenergic lesion induced by DSP-4 impairs the acquisition of avoidance reactions and prevents molecular changes in the amygdala","volume":"94","author":"Radwanska","year":"2010","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neulet.2017.02.060","article-title":"Noradrenergic regulation of plasticity marker expression in the adult rodent piriform cortex","volume":"644","author":"Vadodaria","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1749-6632.2009.04013.x","article-title":"Olfactory impairment in presymptomatic Alzheimer\u2019s disease","volume":"1170","author":"Wilson","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0306-4522(96)00164-9","article-title":"The inducible 70,000 molecular\/weight heat shock protein is expressed in the degenerating dentate hilus and piriform cortex after systemic administration of kainic acid in the rat","volume":"74","author":"Armstrong","year":"1996","journal-title":"Neuroscience"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.brainres.2019.05.035","article-title":"Methamphetamine persistently increases alpha-synuclein and suppresses gene promoter methylation within striatal neurons","volume":"1719","author":"Biagioni","year":"2019","journal-title":"Brain Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.2174\/1570159X18666201116145507","article-title":"C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside","volume":"19","author":"Mylvaganam","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Zatsepina, O.G., Evgen\u2019ev, M.B., and Garbuz, D.G. (2021). Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection. Cells, 10.","DOI":"10.3390\/cells10071638"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1523\/JNEUROSCI.2494-20.2021","article-title":"Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1","volume":"41","author":"Akber","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"15995","DOI":"10.18632\/aging.103900","article-title":"Neuroprotective effects of p62(SQSTM1)-engineered lactic acid bacteria in Alzheimer\u2019s disease: A pre-clinical study","volume":"12","author":"Cecarini","year":"2020","journal-title":"Aging"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/glia.24385","article-title":"Microglia-specific knock-out of NF-\u03baB\/IKK2 increases the accumulation of misfolded \u03b1-synuclein through the inhibition of p62\/sequestosome-1-dependent autophagy in the rotenone model of Parkinson\u2019s disease","volume":"71","author":"Rocha","year":"2023","journal-title":"Glia"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neulet.2005.07.016","article-title":"Modulation of delayed rectifier potassium channels by alpha1-adrenergic activation via protein kinase C zeta and p62 in PC12 cells","volume":"387","author":"Kim","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1046\/j.1471-4159.2003.02137.x","article-title":"Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells","volume":"88","author":"Fornai","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_139","unstructured":"Paxinos, G., and Franklin, K.B.J. (2004). The Mouse Brain in Stereotaxic Coordinates, Academic Press. [2nd ed.]."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neurobiolaging.2021.11.006","article-title":"Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer\u2019s disease","volume":"112","author":"Dahl","year":"2022","journal-title":"Neurobiol. Aging"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/6\/3159\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:11:18Z","timestamp":1760105478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/6\/3159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,9]]},"references-count":141,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25063159"],"URL":"https:\/\/doi.org\/10.3390\/ijms25063159","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,9]]}}}