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Time-series gene expression and IP biomarker data were generated from \u201cbreachers\u201d exposed to controlled, low-level explosive blast during training. Samples from 30 male participants at pre-, post-, and follow-up blast exposure the next day were assayed via RNA-seq and ELISA. A battery of symptom data was also collected at each of these time points that acutely showed elevated symptom reporting related to headache, concentration, dizziness, and taking longer to think, dissipating ~16 h following blast exposure. Evidence for bacterial translocation into circulation following blast exposure was detected by significant stepwise increase in microbial diversity (measured via alpha-diversity p = 0.049). Alterations in levels of IP protein biomarkers (i.e., Zonulin, LBP, Claudin-3, I-FABP) assessed in a subset of these participants (n = 23) further evidenced blast exposure associates with IP. The observed symptom profile was consistent with mild traumatic brain injury and was further associated with changes in bacterial translocation and intestinal permeability, suggesting that IP may be linked to a decrease in cognitive functioning. These preliminary findings show for the first time within real-world military operational settings that exposures to blast can contribute to IP.<\/jats:p>","DOI":"10.3390\/ijms25063549","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T09:13:08Z","timestamp":1711012388000},"page":"3549","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of Blast Exposure in Military Breaching with Intestinal Permeability Blood Biomarkers Associated with Leaky Gut"],"prefix":"10.3390","volume":"25","author":[{"given":"Qingkun","family":"Liu","sequence":"first","affiliation":[{"name":"James J. Peters VA Medical Center, Bronx, NY 10468, USA"},{"name":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6506-9821","authenticated-orcid":false,"given":"Zhaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"James J. Peters VA Medical Center, Bronx, NY 10468, USA"},{"name":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6962-583X","authenticated-orcid":false,"given":"Shengnan","family":"Sun","sequence":"additional","affiliation":[{"name":"James J. Peters VA Medical Center, Bronx, NY 10468, USA"},{"name":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Nemes","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Rocky Mountain Mental Illness, Research, Education and Clinical Care, Department of Veterans Affairs, Aurora, CO 80045, USA"},{"name":"Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hoisington","sequence":"additional","affiliation":[{"name":"Rocky Mountain Mental Illness, Research, Education and Clinical Care, Department of Veterans Affairs, Aurora, CO 80045, USA"},{"name":"Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA"},{"name":"Department of Systems Engineering and Management, Air Force Institute of Technology, Wright-Patterson Air Force Base, OH 45433, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-7294","authenticated-orcid":false,"given":"Maciej","family":"Skotak","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina R.","family":"LaValle","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Ge","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Carr","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Haghighi","sequence":"additional","affiliation":[{"name":"James J. 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