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Despite the interruption of the supraspinal pathways that occurs in spinal cord injury (SCI), the NMJ, innervated by motor neurons below the injury site, has been found to remain intact. This highlights the importance of studying the NMJ in rodent models of various nervous system disorders, such as amyotrophic lateral sclerosis (ALS), Charcot\u2013Marie\u2013Tooth disease (CMT), spinal muscular atrophy (SMA), and spinal and bulbar muscular atrophy (SBMA). The NMJ is also involved in myasthenic disorders, such as myasthenia gravis (MG), and is vulnerable to neurotoxin damage. Thus, it is important to analyze the integrity of the NMJ in rodent models during the early stages of the disease, as this may allow for a better understanding of the condition and potential treatment options. The spinal cord also plays a crucial role in the functioning of the NMJ, as the junction relays information from the spinal cord to the muscle fibers, and the integrity of the NMJ could be disrupted by SCI. Therefore, it is vital to study SCI and muscle function when studying NMJ disorders. This review discusses the formation and function of the NMJ after SCI and potential interventions that may reverse or improve NMJ dysfunction, such as exercise, nutrition, and trophic factors.<\/jats:p>","DOI":"10.3390\/ijms25063520","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:09:36Z","timestamp":1710940176000},"page":"3520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Disruption of Neuromuscular Junction Following Spinal Cord Injury and Motor Neuron Diseases"],"prefix":"10.3390","volume":"25","author":[{"given":"Colin","family":"Nemeth","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA"},{"name":"Department of Neurosurgery, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naren L.","family":"Banik","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA"},{"name":"Department of Neurosurgery, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA"},{"name":"Ralph H. Johnson Veterans Administration Medical Center, 109 Bee Street, Charleston, SC 29401, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6386-9390","authenticated-orcid":false,"given":"Azizul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA"},{"name":"Department of Neurosurgery, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA"},{"name":"Ralph H. Johnson Veterans Administration Medical Center, 109 Bee Street, Charleston, SC 29401, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1016\/j.celrep.2017.11.008","article-title":"Cellular and Molecular Anatomy of the Human Neuromuscular Junction","volume":"21","author":"Jones","year":"2017","journal-title":"Cell Rep."},{"key":"ref_2","unstructured":"Jimsheleishvili, S., Marwaha, K., and Sherman, A.L. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"ii32","DOI":"10.1136\/jnnp.74.suppl_2.ii32","article-title":"The neuromuscular junction disorders","volume":"74","author":"Hill","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1152\/jn.00839.2014","article-title":"Short-term peripheral nerve stimulation ameliorates axonal dysfunction after spinal cord injury","volume":"113","author":"Lee","year":"2015","journal-title":"J. Neurophysiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1099143","DOI":"10.3389\/fnut.2023.1099143","article-title":"Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review","volume":"10","author":"Xu","year":"2023","journal-title":"Front. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12975-016-0495-1","article-title":"Mechanisms of Axonal Damage and Repair after Central Nervous System Injury","volume":"8","author":"Egawa","year":"2017","journal-title":"Transl. Stroke Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fneur.2019.00282","article-title":"Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms","volume":"10","author":"Alizadeh","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/cne.21143","article-title":"Paralysis elicited by spinal cord injury evokes selective disassembly of neuromuscular synapses with and without terminal sprouting in ankle flexors of the adult rat","volume":"500","author":"Burns","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/apha.12153","article-title":"Human spinal cord injury: Motor unit properties and behaviour","volume":"210","author":"Thomas","year":"2014","journal-title":"Acta Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kaufman, C.D., Liu, S.C., Cvetkovic, C., Lee, C.A., Naseri Kouzehgarani, G., Gillette, R., Bashir, R., and Gillette, M.U. (2020). Emergence of functional neuromuscular junctions in an engineered, multicellular spinal cord-muscle bioactuator. APL Bioeng., 4.","DOI":"10.1063\/1.5121440"},{"key":"ref_11","unstructured":"Omar, A., Marwaha, K., and Bollu, P.C. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/bs.ctdb.2017.08.005","article-title":"The Composition, Development, and Regeneration of Neuromuscular Junctions","volume":"126","author":"Liu","year":"2018","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev.neuro.22.1.389","article-title":"Development of the vertebrate neuromuscular junction","volume":"22","author":"Sanes","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0959-4388(03)00046-1","article-title":"Neocortical mechanisms in motor learning","volume":"13","author":"Sanes","year":"2003","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"610964","DOI":"10.3389\/fnmol.2020.610964","article-title":"The Neuromuscular Junction in Health and Disease: Molecular Mechanisms Governing Synaptic Formation and Homeostasis","volume":"13","author":"Cossins","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zou, S., and Pan, B.X. (2022). Post-synaptic specialization of the neuromuscular junction: Junctional folds formation, function, and disorders. Cell Biosci., 12.","DOI":"10.1186\/s13578-022-00829-z"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1152\/physrev.00033.2014","article-title":"Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting","volume":"95","author":"Tintignac","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s40478-022-01402-y","article-title":"Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy","volume":"10","author":"Molotsky","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kotaich, F., Caillol, D., and Bomont, P. (2023). Neurofilaments in health and Charcot-Marie-Tooth disease. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1275155"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.4103\/1673-5374.382226","article-title":"Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotrophic lateral sclerosis: A narrative review","volume":"19","author":"King","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41582-023-00916-w","article-title":"Myasthenia gravis: The changing treatment landscape in the era of molecular therapies","volume":"20","author":"Iorio","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"ref_22","first-page":"e50017","article-title":"Myasthenia Gravis: A Systematic Review","volume":"15","author":"Mishra","year":"2023","journal-title":"Cureus"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41572-019-0079-y","article-title":"Myasthenia gravis","volume":"5","author":"Gilhus","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jneumeth.2014.02.005","article-title":"Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles","volume":"227","author":"Sleigh","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1038\/s41467-020-18140-1","article-title":"The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia","volume":"11","author":"Ham","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1152\/physrev.00017.2017","article-title":"The Biology of Regeneration Failure and Success After Spinal Cord Injury","volume":"98","author":"Tran","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"940","DOI":"10.4103\/1673-5374.355749","article-title":"Clemastine in remyelination and protection of neurons and skeletal muscle after spinal cord injury","volume":"18","author":"Myatich","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3389\/fnmol.2017.00445","article-title":"Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1","volume":"10","author":"Lou","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s13287-022-02877-1","article-title":"Intramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Otzel, D.M., Lee, J., Ye, F., Borst, S.E., and Yarrow, J.F. (2018). Activity-Based Physical Rehabilitation with Adjuvant Testosterone to Promote Neuromuscular Recovery after Spinal Cord Injury. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061701"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Gazzola, M., and Martinat, C. (2023). Unlocking the Complexity of Neuromuscular Diseases: Insights from Human Pluripotent Stem Cell-Derived Neuromuscular Junctions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015291"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Glowacka, A., Ji, B., Szczepankiewicz, A.A., Skup, M., and Gajewska-Wozniak, O. (2022). BDNF Spinal Overexpression after Spinal Cord Injury Partially Protects Soleus Neuromuscular Junction from Disintegration, Increasing VAChT and AChE Transcripts in Soleus but Not Tibialis Anterior Motoneurons. Biomedicines, 10.","DOI":"10.3390\/biomedicines10112851"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Slater, C.R. (2017). The Structure of Human Neuromuscular Junctions: Some Unanswered Molecular Questions. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18102183"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"668065","DOI":"10.3389\/fphar.2022.668065","article-title":"Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids","volume":"13","author":"Alijevic","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Rudolf, R., Khan, M.M., and Witzemann, V. (2019). Motor Endplate-Anatomical, Functional, and Molecular Concepts in the Historical Perspective. Cells, 8.","DOI":"10.3390\/cells8050387"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1146\/annurev.bi.52.070183.004255","article-title":"A molecular description of nerve terminal function","volume":"52","author":"Reichardt","year":"1983","journal-title":"Annu. Rev. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3389\/fncel.2018.00424","article-title":"Myelin Dynamics Throughout Life: An Ever-Changing Landscape?","volume":"12","author":"Williamson","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"22347","DOI":"10.1073\/pnas.1910292116","article-title":"Myelin sheath structure and regeneration in peripheral nerve injury repair","volume":"116","author":"Liu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.1523\/JNEUROSCI.1773-07.2007","article-title":"Three-dimensional architecture of presynaptic terminal cytomatrix","volume":"27","author":"Siksou","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.str.2005.02.005","article-title":"Morphological characterization of molecular complexes present in the synaptic cleft","volume":"13","author":"Lucic","year":"2005","journal-title":"Structure"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.tins.2011.03.002","article-title":"Shaping the synaptic signal: Molecular mobility inside and outside the cleft","volume":"34","author":"Rusakov","year":"2011","journal-title":"Trends Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neuroscience.2021.01.036","article-title":"Extracellular Protons Mediate Presynaptic Homeostatic Potentiation at the Mouse Neuromuscular Junction","volume":"467","author":"Zhu","year":"2021","journal-title":"Neuroscience"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Cijsouw, T., Ramsey, A.M., Lam, T.T., Carbone, B.E., Blanpied, T.A., and Biederer, T. (2018). Mapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins. Proteomes, 6.","DOI":"10.3390\/proteomes6040048"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"609005","DOI":"10.3389\/fnins.2020.609005","article-title":"Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived from Natural Toxins","volume":"14","author":"Ho","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature01748","article-title":"Structure and gating mechanism of the acetylcholine receptor pore","volume":"423","author":"Miyazawa","year":"2003","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1523\/JNEUROSCI.17-16-06226.1997","article-title":"Differential localization of voltage-dependent calcium channel alpha1 subunits at the human and rat neuromuscular junction","volume":"17","author":"Day","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1113\/jphysiol.1997.sp022007","article-title":"The contribution of postsynaptic folds to the safety factor for neuromuscular transmission in rat fast- and slow-twitch muscles","volume":"500","author":"Wood","year":"1997","journal-title":"J. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1523\/JNEUROSCI.3485-15.2016","article-title":"Defects in Neuromuscular Transmission May Underlie Motor Dysfunction in Spinal and Bulbar Muscular Atrophy","volume":"36","author":"Xu","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00702-021-02353-9","article-title":"Ultrastructural characterization of peripheral denervation in a mouse model of Type III spinal muscular atrophy","volume":"128","author":"Fulceri","year":"2021","journal-title":"J. Neural Transm."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1007\/s12035-021-02658-6","article-title":"Neuromuscular Junction Dysfunction in Amyotrophic Lateral Sclerosis","volume":"59","author":"Verma","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Cipriani, S., Phan, V., Medard, J.J., Horvath, R., Lochmuller, H., Chrast, R., Roos, A., and Spendiff, S. (2018). Neuromuscular Junction Changes in a Mouse Model of Charcot-Marie-Tooth Disease Type 4C. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19124072"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1002\/cphy.c210022","article-title":"Structure and Function of the Mammalian Neuromuscular Junction","volume":"12","author":"Davis","year":"2022","journal-title":"Compr. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"12251","DOI":"10.1038\/s41598-021-91094-6","article-title":"NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease","volume":"11","author":"Jarvis","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"135431","DOI":"10.1016\/j.neulet.2020.135431","article-title":"The NMJ as a model synapse: New perspectives on synapse formation, function, and maintenance","volume":"740","author":"Lin","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semcdb.2020.02.011","article-title":"Perisynaptic schwann cells\u2014The multitasking cells at the developing neuromuscular junctions","volume":"104","author":"Gawor","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"12969","DOI":"10.1021\/acsomega.9b00973","article-title":"Toward Building the Neuromuscular Junction: In Vitro Models to Study Synaptogenesis and Neurodegeneration","volume":"4","author":"Natarajan","year":"2019","journal-title":"ACS Omega"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e34625","DOI":"10.7554\/eLife.34625","article-title":"Motoneuron Wnts regulate neuromuscular junction development","volume":"7","author":"Shen","year":"2018","journal-title":"eLife"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1038\/ncomms4569","article-title":"Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1alpha","volume":"5","author":"Arnold","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/nyas.13472","article-title":"Homeostatic synaptic plasticity at the neuromuscular junction in myasthenia gravis","volume":"1412","author":"Wang","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"105807","DOI":"10.1016\/j.phrs.2021.105807","article-title":"Skeletal muscle atrophy: From mechanisms to treatments","volume":"172","author":"Yin","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ydbio.2011.05.667","article-title":"Muscles in a mouse model of spinal muscular atrophy show profound defects in neuromuscular development even in the absence of failure in neuromuscular transmission or loss of motor neurons","volume":"356","author":"Lee","year":"2011","journal-title":"Dev. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bbagrm.2016.12.008","article-title":"Diverse role of survival motor neuron protein","volume":"1860","author":"Singh","year":"2017","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1093\/hmg\/ddn156","article-title":"Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy","volume":"17","author":"Kariya","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/B978-0-444-63432-0.00024-4","article-title":"Neuromuscular junction disorders","volume":"133","author":"Verschuuren","year":"2016","journal-title":"Handb. Clin. Neurol."},{"key":"ref_65","first-page":"1536","article-title":"Approach to Muscle and Neuromuscular Junction Disorders","volume":"25","author":"Pasnoor","year":"2019","journal-title":"Continuum"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ncl.2018.01.008","article-title":"Lambert-Eaton Myasthenic Syndrome","volume":"36","author":"Kesner","year":"2018","journal-title":"Neurol. Clin."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/j.clinph.2014.06.031","article-title":"Lambert-Eaton myasthenic syndrome\u2014Diagnosis, pathogenesis and therapy","volume":"125","author":"Hulsbrink","year":"2014","journal-title":"Clin. Neurophysiol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Carr, A.S., Cardwell, C.R., McCarron, P.O., and McConville, J. (2010). A systematic review of population based epidemiological studies in Myasthenia Gravis. BMC Neurol., 10.","DOI":"10.1186\/1471-2377-10-46"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fnmol.2020.00086","article-title":"Myasthenia Gravis: From the Viewpoint of Pathogenicity Focusing on Acetylcholine Receptor Clustering, Trans-Synaptic Homeostasis and Synaptic Stability","volume":"13","author":"Takamori","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Dresser, L., Wlodarski, R., Rezania, K., and Soliven, B. (2021). Myasthenia Gravis: Epidemiology, Pathophysiology and Clinical Manifestations. J. Clin. Med., 10.","DOI":"10.3390\/jcm10112235"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.12688\/f1000research.8206.1","article-title":"Pathogenesis of myasthenia gravis: Update on disease types, models, and mechanisms","volume":"5","author":"Phillips","year":"2016","journal-title":"F1000Research"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Koneczny, I., and Herbst, R. (2019). Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture. Cells, 8.","DOI":"10.3390\/cells8070671"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"120494","DOI":"10.1016\/j.jns.2022.120494","article-title":"Motor end-plate analysis to diagnose immune-mediated myasthenia gravis in seronegative patients","volume":"443","author":"Nagaoka","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3389\/fneur.2019.01343","article-title":"The Muscle Is Not a Passive Target in Myasthenia Gravis","volume":"10","author":"Vilquin","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1001\/jamaneurol.2014.4740","article-title":"The Future of Research in Myasthenia","volume":"72","author":"Richman","year":"2015","journal-title":"JAMA Neurol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neurobiolaging.2021.03.005","article-title":"Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function","volume":"104","author":"Iyer","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4103\/1673-5374.290880","article-title":"Possible implications of dysregulated nicotinic acetylcholine receptor diffusion and nanocluster formation in myasthenia gravis","volume":"16","author":"Barrantes","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"293","DOI":"10.12998\/wjcc.v3.i3.293","article-title":"Voltage gated calcium channel antibody-related neurological diseases","volume":"3","author":"Kurne","year":"2015","journal-title":"World J. Clin. Cases"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.4081\/ejtm.2016.5962","article-title":"Clinical Features of Neuromuscular Disorders in Patients with N-Type Voltage-Gated Calcium Channel Antibodies","volume":"26","author":"Totzeck","year":"2016","journal-title":"Eur. J. Transl. Myol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3233\/JND-170257","article-title":"Congenital Myasthenic Syndromes or Inherited Disorders of Neuromuscular Transmission: Recent Discoveries and Open Questions","volume":"4","author":"Nicole","year":"2017","journal-title":"J. Neuromuscul. Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1226194","DOI":"10.3389\/fncel.2023.1226194","article-title":"Neuromuscular recovery from botulism involves multiple forms of compensatory plasticity","volume":"17","author":"Machamer","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"ref_82","first-page":"11","article-title":"The action of batulinum toxin at the neuromuscular junction","volume":"59","author":"Sellin","year":"1981","journal-title":"Med. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0960-9822(02)70662-3","article-title":"Dynamic roles at the neuromuscular junction. Schwann cells","volume":"6","year":"1996","journal-title":"Curr. Biol. CB"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Ko, C.P., and Robitaille, R. (2015). Perisynaptic Schwann Cells at the Neuromuscular Synapse: Adaptable, Multitasking Glial Cells. Cold Spring Harb. Perspect. Biol., 7.","DOI":"10.1101\/cshperspect.a020503"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"fcab081","DOI":"10.1093\/braincomms\/fcab081","article-title":"Terminal Schwann cells at the human neuromuscular junction","volume":"3","author":"Alhindi","year":"2021","journal-title":"Brain Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ncl.2018.01.009","article-title":"Practical Anatomy of the Neuromuscular Junction in Health and Disease","volume":"36","author":"Nishimune","year":"2018","journal-title":"Neurol. Clin."},{"key":"ref_87","unstructured":"Basinger, H., and Hogg, J.P. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Iyer, S.R., Shah, S.B., and Lovering, R.M. (2021). The Neuromuscular Junction: Roles in Aging and Neuromuscular Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158058"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/brv.12675","article-title":"Motor function recovery: Deciphering a regenerative niche at the neuromuscular synapse","volume":"96","author":"Zelada","year":"2021","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"ref_90","first-page":"139","article-title":"Neuromuscular Junction-on-a-Chip for Amyotrophic Lateral Sclerosis Modeling","volume":"2736","author":"Larijani","year":"2024","journal-title":"Methods Mol. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"11695","DOI":"10.1038\/s41598-021-91203-5","article-title":"Bioengineered model of the human motor unit with physiologically functional neuromuscular junctions","volume":"11","author":"Rimington","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_92","unstructured":"Sam, C., and Bordoni, B. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Masugi, Y., Obata, H., Inoue, D., Kawashima, N., and Nakazawa, K. (2017). Neural effects of muscle stretching on the spinal reflexes in multiple lower-limb muscles. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180275"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s00221-019-05536-9","article-title":"Remote muscle contraction enhances spinal reflexes in multiple lower-limb muscles elicited by transcutaneous spinal cord stimulation","volume":"237","author":"Masugi","year":"2019","journal-title":"Exp. Brain Res."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Kuo, I.Y., and Ehrlich, B.E. (2015). Signaling in muscle contraction. Cold Spring Harb. Perspect. Biol., 7.","DOI":"10.1101\/cshperspect.a006023"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2425180","DOI":"10.1155\/2017\/2425180","article-title":"Understanding Neuromuscular System Plasticity to Improve Motor Function in Health, Disease, and Injury","volume":"2017","author":"Yue","year":"2017","journal-title":"Neural Plast."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e57515","DOI":"10.7554\/eLife.57515","article-title":"Acetylcholine in action","volume":"9","author":"Wall","year":"2020","journal-title":"eLife"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"15338","DOI":"10.1038\/s41598-020-72524-3","article-title":"Dynamic regulation of the cholinergic system in the spinal central nervous system","volume":"10","author":"Rima","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Gulino, R., Vicario, N., Giunta, M.A.S., Spoto, G., Calabrese, G., Vecchio, M., Gulisano, M., Leanza, G., and Parenti, R. (2019). Neuromuscular Plasticity in a Mouse Neurotoxic Model of Spinal Motoneuronal Loss. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061500"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1089\/neu.2020.7396","article-title":"Models of Care Delivery from Rehabilitation to Community for Spinal Cord Injury: A Scoping Review","volume":"38","author":"Ho","year":"2021","journal-title":"J. Neurotrauma"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.pmr.2014.05.001","article-title":"Functional electrical stimulation and spinal cord injury","volume":"25","author":"Ho","year":"2014","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1310\/sci1901-1","article-title":"Causes of spinal cord injury","volume":"19","author":"Chen","year":"2013","journal-title":"Top. Spinal Cord Inj. Rehabil."},{"key":"ref_103","unstructured":"Bennett, J., Das, J.M., and Emmady, P.D. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1093\/neuros\/nyw080","article-title":"Traumatic Spinal Cord Injury-Repair and Regeneration","volume":"80","author":"Ahuja","year":"2017","journal-title":"Neurosurgery"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1152\/japplphysiol.00282.2009","article-title":"Neuromuscular transmission failure and muscle fatigue in ankle muscles of the adult rat after spinal cord injury","volume":"107","author":"Lemay","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Rodriguez, G.M., and Gater, D.R. (2022). Neurogenic Bowel and Management after Spinal Cord Injury: A Narrative Review. J. Pers. Med., 12.","DOI":"10.3390\/jpm12071141"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e143771","DOI":"10.1172\/JCI143771","article-title":"Gastrointestinal motility disorders in neurologic disease","volume":"131","author":"Camilleri","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.20529.1","article-title":"Neurogenic bowel dysfunction","volume":"8","author":"Emmanuel","year":"2019","journal-title":"F1000Research"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1310\/sci18-00019","article-title":"Identifying and Classifying Quality of Life Tools for Assessing Neurogenic Bowel Dysfunction after Spinal Cord Injury","volume":"25","author":"Choukou","year":"2019","journal-title":"Top. Spinal Cord Inj. Rehabil."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"113377","DOI":"10.1016\/j.expneurol.2020.113377","article-title":"Diminished enteric neuromuscular transmission in the distal colon following experimental spinal cord injury","volume":"331","author":"White","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-1838(89)90128-8","article-title":"Properties of excitatory junction potentials and currents in smooth muscle cells of the mouse vas deferens","volume":"27","author":"Blakeley","year":"1989","journal-title":"J. Auton Nerv. Syst."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/1874609812666190603165746","article-title":"An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies","volume":"12","author":"Khosa","year":"2019","journal-title":"Curr. Aging Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/BF01262429","article-title":"Ultrastructural studies of young and old mouse neuromuscular junctions","volume":"11","author":"Fahim","year":"1982","journal-title":"J. Neurocytol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s42466-023-00251-x","article-title":"Guideline \u201cMotor neuron diseases\u201d of the German Society of Neurology (Deutsche Gesellschaft fur Neurologie)","volume":"5","author":"Petri","year":"2023","journal-title":"Neurol. Res. Pract."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1007\/s00415-023-11811-1","article-title":"Economic evaluation of Motor Neuron Diseases: A nationwide cross-sectional analysis in Germany","volume":"270","author":"Heinrich","year":"2023","journal-title":"J. Neurol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1093\/hmg\/ddv332","article-title":"Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNDelta7 mouse model of SMA","volume":"24","author":"Iyer","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/hmg\/ddm367","article-title":"Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy","volume":"17","author":"Murray","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Feng, Z., Lam, S., Tenn, E.S., Ghosh, A.S., Cantor, S., Zhang, W., Yen, P.F., Chen, K.S., Burden, S., and Paushkin, S. (2021). Activation of Muscle-Specific Kinase (MuSK) Reduces Neuromuscular Defects in the Delta7 Mouse Model of Spinal Muscular Atrophy (SMA). Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158015"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fnana.2016.00006","article-title":"Neuromuscular Junctions as Key Contributors and Therapeutic Targets in Spinal Muscular Atrophy","volume":"10","author":"Boido","year":"2016","journal-title":"Front. Neuroanat."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Ng, S.Y., and Ljubicic, V. (2020). Recent insights into neuromuscular junction biology in Duchenne muscular dystrophy: Impacts, challenges, and opportunities. EBioMedicine, 61.","DOI":"10.1016\/j.ebiom.2020.103032"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Jones, R.A., Reich, C.D., Dissanayake, K.N., Kristmundsdottir, F., Findlater, G.S., Ribchester, R.R., Simmen, M.W., and Gillingwater, T.H. (2016). NMJ-morph reveals principal components of synaptic morphology influencing structure-function relationships at the neuromuscular junction. Open Biol., 6, Correction in Open Biol. 2017, 7, 160335.","DOI":"10.1098\/rsob.160335"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41598-019-57085-4","article-title":"The effect of NAMPT deletion in projection neurons on the function and structure of neuromuscular junction (NMJ) in mice","volume":"10","author":"Lundt","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s12178-015-9268-9","article-title":"Gene and cell therapy for muscle regeneration","volume":"8","author":"Stilhano","year":"2015","journal-title":"Curr. Rev. Musculoskelet Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"8860","DOI":"10.1523\/JNEUROSCI.0860-18.2018","article-title":"Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4","volume":"38","author":"Zhao","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.freeradbiomed.2014.05.015","article-title":"Caloric restriction and the aging process: A critique","volume":"73","author":"Sohal","year":"2014","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1874609811104030209","article-title":"Motor unit and neuromuscular junction remodeling with aging","volume":"4","author":"Deschenes","year":"2011","journal-title":"Curr. Aging Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.1002220107","article-title":"Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise","volume":"107","author":"Valdez","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fphys.2015.00252","article-title":"Pre- and postsynaptic changes in the neuromuscular junction in dystrophic mice","volume":"6","author":"Pratt","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Limanaqi, F., Busceti, C.L., Biagioni, F., Cantini, F., Lenzi, P., and Fornai, F. (2020). Cell-Clearing Systems Bridging Repeat Expansion Proteotoxicity and Neuromuscular Junction Alterations in ALS and SBMA. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114021"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Lienard, C., Pintart, A., and Bomont, P. (2024). Neuronal Autophagy: Regulations and Implications in Health and Disease. Cells, 13.","DOI":"10.3390\/cells13010103"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.neuron.2022.01.017","article-title":"The different autophagy degradation pathways and neurodegeneration","volume":"110","author":"Fleming","year":"2022","journal-title":"Neuron"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"E8294","DOI":"10.1073\/pnas.1704294114","article-title":"Distinct roles for motor neuron autophagy early and late in the SOD1(G93A) mouse model of ALS","volume":"114","author":"Rudnick","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Sidibe, D.K., Kulkarni, V.V., Dong, A., Herr, J.B., Vogel, M.C., Stempel, M.H., and Maday, S. (2022). Brain-derived neurotrophic factor stimulates the retrograde pathway for axonal autophagy. J. Biol. Chem., 298.","DOI":"10.1101\/2022.08.08.503181"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1196\/annals.1405.016","article-title":"The role of glial cells in the formation and maintenance of the neuromuscular junction","volume":"1132","author":"Feng","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2010.10.007","article-title":"FOXO\/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging","volume":"143","author":"Demontis","year":"2010","journal-title":"Cell"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.2174\/1389450111007011250","article-title":"Skeletal muscle in motor neuron diseases: Therapeutic target and delivery route for potential treatments","volume":"11","author":"Dupuis","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jchemneu.2016.03.003","article-title":"Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis","volume":"76","author":"Clark","year":"2016","journal-title":"J. Chem. Neuroanat."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13041-020-0561-1","article-title":"Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs","volume":"13","author":"Onodera","year":"2020","journal-title":"Mol. Brain"},{"key":"ref_139","first-page":"118","article-title":"Protective effects of long-term lithium administration in a slowly progressive SMA mouse model","volume":"155","author":"Biagioni","year":"2017","journal-title":"Arch Ital Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.neuroscience.2015.06.002","article-title":"Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate","volume":"301","author":"Wang","year":"2015","journal-title":"Neuroscience"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/6\/3520\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:16:56Z","timestamp":1760105816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/6\/3520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,20]]},"references-count":140,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijms25063520"],"URL":"https:\/\/doi.org\/10.3390\/ijms25063520","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,20]]}}}