{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:29:18Z","timestamp":1790998158066,"version":"4.1.0"},"reference-count":136,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mental disorders account for one of the most prevalent categories of the burden of disease worldwide, with depression expected to be the largest contributor by 2030, closely followed by anxiety. The COVID-19 pandemic possibly exacerbated these challenges, especially amongst adolescents, who experienced isolation, disrupted routines, and limited healthcare access. Notably, the pandemic has been associated with long-term neurological effects known as \u201clong-COVID\u201d, characterized by both cognitive and psychopathological symptoms. In general, psychiatric disorders, including those related to long-COVID, are supposed to be due to widespread inflammation leading to neuroinflammation. Recently, the endocannabinoid system (ECS) emerged as a potential target for addressing depression and anxiety pathophysiology. Specifically, natural or synthetic cannabinoids, able to selectively interact with cannabinoid type-2 receptor (CB2R), recently revealed new therapeutic potential in neuropsychiatric disorders with limited or absent psychotropic activity. Among the most promising natural CB2R ligands, the bicyclic sesquiterpene \u03b2-caryophyllene (BCP) has emerged as an excellent anti-inflammatory and antioxidant therapeutic agent. This review underscores BCP\u2019s immunomodulatory and anti-inflammatory properties, highlighting its therapeutic potential for the management of depression and anxiety.<\/jats:p>","DOI":"10.3390\/ijms25063203","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T08:56:41Z","timestamp":1710147401000},"page":"3203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Beta-Caryophyllene, a Cannabinoid Receptor Type 2 Selective Agonist, in Emotional and Cognitive Disorders"],"prefix":"10.3390","volume":"25","author":[{"given":"Caterina","family":"Ricardi","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4972-7927","authenticated-orcid":false,"given":"Serena","family":"Barachini","sequence":"additional","affiliation":[{"name":"Hematology Division, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Consoli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-5829","authenticated-orcid":false,"given":"Donatella","family":"Marazziti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pisa, 56126 Pisa, Italy"},{"name":"UniCamillus, Saint Camillus International University of Health and Medical Sciences, 00151 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2664-6091","authenticated-orcid":false,"given":"Beatrice","family":"Polini","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-5820","authenticated-orcid":false,"given":"Grazia","family":"Chiellini","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(13)61611-6","article-title":"Global Burden of Disease Attributable to Mental and Substance Use Disorders: Findings from the Global Burden of Disease Study 2010","volume":"382","author":"Whiteford","year":"2013","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1017\/S1092852920000140","article-title":"Impact of Economic Crisis on Mental Health: A 10-Year Challenge","volume":"26","author":"Marazziti","year":"2021","journal-title":"CNS Spectr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.euroneuro.2021.10.004","article-title":"Results of the COVID-19 Mental Health International for the General Population (COMET-G) Study","volume":"54","author":"Fountoulakis","year":"2022","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Jones, E.A.K., Mitra, A.K., and Bhuiyan, A.R. (2021). Impact of COVID-19 on Mental Health in Adolescents: A Systematic Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18052470"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jad.2022.04.130","article-title":"Social Anxiety and Behavioral Assessments of Social Cognition: A Systematic Review","volume":"311","author":"Alvi","year":"2022","journal-title":"J. Affect. Disord."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.biopsych.2022.11.003","article-title":"Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology","volume":"93","author":"Goldsmith","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pbb.2005.01.029","article-title":"Endocannabinoid System and Stress and Anxiety Responses","volume":"81","author":"Viveros","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neuroscience.2011.11.057","article-title":"Fear Relief-toward a New Conceptual Frame Work and What Endocannabinoids Gotta Do with It","volume":"204","author":"Riebe","year":"2012","journal-title":"Neuroscience"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/0269881111408958","article-title":"The Endocannabinoid System in Anxiety, Fear Memory and Habituation","volume":"26","author":"Ruehle","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e408","DOI":"10.1038\/tp.2014.53","article-title":"Central Anandamide Deficiency Predicts Stress-Induced Anxiety: Behavioral Reversal through Endocannabinoid Augmentation","volume":"4","author":"Bluett","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/mp.2012.72","article-title":"Convergent Translational Evidence of a Role for Anandamide in Amygdala-Mediated Fear Extinction, Threat Processing and Stress-Reactivity","volume":"18","author":"MacPherson","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1523\/JNEUROSCI.2737-14.2015","article-title":"Corticotropin-Releasing Hormone Drives Anandamide Hydrolysis in the Amygdala to Promote Anxiety","volume":"35","author":"Gray","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fnbeh.2011.00034","article-title":"The Role of Cannabinoids in Modulating Emotional and Non-Emotional Memory Processes in the Hippocampus","volume":"5","author":"Akirav","year":"2011","journal-title":"Front. Behav. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Tadijan, A., Vla\u0161i\u0107, I., Vlaini\u0107, J., \u0110iki\u0107, D., Or\u0161oli\u0107, N., and Jazvin\u0161\u0107ak Jembrek, M. (2022). Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions. Antioxidants, 11.","DOI":"10.3390\/antiox11102049"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/aps.2016.149","article-title":"Brain Cannabinoid Receptor 2: Expression, Function and Modulation","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-21737-2_1","article-title":"Endocannabinoid System Components: Overview and Tissue Distribution","volume":"1162","author":"Joshi","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"866052","DOI":"10.3389\/fpsyt.2022.866052","article-title":"Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders","volume":"13","author":"Morcuende","year":"2022","journal-title":"Front. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Hashiesh, H.M., Sharma, C., Goyal, S.N., Sadek, B., Jha, N.K., Kaabi, J.A., and Ojha, S. (2021). A Focused Review on CB2 Receptor-Selective Pharmacological Properties and Therapeutic Potential of \u03b2-Caryophyllene, a Dietary Cannabinoid. Biomed. Pharmacother., 140.","DOI":"10.1016\/j.biopha.2021.111639"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Scandiffio, R., Geddo, F., Cottone, E., Querio, G., Antoniotti, S., Gallo, M.P., Maffei, M.E., and Bovolin, P. (2020). Protective Effects of (E)-\u03b2-Caryophyllene (BCP) in Chronic Inflammation. Nutrients, 12.","DOI":"10.3390\/nu12113273"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/1570159X17666190903103923","article-title":"The \u201cEntourage Effect\u201d: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders","volume":"18","author":"Ferber","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Rathod, S.S., Agrawal, Y.O., Nakhate, K.T., Meeran, M.F.N., Ojha, S., and Goyal, S.N. (2023). Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System. Biomedicines, 11.","DOI":"10.3390\/biomedicines11102642"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/sj.bjp.0707505","article-title":"Cannabinoid CB2 Receptors in Human Brain Inflammation","volume":"153","author":"Benito","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/glia.22366","article-title":"CD200-CD200R1 Interaction Contributes to Neuroprotective Effects of Anandamide on Experimentally Induced Inflammation","volume":"60","author":"Mestre","year":"2012","journal-title":"Glia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/nyas.13712","article-title":"Inflammation in Psychiatric Disorders: What Comes First?","volume":"1437","author":"Bauer","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s11481-013-9445-9","article-title":"Cannabinoid Receptor 2: Potential Role in Immunomodulation and Neuroinflammation","volume":"8","author":"Rom","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12031-014-0243-5","article-title":"Trans-Caryophyllene Suppresses Hypoxia-Induced Neuroinflammatory Responses by Inhibiting NF-\u03baB Activation in Microglia","volume":"54","author":"Guo","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/glia.20108","article-title":"Synthetic Cannabinoid WIN55,212-2 Inhibits Generation of Inflammatory Mediators by IL-1beta-Stimulated Human Astrocytes","volume":"49","author":"Sheng","year":"2005","journal-title":"Glia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"134779","DOI":"10.1016\/j.neulet.2020.134779","article-title":"JWH133 Inhibits MPP+-Induced Inflammatory Response and Iron Influx in Astrocytes","volume":"720","author":"Jia","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Alkaitis, M.S., Solorzano, C., Landry, R.P., Piomelli, D., DeLeo, J.A., and Romero-Sandoval, E.A. (2010). Evidence for a Role of Endocannabinoids, Astrocytes and P38 Phosphorylation in the Resolution of Postoperative Pain. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010891"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s11481-009-9147-5","article-title":"WIN55,212-2 Inhibits Production of CX3CL1 by Human Astrocytes: Involvement of P38 MAP Kinase","volume":"4","author":"Sheng","year":"2009","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12974-020-01784-7","article-title":"Exogenous Activation of Cannabinoid-2 Receptor Modulates TLR4\/MMP9 Expression in a Spinal Cord Ischemia Reperfusion Rat Model","volume":"17","author":"Jing","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.nbd.2009.01.014","article-title":"Cannabinoids Attenuate the Effects of Aging upon Neuroinflammation and Neurogenesis","volume":"34","author":"Marchalant","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1074\/jbc.M111.291294","article-title":"CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling","volume":"287","author":"Palazuelos","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"828895","DOI":"10.3389\/fpsyt.2022.828895","article-title":"Potential Role of Cannabinoid Type 2 Receptors in Neuropsychiatric and Neurodegenerative Disorders","volume":"13","author":"Ishiguro","year":"2022","journal-title":"Front. Psychiatry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/FBP.0000000000000068","article-title":"Consequences of Early Life Stress on the Expression of Endocannabinoid-Related Genes in the Rat Brain","volume":"25","author":"Marco","year":"2014","journal-title":"Behav. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1196\/annals.1432.036","article-title":"Functional Expression of Brain Neuronal CB2 Cannabinoid Receptors Are Involved in the Effects of Drugs of Abuse and in Depression","volume":"1139","author":"Onaivi","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s13311-018-0610-y","article-title":"Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims","volume":"15","author":"Navarrete","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Onaivi, E.S., Ishiguro, H., Gong, J.-P., Patel, S., Meozzi, P.A., Myers, L., Perchuk, A., Mora, Z., Tagliaferro, P.A., and Gardner, E. (2008). Brain Neuronal CB2 Cannabinoid Receptors in Drug Abuse and Depression: From Mice to Human Subjects. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001640"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/npp.2011.34","article-title":"Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice","volume":"36","author":"Navarrete","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The Role of Inflammation in Depression: From Evolutionary Imperative to Modern Treatment Target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12974-021-02100-7","article-title":"On Inflammatory Hypothesis of Depression: What Is the Role of IL-6 in the Middle of the Chaos?","volume":"18","author":"Roohi","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"107653","DOI":"10.1016\/j.intimp.2021.107653","article-title":"Neurogenic Hypothesis of Positive Psychology in Stress-Induced Depression: Adult Hippocampal Neurogenesis, Neuroinflammation, and Stress Resilience","volume":"97","author":"Wu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.neulet.2015.01.081","article-title":"Acute Systemic LPS-Mediated Inflammation Induces Lasting Changes in Mouse Cortical Neuromodulation and Behavior","volume":"590","author":"Ming","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1177\/0269881117711713","article-title":"Antidepressant-like Effect of a New Selenium-Containing Compound Is Accompanied by a Reduction of Neuroinflammation and Oxidative Stress in Lipopolysaccharide-Challenged Mice","volume":"31","author":"Casaril","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/sj.mp.4002148","article-title":"Lipopolysaccharide-Induced Depressive-like Behavior Is Mediated by Indoleamine 2,3-Dioxygenase Activation in Mice","volume":"14","author":"Lawson","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1567-5769(01)00147-3","article-title":"Differential Expression of the CB2 Cannabinoid Receptor by Rodent Macrophages and Macrophage-like Cells in Relation to Cell Activation","volume":"2","author":"Carlisle","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6974","DOI":"10.1002\/ptr.7318","article-title":"Antidepressant-like Effect of Rosmarinic Acid during LPS-Induced Neuroinflammatory Model: The Potential Role of Cannabinoid Receptors\/PPAR-\u03b3 Signaling Pathway","volume":"35","author":"Lataliza","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s00213-019-5166-y","article-title":"Cannabinoid Receptor 2 Activation Mitigates Lipopolysaccharide-Induced Neuroinflammation and Sickness Behavior in Mice","volume":"236","author":"Sahu","year":"2019","journal-title":"Psychopharmacology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jneuroim.2006.08.001","article-title":"In Vivo Modulation of LPS-Induced Alterations in Brain and Peripheral Cytokines and HPA Axis Activity by Cannabinoids","volume":"181","author":"Roche","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1111\/bph.12607","article-title":"Regulatory Role of the Cannabinoid CB2 Receptor in Stress-Induced Neuroinflammation in Mice","volume":"171","author":"Zoppi","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_52","first-page":"e11396","article-title":"Neuroplasticity and the Biological Role of Brain Derived Neurotrophic Factor in the Pathophysiology and Management of Depression","volume":"12","author":"Chakrapani","year":"2020","journal-title":"Cureus"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5498\/wjp.v12.i1.77","article-title":"Brain-Derived Neurotrophic Factor and Inflammation in Depression: Pathogenic Partners in Crime?","volume":"12","author":"Porter","year":"2022","journal-title":"World J. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neuropharm.2013.05.034","article-title":"Synaptic Plasticity Alterations Associated with Memory Impairment Induced by Deletion of CB2 Cannabinoid Receptors","volume":"73","author":"Caltana","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuropharm.2017.01.027","article-title":"A Selective CB2R Agonist (JWH133) Restores Neuronal Circuit after Germinal Matrix Hemorrhage in the Preterm via CX3CR1+ Microglia","volume":"119","author":"Tang","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1111\/j.1476-5381.2010.00819.x","article-title":"Depression-Resistant Endophenotype in Mice Overexpressing Cannabinoid CB2 Receptors","volume":"160","author":"Manzanares","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.phrs.2013.05.001","article-title":"Sex-Dependent Changes in Brain CB1R Expression and Functionality and Immune CB2R Expression as a Consequence of Maternal Deprivation and Adolescent Cocaine Exposure","volume":"74","author":"Assis","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neuroscience.2017.03.061","article-title":"Anxious Behavior Induces Elevated Hippocampal Cb2 Receptor Gene Expression","volume":"352","author":"Robertson","year":"2017","journal-title":"Neuroscience"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/0269881110379507","article-title":"Overexpression of CB2 Cannabinoid Receptors Decreased Vulnerability to Anxiety and Impaired Anxiolytic Action of Alprazolam in Mice","volume":"25","author":"Manzanares","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.physbeh.2014.06.003","article-title":"\u03b2-Caryophyllene, a CB2 Receptor Agonist Produces Multiple Behavioral Changes Relevant to Anxiety and Depression in Mice","volume":"135","author":"Bahi","year":"2014","journal-title":"Physiol. Behav."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/s41386-020-0696-x","article-title":"Cannabinoid CB2 Receptors Mediate the Anxiolytic-like Effects of Monoacylglycerol Lipase Inhibition in a Rat Model of Predator-Induced Fear","volume":"45","author":"Ivy","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11920-019-1026-z","article-title":"Cannabinoid Regulation of Fear and Anxiety: An Update","volume":"21","author":"Papagianni","year":"2019","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Marazziti, D., Carmassi, C., Cappellato, G., Chiarantini, I., Massoni, L., Mucci, F., Arone, A., Violi, M., Palermo, S., and De Iorio, G. (2023). Novel Pharmacological Targets of Post-Traumatic Stress Disorders. Life, 13.","DOI":"10.3390\/life13081731"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/bs.apha.2017.03.007","article-title":"CB1 and CB2 Receptor Pharmacology","volume":"80","author":"Howlett","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/21505594.2017.1389369","article-title":"Effects of Cannabinoid Receptor Type 2 in Respiratory Syncytial Virus Infection in Human Subjects and Mice","volume":"9","author":"Tahamtan","year":"2018","journal-title":"Virulence"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Costantino, C.M., Gupta, A., Yewdall, A.W., Dale, B.M., Devi, L.A., and Chen, B.K. (2012). Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033961"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1189\/jlb.1012523","article-title":"Attenuation of HIV-1 Replication in Macrophages by Cannabinoid Receptor 2 Agonists","volume":"93","author":"Ramirez","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"105923","DOI":"10.1016\/j.intimp.2019.105923","article-title":"Combination of Imipramine, a Sphingomyelinase Inhibitor, and \u03b2-Caryophyllene Improve Their Therapeutic Effects on Experimental Autoimmune Encephalomyelitis (EAE)","volume":"77","author":"Askari","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Alberti, T.B., Barbosa, W.L.R., Vieira, J.L.F., Raposo, N.R.B., and Dutra, R.C. (2017). (-)-\u03b2-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18040691"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.exppara.2017.02.012","article-title":"Anti-Leishmania Activity of Essential Oil of Myracrodruon Urundeuva (Engl.) Fr. All.: Composition, Cytotoxity and Possible Mechanisms of Action","volume":"175","author":"Carvalho","year":"2017","journal-title":"Exp. Parasitol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.foodchem.2013.04.044","article-title":"Anti-Inflammatory Effects of 27 Selected Terpenoid Compounds Tested through Modulating Th1\/Th2 Cytokine Secretion Profiles Using Murine Primary Splenocytes","volume":"141","author":"Ku","year":"2013","journal-title":"Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.1002\/jsfa.9861","article-title":"Anti-Inflammatory Activity of \u03b2-Caryophyllene Combined with Docosahexaenoic Acid in a Model of Sepsis Induced by Staphylococcus Aureus in Mice","volume":"99","author":"Brito","year":"2019","journal-title":"J. Sci. Food Agric."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3233\/CH-151996","article-title":"Cannabinoid 2 Receptor Activation Reduces Leukocyte Adhesion and Improves Capillary Perfusion in the Iridial Microvasculature during Systemic Inflammation","volume":"61","author":"Toguri","year":"2015","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"978678","DOI":"10.1155\/2014\/978678","article-title":"Experimental Cannabinoid 2 Receptor-Mediated Immune Modulation in Sepsis","volume":"2014","author":"Sardinha","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s11064-017-2202-3","article-title":"\u03b2-Caryophyllene Pretreatment Alleviates Focal Cerebral Ischemia-Reperfusion Injury by Activating PI3K\/Akt Signaling Pathway","volume":"42","author":"Zhang","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"116915","DOI":"10.1016\/j.lfs.2019.116915","article-title":"\u03b2-Caryophyllene Protects against Ischemic Stroke by Promoting Polarization of Microglia toward M2 Phenotype via the TLR4 Pathway","volume":"237","author":"Tian","year":"2019","journal-title":"Life Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.ajpath.2012.11.024","article-title":"Activation of Cannabinoid CB2 Receptor-Mediated AMPK\/CREB Pathway Reduces Cerebral Ischemic Injury","volume":"182","author":"Choi","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s11064-016-1826-z","article-title":"\u03b2-Caryophyllene Attenuates Focal Cerebral Ischemia-Reperfusion Injury by Nrf2\/HO-1 Pathway in Rats","volume":"41","author":"Lou","year":"2016","journal-title":"Neurochem. Res."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Wyganowska-Swiatkowska, M., Nohawica, M., Grocholewicz, K., and Nowak, G. (2020). Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134639"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1111\/bph.13497","article-title":"An Update on PPAR Activation by Cannabinoids","volume":"173","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2174\/1566524020666200217102508","article-title":"Metaxalone Suppresses Production of Inflammatory Cytokines Associated with Painful Conditions in Mouse Macrophages RAW264.7 Cells in Vitro: Synergistic Effect with \u03b2-Caryophyllene","volume":"20","author":"Yamaguchi","year":"2020","journal-title":"Curr. Mol. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0803601105","article-title":"Beta-Caryophyllene Is a Dietary Cannabinoid","volume":"105","author":"Gertsch","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.phymed.2018.02.004","article-title":"Anti-Inflammatory and Anti-Edematogenic Action of the Croton Campestris A. St.-Hil (Euphorbiaceae) Essential Oil and the Compound \u03b2-Caryophyllene in in Vivo Models","volume":"41","author":"Pessoa","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.euroneuro.2013.10.008","article-title":"The Cannabinoid CB2 Receptor-Selective Phytocannabinoid Beta-Caryophyllene Exerts Analgesic Effects in Mouse Models of Inflammatory and Neuropathic Pain","volume":"24","author":"Klauke","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Aly, E., Khajah, M.A., and Masocha, W. (2019). \u03b2-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain. Molecules, 25.","DOI":"10.3390\/molecules25010106"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Wang, Y., Gao, Y., Tang, S., Lu, L., Zhang, L., Bu, X., Li, H., Hu, X., Hu, X., and Jiang, P. (2020). Large-Scale Network Dysfunction in the Acute State Compared to the Remitted State of Bipolar Disorder: A Meta-Analysis of Resting-State Functional Connectivity. EBioMedicine, 54.","DOI":"10.1016\/j.ebiom.2020.102742"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Askari, V.R., Baradaran Rahimi, V., and Shafiee-Nick, R. (2023). Low Doses of \u03b2-Caryophyllene Reduced Clinical and Paraclinical Parameters of an Autoimmune Animal Model of Multiple Sclerosis: Investigating the Role of CB2 Receptors in Inflammation by Lymphocytes and Microglial. Brain Sci., 13.","DOI":"10.3390\/brainsci13071092"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"112012","DOI":"10.1016\/j.bbr.2019.112012","article-title":"The Cannabinoid Receptor 2 Agonist, \u03b2-Caryophyllene, Improves Working Memory and Reduces Circulating Levels of Specific Proinflammatory Cytokines in Aged Male Mice","volume":"372","author":"Lindsey","year":"2019","journal-title":"Behav. Brain Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1089\/jmf.2019.0111","article-title":"\u03b2-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB\/c Mice","volume":"23","year":"2020","journal-title":"J. Med. Food"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biopha.2018.11.039","article-title":"Beta-Caryophyllene Alleviates Diet-Induced Neurobehavioral Changes in Rats: The Role of CB2 and PPAR-\u03b3 Receptors","volume":"110","author":"Youssef","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuropharm.2017.07.015","article-title":"Antiallodynic Effect of \u03b2-Caryophyllene on Paclitaxel-Induced Peripheral Neuropathy in Mice","volume":"125","author":"Segat","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fphar.2017.00002","article-title":"\u03b2-Caryophyllene\/Hydroxypropyl-\u03b2-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway","volume":"8","author":"Lou","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11010-016-2733-y","article-title":"\u03b2-Caryophyllene, a Phytocannabinoid Attenuates Oxidative Stress, Neuroinflammation, Glial Activation, and Salvages Dopaminergic Neurons in a Rat Model of Parkinson Disease","volume":"418","author":"Ojha","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000362689","article-title":"\u03b2-Caryophyllene Ameliorates the Alzheimer-Like Phenotype in APP\/PS1 Mice through CB2 Receptor Activation and the PPAR\u03b3 Pathway","volume":"94","author":"Cheng","year":"2014","journal-title":"Pharmacology"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12944-018-0661-4","article-title":"Acute Administration of Beta-Caryophyllene Prevents Endocannabinoid System Activation during Transient Common Carotid Artery Occlusion and Reperfusion","volume":"17","author":"Poddighe","year":"2018","journal-title":"Lipids Health Dis."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3389\/fnins.2016.00321","article-title":"Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson\u2019s Disease","volume":"10","author":"Javed","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Viveros-Paredes, J.M., Gonz\u00e1lez-Casta\u00f1eda, R.E., Gertsch, J., Chaparro-Huerta, V., L\u00f3pez-Roa, R.I., V\u00e1zquez-Valls, E., Beas-Zarate, C., Camins-Espuny, A., and Flores-Soto, M.E. (2017). Neuroprotective Effects of \u03b2-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson\u2019s Disease Induced by MPTP. Pharmaceuticals, 10.","DOI":"10.3390\/ph10030060"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.biopha.2018.03.168","article-title":"\u03b2-Caryophyllene (BCP) Ameliorates MPP+ Induced Cytotoxicity","volume":"103","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.neurobiolaging.2012.06.005","article-title":"CB2 Receptor and Amyloid Pathology in Frontal Cortex of Alzheimer\u2019s Disease Patients","volume":"34","author":"Solas","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2174\/156800705774933023","article-title":"Endocannabinoids in Neuroimmunology and Stress","volume":"4","author":"Carrier","year":"2005","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.2174\/138161208785740054","article-title":"Role of Cannabinoids and Endocannabinoids in Cerebral Ischemia","volume":"14","author":"Hillard","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"112439","DOI":"10.1016\/j.bbr.2019.112439","article-title":"Antidepressant-like Effects of \u03b2-Caryophyllene on Restraint plus Stress-Induced Depression","volume":"380","author":"Hwang","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref_103","first-page":"36","article-title":"Anticonvulsant, Anxiolytic and Antidepressant Properties of the \u03b2-Caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems","volume":"14","author":"Feitosa","year":"2021","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Machado, K.D.C., Paz, M.F.C.J., Oliveira Santos, J.V.D., Da Silva, F.C.C., Tchekalarova, J.D., Salehi, B., Islam, M.T., Setzer, W.N., Sharifi-Rad, J., and De Castro E Sousa, J.M. (2020). Anxiety Therapeutic Interventions of \u03b2-Caryophyllene: A Laboratory-Based Study. Nat. Prod. Commun., 15.","DOI":"10.1177\/1934578X20962229"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.pnpbp.2012.04.012","article-title":"The Anxiolytic-like Effect of an Essential Oil Derived from Spiranthera Odoratissima A. St. Hil. Leaves and Its Major Component, \u03b2-Caryophyllene, in Male Mice","volume":"38","author":"Galdino","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Mony, T.J., Elahi, F., Choi, J.W., and Park, S.J. (2022). Neuropharmacological Effects of Terpenoids on Preclinical Animal Models of Psychiatric Disorders: A Review. Antioxidants, 11.","DOI":"10.3390\/antiox11091834"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/0960327111412805","article-title":"Therapeutic Effects of Propolis Essential Oil on Anxiety of Restraint-Stressed Mice","volume":"31","author":"Li","year":"2012","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Sudeep, H.V., Venkatakrishna, K., Raj, A., Reethi, B., and Shyamprasad, K. (2022). ViphyllinTM, a Standardized Extract from Black Pepper Seeds, Mitigates Intestinal Inflammation, Oxidative Stress, and Anxiety-like Behavior in DSS-Induced Colitis Mice. J. Food Biochem., 46.","DOI":"10.1111\/jfbc.14306"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"17250","DOI":"10.1038\/s41598-022-21552-2","article-title":"Effects of Super-Class Cannabis Terpenes Beta-Caryophyllene and Alpha-Pinene on Zebrafish Behavioural Biomarkers","volume":"12","author":"Johnson","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/jmf.2018.0157","article-title":"\u03b2-Caryophyllene, a Natural Sesquiterpene, Attenuates Neuropathic Pain and Depressive-Like Behavior in Experimental Diabetic Mice","volume":"22","year":"2019","journal-title":"J. Med. Food"},{"key":"ref_111","first-page":"831","article-title":"Inflammation in COVID-19: From Pathogenesis to Treatment","volume":"14","author":"Wong","year":"2021","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"590201","DOI":"10.3389\/fphar.2021.590201","article-title":"\u03b2-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid Can Be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19","volume":"12","author":"Jha","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cytogfr.2020.05.008","article-title":"Acute Inflammation and Pathogenesis of SARS-CoV-2 Infection: Cannabidiol as a Potential Anti-Inflammatory Treatment?","volume":"53","author":"Costiniuk","year":"2020","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"589438","DOI":"10.3389\/fphar.2020.589438","article-title":"Use of Cannabinoids to Treat Acute Respiratory Distress Syndrome and Cytokine Storm Associated with Coronavirus Disease-2019","volume":"11","author":"Nagarkatti","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1089\/acm.2020.0144","article-title":"Cannabis in the Time of Coronavirus Disease 2019: The Yin and Yang of the Endocannabinoid System in Immunocompetence","volume":"26","author":"Sexton","year":"2020","journal-title":"J. Altern. Complement. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ijbiomac.2020.12.020","article-title":"Assessment of Antiviral Potencies of Cannabinoids against SARS-CoV-2 Using Computational and in Vitro Approaches","volume":"168","author":"Raj","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbi.2020.04.079","article-title":"SARS-CoV2 Induced Respiratory Distress: Can Cannabinoids Be Added to Anti-Viral Therapies to Reduce Lung Inflammation?","volume":"87","author":"Byrareddy","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1111\/bph.15157","article-title":"The Potential of Cannabidiol in the COVID-19 Pandemic","volume":"177","author":"Esposito","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Iorio, R., Celenza, G., and Petricca, S. (2022). Multi-Target Effects of \u00df-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation. Antioxidants, 11.","DOI":"10.3390\/antiox11061199"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"849","DOI":"10.2131\/jts.39.849","article-title":"Antigenotoxic Capacity of Beta-Caryophyllene in Mouse, and Evaluation of Its Antioxidant and GST Induction Activities","volume":"39","year":"2014","journal-title":"J. Toxicol. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mrgentox.2010.04.008","article-title":"Inhibition by \u03b2-Caryophyllene of Ethyl Methanesulfonate-Induced Clastogenicity in Cultured Human Lymphocytes","volume":"699","author":"Mazzanti","year":"2010","journal-title":"Mutat. Res.\/Genet. Toxicol. Environ. Mutagen."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/tox.22136","article-title":"Mutagenicity of Cigarette Butt Waste in the Bacterial Reverse Mutation Assay: The Protective Effects of \u03b2-Caryophyllene and \u03b2-Caryophyllene Oxide","volume":"31","author":"Mazzanti","year":"2016","journal-title":"Environ. Toxicol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2478\/acph-2019-0003","article-title":"Sesquiterpenes \u03b1-Humulene and \u03b2-Caryophyllene Oxide Enhance the Efficacy of 5-Fluorouracil and Oxaliplatin in Colon Cancer Cells","volume":"69","year":"2019","journal-title":"Acta Pharm."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"116750","DOI":"10.1016\/j.lfs.2019.116750","article-title":"Anti-Arthritic Effect of \u03b2-Caryophyllene and Its Ameliorative Role on Methotrexate and\/or Leflunomide-Induced Side Effects in Arthritic Rats","volume":"233","author":"Galal","year":"2019","journal-title":"Life Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4166\/kjg.2019.74.4.199","article-title":"Inhibitory Effects of \u03b2-caryophyllene on Helicobacter pylori Infection: A Randomized Double-blind, Placebo-controlled Study","volume":"74","author":"Shim","year":"2019","journal-title":"Korean J. Gastroenterol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"358","DOI":"10.23736\/S0026-4806.18.05710-5","article-title":"Observational Clinical and Nerve Conduction Study on Effects of a Nutraceutical Combination on Painful Diabetic Distal Symmetric Sensory-Motor Neuropathy in Patients with Diabetes Type 1 and Type 2","volume":"109","author":"Semprini","year":"2018","journal-title":"Minerva Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ctcp.2018.10.004","article-title":"Effects of a Massage-like Essential Oil Application Procedure Using Copaiba and Deep Blue Oils in Individuals with Hand Arthritis","volume":"33","author":"Bahr","year":"2018","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.esxm.2020.06.001","article-title":"Olfactory Exposure to \u03b2-Caryophyllene Increases Testosterone Levels in Women\u2019s Saliva","volume":"8","author":"Tarumi","year":"2020","journal-title":"Sex. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.2174\/1381612824666180912151412","article-title":"\u03b2-Caryophyllene Delivery Systems: Enhancing the Oral Pharmacokinetic and Stability","volume":"24","author":"Santos","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"111824","DOI":"10.1016\/j.msec.2020.111824","article-title":"\u03b2-Caryophyllene Nanoparticles Design and Development: Controlled Drug Delivery of Cannabinoid CB2 Agonist as a Strategic Tool towards Neurodegeneration","volume":"121","author":"Alberti","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"M\u00f6dinger, Y., Knaub, K., Dharsono, T., Wacker, R., Meyrat, R., Land, M.H., Petraglia, A.L., and Sch\u00f6n, C. (2022). Enhanced Oral Bioavailability of \u03b2-Caryophyllene in Healthy Subjects Using the VESIsorb\u00ae Formulation Technology, a Novel Self-Emulsifying Drug Delivery System (SEDDS). Molecules, 27.","DOI":"10.3390\/molecules27092860"},{"key":"ref_132","first-page":"42","article-title":"Relative Bioavailability Comparison of Different Coenzyme Q10 Formulations with a Novel Delivery System","volume":"15","author":"Liu","year":"2009","journal-title":"Altern. Ther. Health Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1080\/14786419.2010.497147","article-title":"A Validated HPTLC Method for Determination of Trans-Caryophyllene from Polyherbal Formulations","volume":"24","author":"Patra","year":"2010","journal-title":"Nat. Prod. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejpb.2015.07.012","article-title":"Controlled Delivery of a New Broad Spectrum Antibacterial Agent against Colitis: In Vitro and in Vivo Performance","volume":"96","author":"Siepmann","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Geddo, F., Scandiffio, R., Antoniotti, S., Cottone, E., Querio, G., Maffei, M.E., Bovolin, P., and Gallo, M.P. (2019). PipeNig\u00ae-FL, a Fluid Extract of Black Pepper (Piper Nigrum L.) with a High Standardized Content of Trans-\u03b2-Caryophyllene, Reduces Lipid Accumulation in 3T3-L1 Preadipocytes and Improves Glucose Uptake in C2C12 Myotubes. Nutrients, 11.","DOI":"10.3390\/nu11112788"},{"key":"ref_136","first-page":"e47128","article-title":"Efficacy of Siddha Therapeutics on Mantha Sanni (Autism Spectrum Disorder) Among Pediatric Patients: An Interventional Non-Randomized Open-Label Clinical Trial","volume":"15","author":"Elangovan","year":"2023","journal-title":"Cureus"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/6\/3203\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:11:59Z","timestamp":1760105519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/6\/3203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":136,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25063203"],"URL":"https:\/\/doi.org\/10.3390\/ijms25063203","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,11]]}}}