{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:05:15Z","timestamp":1793235915816,"version":"4.5.0"},"reference-count":171,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Associazione Medica Triestina"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden, and it is currently gaining increasing interest in relation to its potential impact on central nervous system (CNS) diseases, especially concerning cognitive deterioration and dementias. Overall, scientific research nowadays extends to different levels, exploring NAFLD\u2019s putative proinflammatory mechanism of such dysmetabolic conditions, spreading out from the liver to a multisystemic involvement. The aim of this review is to analyze the most recent scientific literature on cognitive involvement in NAFLD, as well as understand its underlying potential background processes, i.e., neuroinflammation, the role of microbiota in the brain\u2013liver\u2013gut axis, hyperammonemia neurotoxicity, insulin resistance, free fatty acids, and vitamins.<\/jats:p>","DOI":"10.3390\/ijms25063337","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T09:32:30Z","timestamp":1710495150000},"page":"3337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9910-3514","authenticated-orcid":false,"given":"Mauro","family":"Giuffr\u00e8","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (Digestive Diseases), Yale School of Medicine, New Haven, CT 06511, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-1905","authenticated-orcid":false,"given":"Nicola","family":"Merli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-8683","authenticated-orcid":false,"given":"Maura","family":"Pugliatti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation, University of Ferrara, 44124 Ferrara, Italy"},{"name":"Interdepartmental Research Center for Multiple Sclerosis and Other Inflammatory and Degenerative Disorders of the Nervous System, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9731-2697","authenticated-orcid":false,"given":"Rita","family":"Moretti","sequence":"additional","affiliation":[{"name":"Department of Clinical, Medical and Surgical Sciences, University of Trieste, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jhep.2018.05.036","article-title":"Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016\u20132030","volume":"69","author":"Estes","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"George, E.S., Sood, S., Daly, R.M., and Tan, S.-Y. (2022). Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review. BMC Geriatr., 22.","DOI":"10.1186\/s12877-021-02721-w"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1136\/flgastro-2022-102122","article-title":"What\u2019s new in non-alcoholic fatty liver disease?","volume":"13","author":"Spiers","year":"2022","journal-title":"Frontline Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S2468-1253(19)30419-4","article-title":"Prevalence of steatosis and fibrosis in young adults in the UK: A population-based study","volume":"5","author":"Abeysekera","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Alexander, M., Loomis, A.K., van der Lei, J., Duarte-Salles, T., Prieto-Alhambra, D., Ansell, D., Pasqua, A., Lapi, F., Rijnbeek, P., and Mosseveld, M. (2019). Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: Real-world study of 18 million patients in four European cohorts. BMC Med., 17.","DOI":"10.1186\/s12916-019-1321-x"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1111\/jgh.15009","article-title":"Nonalcoholic fatty liver disease burden: Australia, 2019\u20132030","volume":"35","author":"Roberts","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.21037\/hbsn.2018.12.05","article-title":"Nonalcoholic fatty liver disease (NAFLD) prevention: Role of Mediterranean diet and physical activity","volume":"8","author":"Trovato","year":"2019","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.20466","article-title":"Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity","volume":"40","author":"Browning","year":"2004","journal-title":"Hepatology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1111\/jgh.15363","article-title":"Relationship between dietary patterns and non-alcoholic fatty liver disease: A systematic review and meta-analysis","volume":"36","author":"Mansoori","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.jhep.2021.07.035","article-title":"Metabolic dysfunction-associated fatty liver disease is associated with increased all-cause mortality in the United States","volume":"75","author":"Kim","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Colognesi, M., Gabbia, D., and de Martin, S. (2020). Depression and Cognitive Impairment-Extrahepatic Manifestations of NAFLD and NASH. Biomedicines, 8.","DOI":"10.3390\/biomedicines8070229"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/hep.22752","article-title":"Liver disease as a risk factor for cognitive decline and dementia: An under-recognized issue","volume":"49","author":"Yilmaz","year":"2009","journal-title":"Hepatology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"14185","DOI":"10.3748\/wjg.v20.i39.14185","article-title":"Nonalcoholic fatty liver disease and aging: Epidemiology to management","volume":"20","author":"Bertolotti","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_14","unstructured":"GBD 2016 Dementia Collaborators (2019). Global, regional, and national burden of Alzheimer\u2019s disease and other dementias, 1990\u20132016, a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol., 18, 88\u2013106."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2471\/BLT.13.118422","article-title":"Prevalences of dementia and cognitive impairment among older people in sub-Saharan Africa: A systematic review","volume":"91","author":"Mavrodaris","year":"2013","journal-title":"Bull. World Health Organ."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1478-3231.2005.01012.x","article-title":"Cognition in liver disease","volume":"25","author":"Collie","year":"2005","journal-title":"Liver Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1176\/appi.neuropsych.12040091","article-title":"Cognitive function in patients with alcoholic and nonalcoholic chronic liver disease","volume":"26","author":"Brodersen","year":"2014","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1002\/hep.23216","article-title":"Spectrum of neurocognitive impairment in cirrhosis: Implications for the assessment of hepatic encephalopathy","volume":"50","author":"Bajaj","year":"2009","journal-title":"Hepatology"},{"key":"ref_19","first-page":"54","article-title":"Biomarkers for the diagnosis of Alzheimer\u2019s disease, dementia Lewy body, frontotemporal dementia and vascular dementia","volume":"32","author":"MacLin","year":"2019","journal-title":"Gen. Psychiatr."},{"key":"ref_20","first-page":"afac173","article-title":"Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: A meta-analysis and systematic review of epidemiology studies","volume":"51","author":"Bai","year":"2022","journal-title":"Age Ageing"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-0447.2008.01326.x","article-title":"Rate of progression of mild cognitive impairment to dementia--meta-analysis of 41 robust inception cohort studies","volume":"119","author":"Mitchell","year":"2009","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1007\/s10620-013-2657-2","article-title":"Functional Impairment in Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease Is Significant and Persists over 3 Years of Follow-Up","volume":"58","author":"Elliott","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s40271-020-00485-w","article-title":"Development of a Patient-Reported Outcome Measure for Non-Alcoholic Steatohepatitis (NASH-CHECK): Results of a Qualitative Study","volume":"14","author":"Doward","year":"2021","journal-title":"Patient Patient-Centered Outcomes Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kj\u00e6rgaard, K., Mikkelsen, A.C.D., Wernberg, C.W., Gr\u00f8nkj\u00e6r, L.L., Eriksen, P.L., Damholdt, M.F., Mookerjee, R.P., Vilstrup, H., Lauridsen, M.M., and Thomsen, K.L. (2021). Cognitive Dysfunction in Non-Alcoholic Fatty Liver Disease\u2014Current Knowledge, Mechanisms and Perspectives. J. Clin. Med., 10.","DOI":"10.3390\/jcm10040673"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.psym.2018.06.001","article-title":"Cognitive Performance in Individuals With Non-Alcoholic Fatty Liver Disease and\/or Type 2 Diabetes Mellitus","volume":"59","author":"Weinstein","year":"2018","journal-title":"Psychosomatics"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"594A","DOI":"10.1002\/hep.28218","article-title":"Poster Session 2, Advances in Imaging and Noninvasive Markers of Fibrosis; Bile Acids, Cholangiocyte Biology, and Experimental Cholestasis","volume":"62","author":"Staugaard","year":"2015","journal-title":"Hepatology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1111\/liv.14161","article-title":"Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study","volume":"39","author":"Weinstein","year":"2019","journal-title":"Liver Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e3446","DOI":"10.1097\/MD.0000000000003446","article-title":"The Presence of White Matter Lesions Is Associated With the Fibrosis Severity of Nonalcoholic Fatty Liver Disease","volume":"95","author":"Petta","year":"2016","journal-title":"Medicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.3389\/fmed.2021.738835","article-title":"Non-alcoholic Fatty Liver Disease and Longitudinal Cognitive Changes in Middle-Aged and Elderly Adults","volume":"8","author":"Liu","year":"2022","journal-title":"Front. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1212\/WNL.0000000000002498","article-title":"Nonalcoholic fatty liver disease is associated with cognitive function in adults","volume":"86","author":"Seo","year":"2016","journal-title":"Neurology"},{"key":"ref_32","first-page":"2097435","article-title":"Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease","volume":"2018","year":"2018","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/MEG.0000000000001131","article-title":"Cognitive assessment of patients with nonalcoholic fatty liver disease","volume":"30","author":"Celikbilek","year":"2018","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Cushman, M., Callas, P.W., Alexander, K.S., Wadley, V., Zakai, N.A., Lidofsky, S.D., Unverzagt, F.W., and Judd, S.E. (2023). Nonalcoholic fatty liver disease and cognitive impairment: A prospective cohort study. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0282633"},{"key":"ref_35","first-page":"1034","article-title":"Association between Metabolic Dysfunction-associated Fatty Liver Disease and Cognitive Impairment","volume":"10","author":"Yu","year":"2022","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"12614","DOI":"10.1038\/s41598-022-16788-x","article-title":"Associations between non-alcoholic fatty liver disease and cognitive impairment and the effect modification of inflammation","volume":"12","author":"Kang","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e574","DOI":"10.1212\/WNL.0000000000200853","article-title":"Nonalcoholic Fatty Liver Disease and Risk of Dementia","volume":"99","author":"Shang","year":"2022","journal-title":"Neurology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3350\/cmh.2021.0332","article-title":"Association of non-alcoholic fatty liver disease with incident dementia later in life among elder adults","volume":"28","author":"Jeong","year":"2022","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e12065","DOI":"10.1002\/trc2.12065","article-title":"Liver fibrosis score, physical frailty, and the risk of dementia in older adults: The Italian Longitudinal Study on Aging","volume":"6","author":"Solfrizzi","year":"2020","journal-title":"Alzheimers Dement."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Moretti, R., Giuffr\u00e9, M., Croc\u00e8, L.S., Gazzin, S., and Tiribelli, C. (2022). Nonalcoholic Fatty Liver Disease and Altered Neuropsychological Functions in Patients with Subcortical Vascular Dementia. J. Pers. Med., 12.","DOI":"10.3390\/jpm12071106"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1111\/ene.15416","article-title":"Nonalcoholic fatty liver disease, serum cytokines, and dementia among rural-dwelling older adults in China: A population-based study","volume":"29","author":"Wang","year":"2022","journal-title":"Eur. J. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12933-018-0670-7","article-title":"Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): A case control study","volume":"17","author":"Tuttolomondo","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Takahashi, A., Kono, S., Wada, A., Oshima, S., Abe, K., Imaizumi, H., Fujita, M., Hayashi, M., Okai, K., and Miura, I. (2017). Reduced brain activity in female patients with non-alcoholic fatty liver disease as measured by near-infrared spectroscopy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0174169"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/jamaneurol.2017.3229","article-title":"Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study","volume":"75","author":"Weinstein","year":"2018","journal-title":"JAMA Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1210\/clinem\/dgad352","article-title":"The Presence and Severity of NAFLD are Associated With Cognitive Impairment and Hippocampal Damage","volume":"108","author":"Miao","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e16048","DOI":"10.1111\/ene.16048","article-title":"Nonalcoholic fatty liver disease, liver fibrosis, and structural brain imaging: The Cross-Cohort Collaboration","volume":"31","author":"Weinstein","year":"2024","journal-title":"Eur. J. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8","DOI":"10.31083\/j.jin2201008","article-title":"Aberrant Spontaneous Brain Activity and its Association with Cognitive Function in Non-Obese Nonalcoholic Fatty Liver Disease: A Resting-State fMRI Study","volume":"22","author":"Xu","year":"2023","journal-title":"J. Integr. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/NNR.0000000000000319","article-title":"Association of CTRP13 With Liver Enzymes and Cognitive Symptoms in Nonalcoholic Fatty Liver Disease","volume":"68","author":"An","year":"2019","journal-title":"Nurs. Res."},{"key":"ref_49","first-page":"27","article-title":"Protein-protein interaction analysis of Alzheimer`s disease and NAFLD based on systems biology methods unhide common ancestor pathways","volume":"11","author":"Karbalaei","year":"2018","journal-title":"Gastroenterol. Hepatol. Bed. Bench."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-015-0467-5","article-title":"Non-alcoholic fatty liver disease induces signs of Alzheimer\u2019s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model","volume":"13","author":"Kim","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e197978","DOI":"10.1001\/jamanetworkopen.2019.7978","article-title":"Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers","volume":"2","author":"Nho","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3233\/JAD-215409","article-title":"Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-\u03b2 and Tau Pathology in Middle-Aged Adults: The Framingham Study","volume":"86","author":"Weinstein","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"985109","DOI":"10.3389\/fnagi.2022.985109","article-title":"Risk of dementia or cognitive impairment in non-alcoholic fatty liver disease: A systematic review and meta-analysis","volume":"14","author":"Wang","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Cheon, S.Y., and Song, J. (2022). Novel insights into non-alcoholic fatty liver disease and dementia: Insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation. Cell Biosci., 12.","DOI":"10.1186\/s13578-022-00836-0"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1038\/s41598-020-63803-0","article-title":"Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes","volume":"10","author":"Han","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1021\/acs.jafc.1c00751","article-title":"Dietary Polyphenols to Combat Nonalcoholic Fatty Liver Disease via the Gut\u2013Brain\u2013Liver Axis: A Review of Possible Mechanisms","volume":"69","author":"Wang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/oby.21767","article-title":"Nonalcoholic fatty liver disease and measures of early brain health in middle-aged adults: The CARDIA study","volume":"25","author":"VanWagner","year":"2017","journal-title":"Obesity"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Gerber, Y., VanWagner, L.B., Yaffe, K., Terry, J.G., Rana, J.S., Reis, J.P., and Sidney, S. (2021). Non-alcoholic fatty liver disease and cognitive function in middle-aged adults: The CARDIA study. BMC Gastroenterol., 21.","DOI":"10.1186\/s12876-021-01681-0"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"120117","DOI":"10.1016\/j.jns.2021.120117","article-title":"Association of chronic liver disease with cognition and brain volumes in two randomized controlled trial populations","volume":"434","author":"Basu","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11011-011-9269-3","article-title":"Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy","volume":"27","author":"Felipo","year":"2012","journal-title":"Metab. Brain Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"100218","DOI":"10.1016\/j.jhepr.2020.100218","article-title":"Non-alcoholic fatty liver disease does not increase dementia risk although histology data might improve risk prediction","volume":"3","author":"Shang","year":"2021","journal-title":"JHEP Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s10620-020-06644-1","article-title":"Incident Dementia in Elderly Patients with Nonalcoholic Fatty Liver Disease in Germany","volume":"66","author":"Labenz","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"E565","DOI":"10.1212\/WNL.0000000000200770","article-title":"Association of Nonalcoholic Fatty Liver Disease and Fibrosis With Incident Dementia and Cognition: The Rotterdam Study","volume":"99","author":"Xiao","year":"2022","journal-title":"Neurology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e00203","DOI":"10.1097\/HC9.0000000000000203","article-title":"The prevalence and risk factors for cognitive impairment in obesity and NAFLD","volume":"7","author":"Wernberg","year":"2023","journal-title":"Hepatol. Commun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jpsychires.2023.03.041","article-title":"NAFLD does not increase the risk of incident dementia: A prospective study and meta-analysis","volume":"161","author":"Huang","year":"2023","journal-title":"J. Psychiatr. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41574-021-00498-x","article-title":"Brain insulin signalling in metabolic homeostasis and disease","volume":"17","author":"Scherer","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/s10620-015-3564-5","article-title":"Prevalence of Insulin Resistance in Subjects with Nonalcoholic Fatty Liver Disease and Its Predictors in a Chinese Population","volume":"60","author":"Li","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1111\/j.1471-4159.2005.03155.x","article-title":"A biochemical and functional characterization of diet-induced brain insulin resistance","volume":"93","author":"Mielke","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4981814","DOI":"10.1155\/2020\/4981814","article-title":"Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer\u2019s Disease","volume":"2020","author":"Sun","year":"2020","journal-title":"J. Diabetes Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neurobiolaging.2008.04.002","article-title":"Defects in IGF-1 receptor, insulin receptor and IRS-1\/2 in Alzheimer\u2019s disease indicate possible resistance to IGF-1 and insulin signalling","volume":"31","author":"Moloney","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11011-011-9261-y","article-title":"Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction","volume":"26","author":"Ghareeb","year":"2011","journal-title":"Metab. Brain Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1474-4422(04)00681-7","article-title":"Insulin and neurodegenerative disease: Shared and specific mechanisms","volume":"3","author":"Craft","year":"2004","journal-title":"Lancet Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bcp.2013.12.012","article-title":"Brain metabolic dysfunction at the core of Alzheimer\u2019s disease","volume":"88","author":"Tong","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2045-8118-11-8","article-title":"Impact of altered glycaemia on blood-brain barrier endothelium: An in vitro study using the hCMEC\/D3 cell line","volume":"11","author":"Sajja","year":"2014","journal-title":"Fluids Barriers CNS"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/jnnp.74.1.70","article-title":"Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging","volume":"74","author":"Starr","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e24061","DOI":"10.1002\/jcla.24061","article-title":"Association between apolipoprotein E gene polymorphism and nonalcoholic fatty liver disease in Southern China: A case-control study","volume":"35","author":"Liu","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Rizzo, M.R., Fasano, R., and Paolisso, G. (2020). Adiponectin and Cognitive Decline. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062010"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5009\/gnl.2012.6.2.149","article-title":"NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications","volume":"6","author":"Farrell","year":"2012","journal-title":"Gut Liver"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.cgh.2018.11.037","article-title":"Liver Fat Is Associated With Markers of Inflammation and Oxidative Stress in Analysis of Data From the Framingham Heart Study","volume":"17","author":"Fricker","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"153994","DOI":"10.1016\/j.metabol.2019.153994","article-title":"Fibroblast growth factor 21 in non-alcoholic fatty liver disease","volume":"101","author":"Tucker","year":"2019","journal-title":"Metabolism"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1097\/CM9.0000000000002135","article-title":"Retinol-binding protein-4 and nonalcoholic fatty liver disease","volume":"135","author":"Huang","year":"2022","journal-title":"Chin. Med. J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"6889533","DOI":"10.1155\/2021\/6889533","article-title":"The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD","volume":"2021","author":"Hong","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1530\/EJE-11-0864","article-title":"Fetuin A in nonalcoholic fatty liver disease: In vivo and in vitro studies","volume":"166","author":"Haukeland","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1097\/00003246-200209000-00019","article-title":"Tumor necrosis factor-alpha and interleukin-1beta mediate endothelial permeability induced by lipopolysaccharide-stimulated whole blood","volume":"30","author":"Nooteboom","year":"2002","journal-title":"Crit. Care Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.biopha.2018.12.064","article-title":"Cysteinyl leukotriene receptor type 1 (CysLT1R) antagonist zafirlukast protects against TNF-\u03b1-induced endothelial inflammation","volume":"111","author":"Zhou","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.31658","article-title":"Myeloid-Cell-Specific IL-6 Signaling Promotes MicroRNA-223-Enriched Exosome Production to Attenuate NAFLD-Associated Fibrosis","volume":"74","author":"Hou","year":"2021","journal-title":"Hepatology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41575-021-00473-x","article-title":"New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology","volume":"18","author":"Giraldez","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.3748\/wjg.v26.i40.6141","article-title":"Role of gut microbiota via the gut-liver-brain axis in digestive diseases","volume":"26","author":"Ding","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Jang, D.-I., Lee, A.-H., Shin, H.-Y., Song, H.-R., Park, J.-H., Kang, T.-B., Lee, S.-R., and Yang, S.-H. (2021). The Role of Tumor Necrosis Factor Alpha (TNF-\u03b1) in Autoimmune Disease and Current TNF-\u03b1 Inhibitors in Therapeutics. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052719"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"630265","DOI":"10.1155\/2015\/630265","article-title":"Interleukin-1 Family Cytokines in Liver Diseases","volume":"2015","author":"Tsutsui","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_92","first-page":"710","article-title":"IL-6 increases endothelial permeability in vitro","volume":"131","author":"Maruo","year":"1992","journal-title":"Endocrinology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.molmed.2018.03.005","article-title":"IL-1 family cytokine pathways underlying NAFLD: Towards new treatment strategies","volume":"24","author":"Mirea","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.thromres.2008.03.013","article-title":"Effects of IL-1beta and IL-6 on tissue-type plasminogen activator expression in vascular endothelial cells","volume":"123","author":"Larsson","year":"2008","journal-title":"Thromb. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1365-2249.2006.03074.x","article-title":"Modulation of endothelial monolayer permeability induced by plasma obtained from lipopolysaccharide-stimulated whole blood","volume":"144","author":"Nooteboom","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Goumans, M.J., and ten Dijke, P. (2018). TGF-\u03b2 Signaling in Control of Cardiovascular Function. Cold Spring Harb. Perspect. Biol., 10.","DOI":"10.1101\/cshperspect.a022210"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/00004647-199808000-00003","article-title":"Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat","volume":"18","author":"Rothwell","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainres.2018.04.023","article-title":"TNF-\u03b1-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between I\u03baB-NF\u03baB and JAK-STAT3 pathways","volume":"1692","author":"Matsumoto","year":"2018","journal-title":"Brain Res."},{"key":"ref_99","first-page":"929","article-title":"Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis","volume":"13","author":"Moratalla","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.2741\/1948","article-title":"Gene therapy of focal cerebral ischemia using defective recombinant adeno-associated virus vectors","volume":"11","author":"Tsai","year":"2006","journal-title":"Front. Biosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1073\/pnas.94.4.1500","article-title":"Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the\u2009brain","volume":"94","author":"Heyser","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"10061","DOI":"10.1073\/pnas.90.21.10061","article-title":"Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6","volume":"90","author":"Campbell","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(96)01277-2","article-title":"Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury","volume":"751","author":"Yang","year":"1997","journal-title":"Brain Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1002\/alz.12482","article-title":"The impact of diabetes on cognitive impairment and its progression to dementia","volume":"17","author":"Dove","year":"2021","journal-title":"Alzheimers Dement."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer\u2019s disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Fiorillo, A., Gallego, J.-J., Casanova-Ferrer, F., Gim\u00e9nez-Garz\u00f3, C., Urios, A., Ballester, M.-P., Durb\u00e1n, L., Rios, M.-P., Meg\u00edas, J., and Miguel, T.S. (2023). Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210407"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jhep.2022.08.008","article-title":"Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction","volume":"78","author":"Hadjihambi","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.molmet.2017.10.005","article-title":"AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice","volume":"6","author":"Carneiro","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"G889","DOI":"10.1152\/ajpgi.00161.2019","article-title":"A story of liver and gut microbes: How does the intestinal flora affect liver disease? A review of the literature","volume":"318","author":"Campigotto","year":"2020","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Giuffr\u00e8, M., Moretti, R., Campisciano, G., da Silveira, A.B.M., Monda, V.M., Comar, M., Di Bella, S., Antonello, R.M., Luzzati, R., and Croc\u00e8, L.S. (2020). You Talking to Me? Says the Enteric Nervous System (ENS) to the Microbe. How Intestinal Microbes Interact with the ENS. J. Clin. Med., 9.","DOI":"10.3390\/jcm9113705"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Giuffr\u00e8, M., Gazzin, S., Zoratti, C., Llido, J.P., Lanza, G., Tiribelli, C., and Moretti, R. (2022). Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415564"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Giuffr\u00e8, M., and Moretti, R. (2023). The Gut-Liver-Brain Axis: From the Head to the Feet. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115662"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1161\/STROKEAHA.121.036800","article-title":"Gut Microbiota and Their Metabolites in Stroke: A Double-Edged Sword","volume":"53","author":"Peh","year":"2022","journal-title":"Stroke"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Ferri, C., Castellazzi, M., Merli, N., Laudisi, M., Baldin, E., Baldi, E., Mancabelli, L., Ventura, M., and Pugliatti, M. (2023). Gut Microbiota Changes during Dimethyl Fumarate Treatment in Patients with Multiple Sclerosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032720"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Varesi, A., Pierella, E., Romeo, M., Piccini, G.B., Alfano, C., Bj\u00f8rklund, G., Oppong, A., Ricevuti, G., Esposito, C., and Chirumbolo, S. (2022). The Potential Role of Gut Microbiota in Alzheimer\u2019s Disease: From Diagnosis to Treatment. Nutrients, 14.","DOI":"10.3390\/nu14030668"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neurobiolaging.2016.08.019","article-title":"Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly","volume":"49","author":"Cattaneo","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"13537","DOI":"10.1038\/s41598-017-13601-y","article-title":"Gut microbiome alterations in Alzheimer\u2019s disease","volume":"7","author":"Vogt","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.chom.2020.07.007","article-title":"Microbiota and Fatty Liver Disease\u2014The Known, the Unknown, and the Future","volume":"28","author":"Lang","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s13238-016-0338-6","article-title":"Human gut microbiota: The links with dementia development","volume":"8","author":"Alkasir","year":"2017","journal-title":"Protein Cell"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"934113","DOI":"10.3389\/fnut.2022.934113","article-title":"Gut microbiota\u2013mitochondrial inter-talk in non-alcoholic fatty liver disease","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Higarza, S.G., Arboleya, S., Gueimonde, M., G\u00f3mez-L\u00e1zaro, E., Arias, J.L., and Arias, N. (2019). Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0223019"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"112762","DOI":"10.1016\/j.physbeh.2019.112762","article-title":"Modulation of hippocampal TLR4\/BDNF signal pathway using probiotics is a step closer towards treating cognitive impairment in NASH model","volume":"214","author":"Mohammed","year":"2020","journal-title":"Physiol. Behav."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.dld.2023.07.014","article-title":"Association between the gut microbiota and nonalcoholic fatty liver disease: A two-sample Mendelian randomization study","volume":"55","author":"Li","year":"2023","journal-title":"Dig. Liver Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s11064-016-2014-x","article-title":"Neurotoxicity of Ammonia","volume":"42","author":"Oja","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnmol.2016.00057","article-title":"Ammonia as a Potential Neurotoxic Factor in Alzheimer\u2019s Disease","volume":"9","author":"Adlimoghaddam","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/jcbfm.2010.22","article-title":"Blood\u2013brain barrier permeability for ammonia in patients with different grades of liver fibrosis is not different from healthy controls","volume":"30","author":"Goldbecker","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12979-015-0029-9","article-title":"Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment","volume":"12","author":"Elahy","year":"2015","journal-title":"Immun. Ageing"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1665-2681(19)31785-5","article-title":"Hepatic encephalopathy, ammonia, glutamate, glutamine and oxidative stress","volume":"8","author":"Lemberg","year":"2009","journal-title":"Ann. Hepatol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s11011-014-9494-7","article-title":"Cerebral effects of ammonia in liver disease: Current hypotheses","volume":"29","author":"Ott","year":"2014","journal-title":"Metab. Brain Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1515\/CCLM.2008.118","article-title":"Free fatty acids as a cardiovascular risk factor","volume":"46","author":"Pilz","year":"2008","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Pin\u00e7on, A., De Montgolfier, O., Akkoyunlu, N., Daneault, C., Pouliot, P., Villeneuve, L., Lesage, F., Levy, B.I., Thorin-Trescases, N., and Thorin, E. (2019). Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP\/PS1 Mice. Metabolites, 9.","DOI":"10.3390\/metabo9050104"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.bbalip.2016.03.005","article-title":"Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer\u2019s disease","volume":"1861","author":"Guschina","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/npp.2014.196","article-title":"Transgenic increase in n-3\/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation","volume":"40","author":"Delpech","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.2337\/db11-1521","article-title":"Monounsaturated fatty acids prevent the aversive effects of obesity on locomotion, brain activity, and sleep behavior","volume":"61","author":"Sartorius","year":"2012","journal-title":"Diabetes"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cyto.2015.02.025","article-title":"Toll-like receptors: Activation, signalling and transcriptional modulation","volume":"74","year":"2015","journal-title":"Cytokine"},{"key":"ref_136","first-page":"e16855","article-title":"The Role of Vitamins in Non-Alcoholic Fatty Liver Disease: A Systematic Review","volume":"13","author":"Abe","year":"2021","journal-title":"Cureus"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00401-017-1669-y","article-title":"Marginal vitamin A deficiency facilitates Alzheimer\u2019s pathogenesis","volume":"133","author":"Zeng","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e9838","DOI":"10.7717\/peerj.9838","article-title":"Association between serum and dietary antioxidant micronutrients and advanced liver fibrosis in non-alcoholic fatty liver disease: An observational study","volume":"8","author":"Coelho","year":"2020","journal-title":"PeerJ"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4137\/IMI.S31451","article-title":"The Role of Vitamins in the Pathogenesis of Non-alcoholic Fatty Liver Disease","volume":"11","author":"Li","year":"2016","journal-title":"Integr. Med. Insights"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Saeed, A., Dullaart, R.P.F., Schreuder, T.C.M.A., Blokzijl, H., and Faber, K.N. (2017). Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients, 10.","DOI":"10.3390\/nu10010029"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrn2212","article-title":"Retinoic acid in the development, regeneration and maintenance of the nervous system","volume":"8","author":"Maden","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3233\/JAD-1999-14-502","article-title":"Diet and oxidative stress: A novel synthesis of epidemiological data on Alzheimer\u2019s disease","volume":"1","author":"Smith","year":"1999","journal-title":"J. Alzheimers Dis."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Kennedy, D.O. (2016). B Vitamins and the Brain: Mechanisms, Dose and Efficacy\u2014A Review. Nutrients, 8.","DOI":"10.3390\/nu8020068"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/jnc.13092","article-title":"Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6\/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells","volume":"134","author":"Uchida","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1471-4159.2007.04773.x","article-title":"Vitamin transport and homeostasis in mammalian brain: Focus on Vitamins B and E","volume":"103","author":"Spector","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1111\/bph.13513","article-title":"Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing","volume":"173","author":"Zhou","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"132","DOI":"10.12688\/f1000research.12120.1","article-title":"NAD+ biosynthesis, aging, and disease","volume":"7","author":"Imai","year":"2018","journal-title":"F1000Research"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Guarino, M., and Dufour, J.F. (2019). Nicotinamide and NAFLD: Is There Nothing New Under the Sun?. Metabolites, 9.","DOI":"10.3390\/metabo9090180"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Gasperi, V., Sibilano, M., Savini, I., and Catani, M.V. (2019). Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040974"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.aac4854","article-title":"NAD+ in aging, metabolism, and neurodegeneration","volume":"350","author":"Verdin","year":"2015","journal-title":"Science"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","article-title":"Mitophagy and Alzheimer\u2019s Disease: Cellular and Molecular Mechanisms","volume":"40","author":"Kerr","year":"2017","journal-title":"Trends Neurosci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40478-018-0511-7","article-title":"Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA)","volume":"6","author":"Burwinkel","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2016.04.060","article-title":"Nicotinamide mononucleotide protects against \u03b2-amyloid oligomer-induced cognitive impairment and neuronal death","volume":"1643","author":"Wang","year":"2016","journal-title":"Brain Res."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Mahamid, M., Mahroum, N., Bragazzi, N.L., Shalaata, K., Yavne, Y., Adawi, M., Amital, H., and Watad, A. (2018). Folate and B12 Levels Correlate with Histological Severity in NASH Patients. Nutrients, 10.","DOI":"10.3390\/nu10040440"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3233\/JAD-220410","article-title":"Serum Homocysteine, Vitamin B12, Folate, and Their Association with Mild Cognitive Impairment and Subtypes of Dementia","volume":"90","author":"Song","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Moretti, R., Giuffr\u00e9, M., Caruso, P., Gazzin, S., and Tiribelli, C. (2021). Homocysteine in Neurology: A Possible Contributing Factor to Small Vessel Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042051"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.livres.2021.03.004","article-title":"Vitamins and non-alcoholic fatty liver disease: A Molecular Insight\u22c6","volume":"5","author":"Raza","year":"2021","journal-title":"Liver Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jcmgh.2018.07.004","article-title":"Micronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis","volume":"6","author":"Young","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Rucker, R.B., Zempleni, J., Suttie, J.W., and McCormick, D.B. (2007). Handbook of Vitamins, Taylor & Francis Ltd.","DOI":"10.1201\/9781420005806"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1474-4422(06)70598-1","article-title":"Vitamin B12, folic acid, and the nervous system","volume":"5","author":"Reynolds","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.4088\/JCP.v69n0901","article-title":"L-methylfolate: A vitamin for your monoamines","volume":"69","author":"Stahl","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ejphar.2005.11.047","article-title":"Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis","volume":"530","author":"Moat","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_163","first-page":"1681","article-title":"Correlation between serum 25-OH vitamin D expression and non-alcoholic fatty liver disease","volume":"19","author":"Cai","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2147\/DMSO.S286334","article-title":"The Impact of Vitamin D in Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study in Patients with Morbid Obesity","volume":"14","author":"Neves","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.3748\/wjg.v23.i19.3407","article-title":"Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease","volume":"23","author":"Barchetta","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.3748\/wjg.v26.i38.5812","article-title":"Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?","volume":"26","author":"Cao","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Barchetta, I., Cimini, F.A., and Cavallo, M.G. (2020). Vitamin D and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): An Update. Nutrients, 12.","DOI":"10.3390\/nu12113302"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mce.2017.05.035","article-title":"Vitamin D and the brain: Genomic and non-genomic actions","volume":"453","author":"Cui","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Cui, C., Xu, P., Li, G., Qiao, Y., Han, W., Geng, C., Liao, D., Yang, M., Chen, D., and Jiang, P. (2019). Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system. Redox Biol., 26.","DOI":"10.1016\/j.redox.2019.101295"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fphar.2020.00161","article-title":"Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage\/Microglia Activation","volume":"11","author":"Sartori","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/6\/3337\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:14:06Z","timestamp":1760105646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/6\/3337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":171,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25063337"],"URL":"https:\/\/doi.org\/10.3390\/ijms25063337","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,15]]}}}