{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:48:57Z","timestamp":1792622937640,"version":"4.5.0"},"reference-count":76,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mitochondria are eukaryotic cellular organelles that function in energy metabolism, ROS production, and programmed cell death. Cutaneous epithelial and hair follicle dermal papilla cells are energy-rich cells that thereby may be affected by mitochondrial dysfunction and DNA mutation accumulation. In this review, we aimed to summarize the medical literature assessing dermatologic conditions and outcomes associated with mitochondrial dysfunction. A search of PubMed and Embase was performed with subsequent handsearching to retrieve additional relevant articles. Mitochondrial DNA (mtDNA) deletions, mutation accumulation, and damage are associated with phenotypic signs of cutaneous aging, hair loss, and impaired wound healing. In addition, several dermatologic conditions are associated with aberrant mitochondrial activity, such as systemic lupus erythematosus, psoriasis, vitiligo, and atopic dermatitis. Mouse model studies have better established causality between mitochondrial damage and dermatologic outcomes, with some depicting reversibility upon restoration of mitochondrial function. Mitochondrial function mediates a variety of dermatologic conditions, and mitochondrial components may be a promising target for therapeutic strategies.<\/jats:p>","DOI":"10.3390\/ijms25063303","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T09:32:30Z","timestamp":1710495150000},"page":"3303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0338-5607","authenticated-orcid":false,"given":"Nicole","family":"Natarelli","sequence":"first","affiliation":[{"name":"Morsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL 33602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimrit","family":"Gahoonia","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine, Touro University, 1310 Club Dr, Vallejo, CA 94592, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaliz","family":"Aflatooni","sequence":"additional","affiliation":[{"name":"Morsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL 33602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahibjot","family":"Bhatia","sequence":"additional","affiliation":[{"name":"College of Medicine, California Northstate University, 9700 W Taron Dr, Elk Grove, CA 95757, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7205-8162","authenticated-orcid":false,"given":"Raja K.","family":"Sivamani","sequence":"additional","affiliation":[{"name":"College of Medicine, California Northstate University, 9700 W Taron Dr, Elk Grove, CA 95757, USA"},{"name":"Integrative Skin Science and Research, 1495 River Park Drive, Sacramento, CA 95819, USA"},{"name":"Pacific Skin Institute, 1495 River Park Dr Suite 200, Sacramento, CA 95815, USA"},{"name":"Department of Dermatology, University of California-Davis, 3301 C St #1400, Sacramento, CA 95816, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"ref_1","first-page":"417","article-title":"Mitochondria: Structure and function","volume":"147","author":"Sherratt","year":"1991","journal-title":"Rev. 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