{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:42:15Z","timestamp":1787496135385,"version":"build-2736575974"},"reference-count":27,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Region \u00d6rebro County research committee","award":["OLL-779321"],"award-info":[{"award-number":["OLL-779321"]}]},{"name":"Region \u00d6rebro County research committee","award":["OLL-811611"],"award-info":[{"award-number":["OLL-811611"]}]},{"name":"Region \u00d6rebro County research committee","award":["OLL-869141"],"award-info":[{"award-number":["OLL-869141"]}]},{"name":"Region \u00d6rebro County research committee","award":["AV2018"],"award-info":[{"award-number":["AV2018"]}]},{"name":"Lions Cancer Research Fund in Uppsala","award":["OLL-779321"],"award-info":[{"award-number":["OLL-779321"]}]},{"name":"Lions Cancer Research Fund in Uppsala","award":["OLL-811611"],"award-info":[{"award-number":["OLL-811611"]}]},{"name":"Lions Cancer Research Fund in Uppsala","award":["OLL-869141"],"award-info":[{"award-number":["OLL-869141"]}]},{"name":"Lions Cancer Research Fund in Uppsala","award":["AV2018"],"award-info":[{"award-number":["AV2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Urinary bladder cancer (BC) represents a major health issue, and identifying novel biomarkers for early disease detection and outcome prediction is paramount. It has already been established that the immune system plays a role in tumour initiation and progression in which the inflammatory marker pentraxin 3 (PTX3) might be involved, presenting a variety of functions in different cancers. The aim of this study was to investigate whether plasma levels of PTX3 could be used as a biomarker for patients with BC. Plasma levels of PTX3 were determined in 118 BC patients and 50 controls by ELISA. Patients with BC had significantly higher PTX3 levels compared to controls. The value as a diagnostic biomarker is probably limited, however, since no significant difference in PTX3 levels was seen between patients with non-muscle-invasive BC and controls; they were seen only between patients with muscle-invasive disease and controls. However, the potential value of PTX3 as a prognostic biomarker was indicated by significantly higher PTX3 levels in patients who developed metastatic disease during follow-up compared to patients who did not develop metastatic disease. The conclusions from this study are that plasma levels of PTX3 have limited value as a diagnostic biomarker, although they have potential as a prognostic biomarker for patients with BC.<\/jats:p>","DOI":"10.3390\/ijms25063473","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T05:04:12Z","timestamp":1710911052000},"page":"3473","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Plasma Levels of Pentraxin 3: A Potential Prognostic Biomarker in Urinary Bladder Cancer Patients"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5439-4850","authenticated-orcid":false,"given":"Anders","family":"Vikerfors","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine and Health, \u00d6rebro University, 703 62 \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2850-6009","authenticated-orcid":false,"given":"Sabina","family":"Davidsson","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine and Health, \u00d6rebro University, 703 62 \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8457-7592","authenticated-orcid":false,"given":"Jessica","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine and Health, \u00d6rebro University, 703 62 \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Jerlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine and Health, \u00d6rebro University, 703 62 \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.eururo.2016.10.008","article-title":"Global Burden of Urologic Cancers, 1990\u20132013","volume":"71","author":"Dy","year":"2017","journal-title":"Eur. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.eururo.2016.06.010","article-title":"Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends","volume":"71","author":"Antoni","year":"2017","journal-title":"Eur. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1200\/JCO.2005.07.757","article-title":"Long-Term Survival Results of a Randomized Trial Comparing Gemcitabine Plus Cisplatin, with Methotrexate, Vinblastine, Doxorubicin, Plus Cisplatin in Patients with Bladder Cancer","volume":"23","author":"Maase","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s40273-014-0194-2","article-title":"The Health Economics of Bladder Cancer: An Updated Review of the Published Literature","volume":"32","author":"Yeung","year":"2014","journal-title":"Pharmacoeconomics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/21681805.2019.1632380","article-title":"Incidence, survival and mortality trends of bladder cancer in Sweden 1997\u20132016","volume":"53","author":"Sherif","year":"2019","journal-title":"Scand. J. Urol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Russo, P., Marino, F., Rossi, F., Bizzarri, F.P., Ragonese, M., Dibitetto, F., Filomena, G.B., Marafon, D.P., Ciccarese, C., and Iacovelli, R. (2023). Is Systemic Immune-Inflammation Index a Real Non-Invasive Biomarker to Predict Oncological Outcomes in Patients Eligible for Radical Cystectomy?. Medicina, 59.","DOI":"10.3390\/medicina59122063"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"511","DOI":"10.56434\/j.arch.esp.urol.20237607.63","article-title":"Systemic Immune Inflammation Index and T-Staging Predict Prognosis in Patients with Muscle-Invasive Bladder Cancer","volume":"76","author":"Zhang","year":"2023","journal-title":"Arch. Esp. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Lee, J., Yoo, S., Choo, M.S., Cho, M.C., Son, H., and Jeong, H. (2023). Prognostic Role of Preoperative Neutrophil-To-Lymphocyte Ratio (NLR) and Recurrence at First Evaluation after Bacillus Calmette-Guerin (BCG) Induction in Non-Muscle-Invasive Bladder Cancer. Diagnostics, 13.","DOI":"10.3390\/diagnostics13193114"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.euros.2023.11.003","article-title":"Microbiome Profiling in Bladder Cancer Patients Using the First-morning Urine Sample","volume":"59","author":"Nardelli","year":"2024","journal-title":"Eur. Urol. Open Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/978-1-4419-0901-5_7","article-title":"Pattern recognition by pentraxins","volume":"653","author":"Agrawal","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev.immunol.23.021704.115756","article-title":"Pentraxins at the Crossroads between Innate Immunity, Inflammation, Matrix Deposition, and Female Fertility","volume":"23","author":"Garlanda","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1152\/physrev.00016.2017","article-title":"PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer","volume":"98","author":"Garlanda","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_13","first-page":"649","article-title":"Knockdown of the inflammatory factor pentraxin-3 suppresses growth and invasion of lung adenocarcinoma through the AKT and NF-kappa B pathways","volume":"28","author":"Hu","year":"2014","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/ijc.29822","article-title":"Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients","volume":"138","author":"Infante","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"20276","DOI":"10.1038\/s41598-020-77332-3","article-title":"Serum pentraxin 3 as a biomarker of hepatocellular carcinoma in chronic hepatitis B virus infection","volume":"10","author":"Deng","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e11780","DOI":"10.1097\/MD.0000000000011780","article-title":"Increased serum pentraxin-3 level predicts poor prognosis in patients with colorectal cancer after curative surgery, a cohort study","volume":"97","author":"Liu","year":"2018","journal-title":"Medicine"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Goodison, S., Chang, M., Dai, Y., Urquidi, V., and Rosser, C.J. (2012). A multi-analyte assay for the non-invasive detection of bladder cancer. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047469"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.juro.2012.07.094","article-title":"Diagnostic Potential of Urinary \u03b11-Antitrypsin and Apolipoprotein E in the Detection of Bladder Cancer","volume":"188","author":"Urquidi","year":"2012","journal-title":"J. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Matarazzo, S., Melocchi, L., Rezzola, S., Grillo, E., Maccarinelli, F., Giacomini, A., Turati, M., Taranto, S., Zammataro, L., and Cerasuolo, M. (2019). Long Pentraxin-3 Follows and Modulates Bladder Cancer Progression. Cancers, 11.","DOI":"10.3390\/cancers11091277"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7585","DOI":"10.18632\/aging.103169","article-title":"PTX3 modulates the immunoflogosis in tumor microenvironment and is a prognostic factor for patients with clear cell renal cell carcinoma","volume":"12","author":"Netti","year":"2020","journal-title":"Aging"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Di Caro, G., Carvello, M., Pesce, S., Erreni, M., Marchesi, F., Todoric, J., Sacchi, M., Montorsi, M., Allavena, P., and Spinelli, A. (2016). Circulating Inflammatory Mediators as Potential Prognostic Markers of Human Colorectal Cancer. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156669"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jneuroim.2013.04.009","article-title":"The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas","volume":"260","author":"Locatelli","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1158\/1078-0432.CCR-10-3024","article-title":"Pentraxin-3 Is a Novel Biomarker of Lung Carcinoma","volume":"17","author":"Diamandis","year":"2011","journal-title":"J. Clin. Cancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/107327481702400113","article-title":"Urothelial Carcinoma with Squamous Differentiation is Associated with High Tumor Stage and Pelvic Lymph-Node Metastasis","volume":"24","author":"Liu","year":"2017","journal-title":"Cancer Control"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1586\/14737140.7.7.1015","article-title":"Clinical and therapeutic significance of aberrant differentiation patterns in bladder cancer","volume":"7","author":"Black","year":"2007","journal-title":"Expert. Rev. Anticancer Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.eururo.2018.09.001","article-title":"Epidemiology of Bladder Cancer: A Systematic Review and Contemporary Update of Risk Factors in 2018","volume":"74","author":"Cumberbatch","year":"2018","journal-title":"Eur. Urol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e016606","DOI":"10.1136\/bmjopen-2017-016606","article-title":"Cohort profile: The Swedish National Register of Urinary Bladder Cancer (SNRUBC) and the Bladder Cancer Data Base Sweden (BladderBaSe)","volume":"7","author":"Liedberg","year":"2017","journal-title":"J. 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