{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:33:55Z","timestamp":1767836035138,"version":"3.49.0"},"reference-count":71,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T00:00:00Z","timestamp":1710028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Metabolic memory refers to the long-term effects of achieving early glycemic control and the adverse implications of high blood glucose levels, including the development and progression of diabetes complications. Our study aimed to investigate whether the phenomenon of metabolic memory plays a role in the immune profile of young patients with uncomplicated type 1 diabetes (T1D). The study group included 67 patients with uncomplicated type 1 diabetes with a mean age of 15.1 \u00b1 2.3 years and a minimum disease duration of 1.2 years. The control group consisted of 27 healthy children and adolescents with a mean age of 15.1 \u00b1 2.3 years. Patients were divided into three groups according to their HbA1c levels at the onset of T1D, and the average HbA1c levels after one and two years of disease duration. The subgroup A1 had the lowest initial HbA1c values, while the subgroup C had the highest initial HbA1c values. Cytokine levels (including TNF-\u03b1, IL-35, IL-4, IL-10, IL-18, and IL-12) were measured in all study participants. Our data analysis showed that subgroup A1 was characterized by significantly higher levels of IL-35 and IL-10 compared to all other groups, and significantly higher levels of IL-4 compared to group B. Additionally, a comparative analysis of cytokine levels between the groups of diabetic patients and healthy controls demonstrated that subgroup A1 had significantly higher levels of anti-inflammatory cytokines. The lipid profile was also significantly better in subgroup A1 compared to all other patient groups. Based on our findings, it appears that an inflammatory process, characterized by an imbalance between the pro- and anti-inflammatory cytokines, is associated with poor glycemic control at the onset of diabetes and during the first year of disease duration. These findings also suggest that both metabolic memory and inflammation contribute to the abnormal lipid profile in patients with type 1 diabetes.<\/jats:p>","DOI":"10.3390\/ijms25063190","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T06:05:30Z","timestamp":1710137130000},"page":"3190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Impact of Metabolic Memory on Immune Profile in Young Patients with Uncomplicated Type 1 Diabetes"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-3862","authenticated-orcid":false,"given":"Jolanta","family":"Neubauer-Geryk","sequence":"first","affiliation":[{"name":"Clinical Physiology Unit, Medical Simulation Centre, Medical University of Gda\u0144sk, 80-204 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Wielicka","sequence":"additional","affiliation":[{"name":"Clinical Physiology Unit, Medical Simulation Centre, Medical University of Gda\u0144sk, 80-204 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"My\u015bliwiec","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gda\u0144sk, 80-211 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-3791","authenticated-orcid":false,"given":"Katarzyna","family":"Zorena","sequence":"additional","affiliation":[{"name":"Department of Immunobiology and Environment Microbiology, Medical University of Gda\u0144sk, 80-211 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek","family":"Bieniaszewski","sequence":"additional","affiliation":[{"name":"Clinical Physiology Unit, Medical Simulation Centre, Medical University of Gda\u0144sk, 80-204 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2337\/diab.36.7.808","article-title":"Progression of Incipient Diabetic Retinopathy during Good Glycemic Control","volume":"36","author":"Engerman","year":"1987","journal-title":"Diabetes"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Diabetes Control and Complications Trial (DCCT)\/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group (2015). Effect of Intensive Diabetes Therapy on the Progression of Diabetic Retinopathy in Patients with Type 1 Diabetes: 18 Years of Follow-up in the DCCT\/EDIC. Diabetes, 64, 631\u2013642.","DOI":"10.2337\/db14-0930"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.2337\/dc20-3097","article-title":"Understanding Metabolic Memory: The Prolonged Influence of Glycemia during the Diabetes Control and Complications Trial (DCCT) on Future Risks of Complications during the Study of the Epidemiology of Diabetes Interventions and Complications (EDIC)","volume":"44","author":"Lachin","year":"2021","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.2337\/db13-1251","article-title":"Evaluating the Role of Epigenetic Histone Modifications in the Metabolic Memory of Type 1 Diabetes","volume":"63","author":"Miao","year":"2014","journal-title":"Diabetes"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1056\/NEJMoa052187","article-title":"Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes","volume":"353","author":"Nathan","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"870","DOI":"10.2337\/diabetes.48.4.870","article-title":"Skin Collagen Glycation, Glycoxidation, and Crosslinking Are Lower in Subjects with Long-Term Intensive versus Conventional Therapy of Type 1 Diabetes: Relevance of Glycated Collagen Products versus HbA(1c) as Markers of Diabetic Complications","volume":"48","author":"Monnier","year":"1999","journal-title":"Diabetes"},{"key":"ref_7","first-page":"E685","article-title":"Activation of NADPH Oxidase by AGE Links Oxidant Stress to Altered Gene Expression via RAGE","volume":"280","author":"Wautier","year":"2001","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.atherosclerosis.2014.09.006","article-title":"Blood Pressure Disturbances and Endothelial Dysfunction Markers in Children and Adolescents with Type 1 Diabetes","volume":"237","author":"Machnica","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2337\/diabetes.53.1.195","article-title":"Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes","volume":"53","author":"Loomans","year":"2004","journal-title":"Diabetes"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1084\/jem.20090889","article-title":"Diabetic Retinopathy Is Associated with Bone Marrow Neuropathy and a Depressed Peripheral Clock","volume":"206","author":"Busik","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1111\/dom.15213","article-title":"Glycated Haemoglobin in the First Year after Diagnosis of Type 1 Diabetes Is an Independent Risk Factor for Diabetic Retinopathy: The IMDIAB 25 Years Follow-up Study","volume":"25","author":"Maddaloni","year":"2023","journal-title":"Diabetes Obes. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2337\/dc14-1203","article-title":"Impact of HbA1c, Followed from Onset of Type 1 Diabetes, on the Development of Severe Retinopathy and Nephropathy: The VISS Study (Vascular Diabetic Complications in Southeast Sweden)","volume":"38","author":"Nordwall","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.2337\/db08-0645","article-title":"Lymphocytes from Patients with Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation: An Epigenetic Study in Diabetes","volume":"57","author":"Miao","year":"2008","journal-title":"Diabetes"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrg2045","article-title":"Environmental Epigenomics and Disease Susceptibility","volume":"8","author":"Jirtle","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature05913","article-title":"Perceptions of Epigenetics","volume":"447","author":"Bird","year":"2007","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.1191078","article-title":"Molecular Signals of Epigenetic States","volume":"330","author":"Bonasio","year":"2010","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin Modifications and Their Function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.6254144","article-title":"DNA Methylation and Gene Function","volume":"210","author":"Razin","year":"1980","journal-title":"Science"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the Histone Code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Alnek, K., Kisand, K., Heilman, K., Peet, A., Varik, K., and Uibo, R. (2015). Increased Blood Levels of Growth Factors, Proinflammatory Cytokines, and Th17 Cytokines in Patients with Newly Diagnosed Type 1 Diabetes. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142976"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2337\/diacare.27.6.1259","article-title":"Biological Variation in HbA1c Predicts Risk of Retinopathy and Nephropathy in Type 1 Diabetes","volume":"27","author":"McCarter","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"117151","DOI":"10.1016\/j.atherosclerosis.2023.05.020","article-title":"Sustained Low-Grade Inflammation in Young Participants with Childhood Onset Type 1 Diabetes: The Norwegian Atherosclerosis and Childhood Diabetes (ACD) Study","volume":"379","author":"Simeunovic","year":"2023","journal-title":"Atherosclerosis"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13854","DOI":"10.1074\/jbc.M609446200","article-title":"Genome-Wide Analysis of Histone Lysine Methylation Variations Caused by Diabetic Conditions in Human Monocytes","volume":"282","author":"Miao","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"16335","DOI":"10.1074\/jbc.M111.330373","article-title":"Profiles of Epigenetic Histone Post-Translational Modifications at Type 1 Diabetes Susceptible Genes","volume":"287","author":"Miao","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/jcb.22644","article-title":"Role of Histone Acetylation in the Development of Diabetic Retinopathy and the Metabolic Memory Phenomenon","volume":"110","author":"Zhong","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2337\/diacare.14.1.63","article-title":"Serum Levels of Tumor Necrosis Factor and IL-1\u03b1 and IL-1\u03b2 in Diabetic Patients","volume":"14","author":"Mooradian","year":"1991","journal-title":"Diabetes Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1055\/s-2007-978857","article-title":"Significance of Tumor Necrosis Factor \u03b1 in Patients with Long-Standing Type-I Diabetes Mellitus","volume":"30","author":"Zorena","year":"1998","journal-title":"Horm. Metab. Res."},{"key":"ref_28","first-page":"155","article-title":"Interleukin-12, Vascular Endothelial Growth Factor and Tumor Necrosis Factor-Alpha in the Process of Neoangiogenesis of Diabetic Retinopathy in Children","volume":"109","author":"Zorena","year":"2007","journal-title":"Klin. Oczna"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1161\/01.ATV.18.8.1199","article-title":"Relation between Plasma Tumor Necrosis Factor-\u03b1 and Insulin Sensitivity in Elderly Men with Non-Insulin-Dependent Diabetes Mellitus","volume":"18","author":"Nilsson","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014An Inflammatory Disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"dos Santos Haber, J.F., Barbalho, S.M., Sgarbi, J.A., de Argollo Haber, R.S., de Labio, R.W., Laurindo, L.F., Chagas, E.F.B., and Pay\u00e3o, S.L.M. (2023). The Relationship between Type 1 Diabetes Mellitus, TNF-\u03b1, and IL-10 Gene Expression. Biomedicines, 11.","DOI":"10.3390\/biomedicines11041120"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0026-0495(97)90311-5","article-title":"Glycation, Oxidation, and Lipoxidation in the Development of Diabetic Complications","volume":"46","author":"Kennedy","year":"1997","journal-title":"Metabolism"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jdiacomp.2008.10.002","article-title":"Resistance of retinal inflammatory mediators to suppress after reinstitution of good glycemic control: Novel mechanism for metabolic memory","volume":"24","author":"Chan","year":"2010","journal-title":"J. Diabetes Complicat."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.2337\/db11-0784","article-title":"Prevention of Autoimmune Diabetes by Ectopic Pancreatic \u03b2-Cell Expression of Interleukin-35","volume":"61","author":"Bettini","year":"2012","journal-title":"Diabetes"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/eji.201646493","article-title":"\u0392-cell-specific IL-35 Therapy Suppresses Ongoing Autoimmune Diabetes in NOD Mice","volume":"47","author":"Manzoor","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Lin, Y., Huang, Y., Lu, Z., Luo, C., Shi, Y., Zeng, Q., Cao, Y., Liu, L., Wang, X., and Ji, Q. (2012). Decreased Plasma IL-35 Levels Are Related to the Left Ventricular Ejection Fraction in Coronary Artery Diseases. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052490"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3590389","DOI":"10.1155\/2020\/3590389","article-title":"Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes","volume":"2020","author":"Wegeberg","year":"2020","journal-title":"Mediators Inflamm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molimm.2014.12.012","article-title":"Increased Expression of IL-18 in the Serum and Islets of Type 1 Diabetics","volume":"64","author":"Harms","year":"2015","journal-title":"Mol. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1161\/01.ATV.0000163843.70369.12","article-title":"Elevated Interleukin-18 Levels Are Associated with the Metabolic Syndrome Independent of Obesity and Insulin Resistance","volume":"25","author":"Hung","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00262-011-1104-5","article-title":"Dual Biological Effects of the Cytokines Interleukin-10 and Interferon-\u03b3","volume":"60","author":"Wilke","year":"2011","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s40618-016-0514-9","article-title":"Association between Type 1, Type 2 Cytokines, Diabetic Autoantibodies and 25-Hydroxyvitamin D in Children with Type 1 Diabetes","volume":"39","author":"Talaat","year":"2016","journal-title":"J. Endocrinol. Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.immuni.2019.03.011","article-title":"The Immunobiology of the Interleukin-12 Family: Room for Discovery","volume":"50","author":"Hunter","year":"2019","journal-title":"Immunity"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s10753-014-9878-1","article-title":"Elevated Levels of Serum IL-12 and IL-18 Are Associated with Lower Frequencies of CD4+CD25highFOXP3+ Regulatory T Cells in Young Patients with Type 1 Diabetes","volume":"37","year":"2014","journal-title":"Inflammation"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Li, X., Mai, J., Virtue, A., Yin, Y., Gong, R., Sha, X., Gutchigian, S., Frisch, A., Hodge, I., and Jiang, X. (2012). IL-35 Is a Novel Responsive Anti-Inflammatory Cytokine\u2014A New System of Categorizing Anti-Inflammatory Cytokines. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033628"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Balzano-Nogueira, L., Ramirez, R., Zamkovaya, T., Dailey, J., Ardissone, A.N., Chamala, S., Serrano-Qu\u00edlez, J., Rubio, T., Haller, M.J., and Concannon, P. (2021). Integrative Analyses of TEDDY Omics Data Reveal Lipid Metabolism Abnormalities, Increased Intracellular ROS and Heightened Inflammation Prior to Autoimmunity for Type 1 Diabetes. Genome Biol., 22.","DOI":"10.1186\/s13059-021-02262-w"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1210\/jc.2010-2363","article-title":"Endothelial Dysfunction Is Related to Poor Glycemic Control in Adolescents with Type 1 Diabetes under 5 Years of Disease: Evidence of Metabolic Memory","volume":"96","author":"Rohde","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"The Diabetes Control and Complications Trial (DCCT), and Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group (2016). Intensive Diabetes Treatment and Cardiovascular Outcomes in Type1 Diabetes: The DCCT\/EDIC Study 30-Year Follow-Up. Diabetes Care, 39, 686\u2013693.","DOI":"10.2337\/dc15-1990"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Klimontov, V.V., Mavlianova, K.R., Orlov, N.B., Semenova, J.F., and Korbut, A.I. (2023). Serum Cytokines and Growth Factors in Subjects with Type 1 Diabetes: Associations with Time in Ranges and Glucose Variability. Biomedicines, 11.","DOI":"10.3390\/biomedicines11102843"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"03946320231209821","DOI":"10.1177\/03946320231209821","article-title":"Correlation Analysis between Cytokines\u2019 Profile, Autoimmune Antibodies and the Duration of Type 1 Diabetes: A Case Control Study in a Specialized Children\u2019s Centre in Riyadh","volume":"37","author":"Babiker","year":"2023","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/bs.acc.2016.02.001","article-title":"Cytokines and Pancreatic \u03b2-Cell Apoptosis","volume":"75","author":"Berchtold","year":"2016","journal-title":"Adv. Clin. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2009.21","article-title":"The Role of Inflammation in Insulitis and \u03b2-Cell Loss in Type 1 Diabetes","volume":"5","author":"Eizirik","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1042\/BSR20090021","article-title":"Human and Rodent Pancreatic Beta-Cells Express IL-4 Receptors and IL-4 Protects against Beta-Cell Apoptosis by Activation of the PI3K and JAK\/STAT Pathways","volume":"30","author":"Kaminski","year":"2010","journal-title":"Biosci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1089\/ham.2014.1001","article-title":"Changes in the Levels of Cytokines in Both Diabetic\/Non-Diabetic Type i Children Living in a Moderate Altitude Area in Saudi Arabia","volume":"15","author":"Allam","year":"2014","journal-title":"High Alt. Med. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"107758","DOI":"10.1016\/j.jdiacomp.2020.107758","article-title":"Metformin Alters Peripheral Blood Mononuclear Cells (PBMC) Senescence Biomarkers Gene Expression in Type 2 Diabetic Patients","volume":"35","author":"Alshahrani","year":"2021","journal-title":"J. Diabetes Complicat."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Writing Group for the DCCT, and EDIC Research Group (2016). Coprogression of Cardiovascular Risk Factors in Type 1 Diabetes during 30 Years of Follow-up in the DCCT\/EDIC Study. Diabetes Care, 39, 1621\u20131630.","DOI":"10.2337\/dc16-0502"},{"key":"ref_56","first-page":"e43416","article-title":"Glycemic Control and Metabolic Parameters in Children and Adolescents With Type 1 Diabetes","volume":"13","author":"Canha","year":"2023","journal-title":"Cureus"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.2337\/dc23-S006","article-title":"6. Glycemic Targets: Standards of Care in Diabetes\u20142023","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/pedi.12530","article-title":"Predictors of Glycemic Control in the First Year of Diagnosis of Childhood Onset Type 1 Diabetes: A Systematic Review of Quantitative Evidence","volume":"19","author":"Charalampopoulos","year":"2018","journal-title":"Pediatr. Diabetes"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tem.2020.01.015","article-title":"Dyslipidemia in Type 1 Diabetes: A Masked Danger","volume":"31","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00125-010-1706-z","article-title":"The Shape of the Metabolic Memory of HbA1c: Re-Analysing the DCCT with Respect to Time-Dependent Effects","volume":"53","author":"Lind","year":"2010","journal-title":"Diabetologia"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"The Diabetes Control and Complications Trial Research Group (1993). The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus. N. Engl. J. Med., 329, 977\u2013986.","DOI":"10.1056\/NEJM199309303291401"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Qiao, Y., Chen, Y., Pan, Y., Tian, F., Xu, Y., Zhang, X., and Zhao, H. (2017). The Change of Serum Tumor Necrosis Factor Alpha in Patients with Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176157"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4685976","DOI":"10.1155\/2016\/4685976","article-title":"High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1","volume":"2016","author":"Kowalewska","year":"2016","journal-title":"Dis. Markers"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0140-6736(18)31506-X","article-title":"Excess Mortality and Cardiovascular Disease in Young Adults with Type 1 Diabetes in Relation to Age at Onset: A Nationwide, Register-Based Cohort Study","volume":"392","author":"Rawshani","year":"2018","journal-title":"Lancet"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2796.2000.00705.x","article-title":"Tumour Necrosis Factor-alpha Plasma Level in Patients with Type 1 Diabetes Mellitus and Its Association with Glycaemic Control and Cardiovascular Risk Factors","volume":"248","author":"Lechleitner","year":"2000","journal-title":"J. Intern. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.yjmcc.2014.02.012","article-title":"TNF-\u03b1 Promotes Early Atherosclerosis by Increasing Transcytosis of LDL across Endothelial Cells: Crosstalk between NF-\u039aB and PPAR-\u03b3","volume":"72","author":"Zhang","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Overgaard, A.J., Madsen, J.O.B., Pociot, F., Johannesen, J., and St\u00f8rling, J. (2020). Systemic TNF\u03b1 Correlates with Residual \u03b2-Cell Function in Children and Adolescents Newly Diagnosed with Type 1 Diabetes. BMC Pediatr., 20.","DOI":"10.1186\/s12887-020-02339-8"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9134280","DOI":"10.1155\/2019\/9134280","article-title":"Factors Affecting Cardiovascular Risk in Children, Adolescents, and Young Adults with Type 1 Diabetes","volume":"2019","author":"Stankute","year":"2019","journal-title":"J. Diabetes Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2337\/dc16-2193","article-title":"Predictors of Dyslipidemia over Time in Youth with Type 1 Diabetes: For the SEARCH for Diabetes in Youth Study","volume":"40","author":"Shah","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1515\/jpem-2016-0307","article-title":"Non-HDL-Cholesterol and C-Reactive Protein in Children and Adolescents with Type 1 Diabetes","volume":"30","author":"Prado","year":"2017","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/pedi.13454","article-title":"Clinical Practice Consensus Guidelines 2022: Definition, Epidemiology, and Classification of Diabetes in Children and Adolescents","volume":"23","author":"Libman","year":"2022","journal-title":"Pediatr. 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