{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:26:36Z","timestamp":1789194396113,"version":"build-2803163510"},"reference-count":70,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"faculty of Medicine at the RWTH Aachen University","award":["OC1-3"],"award-info":[{"award-number":["OC1-3"]}]},{"name":"faculty of Medicine at the RWTH Aachen University","award":["DFG-NE1650\/9-1"],"award-info":[{"award-number":["DFG-NE1650\/9-1"]}]},{"name":"faculty of Medicine at the RWTH Aachen University","award":["WO2031\/5-1"],"award-info":[{"award-number":["WO2031\/5-1"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["OC1-3"],"award-info":[{"award-number":["OC1-3"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["DFG-NE1650\/9-1"],"award-info":[{"award-number":["DFG-NE1650\/9-1"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["WO2031\/5-1"],"award-info":[{"award-number":["WO2031\/5-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Periodontal defects\u2019 localization affects wound healing and bone remodeling, with faster healing in the upper jaw compared to the lower jaw. While differences in blood supply, innervation, and odontogenesis contribute, cell-intrinsic variances may exist. Few studies explored cell signaling in periodontal ligament stem cells (PDLSC), overlooking mandible-maxilla disparitiesUsing kinomics technology, we investigated molecular variances in PDLSC. Characterization involved stem cell surface markers, proliferation, and differentiation capacities. Kinase activity was analyzed via multiplex kinase profiling, mapping differential activity in known gene regulatory networks. Upstream kinase analysis identified stronger EphA receptor expression in the mandible, potentially inhibiting osteogenic differentiation. The PI3K-Akt pathway showed higher activity in lower-jaw PDLSC. PDLSC from the upper jaw exhibit superior proliferation and differentiation capabilities. Differential activation of gene regulatory pathways in upper vs. lower-jaw PDLSC suggests implications for regenerative therapies.<\/jats:p>","DOI":"10.3390\/ijms25063207","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T03:55:34Z","timestamp":1710215734000},"page":"3207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identifying Differences in Molecular Characteristics Relevant for Remodeling of Periodontal Ligament Stem Cells from the Upper and Lower Jaw"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5992-510X","authenticated-orcid":false,"given":"Hanna","family":"Malyaran","sequence":"first","affiliation":[{"name":"Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"BioInterface Group, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, 52056 Aachen, Germany"},{"name":"Department of Orthodontics, University Hospital of RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-935X","authenticated-orcid":false,"given":"Rogerio B.","family":"Craveiro","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University Hospital of RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Mert","sequence":"additional","affiliation":[{"name":"Division of Hand, Plastic and Aesthetic Surgery, LMU University Hospital Munich, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Niederau","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University Hospital of RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1423-8901","authenticated-orcid":false,"given":"Sanne L.","family":"Maas","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-6278","authenticated-orcid":false,"given":"Emiel P. 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Analysis of precursor cells for osteogenic and hematopoietic tissues","volume":"6","author":"Friedenstein","year":"1968","journal-title":"Transplantation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.18632\/aging.101007","article-title":"Paracrine effects of human adipose-derived mesenchymal stem cells in inflammatory stress-induced senescence features of osteoarthritic chondrocytes","volume":"8","author":"Platas","year":"2016","journal-title":"Aging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/jbm.b.35234","article-title":"The influences of PEG-functionalized graphdiyne on cell growth and osteogenic differentiation of bone marrow mesenchymal stem cells","volume":"111","author":"Li","year":"2023","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.arthro.2015.09.010","article-title":"Adipose-Derived Mesenchymal Stem Cells with Microfracture Versus Microfracture Alone: 2-Year Follow-up of a Prospective Randomized Trial","volume":"32","author":"Koh","year":"2016","journal-title":"Arthrosc. J. Arthrosc. Relat. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0022034509340867","article-title":"Mesenchymal stem cells derived from dental tissues vs. those from other sources: Their biology and role in regenerative medicine","volume":"88","author":"Huang","year":"2009","journal-title":"J. Dent. Res."},{"key":"ref_6","first-page":"e469","article-title":"Autologous dental pulp mesenchymal stem cells for inferior third molar post-extraction socket healing: A split-mouth randomised clinical trial","volume":"23","author":"Barbier","year":"2018","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s12015-016-9665-5","article-title":"Stem Cells in Bone Regeneration","volume":"12","author":"Walmsley","year":"2016","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.job.2019.12.001","article-title":"Oral stem cells in intraoral bone formation","volume":"62","author":"Sybil","year":"2020","journal-title":"J. Oral Biosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s13167-018-0156-4","article-title":"Stem cells and tooth regeneration: Prospects for personalized dentistry","volume":"10","author":"Mozaffari","year":"2019","journal-title":"EPMA J."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"La Noce, M., Stellavato, A., Vassallo, V., Cammarota, M., Laino, L., Desiderio, V., Del Vecchio, V., Nicoletti, G.F., Tirino, V., and Papaccio, G. (2021). Hyaluronan-Based Gel Promotes Human Dental Pulp Stem Cells Bone Differentiation by Activating YAP\/TAZ Pathway. Cells, 10.","DOI":"10.21203\/rs.3.rs-740744\/v1"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4103\/jisp.jisp_314_22","article-title":"Regeneration of periodontal ligament fibers around mini dental implants and their attachment to the bone in an animal model: A radiographic and histological study","volume":"27","author":"Kukreja","year":"2023","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3727\/096368914X678346","article-title":"Epithelial and mesenchymal stem cells from the umbilical cord lining membrane","volume":"23","author":"Lim","year":"2014","journal-title":"Cell Transplant."},{"key":"ref_13","unstructured":"Norton, N.S. (2016). Netter\u2019s Head and Neck Anatomy for Dentistry, Elsevier. [3rd ed.]."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/clr.12064","article-title":"Bone tissue in different parts of the edentulous maxilla and mandible","volume":"24","author":"Lindhe","year":"2013","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Dorj, O., Lee, W.-F., Salamanca, E., Pan, Y.-H., Wu, Y.-F., Hsu, Y.-S., Lin, J.C.Y., Lin, Y.-D., Choy, C.-S., and Chang, W.-J. (2021). Guided Tissue Regeneration Treatment Yields Better Results in Class II Furcations in the Mandible Than in the Maxilla: A Retrospective Study. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18147447"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/JPER.22-0706","article-title":"Comparative analysis of proliferative and multilineage differentiation potential of human periodontal ligament stem cells from maxillary and mandibular molars","volume":"94","author":"Mert","year":"2023","journal-title":"J. Periodontol."},{"key":"ref_17","first-page":"9723806","article-title":"Maxillary Osteomyelitis: A Rare Entity","volume":"2016","author":"Habib","year":"2016","journal-title":"Case Rep. Otolaryngol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Roth, C.E., Craveiro, R.B., Niederau, C., Malyaran, H., Neuss, S., Jankowski, J., and Wolf, M. (2022). Mechanical Compression by Simulating Orthodontic Tooth Movement in an In Vitro Model Modulates Phosphorylation of AKT and MAPKs via TLR4 in Human Periodontal Ligament Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158062"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrm2203","article-title":"Mechanisms of specificity in protein phosphorylation","volume":"8","author":"Ubersax","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nrg2707","article-title":"Kinase mutations in human disease: Interpreting genotype-phenotype relationships","volume":"11","author":"Lahiry","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00441-004-0951-1","article-title":"Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues","volume":"319","author":"Luukko","year":"2005","journal-title":"Cell Tissue Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.7150\/ijms.5.263","article-title":"Eph receptors and ephrin signaling pathways: A role in bone homeostasis","volume":"5","author":"Edwards","year":"2008","journal-title":"Int. J. Med. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-60761-795-2_1","article-title":"The MAP kinase signaling cascades: A system of hundreds of components regulates a diverse array of physiological functions","volume":"661","author":"Keshet","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"37498","DOI":"10.52965\/001c.37498","article-title":"Stem cells: A comprehensive review of origins and emerging clinical roles in medical practice","volume":"14","author":"Poliwoda","year":"2022","journal-title":"Orthop. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4252\/wjsc.v13.i6.605","article-title":"Therapeutic potential of periodontal ligament stem cells","volume":"13","author":"Queiroz","year":"2021","journal-title":"World J. Stem Cells"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo","volume":"97","author":"Gronthos","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"key":"ref_28","first-page":"495","article-title":"Multipotent cells from the human third molar: Feasibility of cell-based therapy for liver disease","volume":"76","author":"Ikeda","year":"2008","journal-title":"Differ. Res. Biol. Divers."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Sonoyama, W., Liu, Y., Fang, D., Yamaza, T., Seo, B.-M., Zhang, C., Liu, H., Gronthos, S., Wang, C.-Y., and Shi, S. (2006). Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS ONE, 1.","DOI":"10.1371\/journal.pone.0000079"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7787","DOI":"10.4049\/jimmunol.0902318","article-title":"Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis","volume":"183","author":"Zhang","year":"2009","journal-title":"J. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1359\/JBMR.041117","article-title":"Alveolar bone marrow as a cell source for regenerative medicine: Differences between alveolar and iliac bone marrow stromal cells","volume":"20","author":"Matsubara","year":"2005","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/ar.1092110305","article-title":"Progenitor cell populations in the periodontal ligament of mice","volume":"211","author":"McCulloch","year":"1985","journal-title":"Anat. Rec."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1600-051X.2010.01588.x","article-title":"Tissue-engineered ligament: Implant constructs for tooth replacement","volume":"37","author":"Gault","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s00223-006-0040-4","article-title":"Ovine periodontal ligament stem cells: Isolation, characterization, and differentiation potential","volume":"79","author":"Gronthos","year":"2006","journal-title":"Calcif. Tissue Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1601-0825.2009.01593.x","article-title":"Utility of PDL progenitors for in vivo tissue regeneration: A report of 3 cases","volume":"16","author":"Feng","year":"2010","journal-title":"Oral Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13287-016-0288-1","article-title":"Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: A randomized clinical trial","volume":"7","author":"Chen","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/jre.12455","article-title":"Efficacy of stem cells on periodontal regeneration: Systematic review of pre-clinical studies","volume":"52","author":"Tassi","year":"2017","journal-title":"J. Periodontal Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1089\/scd.2019.0025","article-title":"Periodontal Ligament Stem Cells: Current Knowledge and Future Perspectives","volume":"28","author":"Trubiani","year":"2019","journal-title":"Stem Cells Dev."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Passarelli, P.C., Pagnoni, S., Piccirillo, G.B., DeSantis, V., Benegiamo, M., Liguori, A., Papa, R., Papi, P., Pompa, G., and D\u2019Addona, A. (2020). Reasons for Tooth Extractions and Related Risk Factors in Adult Patients: A Cohort Study. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17072575"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/JLB.1RU0818-310R","article-title":"Macrophage immunomodulation in chronic osteolytic diseases-the case of periodontitis","volume":"105","author":"Sima","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13287-017-0503-8","article-title":"Repeated intra-articular injection of allogeneic mesenchymal stem cells causes an adverse response compared to autologous cells in the equine model","volume":"8","author":"Joswig","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"27298","DOI":"10.1074\/jbc.M702811200","article-title":"Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription","volume":"282","author":"Almeida","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41368-019-0060-3","article-title":"Stem cell-based bone and dental regeneration: A view of microenvironmental modulation","volume":"11","author":"Zheng","year":"2019","journal-title":"Int. J. Oral Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3595941","DOI":"10.1155\/2016\/3595941","article-title":"In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration","volume":"2016","author":"Szepesi","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/scd.2008.0113","article-title":"Multiple differentiation capacity of STRO-1+\/CD146+ PDL mesenchymal progenitor cells","volume":"18","author":"Xu","year":"2009","journal-title":"Stem Cells Dev."},{"key":"ref_47","first-page":"216","article-title":"Chondrogenic differentiation of adult human periodontal ligament stem cells in vitro","volume":"41","author":"Zhang","year":"2006","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kou Qiang Yi Xue Za Zhi = Chin. J. Stomatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1601-6343.2007.00399.x","article-title":"Isolation and characterization of multipotent human periodontal ligament stem cells","volume":"10","author":"Gay","year":"2007","journal-title":"Orthod. Craniofacial Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1007\/s00018-014-1633-0","article-title":"Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics","volume":"71","author":"Gucciardo","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cell.2008.03.011","article-title":"Eph-ephrin bidirectional signaling in physiology and disease","volume":"133","author":"Pasquale","year":"2008","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrc2806","article-title":"Eph receptors and ephrins in cancer: Bidirectional signalling and beyond","volume":"10","author":"Pasquale","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s00018-011-0900-6","article-title":"Eph-dependent cell-cell adhesion and segregation in development and cancer","volume":"69","author":"Nievergall","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.biocel.2008.07.019","article-title":"Eph\/ephrin signaling in epithelial development and homeostasis","volume":"41","author":"Miao","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Eph Nomenclature Committee (1997). Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. Cell, 90, 403\u2013404.","DOI":"10.1016\/S0092-8674(00)80500-0"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1073\/pnas.93.1.145","article-title":"Embryonic stem cells express multiple Eph-subfamily receptor tyrosine kinases","volume":"93","author":"Lickliter","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.stem.2010.11.009","article-title":"EphB signaling controls lineage plasticity of adult neural stem cell niche cells","volume":"7","author":"Nomura","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1016\/j.cub.2017.01.003","article-title":"Ephs and ephrins","volume":"27","author":"Taylor","year":"2017","journal-title":"Curr. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.bbamcr.2015.05.006","article-title":"Oleic acid enhances the motility of umbilical cord blood derived mesenchymal stem cells through EphB2-dependent F-actin formation","volume":"1853","author":"Jung","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.7150\/thno.65694","article-title":"Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bone.2013.08.028","article-title":"After repeated division, bone marrow stromal cells express inhibitory factors with osteogenic capabilities, and EphA5 is a primary candidate","volume":"57","author":"Yamada","year":"2013","journal-title":"Bone"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","article-title":"The phosphoinositide 3-kinase pathway","volume":"296","author":"Cantley","year":"2002","journal-title":"Science"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1042\/CBI20100544","article-title":"Suppression of the PI3K-Akt pathway is involved in the decreased adhesion and migration of bone marrow-derived mesenchymal stem cells from non-obese diabetic mice","volume":"35","author":"Li","year":"2011","journal-title":"Cell Biol. Int."},{"key":"ref_63","first-page":"748","article-title":"The roles of PI3K\/Akt signaling pathway in regulating MC3T3-E1 preosteoblast proliferation and differentiation on SLA and SLActive titanium surfaces","volume":"101","author":"Gu","year":"2012","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1126\/science.1107627","article-title":"Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation","volume":"308","author":"Kratchmarova","year":"2005","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/10799893.2019.1625061","article-title":"Dexamethasone suppresses osteogenesis of osteoblast via the PI3K\/Akt signaling pathway in vitro and in vivo","volume":"39","author":"Pan","year":"2019","journal-title":"J. Recept. Signal Transduct."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-9036-8_13","article-title":"Profiling Activity of Cellular Kinases in Migrating T-Cells","volume":"1930","author":"Chirumamilla","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8488","DOI":"10.1073\/pnas.1314810111","article-title":"Visual account of protein investment in cellular functions","volume":"111","author":"Liebermeister","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","first-page":"100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/bioinformatics\/btu684","article-title":"DOSE: An R\/Bioconductor package for disease ontology semantic and enrichment analysis","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1039\/C5MB00663E","article-title":"ReactomePA: An R\/Bioconductor package for reactome pathway analysis and visualization","volume":"12","author":"Yu","year":"2016","journal-title":"Mol. 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