{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:09:32Z","timestamp":1789139372908,"version":"build-2803163510"},"reference-count":334,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["PID2019-105838RB-C31"],"award-info":[{"award-number":["PID2019-105838RB-C31"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["PLEC2022-009507"],"award-info":[{"award-number":["PLEC2022-009507"]}]},{"name":"State Plan for Scientific and Technical Research and Innovation 2021\u20132023 from the Spanish Ministry of Science and Innovation","award":["PID2019-105838RB-C31"],"award-info":[{"award-number":["PID2019-105838RB-C31"]}]},{"name":"State Plan for Scientific and Technical Research and Innovation 2021\u20132023 from the Spanish Ministry of Science and Innovation","award":["PLEC2022-009507"],"award-info":[{"award-number":["PLEC2022-009507"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The phrase \u201cLet food be thy medicine\u2026\u201d means that food can be a form of medicine and medicine can be a form of food; in other words, that the diet we eat can have a significant impact on our health and well-being. Today, this phrase is gaining prominence as more and more scientific evidence suggests that one\u2019s diet can help prevent and treat disease. A diet rich in fruits, vegetables, whole grains, and lean protein can help reduce the risk of heart disease, cancer, diabetes, and other health problems and, on the other hand, a diet rich in processed foods, added sugars, and saturated fats can increase the risk of the same diseases. Electrophilic compounds in the diet can have a significant impact on our health, and they are molecules that covalently modify cysteine residues present in the thiol-rich Keap1 protein. These compounds bind to Keap1 and activate NRF2, which promotes its translocation to the nucleus and its binding to DNA in the ARE region, triggering the antioxidant response and protecting against oxidative stress. These compounds include polyphenols and flavonoids that are nucleophilic but are converted to electrophilic quinones by metabolic enzymes such as polyphenol oxidases (PPOs) and sulfur compounds present in foods such as the Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) and garlic. This review summarizes our current knowledge on this subject.<\/jats:p>","DOI":"10.3390\/ijms25063521","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:09:36Z","timestamp":1710940176000},"page":"3521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2"],"prefix":"10.3390","volume":"25","author":[{"given":"Celia Mar\u00eda Curieses","family":"Andr\u00e9s","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico Universitario of Valladolid, Avda. de Ram\u00f3n y Cajal, 3, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-5565","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"P\u00e9rez de la Lastra","sequence":"additional","affiliation":[{"name":"Institute of Natural Products and Agrobiology, CSIC-Spanish Research Council, Avda. Astrof\u00edsico Fco. S\u00e1nchez, 3, 38206 La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-9547","authenticated-orcid":false,"given":"Elena","family":"Bustamante Munguira","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario of Valladolid, Avda. de Ram\u00f3n y Cajal, 3, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1583-7439","authenticated-orcid":false,"given":"Celia Andr\u00e9s","family":"Juan","sequence":"additional","affiliation":[{"name":"Cinquima Institute and Department of Organic Chemistry, Faculty of Sciences, Valladolid University, Paseo de Bel\u00e9n, 7, 47011 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-893X","authenticated-orcid":false,"given":"Francisco J.","family":"Plou","sequence":"additional","affiliation":[{"name":"Institute of Catalysis and Petrochemistry, CSIC-Spanish Research Council, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"P\u00e9rez Lebe\u00f1a","sequence":"additional","affiliation":[{"name":"Sistemas de Biotecnolog\u00eda y Recursos Naturales, 47625 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e260","DOI":"10.1016\/j.clnme.2013.10.002","article-title":"Let not thy food be confused with thy medicine: The Hippocratic misquotation","volume":"8","author":"Cardenas","year":"2013","journal-title":"e-SPEN J."},{"key":"ref_2","first-page":"1","article-title":"Diet, nutrition and the prevention of chronic diseases","volume":"916","author":"Who","year":"2003","journal-title":"World Health Organ. 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